Thyroglobulin levels and thyroglobulin/thyrotropin ratio could predict the success of the ablative/therapeutic 131I in the differentiated thyroid cancers.

Abstract:

BACKGROUND:Stimulated thyroglobulin (STg) levels in patients with differentiated thyroid carcinomas (DTCs) after total thyroidectomy (TT) and before radioactive iodine (131I) ablation/therapy (RIT) are predictive of therapeutic success but can be influenced by the thyroid-stimulating hormone (TSH) level. OBJECTIVES:This study compared the reliability of the STg/TSH ratio and STg measurement in predicting the success of RIT. METHODS:Sixty-three DTC patients submitted to TT were assessed retrospectively to compare the ability of STg level and the STg/TSH ratio to predict successful RIT. RESULTS:In this study 48 (76.2%) patients had successful RIT. The successful and unsuccessful groups received different 131I doses and had different STg levels and STg/TSH ratios. The STg and STg/TSH ratio cutoff values that predicted successful RIT were 4.41 ng/mL (sensitivity of 86.7% and specificity of 77%) and 0.093 (sensitivity of 80% and specificity of 79.2%), respectively. Age, STg level, STg/TSH ratio, and 131I dose were associated with successful RIT, but after multivariate analysis only STg remained associated (p < 0.05). CONCLUSION:In conclusion, our data suggest that the STg/TSH ratio and measurement of STg are equally reliable in predicting successful RIT in DTC patients.

journal_name

Endocr Res

journal_title

Endocrine research

authors

Trevizam PG,Tagliarini JV,Castilho EC,de Alencar Marques M,Kiy Y,Mazeto GMFS

doi

10.3109/07435800.2016.1173056

subject

Has Abstract

pub_date

2017-02-01 00:00:00

pages

42-48

issue

1

eissn

0743-5800

issn

1532-4206

journal_volume

42

pub_type

杂志文章
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  • Lymph node fine-needle aspiration washout thyroglobulin in papillary thyroid cancer: Diagnostic value and the effect of thyroglobulin antibodies.

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    更新日期:2004-08-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:1995-02-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2004-11-01 00:00:00

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    authors: Faam B,Daneshpour MS,Hedayati M,Halalkhor S,Mansournia MA,Zarkesh M,Azizi F

    更新日期:2014-01-01 00:00:00

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    pub_type: 杂志文章

    doi:10.3109/07435809509030425

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