Abstract:
AIM:To evaluate, retrospectively, the frequency of antithyroid antibodies (ATA) in patients with type 1 diabetes (T1D). MATERIALS AND METHODS:Antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and antithyroid-stimulating hormone receptor antibodies (TSHR-Ab) were determined by enzyme-linked immunosorbent assay. Sera of 312 patients (166 children and 146 adults) with T1D were analyzed. Sera of 276 healthy subjects (87 children and 189 blood donors) served as controls. RESULTS:Out of 312 patients with T1D, 44 (14%) had ATA (TPO-Ab or TG-Ab or TSHR-Ab). The frequency of ATA in patients with T1D was significantly higher than in the control group (14% vs. 2.8%; p<10(-5)). ATA were significantly more frequent in adult patients with T1D than in the blood donor group (20% vs. 1.6%; p<10(-8)). The frequency of ATA in adult patients was significantly higher than in pediatric patients (20% vs. 9%; p=0.006). The frequency of TPO-Ab and TG-Ab was significantly higher in patients with T1D than in the control group (13.5% vs. 2%; p<10(-8) and 7% vs. 2.2%, p=0.008), respectively. Out of 312 patients with T1D, only one had TSHR-Ab. The simultaneous presence of three autoantibodies was found in one patient with T1D. CONCLUSION:ATA were frequent in patients with T1D. Serological screening of autoimmune thyroid disease is suggested in patients with T1D.
journal_name
Endocr Resjournal_title
Endocrine researchauthors
Sakly W,Mankaï A,Achour A,Thabet Y,Ouertani M,Boughammoura L,Harbi A,Chaieb L,Sfar MT,Ghedira Idoi
10.3109/07435800.2011.639318subject
Has Abstractpub_date
2012-01-01 00:00:00pages
59-66issue
2eissn
0743-5800issn
1532-4206journal_volume
37pub_type
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journal_title:Endocrine research
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journal_title:Endocrine research
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doi:10.3109/07435808709035466
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journal_title:Endocrine research
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journal_title:Endocrine research
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pub_type: 临床试验,杂志文章
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journal_title:Endocrine research
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journal_title:Endocrine research
pub_type: 临床试验,杂志文章
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更新日期:2014-01-01 00:00:00
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doi:10.1080/07435808909039099
更新日期:1989-01-01 00:00:00
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journal_title:Endocrine research
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更新日期:1998-08-01 00:00:00
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doi:10.3109/07435800009048616
更新日期:2000-11-01 00:00:00
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journal_title:Endocrine research
pub_type: 杂志文章
doi:10.1081/erc-120037729
更新日期:2004-05-01 00:00:00