Ovine 11 beta-hydroxysteroid dehydrogenase: from gene to function.

abstract：:Neuropeptide Y (NPY) and calcitonin gene-related peptide (CGRP) are both intrapancreatic neuropeptides that are known to inhibit stimulated insulin secretion. In the present study, we examined their influences on basal and stimulated glucagon and insulin secretion in the mouse. Either NPY or CGRP was injected intraven...

journal_title：Endocrine research

authors： Pettersson M,Lundquist I,Ahrén B

更新日期：1987-01-01 00:00:00

abstract：:The determination of DNA ploidy and the study of the cell cycle in adrenocortical tumoral cells could help in the distinction between benign and malignant lesions and also in the prediction of the biological behaviour of these tumors. We analysed 32 cases of adrenal tissue (8 normal adrenals--N, 12 benign adenomas--A ...

journal_title：Endocrine research

authors： Pignatelli D,Leitão D,Maia M,Schmidt F

更新日期：1998-08-01 00:00:00

abstract：:The MA-10 mouse Leydig tumor cell line produces large amounts of steroids only in response to hormonal stimulation while the R2C rat Leydig tumor cell line is constitutively steroidogenic in nature. In an effort to uncover the potential reasons for constitutive steroidogenesis in R2C cells, we have recently shown that...

journal_title：Endocrine research

authors： Rao RM,Jo Y,Babb-Tarbox M,Syapin PJ,Stocco DM

更新日期：2002-11-01 00:00:00

abstract：:The prostate gland of humans and other animals has the unique function of accumulating and secreting extraordinarily high levels of citrate. The prostate secretory epithelial cells synthesize citrate which, due to a limiting mitochondrial (m-) aconitase, accumulates rather than being oxidized. Thus citrate is essentia...

journal_title：Endocrine research

authors： Costello LC,Liu Y,Zou J,Franklin RB

更新日期：2000-02-01 00:00:00

abstract：:Fifteen patients affected by new-onset Graves' disease with ophthalmopathy have been examined for lymphocyte subset phenotypes by two-colour cytometric analysis. CD5+ B cells were significantly increased in comparison to the normal population (43.2 +/- 20.6% versus 19.5 +/- 6.9%; p < 0.0009); total T cells showed a no...

journal_title：Endocrine research

authors： Afeltra A,Paggi A,Ferri GM,Amoroso A,Di Prima MA,Startari S,Faralli AR,Bonomo L

更新日期：1993-03-01 00:00:00

abstract：:We established cell lines from adrenal tumors of transgenic mice harboring the large T-antigen of simian virus 40 under the control of the adrenocortical specific promoter of the scavenger aldose reductase-like akr1b7 gene. Mass spectrometry analyses of serum-supplemented or serum-free culture media showed that ATC1 l...

journal_title：Endocrine research

authors： Ragazzon B,Lefrançois-Martinez AM,Val P,Tournaire C,Berger M,Gachancard-Bouya JL,Bègue RJ,Veyssière G,Martinez A

更新日期：2004-11-01 00:00:00

abstract：:We report a novel mutant of the luteinizing hormone receptor (LHR) in a case of familial Leydig cell hypoplasia and pseudohermaphrotidism. The proband was homozygous for two missense mutations, T1121C and C1175T, causing substitutions I374T and T3921. The molecular effects of the mutations were investigated by heterol...

journal_title：Endocrine research

authors： Pals-Rylaarsdam R,Liu G,Brickman W,Duranteau L,Monroe J,El-Awady MK,Gad YZ,Shenker A

更新日期：2005-01-01 00:00:00

abstract：:A comparative study (n = 20) of serum levels of leutinizing hormone (LH) and testosterone (T) between male trained athletes (high-school students, 16-18 years old) living in North and South Shouna in the Jordan Valley (JV), 320-360 meters below sea level, and those living in Ramtha and Irbid, 550-650 meters above sea ...

journal_title：Endocrine research

authors： Bani Hani I,El-Migdadi F,Shotar A,Abudheese R,Bashir N

更新日期：2001-02-01 00:00:00

abstract：:In the guinea pig adrenal the cells of the outer zone secrete high levels of steroid and respond to ACTH with increased synthesis of cholesterol and steroid. The outer zone consists of two cell types: zona fasciculata (ZF) and zona glomerulosa (ZG). To determine the relative contribution of ZF and ZG to the outer zone...

journal_title：Endocrine research

authors： Brody RI,Black VH

更新日期：1991-01-01 00:00:00

abstract：:Maternal smoking is considered to be a risk factor for low birth weight. It is hypothesized that alteration in leptin concentration may be associated with reduced fetal growth. In this study, we assess the effect of smoking during pregnancy on maternal and neonatal serum leptin concentrations, and also on breast milk ...

journal_title：Endocrine research

authors： Ozkan B,Ermis B,Tastekin A,Doneray H,Yildirim A,Ors R

更新日期：2005-01-01 00:00:00

abstract：:Tumor-promoting phorbol esters are believed to affect cell functions by activating a Ca+2-and lipid-dependent protein kinase (protein kinase C). 12-0-Tetradecanoyl phorbol-13-acetate (TPA) inhibits LH stimulation of progesterone (P) accumulation in rat granulosa cells. To determine the mechanisms by which TPA inhibits...

journal_title：Endocrine research

authors： Kawai Y,Clark MR

更新日期：1986-01-01 00:00:00

abstract：:The sexual dimorphism of life span and caloric restriction effects in numerous species suggest that estradiol (E2) is protective against oxidative damage. The only direct test of E2's protective effect in mice against in vivo oxidative stress to date may have been confounded by E2's direct chemical action as an antiox...

journal_title：Endocrine research

authors： Bokov AF,Ko D,Richardson A

更新日期：2009-01-01 00:00:00

abstract：:The question of whether ethanol's (ETOH's) known suppressive effect on serum luteinizing hormone (LH) could be mediated directly at the anterior pituitary level was addressed by examining the effects of ETOH in vitro on release of LH from cultured male rat pituitary cells. The impact of added ethanol concentrations ra...

journal_title：Endocrine research

authors： Emanuele MA,Tentler J,Emanuele NV,Reda D,Kirsteins L,Lawrence AM

更新日期：1989-01-01 00:00:00

abstract：:Pretreatment of confluent human fibroblast cultures for two days in dexamethasone, serum free medium increased 10-20 fold the sensitivity of the cells to insulin-like growth factor I (IGF I) stimulation of amino acid uptake using the amino acid analog alpha-aminoisobutyric acid (AIB). This increased sensitivity result...

journal_title：Endocrine research

authors： Heath-Monnig E,Daughaday WH

更新日期：1989-01-01 00:00:00

abstract：:Endothelin-1 (ET-1) is involved in adrenal steroid secretion but its cell origin remains unclear. We showed, using RT-PCR the expression of the mRNAs for preproET-1 and ECE-1 in primary cultures of human adrenal cells enriched in glomerulosa cells. Since these expressions could be due to contamination of steroid secre...

journal_title：Endocrine research

authors： Mathieu MN,Hamroun D,Pouzeratte Y,Guérineau NC,Guillon G,Chevillard C

更新日期：1998-08-01 00:00:00

abstract：:Mouse Y1 adrenocortical tumor cells harbor amplified and overexpressed c-Ki-ras gene, displaying relatively high constitutive levels of Ras x GTP. Here we report that Y1 cells also constitutively display high levels of phosphorylated AKT/PKB, that are dependent on Ras x GTP and PI3K. ACTH rapidly causes dephosphorylat...

journal_title：Endocrine research

authors： Forti FL,Armelin HA

更新日期：2000-11-01 00:00:00

abstract：:Islets derived from patients with persistent hyperinsulinemic hypoglycemia of infancy, PHHI, show a significant capacity to proliferate in vitro without the addition of growth factors. However, as with other differentiated cells, PHHI-derived islet cells show a loss of differentiated function with repeated subculture....

journal_title：Endocrine research

authors： Webb M,James RF

更新日期：2005-01-01 00:00:00

abstract：:The present work was to study if the alpha-melanocyte-stimulating hormone (alpha-MSH) was involved in activation of the pituitary-adrenal axis (PAA) in rats. The hormone increased plasma corticosterone (CORT) level, and induced an anxiogenic response as indicated by results from the elevated plus-maze test. Intracereb...

journal_title：Endocrine research

authors： Vecsernyés M,Biró E,Gardi J,Julesz J,Telegdy G

更新日期：2000-08-01 00:00:00

abstract：:The presence of vasoactive intestinal peptide and neuropeptide Y in thyroid nerves and their effects on thyroid blood flow are well known. However, the effects of these two neuropeptides on the various processes involved in thyroid hormone biosynthesis and release have not been fully explored. We have now tested these...

journal_title：Endocrine research

authors： Pietrzyk Z,Michalkiewicz M,Huffman LJ,Hedge GA

更新日期：1992-01-01 00:00:00

abstract：:The Ca2(+)-ATPase of plasma membranes from a variety of tissues is subject to stimulation in vitro, and apparently in vivo, by physiological concentrations of iodothyronines regarded as biologically active in other bioassay systems. This calmodulin-dependent action of thyroid hormone is nongenomic, that is, directly o...

journal_title：Endocrine research

authors： Davis PJ,Davis FB,Lawrence WD

更新日期：1989-01-01 00:00:00

abstract：OBJECTIVE:Some similar factors, such as genetic susceptibility and subinflammation/autoimmunity, contribute to development of both polycystic ovary syndrome (PCOS) and Hashimoto's thyroiditis (HT), suggesting a potential pathogenic link between the two common disorders. In this study, we investigated the relationship b...

journal_title：Endocrine research

authors： Arduc A,Aycicek Dogan B,Bilmez S,Imga Nasiroglu N,Tuna MM,Isik S,Berker D,Guler S

更新日期：2015-01-01 00:00:00

abstract：INTRODUCTION:Impairments in neuroendocrine regulation of food intake and postprandial satiety are leading causes to obesity. Ghrelin peptide is a GI hormone known to increase food intake partly through induction of growth hormone. The regulation of ghrelin production is still unknown. OBJECTIVE:The aim of the current ...

journal_title：Endocrine research

authors： Haddad H,Mroueh M,Faour WH,Daher C

更新日期：2014-01-01 00:00:00

abstract：:Purpose: Testotoxicosis is an autosomal dominant form of limited gonadotropin-independent precocious puberty in boys. It is caused by a heterozygous constitutively activating mutation of the LHCGR gene encoding the luteinizing/hormone receptor (LHR). Some twenty mutations of the LHCGR gene have been reported. Most of ...

journal_title：Endocrine research

authors： Daussac A,Barat P,Servant N,Yacoub M,Missonier S,Lavran F,Gaspari L,Sultan C,Paris F

更新日期：2020-02-01 00:00:00

abstract：AIM:To evaluate, retrospectively, the frequency of antithyroid antibodies (ATA) in patients with type 1 diabetes (T1D). MATERIALS AND METHODS:Antithyroperoxidase antibodies (TPO-Ab), antithyroglobulin antibodies (TG-Ab), and antithyroid-stimulating hormone receptor antibodies (TSHR-Ab) were determined by enzyme-linked...

journal_title：Endocrine research

authors： Sakly W,Mankaï A,Achour A,Thabet Y,Ouertani M,Boughammoura L,Harbi A,Chaieb L,Sfar MT,Ghedira I

更新日期：2012-01-01 00:00:00

abstract：:There is controversy concerning the effects of progestins on bone. Norethindrone acetate (NETA) is synthetic progesterone that also has estrogenic and androgenic effects. We tested its effects on hormone levels, lipids and biochemical markers of bone turnover in postmenopausal women who were on estrogen replacement th...

journal_title：Endocrine research

authors： Onobrakpeya OA,Fall PM,Willard A,Chakravarthi P,Hansen A,Raisz LG

更新日期：2001-11-01 00:00:00

abstract：:CYP17 is not expressed in adult mouse adrenal glands but is expressed in a subset of fetal adrenocortical cells, indicating the potential to produce both corticosterone and cortisol during murine embryogenesis. CYP11A is expressed in the fetal adrenal but also in developing hindgut, which will form the colon, and in c...

journal_title：Endocrine research

authors： Keeney DS

更新日期：1995-02-01 00:00:00

abstract：INTRODUCTION:Adenosine deaminase (ADA), purine nucleoside phosphorylase (PNPase), S-adenosylhomocysteine hydrolase (SAHH), 5'-nucleotidase (5N), and deoxycytidine kinase (dCK) are involved in purine salvage metabolism. Changes of the activities of the above enzymes have been observed in blood cells in patients with imm...

journal_title：Endocrine research

authors： Karbownik M,Zasada K,Wyczechowska D,Lewiński A,Fabianowska-Majewska K

更新日期：2002-08-01 00:00:00

abstract：BACKGROUND:It has been suggested that the changes in hormone levels that occur with menopause and aging are related to loss of muscle mass. However, the role of gonadotropins in this process is unknown. OBJECTIVES:To analyze the relationship between follicle-stimulating hormone (FSH) and luteinizing hormone (LH) and l...

journal_title：Endocrine research

authors： García-Martín A,Reyes-García R,García-Castro JM,Muñoz-Garach A,Escobar-Jiménez F,Muñoz-Torres M

更新日期：2013-08-01 00:00:00

abstract：:X-linked adrenoleukodystrophy (X-ALD) is the most common peroxisomal disorder characterized by abnormal accumulation of saturated very long chain fatty acids in tissues and body fluids with predominance in brain white matter and adrenal cortex. The clinical phenotype is highly variable ranging from the severe childhoo...

journal_title：Endocrine research

authors： Gärtner J,Dehmel T,Klusmann A,Roerig P

更新日期：2002-11-01 00:00:00

abstract：:There are several published reports on the prevalence of low vitamin D levels in otherwise healthy Indian population. Vitamin D deficiency has shown variable effect on muscle performance and strength but there is paucity of data on the effect of vitamin D deficiency on muscle energy metabolism. The present study was p...

journal_title：Endocrine research

authors： Rana P,Marwaha RK,Kumar P,Narang A,Devi MM,Tripathi RP,Khushu S

更新日期：2014-01-01 00:00:00