A novel linear programming approach to fluence map optimization for intensity modulated radiation therapy treatment planning.

abstract：:Recently, deep learning technology has achieved various successes in medical image analysis studies including computer-aided diagnosis (CADx). However, current CADx approaches based on deep learning have a limitation in interpreting diagnostic decisions. The limited interpretability is a major challenge for practical ...

journal_title：Physics in medicine and biology

authors： Kim ST,Lee JH,Lee H,Ro YM

更新日期：2018-12-04 00:00:00

abstract：:A stable cryogel dosimeter was prepared using ferrous benzoic xylenol orange (FBX) in a transparent poly-(vinyl alcohol) (PVA) cryogel matrix. Dose response was evaluated for different numbers of freeze-thaw cycles (FTCs), different concentrations of PVA, and ratios of water/dimethyl sulfoxide. Linear relationships be...

journal_title：Physics in medicine and biology

authors： Eyadeh MM,Farrell TJ,Diamond KR

更新日期：2014-04-07 00:00:00

abstract：:Users of nuclear and atomic data for biomedical purposes often have difficulty in identifying the most up-to-date and appropriate sources of such data. The biomedical Subcommittee of the UK Nuclear Data Committee have prepared a list of recommended data sources available at the beginning of 1978 on radioactive decay s...

journal_title：Physics in medicine and biology

authors： Holt PD

更新日期：1979-01-01 00:00:00

abstract：:It is a challenging problem to resolve and identify drug (or non-specific fluorophore) distribution throughout the whole body of small animals in vivo. In this article, an algorithm of unmixing multispectral fluorescence tomography (MFT) images based on independent component analysis (ICA) is proposed to solve this pr...

journal_title：Physics in medicine and biology

authors： Pu H,Zhang G,He W,Liu F,Guang H,Zhang Y,Bai J,Luo J

更新日期：2014-09-07 00:00:00

abstract：:Backscatter factors for orthovoltage x-ray beams are fitted with the expression BSF = 1 + ms/(s + n), where s is field size and m and n are adjustable parameters. The accuracy is better than 0.5%. Good results were also obtained for Cs-137 gamma rays at depth 0.12 cm and Co-60 gamma rays at depth 0.5 cm using the same...

journal_title：Physics in medicine and biology

authors： Xiao Y,Bjärngard B

更新日期：1998-05-01 00:00:00

abstract：:Acidic drinks and foodstuffs can demineralize dental hard tissues, leading to a pathological condition known as dental erosion, which is of increasing clinical concern. The first step in enamel dissolution is a demineralization of the outer few micrometres of tissue, which results in a softening of the structure. The ...

journal_title：Physics in medicine and biology

authors： Barbour ME,Shellis RP

更新日期：2007-02-21 00:00:00

abstract：:Several applications in nuclear medicine require absolute activity quantification of single photon emission computed tomography images. Obtaining a repeatable calibration factor that converts voxel values to activity units is essential for these applications. Because source preparation and measurement of the source ac...

journal_title：Physics in medicine and biology

authors： Anizan N,Wang H,Zhou XC,Wahl RL,Frey EC

更新日期：2015-02-07 00:00:00

abstract：:Cardiac resynchronization therapy (CRT) is an effective procedure for patients with heart failure but 30% of patients do not respond. This may be due to sub-optimal placement of the left ventricular (LV) lead. It is hypothesized that the use of cardiac anatomy, myocardial scar distribution and dyssynchrony information...

journal_title：Physics in medicine and biology

authors： Ma YL,Shetty AK,Duckett S,Etyngier P,Gijsbers G,Bullens R,Schaeffter T,Razavi R,Rinaldi CA,Rhode KS

更新日期：2012-05-21 00:00:00

abstract：:We report a simulation study on diffuse reflective optical computed tomography, in which continuous-wave sources and detectors are placed on the plane surface of a semi-infinite body. We adopted a simple Tikhonov regularization in the inverse problem and demonstrated the feasibility of three-dimensional reconstruction...

journal_title：Physics in medicine and biology

authors： Endoh R,Suzuki A,Fujii M,Nakayama K

更新日期：2004-05-21 00:00:00

abstract：:The original concept of the echo mechanism in diagnostic medical ultrasound--of step impedance discontinuities--is investigated in terms of the numerical implications of more refined models. The effect of a discontinuity in the attenuation coefficients is found to have as much significance as the impedance discontinui...

journal_title：Physics in medicine and biology

authors： Chivers RC,Santosa F

更新日期：1986-08-01 00:00:00

abstract：:Partial volume effects (PVEs) are consequences of the limited spatial resolution in emission tomography. They lead to a loss of signal in tissues of size similar to the point spread function and induce activity spillover between regions. Although PVE can be corrected for by using algorithms that provide the correct ra...

journal_title：Physics in medicine and biology

authors： Boussion N,Hatt M,Lamare F,Bizais Y,Turzo A,Cheze-Le Rest C,Visvikis D

更新日期：2006-04-07 00:00:00

abstract：:Automatic cell cycle analysis (DNA histograms) is usually performed with flow cytometry. In cases when only few cells are available, the DNA content has to be measured with a fluorescence microscope combined with sensitive camera systems (SIT, MCP, cooled CCDs) and a frame grabber for image analysis. The fluorescent c...

journal_title：Physics in medicine and biology

authors： Böcker W,Gantenberg HW,Müller WU,Streffer C

更新日期：1996-03-01 00:00:00

abstract：:The results of optimization of inverse treatment plans depend on a choice of the objective function. Even when the optimal solution for a given cost function can be obtained, a better solution may exist for a given clinical scenario and it could be obtained with a revised objective function. In the approach presented ...

journal_title：Physics in medicine and biology

authors： Bednarz G,Michalski D,Anne PR,Valicenti RK

更新日期：2004-06-21 00:00:00

abstract：:Changes in the relative biological effectiveness (RBE) of the radiation-induced cell killing of human salivary glands (HSG) were assessed along the Bragg peak of a 60 MeV clinical proton beam by means of coupling biophysical models with the results of Monte Carlo radiation transport simulations and experimental measur...

journal_title：Physics in medicine and biology

authors： Parisi A,Olko P,Swakoń J,Horwacik T,Jabłoński H,Malinowski L,Nowak T,Struelens L,Vanhavere F

更新日期：2020-01-10 00:00:00

abstract：:The purpose of this paper is to evaluate the ability of a prototype Compton camera (CC) to measure prompt gamma rays (PG) emitted during delivery of clinical proton pencil beams for prompt gamma imaging (PGI) as a means of providing in vivo verification of the delivered proton radiotherapy beams. A water phantom was i...

journal_title：Physics in medicine and biology

authors： Polf JC,Avery S,Mackin DS,Beddar S

更新日期：2015-09-21 00:00:00

abstract：:A method of radiation dosimetry is described which is based on the radiation-induced initiation of polymerization of a bulk monomer (e.g. methyl methacrylate) containing a small concentration (about 100 ppm) of a compound which is non-fluorescent but which becomes highly fluorescent when it is incorporated into a grow...

journal_title：Physics in medicine and biology

authors： Warman JM,de Haas MP,Luthjens LH

更新日期：2009-05-21 00:00:00

abstract：:Two dosimetry protocols based on absorbed dose to water have recently been implemented: TG-51 and TRS-398. These protocols use different beam-quality indices: %dd(10)x and TPR20,10. The effect of electron contamination in measurements of %dd(10)x has been proposed as a disadvantage of the TG-51. For actual measurement...

journal_title：Physics in medicine and biology

authors： Lopez Medina A,Teijeiro A,Salvador F,Medal D,Vazquez J,Salgado M,Carrion MC

更新日期：2004-01-07 00:00:00

abstract：:K line x-ray fluorescence (KXRF) measurements of bone lead have emerged as a promising new biological marker of internal lead dose in epidemiological studies. Some disagreements exist, however, over the analysis of data at low levels of bone lead concentration. In this study, we performed 30 serial measurements on eac...

journal_title：Physics in medicine and biology

authors： Kim R,Aro A,Rotnitzky A,Amarasiriwardena C,Hu H

更新日期：1995-09-01 00:00:00

abstract：:Fluorescence molecular tomography (FMT) is widely used in preclinical oncology research. FMT is the only imaging technique able to provide 3D distribution of fluorescent probes within thick highly scattering media. However, its integration into clinical medicine has been hampered by its low spatial resolution caused b...

journal_title：Physics in medicine and biology

authors： Nouizi F,Kwong TC,Ruiz J,Cho J,Chan YW,Ikemura K,Erkol H,Sampathkumaran U,Gulsen G

更新日期：2019-01-22 00:00:00

abstract：:In this note a technique is described for direct aperture optimization of components deliverable by a variable aperture collimator (VAC) for intensity-modulated radiation therapy. The first key result found was that, provided a large number of VAC components were selected for optimization, the resulting fluence profil...

journal_title：Physics in medicine and biology

authors： Webb S

更新日期：2004-03-07 00:00:00

abstract：:Ion chamber dosimetry requires a high degree of precision, at all steps within the dosimetric process, in order to ensure accurate dose measurements. This work presents a novel technique for ion chamber volume determination and quality assurance, using micro-computed tomography (micro-CT). Four nominally identical Exr...

journal_title：Physics in medicine and biology

authors： McNiven AL,Umoh J,Kron T,Holdsworth DW,Battista JJ

更新日期：2008-09-21 00:00:00

abstract：:Earlier work on the dielectric properties of cryoprotectant agents is extended using a modified measuring cell and method of data reduction yielding results more efficiently over a temperature range from -75 to +25 degrees C at frequencies from 27 MHz to 3 GHz. Dimethyl sulphoxide and butanediol are investigated at lo...

journal_title：Physics in medicine and biology

authors： Evans S,bin Azeman A

更新日期：1998-10-01 00:00:00

abstract：:An analytical approximation for the scatter to primary dose ratio (SPR) on the central axis was validated against Monte Carlo results and experimental measurements for homogeneous and inhomogeneous phantoms. The analytical approximation only included first-order Compton scatter. The contribution to the total SPR from ...

journal_title：Physics in medicine and biology

authors： Ozard SR,Grein EE

更新日期：2001-06-01 00:00:00

abstract：:This note describes a simple phantom which can be used to check the long term stability and accuracy of relative attenuation measurements made by near infra-red (NIR) spectrometers. The phantom has been calibrated, and the results of the calibration are shown to agree with theoretical predictions of the relative atten...

journal_title：Physics in medicine and biology

authors： Firbank M,Delpy DT

更新日期：1994-09-01 00:00:00

abstract：:We have developed an impedance magnetocardiogram (IMCG) system to detect the change of magnetic field corresponding to changes in blood volume in the heart. A low magnetic field from the electrical activity of the human heart--the so-called magnetocardiogram (MCG)--can be simultaneously detected by using this system. ...

journal_title：Physics in medicine and biology

authors： Kandori A,Miyashita T,Suzuki D,Yokosawa K,Tsukada K

更新日期：2001-02-01 00:00:00

abstract：:Droplets of liquid perfluorocarbon (PFC) are under study as the next generation of contrast agents for ultrasound (US). These droplets can be selectively vaporized into echogenic gas bubbles in situ by externally applied US, with numerous applications to diagnosis and therapy. However, little is known about the mechan...

journal_title：Physics in medicine and biology

authors： Reznik N,Seo M,Williams R,Bolewska-Pedyczak E,Lee M,Matsuura N,Gariepy J,Foster FS,Burns PN

更新日期：2012-11-07 00:00:00

abstract：:A novel meshless reconstruction algorithm for digital tomosynthesis (DT) is presented and assessed against experimental data. The algorithm does not require a three-dimensional grid or mesh allocation and performs a slice-by-slice reconstruction where each slice position can be chosen at runtime. The methodology is ba...

journal_title：Physics in medicine and biology

authors： Soloviev VY,Renforth KL,Dirckx CJ,Wells SG

更新日期：2020-04-20 00:00:00

abstract：:Respiratory research with mice using micro-computed tomography (micro-CT) has been predominantly hindered by the limited resolution and signal-to-noise ratio (SNR) as a result of respiratory motion artefacts. In this study, we develop a novel technique for capturing the lung microstructure in vivo using micro-CT, thro...

journal_title：Physics in medicine and biology

authors： Namati E,Chon D,Thiesse J,Hoffman EA,de Ryk J,Ross A,McLennan G

更新日期：2006-12-07 00:00:00

abstract：:Lymphedema is a common condition involving an abnormal accumulation of lymphatic fluid in the interstitial space that causes swelling, most often in the arm(s) and leg(s). Lymphedema is a significant lifelong concern that can be congenital or develop following cancer treatment or cancer metastasis. Common methods of e...

journal_title：Physics in medicine and biology

authors： Righetti R,Garra BS,Mobbs LM,Kraemer-Chant CM,Ophir J,Krouskop TA

更新日期：2007-11-07 00:00:00

abstract：:A full-field speckle interferometry method for non-contact and prospectively high speed Photoacoustic Tomography is introduced and evaluated as proof of concept. Thermoelastic pressure induced changes of the objects topography are acquired in a repetitive mode without any physical contact to the object. In order to ob...

journal_title：Physics in medicine and biology

authors： Horstmann J,Spahr H,Buj C,Münter M,Brinkmann R

更新日期：2015-05-21 00:00:00