Modeling the radiation-induced cell death in a therapeutic proton beam using thermoluminescent detectors and radiation transport simulations.

abstract：:Optically stimulated luminescent dosimeters (OSLDs) are becoming increasingly popular for measuring an absorbed dose in clinical radiotherapy. OSLDs have known energy dependence, and this is accounted for by either calibrating the OSLD with a specific nominal energy, or using a standard energy correction factor to acc...

journal_title：Physics in medicine and biology

authors： Scarboro SB,Followill DS,Kerns JR,White RA,Kry SF

更新日期：2012-05-07 00:00:00

abstract：:Effective use of the [Formula: see text] decay chain in targeted internal radioimmunotherapy requires the retention of both [Formula: see text] and progeny isotopes at the target site. Imaging-based pharmacokinetic tests of these pharmaceuticals must therefore separately yet simultaneously image multiple isotopes that...

journal_title：Physics in medicine and biology

authors： Robertson AKH,Ramogida CF,Rodríguez-Rodríguez C,Blinder S,Kunz P,Sossi V,Schaffer P

更新日期：2017-06-07 00:00:00

abstract：:Gold nanoparticles (GNPs) have shown potential in recent years as a means of therapeutic dose enhancement in radiation therapy. However, a major challenge in moving towards clinical implementation is the exact characterisation of the dose enhancement they provide. Monte Carlo studies attempt to explore this property, ...

journal_title：Physics in medicine and biology

authors： Koger B,Kirkby C

更新日期：2016-03-07 00:00:00

abstract：:This study aims to develop and test software for assessing and reporting doses for standard patients undergoing computed tomography (CT) examinations in a 320 detector-row cone-beam scanner. The software, called SimDoseCT, is based on the Monte Carlo (MC) simulation code, which was developed to calculate organ doses a...

journal_title：Physics in medicine and biology

authors： Cros M,Joemai RMS,Geleijns J,Molina D,Salvadó M

更新日期：2017-07-17 00:00:00

abstract：:Computational phantoms are commonly used in internal radiation dosimetry to assess the amount and distribution pattern of energy deposited in various parts of the human body from different internal radiation sources. Radiation dose assessments are commonly performed on predetermined reference computational phantoms wh...

journal_title：Physics in medicine and biology

authors： Xie T,Kuster N,Zaidi H

更新日期：2017-07-13 00:00:00

abstract：:We report on a set of cell survival experiments performed in complex field combinations of therapeutic 12C ion beams. CHO cells were exposed to the superposition of two or three fields of 12C ions arranged in a similar way to real patient treatments. Two-dimensional survival distributions were measured and compared wi...

journal_title：Physics in medicine and biology

authors： Krämer M,Wang JF,Weyrather W

更新日期：2003-07-21 00:00:00

abstract：:Coronary flow rate remains complex to assess in clinical practice using non-invasive, non-ionizing imaging tools. In this study, we introduce 3D ultrafast Doppler coronary angiography (3D UDCA), an ultrasound-based method to assess coronary blood flows in three-dimensions at high volume-rate and in one single heartbea...

journal_title：Physics in medicine and biology

authors： Correia M,Maresca D,Goudot G,Villemain O,Bizé A,Sambin L,Tanter M,Ghaleh B,Pernot M

更新日期：2020-06-05 00:00:00

abstract：:A novel digital x-ray detector has been assembled. The imaging system is based on a phosphor-coated charge-coupled device (CCD) obtained by direct deposition of a gadolinium oxysulphide scintillator onto the detector surface. The modulation transfer function has been measured along the two directions of the digital co...

journal_title：Physics in medicine and biology

authors： Gambaccini M,Taibi A,Del Guerra A,Marziani M,Tuffanelli A

更新日期：1996-12-01 00:00:00

abstract：:In fully three-dimensional PET imaging, iterative image reconstruction techniques usually outperform analytical algorithms in terms of image quality provided that an appropriate system model is used. In this study we concentrate on the calculation of an accurate system model for the YAP-(S)PET II small animal scanner,...

journal_title：Physics in medicine and biology

authors： Cecchetti M,Moehrs S,Belcari N,Del Guerra A

更新日期：2013-10-07 00:00:00

abstract：:A number of radiation-therapy-related uses based on a commercially available spreadsheet program have been developed at our facility. The graphics and display capabilities inherent in these spreadsheet programs allow for concise visual results. The spreadsheets are used as an independent check for several types of rad...

journal_title：Physics in medicine and biology

authors： Balog JP,Sibata CH,Podgorsak MB,Shin KH

更新日期：1995-06-01 00:00:00

abstract：:The low energy model of the GEANT4 Monte Carlo toolkit was used to simulate the energy response of a T.P.A. Mk-II ionization chamber under a variety of different conditions. The sample position resulting in the maximum response along the axial direction of the chamber was obtained. The parameters of the simulation wer...

journal_title：Physics in medicine and biology

authors： Seneviratne MD,Reinhard MI,Baldock C

更新日期：2007-07-07 00:00:00

abstract：:This study investigates the dosimetric impact of using population-based Hounsfield units (HUs) and ICRU-based HUs as a function of the number of tissue segments for bulk density assignment toward MRI-based treatment planning in the abdomen. To avoid potential geometric differences between CT and MR images, CT images r...

journal_title：Physics in medicine and biology

authors： Hsu SH,Zawisza I,O'Grady K,Peng Q,Tomé WA

更新日期：2018-07-24 00:00:00

abstract：:The beam orientation optimization (BOO) problem in intensity modulated radiation therapy (IMRT) treatment planning is a nonlinear problem, and existing methods to obtain solutions to the BOO problem are time consuming due to the complex nature of the objective function and size of the solution space. These issues beco...

journal_title：Physics in medicine and biology

authors： Lee CH,Aleman DM,Sharpe MB

更新日期：2011-09-07 00:00:00

abstract：:Magnetoencephalography (MEG) is a non-invasive functional imaging modality based on the measurement of the external magnetic field produced by neural current sources within the brain. The reconstruction of the underlying sources is a severely ill-posed inverse problem typically tackled using either low-dimensional par...

journal_title：Physics in medicine and biology

authors： Jerbi K,Mosher JC,Baillet S,Leahy RM

更新日期：2002-02-21 00:00:00

abstract：:Biomedical fibre-optic sensors are attractive for the measurement of physical, chemical and biochemical parameters and for spectral measurements directly performed on the patient. An overview of fibre-optic sensors for in vivo monitoring is given, with particular attention paid to the advantages that these sensors are...

journal_title：Physics in medicine and biology

authors： Mignani AG,Baldini F

更新日期：1997-05-01 00:00:00

abstract：:As known, in cancer therapy with ion beams the relative biological effectiveness (RBE) of ions changes in the course of their propagation in tissues. Such changes are caused not only by increasing the linear energy transfer (LET) of beam particles with the penetration depth towards the Bragg peak, but also by nuclear ...

journal_title：Physics in medicine and biology

authors： Dewey S,Burigo L,Pshenichnov I,Mishustin I,Bleicher M

更新日期：2017-06-27 00:00:00

abstract：:Estimation of a set of parameters that describe the geometry of the cone-beam computed tomography system plays an important role in the geometrical calibration. In the calibration process, the helical phantom consisting of spherical markers arranged on a helical trajectory has been widely applied. To directly determin...

journal_title：Physics in medicine and biology

authors： Xu M,Zhang C,Liu X,Li D

更新日期：2014-10-07 00:00:00

abstract：:Source anisotropy is a very important factor in the brachytherapy quality assurance of high-dose rate (HDR) 192Ir afterloading stepping sources. If anisotropy is not taken into account then doses received by a brachytherapy patient in certain directions can be in error by a clinically significant amount. Experimental ...

journal_title：Physics in medicine and biology

authors： Baltas D,Giannouli S,Garbi A,Diakonos F,Geramani K,Ioannidis GT,Tsalpatouros A,Uzunoglu N,Kolotas C,Zamboglou N

更新日期：1998-06-01 00:00:00

abstract：:In recent years, optical techniques based on diffusion approximation have demonstrated their ability to gain rich spectral information about bone. However, these methods normally assume homogeneity, while cancellous bone and marrow form a highly heterogeneous two-phase medium. This paper studies the limitations of thi...

journal_title：Physics in medicine and biology

authors： Margallo-Balbás E,Taroni P,Pifferi A,Koolstra JH,v Ruijven LJ,French PJ

更新日期：2010-09-07 00:00:00

abstract：:Indocyanine green (ICG) is a near-infrared dye that has the potential to be used as a tracer for the minimally invasive measurement of cerebral blood flow (CBF). In order to examine the technique, the arterial and cerebral concentrations of ICG were measured in newborn piglets during the bolus passage of ICG at normoc...

journal_title：Physics in medicine and biology

authors： Springett R,Sakata Y,Delpy DT

更新日期：2001-08-01 00:00:00

abstract：:This paper investigates cone-beam tomography for a wide class of x-ray source trajectories called saddles. In particular, a mathematical analysis of the number of intersections between a saddle and an arbitrary plane is given. This analysis demonstrates that axially truncated cone-beam projections acquired along a sad...

journal_title：Physics in medicine and biology

authors： Pack JD,Noo F,Kudo H

更新日期：2004-06-07 00:00:00

abstract：:EEG interictal epileptiform discharges in temporal lobe epilepsy are associated with magnetic fields. The maxima of magnetic spikes recorded over the spherical portions of the head appear fairly symmetric, whereas those over the lower temporal region often have irregular shapes. Furthermore, their magnitude is often u...

journal_title：Physics in medicine and biology

authors： Rose DF,Sato S,Smith PD,White J

更新日期：1987-01-01 00:00:00

abstract：:The free space method using a pair of lens antennas was modified for the complex permittivity measurement of biological samples from 20 to 110 GHz. Two methodologies were used to obtain the complex permittivities by the free space method, which were based on the reflection and transmission coefficients. The measuremen...

journal_title：Physics in medicine and biology

authors： Sasaki K,Segawa H,Mizuno M,Wake K,Watanabe S,Hashimoto O

更新日期：2013-03-07 00:00:00

abstract：:The purpose of this work was to create a computational platform for studying motion in intensity modulated radiotherapy (IMRT). Specifically, the non-uniform rational B-spline (NURB) cardiac and torso (NCAT) phantom was modified for use in a four-dimensional Monte Carlo (4D-MC) simulation system to investigate the eff...

journal_title：Physics in medicine and biology

authors： McGurk R,Seco J,Riboldi M,Wolfgang J,Segars P,Paganetti H

更新日期：2010-03-07 00:00:00

abstract：:A recent paper proposed a novel technique for determining the total body water (TBW) of patients suffering with abnormal hydration levels, using a resonant cavity perturbation method. Current techniques to measure TBW are limited by resolution and technical constraints. However, this new method involves measuring the ...

journal_title：Physics in medicine and biology

authors： Stone DA,Robinson MP

更新日期：2004-05-07 00:00:00

abstract：:The delivery of volumetric modulated arc therapy (VMAT) requires the simultaneous movement of the linear accelerator gantry, multi-leaf collimators and jaws while the dose rate is varied. In this study, a VMAT delivery emulator was developed to accurately predict the characteristics of a given treatment plan, incorpor...

journal_title：Physics in medicine and biology

authors： Boylan CJ,Rowbottom CG,Mackay RI

更新日期：2011-07-07 00:00:00

abstract：:Using Cherenkov radiation in positron emission tomography (PET) has the potential to improve the time of flight (TOF) resolution and reduce the cost of detectors. In previous studies promising TOF results were achieved when lead fluoride (PbF2) crystals were used instead of a scintillator. In this work, a whole-body P...

journal_title：Physics in medicine and biology

authors： Consuegra D,Korpar S,Križan P,Pestotnik R,Razdevšek G,Dolenec R

更新日期：2020-03-06 00:00:00

abstract：:In multiple plan adaptive radiotherapy (ART) strategies of bladder cancer, a library of plans corresponding to different bladder volumes is created based on images acquired in early treatment sessions. Subsequently, the plan for the smallest PTV safely covering the bladder on cone-beam CT (CBCT) is selected as the pla...

journal_title：Physics in medicine and biology

authors： Chai X,van Herk M,Betgen A,Hulshof M,Bel A

更新日期：2012-06-21 00:00:00

abstract：:The probability of a photon (x-ray, gamma-ray, bremsstrahlung, etc) of a given energy E undergoing absorption or scattering when traversing a layer of material Z can be expressed quantitatively in terms of a linear attenuation coefficient mu (cm(-1)). Since mu is dependent on the material's density, rho (g cm(-3)), wh...

journal_title：Physics in medicine and biology

authors： Hubbell JH

更新日期：1999-01-01 00:00:00

abstract：:This is a proof of principle study on an algorithm for optimizing external beam radiotherapy in terms of both photon beamlet energy and fluence. This simultaneous beamlet energy and fluence optimization is denoted modulated photon radiotherapy (XMRT). XMRT is compared with single-energy intensity modulated radiotherap...

journal_title：Physics in medicine and biology

authors： McGeachy P,Villarreal-Barajas JE,Zinchenko Y,Khan R

更新日期：2016-02-21 00:00:00