Abstract：
:Lymphedema is a common condition involving an abnormal accumulation of lymphatic fluid in the interstitial space that causes swelling, most often in the arm(s) and leg(s). Lymphedema is a significant lifelong concern that can be congenital or develop following cancer treatment or cancer metastasis. Common methods of evaluation of lymphedema are mostly qualitative making it difficult to reliably assess the severity of the disease, a key factor in choosing the appropriate treatment. In this paper, we investigate the feasibility of using novel elastographic techniques to differentiate between lymphedematous and normal tissues. This study represents the first step of a larger study aimed at investigating the combined use of elastographic and sonographic techniques for the detection and staging of lymphedema. In this preliminary study, poroelastographic images were generated from the leg (8) and arm (4) subcutis of five normal volunteers and seven volunteers having lymphedema, and the results were compared using statistical analyses. The preliminary results reported in this paper suggest that it may be feasible to perform poroelastography in different lymphedematous tissues in vivo and that poroelastography techniques may be of help in differentiating between normal and lymphedematous tissues.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Righetti R,Garra BS,Mobbs LM,Kraemer-Chant CM,Ophir J,Krouskop TAdoi
10.1088/0031-9155/52/21/013subject
Has Abstractpub_date
2007-11-07 00:00:00pages
6525-41issue
21eissn
0031-9155issn
1361-6560pii
S0031-9155(07)50396-9journal_volume
52pub_type
杂志文章abstract：:An ESTRO booklet and a report of the Netherlands Commission on Radiation Dosimetry have been published recently describing empirical methods for monitor unit (MU) calculations in symmetrical high-energy photon beams. Both documents support the same basic ideas; firstly the separation of head scatter and volume scatter...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/44/12/310
更新日期：1999-12-01 00:00:00
abstract：:In response to the recognized fragility of reactor-produced (99)Mo supply, direct production of (99m)Tc via (100)Mo(p,2n)(99m)Tc reaction using medical cyclotrons has been investigated. However, due to the existence of other Molybdenum (Mo) isotopes in the target, in parallel with (99m)Tc, other technetium (Tc) radioa...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/61/2/542
更新日期：2016-01-21 00:00:00
abstract：:We examined the reasons for the reduction in response of a multidetector radiation counting system when operated at high count-rates and established a convenient method of correction which is accurate to within +/- 1% up to 0-6 X 10(5) counts per second. In its application the method uses the observed count-rates from...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/21/1/009
更新日期：1976-01-01 00:00:00
abstract：:Respiratory-correlated cone-beam CT (CBCT) not only inhibits rapid scanning due to the slow speed of the LINAC head gantry rotation, but its implementation for routine patient imaging is impractical because of the high radiation dose delivered during the process. Digital tomosynthesis (DTS) is a potentially faster tec...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/ab0d50
更新日期：2019-05-02 00:00:00
abstract：:A micro beam synchrotron x-ray fluorescence (muSRXRF) technique has been used to determine the localization of metals in primary invasive ductal carcinoma of breast. Nine samples were examined, all of which were formalin fixed tissues arranged as micro arrays of 1.0 mm diameter and 10 microm thickness. Cu was the part...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/53/11/018
更新日期：2008-06-07 00:00:00
abstract：:Chronic liver disease (CLD) is currently one of the major causes of death worldwide. If not treated, it may lead to cirrhosis, hepatic carcinoma and death. Ultrasound (US) shear wave elastography (SWE) is a relatively new, popular, non-invasive technique among radiologists. Although many studies have been published va...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/abae06
更新日期：2020-11-05 00:00:00
abstract：:In dynamic renal scintigraphy, the main interest is the radiopharmaceutical redistribution as a function of time. Quality control (QC) of renal procedures often relies on phantom experiments to compare image-based results with the measurement setup. A phantom with a realistic anatomy and time-varying activity distribu...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/58/10/3145
更新日期：2013-05-21 00:00:00
abstract：:This study presents the computational dosimetry of contact currents for grounded and ungrounded human models. The uncertainty of the quasi-static (QS) approximation of the in situ electric field induced in a grounded/ungrounded human body due to the contact current is first estimated. Different scenarios of cylindrica...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/58/15/5153
更新日期：2013-08-07 00:00:00
abstract：:Fixed-pattern noise in electronic portal images (EPIs) is normally eliminated by dividing raw image data by an open-field calibration image (OFCI). However, for successful elimination, there must be exact registration between the two image sets. Any movement within the imaging system, such as that which occurs with ga...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/41/11/007
更新日期：1996-11-01 00:00:00
abstract：:Sparse-view CT reconstruction algorithms via total variation (TV) optimize the data iteratively on the basis of a noise- and artifact-reducing model, resulting in significant radiation dose reduction while maintaining image quality. However, the piecewise constant assumption of TV minimization often leads to the appea...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/59/12/2997
更新日期：2014-06-21 00:00:00
abstract：:The purpose of this research is to develop a 4DCBCT-based dose assessment method for calculating actual delivered dose for patients with significant respiratory motion or anatomical changes during the course of SBRT. To address the limitation of 4DCT-based dose assessment, we propose to calculate the delivered dose us...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/61/2/554
更新日期：2016-01-21 00:00:00
abstract：:The quality of radiation therapy delivered for treating cancer patients is related to set-up errors and organ motion. Due to the margins needed to ensure adequate target coverage, many breast cancer patients have been shown to develop late side effects such as pneumonitis and cardiac damage. Breathing-adapted radiatio...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/50/19/020
更新日期：2005-10-07 00:00:00
abstract：:We present a comparison of simulated low-frequency electromagnetic fields in the human body, calculated by means of the electro-quasistatic formulation. The geometrical data in these simulations were provided by an anatomically realistic, high-resolution human body model, while the dielectric properties of the various...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/50/19/N02
更新日期：2005-10-07 00:00:00
abstract：:Speed of sound (SOS) measurements, typically made using 1 MHz broadband pulses, are increasingly used in the clinical diagnosis of bone disorders. Previous in vitro studies indicate that broadband ultrasound pulses are susceptible to distortion in cancellous bone, leading to imprecise arrival time and SOS measurements...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/45/7/317
更新日期：2000-07-01 00:00:00
abstract：:The design and performance of a dosimetric system for the irradiation of thin biological samples with therapeutic proton beams is reported. Protons with initial energies between 40 MeV and 250 MeV are degraded with polystyrene blocks of variable thickness in order to place the sample, an aqueous layer of 10 microm thi...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/47/3/304
更新日期：2002-02-07 00:00:00
abstract：:A rotary positron-emission computed tomography system has been proposed in which detectors are mounted unequally spaced on a ring, so as to provide fine and uniform linear sampling during a 360 degree rotation of the ring around its centre. The usefulness of a simple iterative method for searching for a suitable arran...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/26/3/011
更新日期：1981-05-01 00:00:00
abstract：:The purpose of this work is to provide an evaluation of the mean glandular dose (MGD) for breast computed tomography (CT) with synchrotron radiation in an axial scanning configuration with a partial or total organ volume irradiation, for the in vivo program of breast CT ongoing at the ELETTRA facility (Trieste, Italy)...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/61/2/569
更新日期：2016-01-21 00:00:00
abstract：:Percutaneous coronary interventions are associated with increased radiation exposure compared to most radiological examinations. This prospective study aimed at (1) measuring entrance doses for all in-room personnel, (2) performing an assessment of patient effective dose and intracoronary doses, (3) investigating the ...
journal_title：Physics in medicine and biology
pub_type： 临床试验,杂志文章
doi：10.1088/0031-9155/48/18/307
更新日期：2003-09-21 00:00:00
abstract：:'Patlak analysis' is a common approach used in Fdopa PET studies to calculate the uptake constant (Ki) of the tracer. It is assumed in the Patlak analysis that the reversible compartment of tissue radioactivity used is in effective equilibrium with the tracer in plasma. Therefore, using the data prior to equilibrium i...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/40/7/007
更新日期：1995-07-01 00:00:00
abstract：:In nonlinear optimisation, using exact Hessian computations (full-Newton) hold superior convergence properties over quasi-Newton methods or gradient-based methods. However, for medium-scale problems, computing the Hessian can be computationally expensive and thus time-consuming. For solvers dedicated to a specific pro...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/ab1e17
更新日期：2019-08-14 00:00:00
abstract：:Quality control (QC) data of radiotherapy linear accelerators, collected by Helsinki University Central Hospital between the years 2000 and 2004, were analysed. The goal was to provide information for the evaluation and elaboration of QC of accelerator outputs and to propose a method for QC data analysis. Short- and l...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/51/14/020
更新日期：2006-07-21 00:00:00
abstract：:Most solid-state detectors, including 3D dosimeters, show lower signal in the Bragg peak than expected, a process termed quenching. The purpose of this study was to investigate how variation in chemical composition of a recently developed radiochromic, silicone-based 3D dosimeter influences the observed quenching in p...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/aa512a
更新日期：2017-02-21 00:00:00
abstract：:In this study, two computational phantoms of the newborn patient were used to assess individual organ doses and effective doses delivered during head, chest, abdomen, pelvis, and torso examinations using the Siemens SOMATOM Sensation 16 helical multi-slice computed tomography (MSCT) scanner. The stylized phantom used ...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/51/20/005
更新日期：2006-10-21 00:00:00
abstract：:An optimized configuration of multi-pinhole aperture can improve the spatial resolution and the sensitivity of pinhole SPECT simultaneously. In this study, an optimization strategy of the multi-pinhole configuration with a small detector is proposed for mouse cardiac imaging. A 14 mm-diameter spherical field-of-view (...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/60/2/473
更新日期：2015-01-21 00:00:00
abstract：:IMRT optimization is an iterative process in which many dose calculations may be necessary. A fast and accurate dose calculation engine is essential for the optimization program to converge to a reliable solution in a reasonable time. Previously we developed a fast dose calculation method for IMRT optimization based o...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/49/19/011
更新日期：2004-10-07 00:00:00
abstract：:The in vivo electric conductivity (σ) values of tissue are essential for accurate electromagnetic simulations and specific absorption rate (SAR) assessment for applications such as thermal dose computations in hyperthermia. Currently used σ-values are mostly based on ex vivo measurements. In this study the conductivit...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/61/4/1596
更新日期：2016-02-21 00:00:00
abstract：:Recent theoretical research on spatiobiologically integrated radiotherapy has focused on optimization models that adapt fluence-maps to the evolution of tumor state, for example, cell densities, as observed in quantitative functional images acquired over the treatment course. We propose an optimization model that adap...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/aab4b6
更新日期：2018-03-27 00:00:00
abstract：:Clinical cerebral blood flow (CBF) maps generated through dynamic- susceptibility contrast (DSC) magnetic resonance (MR) perfusion imaging are currently cross-calibrated with PET studies. The cross-calibration is achieved by rescaling the MR CBF values so that normal white matter CBF corresponds to 22 ml/100 g/min. Ex...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/50/6/014
更新日期：2005-03-21 00:00:00
abstract：:Segmentation of liver in abdominal computed tomography (CT) is an important step for radiation therapy planning of hepatocellular carcinoma. Practically, a fully automatic segmentation of liver remains challenging because of low soft tissue contrast between liver and its surrounding organs, and its highly deformable s...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/1361-6560/aabd19
更新日期：2018-05-04 00:00:00
abstract：:Injection of gas into the eye, followed by face-down positioning, is a common protocol for the reseating of the retina in posterior and superior retinal tears and breaks. The physical mechanism by which injected gas helps reattach retinal flaps is often ascribed to the 'buoyancy' force of the injected gas bubble. The ...
journal_title：Physics in medicine and biology
pub_type： 杂志文章
doi：10.1088/0031-9155/49/13/015
更新日期：2004-07-07 00:00:00
