Adaptive treatment-length optimization in spatiobiologically integrated radiotherapy.

abstract：:The measurement of output factors (OF) for the small photon beams generated by Leksell Gamma Knife® (LGK) radiotherapy units is a challenge for the physicist due to the under or over estimation of these factors by a vast majority of the detectors commercially available. Output correction factors, introduced in the int...

journal_title：Physics in medicine and biology

authors： Benmakhlouf H,Johansson J,Paddick I,Andreo P

更新日期：2015-05-21 00:00:00

abstract：:In this paper, we investigate an off-line strategy to incorporate inter-fraction organ motion in IMRT treatment planning. It was suggested that inverse planning could be based on a probability distribution of patient geometries instead of a single snap shot. However, this concept is connected to two intrinsic problems...

journal_title：Physics in medicine and biology

authors： Unkelbach J,Oelfke U

更新日期：2004-09-07 00:00:00

abstract：:Kilo-voltage (KV) cone-beam computed tomography (CBCT) unit mounted onto a linear accelerator treatment system, often referred to as on-board imager (OBI), plays an increasingly important role in image-guided radiation therapy. While the FDK algorithm is currently used for reconstructing images from clinical OBI data,...

journal_title：Physics in medicine and biology

authors： Han X,Pearson E,Pelizzari C,Al-Hallaq H,Sidky EY,Bian J,Pan X

更新日期：2015-06-21 00:00:00

abstract：:Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. Previous work has investigated the accuracy of a deterministic linear...

journal_title：Physics in medicine and biology

authors： Zelyak O,Fallone BG,St-Aubin J

更新日期：2017-12-14 00:00:00

abstract：:This paper presents two methods for absorbed dose determination with ionization chambers at short distance from 60Co and 192Ir brachytherapy sources. The methods are modifications of the Bragg-Gray and large cavity principles given in the IAEA code of practice for high- and medium-energy photon beams. A non-uniformity...

journal_title：Physics in medicine and biology

authors： Tölli H,Johansson KA

更新日期：1998-11-01 00:00:00

abstract：:Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the experiments which have, so far, been done to test them. In problems directly sensiti...

journal_title：Physics in medicine and biology

authors： Makarova A,Gottschalk B,Sauerwein W

更新日期：2017-07-06 00:00:00

abstract：:Recent research has suggested that endothelialization of vascular stents is crucial to reducing the risk of late stent thrombosis. With a resolution of approximately 10 microm, optical coherence tomography (OCT) may be an appropriate imaging modality for visualizing the vascular response to a stent and measuring the p...

journal_title：Physics in medicine and biology

authors： Bonnema GT,Cardinal KO,Williams SK,Barton JK

更新日期：2008-06-21 00:00:00

abstract：:The aim of this study was to develop a model exploiting artificial neural networks (ANNs) to correlate dosimetric and clinical variables with late rectal bleeding in prostate cancer patients undergoing radical radiotherapy and to compare the ANN results with those of a standard logistic regression (LR) analysis. 718 m...

journal_title：Physics in medicine and biology

authors： Tomatis S,Rancati T,Fiorino C,Vavassori V,Fellin G,Cagna E,Mauro FA,Girelli G,Monti A,Baccolini M,Naldi G,Bianchi C,Menegotti L,Pasquino M,Stasi M,Valdagni R

更新日期：2012-03-07 00:00:00

abstract：:Beta emitting 106Ru-applicators are used to treat choroidal melanoma. In order to improve the accuracy and simplify the dosimetry of these applicators, the suitability of using a p-type silicon semiconductor detector has been investigated. The detector is calibrated in a low energy electron beam. An important property...

journal_title：Physics in medicine and biology

authors： Lax I

更新日期：1991-07-01 00:00:00

abstract：:The automatic calibration in Fourier-domain optical coherence tomography (FD-OCT) systems allows for high resolution imaging with precise depth ranging functionality in many complex imaging scenarios, such as microsurgery. However, the accuracy and speed of the existing automatic schemes are limited due to the functio...

journal_title：Physics in medicine and biology

authors： Ratheesh KM,Seah LK,Murukeshan VM

更新日期：2016-11-07 00:00:00

abstract：:In order to analyse the respective roles of ion concentration and fractional volume of the interstitial compartment as determinants of the impedance, Z, of renal medullary tissue, a model was needed in which both these factors could be varied independently. An array of blood cell suspensions ions in saline (different ...

journal_title：Physics in medicine and biology

authors： Niewiadomski W,Sadowski J,Badzyńska B,Rasmussen SN

更新日期：1990-11-01 00:00:00

abstract：:The goal of this study was to assess the impact of set-up uncertainty on compliance with the objectives and constraints of an intensity modulated radiation therapy protocol for early stage cancer of the oropharynx. As the convolution approach to the quantitative study of set-up uncertainties cannot accommodate either ...

journal_title：Physics in medicine and biology

authors： Ploquin N,Song W,Lau H,Dunscombe P

更新日期：2005-08-07 00:00:00

abstract：BACKGROUND:During transcranial electrical stimulation (tES), including transcranial direct current stimulation (tDCS) and transcranial alternating current stimulation (tACS), current density concentration around the electrode edges that is predicted by simplistic skin models does not match experimental observations of ...

journal_title：Physics in medicine and biology

authors： Khadka N,Bikson M

更新日期：2020-09-11 00:00:00

abstract：:A new class of dose calibrator called a micro-dose calibrator, designed to measure radioactivity rates in the range between 1 kBq up to 370 kBq, has been designed and an 8 NaI(Tl)/photo multiplier tube (PMT) module prototype built to evaluate its performance. The design of the micro-dose calibrator is based on the con...

journal_title：Physics in medicine and biology

authors： Adler S,Choyke P

更新日期：2018-09-10 00:00:00

abstract：:Four-dimensional volumetric modulated arc therapy (4D VMAT) is a treatment strategy for lung cancers that aims to exploit relative target and tissue motion to improve organ at risk (OAR) sparing. The algorithm incorporates the entire patient respiratory cycle using 4D CT data into the optimization process. Resulting t...

journal_title：Physics in medicine and biology

authors： Chin E,Loewen SK,Nichol A,Otto K

更新日期：2013-02-21 00:00:00

abstract：:Although radionuclide therapy has been around for a long time, this modality of cancer treatment has been limited mainly to the use of [32P]-phosphate and [131I]-sodium iodide. The last few years, however, have seen an increased interest in this area due to new developments of radionuclides and carrier molecules that ...

journal_title：Physics in medicine and biology

authors： Zweit J

更新日期：1996-10-01 00:00:00

abstract：:Dynamic modulation can be affected by inaccuracies when the required acceleration is larger than the highest allowed by the mechanical characteristics of the whole apparatus. In this study, inertia effects have been investigated with regard to the single absorber 1D modulation, analysing primarily how the acceleration...

journal_title：Physics in medicine and biology

authors： Corletto D,Broggi S,Fiorino C,Mangili P,Calandrino R,Lev A,Gennari D,Rudello F

更新日期：1999-11-01 00:00:00

abstract：:Backscatter factors for orthovoltage x-ray beams are fitted with the expression BSF = 1 + ms/(s + n), where s is field size and m and n are adjustable parameters. The accuracy is better than 0.5%. Good results were also obtained for Cs-137 gamma rays at depth 0.12 cm and Co-60 gamma rays at depth 0.5 cm using the same...

journal_title：Physics in medicine and biology

authors： Xiao Y,Bjärngard B

更新日期：1998-05-01 00:00:00

abstract：:The interest in positron emission tomography (PET) and particularly in hybrid integrated PET/CT systems has significantly increased in the last few years due to the improved quality of the obtained images. Nevertheless, one of the most important limits of the PET imaging technique is still its poor spatial resolution ...

journal_title：Physics in medicine and biology

authors： Rapisarda E,Bettinardi V,Thielemans K,Gilardi MC

更新日期：2010-07-21 00:00:00

abstract：:This work applies a previously developed analytical algorithm to the reconstruction problem in a rotating multi-segment slant-hole (RMSSH) SPECT system. The RMSSH collimator has greater detection efficiency than the parallel-hole collimator with comparable spatial resolution at the expense of limited common volume-of-...

journal_title：Physics in medicine and biology

authors： Huang Q,Xu J,Tsui BM,Gullberg GT

更新日期：2009-07-07 00:00:00

abstract：:DMSA imaging is carried out in nuclear medicine to assess the level of functional renal tissue in patients. This study investigated the use of an artificial neural network to perform diagnostic classification of these scans. Using the radiological report as the gold standard, the network was trained to classify DMSA s...

journal_title：Physics in medicine and biology

authors： Wright JW,Duguid R,McKiddie F,Staff RT

更新日期：2014-04-07 00:00:00

abstract：:We show how the spectral imaging framework should be modified to account for a high fraction of Compton interactions in low Z detector materials such as silicon. Using this framework, where deposited energies differ from actual photon energies, we compare the performance of a silicon strip detector, including the infl...

journal_title：Physics in medicine and biology

authors： Bornefalk H,Danielsson M

更新日期：2010-04-07 00:00:00

abstract：:Images of the human retina are routinely used in clinical practice for the diagnosis and management of eye disease. Increased permeability of retinal blood vessels, which is a clinically significant feature, can be visualized with a process known as fluorescein angiography as leakage of fluorescence dye into the surro...

journal_title：Physics in medicine and biology

authors： Cree MJ,Olson JA,McHardy KC,Sharp PF,Forrester JV

更新日期：1999-01-01 00:00:00

abstract：:An expression for the noise power spectrum of images reconstructed by the discrete filtered backprojection algorithm has been derived. The formulation explicitly includes sampling within the projections, angular sampling, and the two-dimensional sampling implicit in the discrete representation of the image. The effect...

journal_title：Physics in medicine and biology

authors： Kijewski MF,Judy PF

更新日期：1987-05-01 00:00:00

abstract：:Clinical studies have established a strong benefit from adjuvant mild hyperthermia (HT) to radio- and chemotherapy for many tumor sites, including the head and neck (H&N). The recently developed HYPERcollar allows the application of local radiofrequency HT to tumors in the entire H&N. Treatment quality is optimized us...

journal_title：Physics in medicine and biology

authors： Paulides MM,Bakker JF,Hofstetter LW,Numan WC,Pellicer R,Fiveland EW,Tarasek M,Houston GC,van Rhoon GC,Yeo DT,Kotek G

更新日期：2014-05-07 00:00:00

abstract：:This work compared the impact of x-ray tube performance and automatic dose rate control (ADRC) parameter selection on system imaging efficiency of two Siemens angiography systems: a Siemens Megalix x-ray tube installed on an Artis Zee system (denoted 'MEGALIX') and a newer generation Gigalix x-ray tube installed on an...

journal_title：Physics in medicine and biology

authors： Dehairs M,Bosmans H,Marshall NW

更新日期：2020-11-24 00:00:00

abstract：:Magnetic resonance and ultrasound elastography techniques are now important tools for staging high-grade fibrosis in patients with chronic liver disease. However, uncertainty remains about the effects of simple accumulation of fat (steatosis) and inflammation (steatohepatitis) on the parameters that can be measured us...

journal_title：Physics in medicine and biology

authors： Parker KJ,Ormachea J,Drage MG,Kim H,Hah Z

更新日期：2018-05-17 00:00:00

abstract：:Ultrasoft x-rays of 0.3-5 keV have provided a unique tool for the investigation of intracellular mechanisms of radiation action in biological organisms, including mammalian cells. However, their use presents unique practical problems in dosimetry and experimental design. Detailed interpretation of the biological resul...

journal_title：Physics in medicine and biology

authors： Hoshi M,Goodhead DT,Brenner DJ,Bance DA,Chmielewski JJ,Paciotti MA,Bradbury JN

更新日期：1985-10-01 00:00:00

abstract：:The bone suppression technique based on advanced image processing can suppress the conspicuity of bones on chest radiographs, creating soft tissue images obtained by the dual-energy subtraction technique. This study was performed to evaluate the usefulness of bone suppression image processing in image-guided radiation...

journal_title：Physics in medicine and biology

authors： Tanaka R,Sanada S,Sakuta K,Kawashima H

更新日期：2015-05-21 00:00:00

abstract：:The trend towards conformal, intensity modulated radiotherapy treatments has established the need for a true integrating dosimeter. In traditional radiotherapy, radiographic film dosimetry is commonly used. The accuracy and reproducibility of film optical density as an indicator of dose is influenced by several variab...

journal_title：Physics in medicine and biology

authors： Suchowerska N,Hoban P,Butson M,Davison A,Metcalfe P

更新日期：2001-05-01 00:00:00