Imaging of prompt gamma rays emitted during delivery of clinical proton beams with a Compton camera: feasibility studies for range verification.

Abstract:

:The purpose of this paper is to evaluate the ability of a prototype Compton camera (CC) to measure prompt gamma rays (PG) emitted during delivery of clinical proton pencil beams for prompt gamma imaging (PGI) as a means of providing in vivo verification of the delivered proton radiotherapy beams. A water phantom was irradiated with clinical 114 MeV and 150 MeV proton pencil beams. Up to 500 cGy of dose was delivered per irradiation using clinical beam currents. The prototype CC was placed 15 cm from the beam central axis and PGs from 0.2 MeV up to 6.5 MeV were measured during irradiation. From the measured data (2D) images of the PG emission were reconstructed. (1D) profiles were extracted from the PG images and compared to measured depth dose curves of the delivered proton pencil beams. The CC was able to measure PG emission during delivery of both 114 MeV and 150 MeV proton beams at clinical beam currents. 2D images of the PG emission were reconstructed for single 150 MeV proton pencil beams as well as for a 5   ×   5 cm mono-energetic layer of 114 MeV pencil beams. Shifts in the Bragg peak (BP) range were detectable on the 2D images. 1D profiles extracted from the PG images show that the distal falloff of the PG emission profile lined up well with the distal BP falloff. Shifts as small as 3 mm in the beam range could be detected from the 1D PG profiles with an accuracy of 1.5 mm or better. However, with the current CC prototype, a dose of 400 cGy was required to acquire adequate PG signal for 2D PG image reconstruction. It was possible to measure PG interactions with our prototype CC during delivery of proton pencil beams at clinical dose rates. Images of the PG emission could be reconstructed and shifts in the BP range were detectable. Therefore PGI with a CC for in vivo range verification during proton treatment delivery is feasible. However, improvements in the prototype CC detection efficiency and reconstruction algorithms are necessary to make it a clinically viable PGI system.

journal_name

Phys Med Biol

authors

Polf JC,Avery S,Mackin DS,Beddar S

doi

10.1088/0031-9155/60/18/7085

subject

Has Abstract

pub_date

2015-09-21 00:00:00

pages

7085-99

issue

18

eissn

0031-9155

issn

1361-6560

journal_volume

60

pub_type

杂志文章
  • Dosimetry robustness with stochastic optimization.

    abstract::All radiation therapy treatment planning relies on accurate dose calculation. Uncertainties in dosimetric prediction can significantly degrade an otherwise optimal plan. In this work, we introduce a robust optimization method which handles dosimetric errors and warrants for high-quality IMRT plans. Unlike other dose e...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/11/010

    authors: Nohadani O,Seco J,Martin BC,Bortfeld T

    更新日期:2009-06-07 00:00:00

  • Estimation of tissue resistivities from multiple-electrode impedance measurements.

    abstract::In order to measure in vivo resistivity of tissues in the thorax, the possibility of combining anatomical data extracted from high-resolution images with multiple-electrode impedance measurements, a priori knowledge of the range of tissue resistivities, and a priori data on the instrumentation noise is assessed in thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/1/001

    authors: Eyüboğlu BM,Pilkington TC,Wolf PD

    更新日期:1994-01-01 00:00:00

  • The impact of calibration phantom errors on dual-energy digital mammography.

    abstract::Microcalcification is one of the earliest and main indicators of breast cancer. Because dual-energy digital mammography could suppress the contrast between the adipose and glandular tissues of the breast, it is considered a promising technique that will improve the detection of microcalcification. In dual-energy digit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/22/004

    authors: Mou X,Chen X,Sun L,Yu H,Ji Z,Zhang L

    更新日期:2008-11-21 00:00:00

  • Dose error analysis for a scanned proton beam delivery system.

    abstract::All particle beam scanning systems are subject to dose delivery errors due to errors in position, energy and intensity of the delivered beam. In addition, finite scan speeds, beam spill non-uniformities, and delays in detector, detector electronics and magnet responses will all contribute errors in delivery. In this p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/23/S09

    authors: Coutrakon G,Wang N,Miller DW,Yang Y

    更新日期:2010-12-07 00:00:00

  • Experimental verification of numerical simulations of cryosurgery with application to computerized planning.

    abstract::As a part of an ongoing effort to develop computerized planning tools for cryosurgery, an experimental study has been conducted to verify a recently developed numerical technique for bioheat transfer simulations. Experiments were performed on gelatin solution as a phantom material, using proprietary liquid-nitrogen cr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/15/013

    authors: Rossi MR,Rabin Y

    更新日期:2007-08-07 00:00:00

  • Quantitative validation of the 3D SAR profile of hyperthermia applicators using the gamma method.

    abstract::For quality assurance of hyperthermia treatment planning systems, quantitative validation of the electromagnetic model of an applicator is essential. The objective of this study was to validate a finite-difference time-domain (FDTD) model implementation of the Lucite cone applicator (LCA) for superficial hyperthermia....

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/11/010

    authors: de Bruijne M,Samaras T,Chavannes N,van Rhoon GC

    更新日期:2007-06-07 00:00:00

  • A 3D reconstruction algorithm for magneto-acoustic tomography with magnetic induction based on ultrasound transducer characteristics.

    abstract::In this study we present a three-dimensional (3D) reconstruction algorithm for magneto-acoustic tomography with magnetic induction (MAT-MI) based on the characteristics of the ultrasound transducer. The algorithm is investigated to solve the blur problem of the MAT-MI acoustic source image, which is caused by the ultr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/61/24/8762

    authors: Ma R,Zhou X,Zhang S,Yin T,Liu Z

    更新日期:2016-12-21 00:00:00

  • Volume estimation of low-contrast lesions with CT: a comparison of performances from a phantom study, simulations and theoretical analysis.

    abstract::Measurements of lung nodule volume with multi-detector computed tomography (MDCT) have been shown to be more accurate and precise compared to conventional lower dimensional measurements. Quantifying the size of lesions is potentially more difficult when the object-to-background contrast is low as with lesions in the l...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/2/671

    authors: Li Q,Gavrielides MA,Zeng R,Myers KJ,Sahiner B,Petrick N

    更新日期:2015-01-21 00:00:00

  • Strategies to improve 3D whole-body PET image reconstruction.

    abstract::An algorithm is described for three-dimensional whole-body (3DWB) image reconstruction in positron emission tomography. For whole-body applications, improvements to the popular fixed-axial-acceptance-angle technique are achieved by combining axially adjacent projection data available with a long-axis data set. Time-co...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/8/013

    authors: Cutler PD,Xu M

    更新日期:1996-08-01 00:00:00

  • Learning image based surrogate relevance criterion for atlas selection in segmentation.

    abstract::Picking geometrically relevant atlases from the whole training set is crucial to multi-atlas based image segmentation, especially with extensive data of heterogeneous quality in the Big Data era. Unfortunately, there is very limited understanding of how currently used image similarity criteria reveal geometric relevan...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/11/4223

    authors: Zhao T,Ruan D

    更新日期:2016-06-07 00:00:00

  • Validation of the SimSET simulation package for modeling the Siemens Biograph mCT PET scanner.

    abstract::Monte Carlo simulation provides a valuable tool in performance assessment and optimization of system design parameters for PET scanners. SimSET is a popular Monte Carlo simulation toolkit that features fast simulation time, as well as variance reduction tools to further enhance computational efficiency. However, SimSE...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/3/N35

    authors: Poon JK,Dahlbom ML,Casey ME,Qi J,Cherry SR,Badawi RD

    更新日期:2015-02-07 00:00:00

  • Monte Carlo modelling of electron beams from medical accelerators.

    abstract::Monte Carlo simulation of radiation transport is considered to be one of the most accurate methods of radiation therapy dose calculation. With the rapid development of computer technology, Monte Carlo based treatment planning for radiation therapy is becoming practical. A basic requirement for Monte Carlo treatment pl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/0031-9155/44/12/201

    authors: Ma CM,Jiang SB

    更新日期:1999-12-01 00:00:00

  • The utilization of consistency metrics for error analysis in deformable image registration.

    abstract::The aim of this study was to investigate the utility of consistency metrics, such as inverse consistency, in contour-based deformable registration error analysis. Four images were acquired of the same phantom that has experienced varying levels of deformation. The deformations were simulated with deformable image regi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/18/014

    authors: Bender ET,Tomé WA

    更新日期:2009-09-21 00:00:00

  • Comparison of two respiration monitoring systems for 4D imaging with a Siemens CT using a new dynamic breathing phantom.

    abstract::Four-dimensional computed tomography (4D-CT) requires breathing information from the patient, and for this, several systems are available. Testing of these systems, under realistic conditions, requires a phantom with a moving target and an expandable outer contour. An anthropomorphic phantom was developed to simulate ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/9/N131

    authors: Vásquez AC,Runz A,Echner G,Sroka-Perez G,Karger CP

    更新日期:2012-05-07 00:00:00

  • Physical characteristics of the ECAT EXACT3D positron tomograph.

    abstract::The 'EXACT3D' positron tomograph, which is now in routine clinical research use, was developed with the aim of achieving unprecedented sensitivity, high spatial and temporal resolution and simplicity of design using proven detector technology. It consists of six rings of standard detector blocks (CTI/Siemens EXACT HR+...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/9/313

    authors: Spinks TJ,Jones T,Bloomfield PM,Bailey DL,Miller M,Hogg D,Jones WF,Vaigneur K,Reed J,Young J,Newport D,Moyers C,Casey ME,Nutt R

    更新日期:2000-09-01 00:00:00

  • Relative determination of W-values for alpha particles in tissue-equivalent and other gases.

    abstract::W (the average energy to form an ion pair) for 5.4 MeV 241Am alpha particles in a Rossi-type tissue-equivalent (TE) gas, argon and methane was determined to an accuracy better than 0.2% using a new automated data handling system. A vibrating reed electrometer and current digitiser were used to measure the current prod...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/2/005

    authors: Krieger GL,Baum JW,Varma MN,Beach JL

    更新日期:1979-03-01 00:00:00

  • Visually interpretable deep network for diagnosis of breast masses on mammograms.

    abstract::Recently, deep learning technology has achieved various successes in medical image analysis studies including computer-aided diagnosis (CADx). However, current CADx approaches based on deep learning have a limitation in interpreting diagnostic decisions. The limited interpretability is a major challenge for practical ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaef0a

    authors: Kim ST,Lee JH,Lee H,Ro YM

    更新日期:2018-12-04 00:00:00

  • A method for acquiring random range uncertainty probability distributions in proton therapy.

    abstract::In treatment planning we depend upon accurate knowledge of geometric and range uncertainties. If the uncertainty model is inaccurate then the plan will produce under-dosing of the target and/or overdosing of OAR. We aim to provide a method for which centre and site-specific population range uncertainty due to inter-fr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa9502

    authors: Holloway SM,Holloway MD,Thomas SJ

    更新日期:2017-12-19 00:00:00

  • Modelling of the dielectric properties of normal and irradiated skin.

    abstract::We have shown that irradiation changes the dielectric properties of human skin at radiofrequencies. Both the dielectric constant and the conductivity of the irradiated skin decrease, especially at low frequencies. The experimental data were analysed using two bioelectric models. Relevant dielectric parameters were det...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/6/001

    authors: Tamura T,Tenhunen M,Lahtinen T,Repo T,Schwan HP

    更新日期:1994-06-01 00:00:00

  • Computational dosimetry for grounded and ungrounded human models due to contact current.

    abstract::This study presents the computational dosimetry of contact currents for grounded and ungrounded human models. The uncertainty of the quasi-static (QS) approximation of the in situ electric field induced in a grounded/ungrounded human body due to the contact current is first estimated. Different scenarios of cylindrica...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/15/5153

    authors: Chan KH,Hattori J,Laakso I,Hirata A,Taki M

    更新日期:2013-08-07 00:00:00

  • An optimized leaf-setting algorithm for beam intensity modulation using dynamic multileaf collimators.

    abstract::A leaf-setting algorithm is developed for generating arbitrary beam intensity profiles in discrete levels using dynamic multileaf collimators (DMLCs). The algorithm starts with the algebraic expression for the area under the beam profile. It is shown that the coefficients in this expression can be transformed into the...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/6/019

    authors: Ma L,Boyer AL,Xing L,Ma CM

    更新日期:1998-06-01 00:00:00

  • Real-time tracking of tumor motions and deformations along the leaf travel direction with the aid of a synchronized dynamic MLC leaf sequencer.

    abstract::Advanced radiotherapeutical techniques like intensity-modulated radiation therapy (IMRT) are based on an accurate knowledge of the location of the radiation target. An accurate dose delivery, therefore, requires a method to account for the inter- and intrafractional target motion and the target deformation occurring d...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/22/N01

    authors: Tacke M,Nill S,Oelfke U

    更新日期:2007-11-21 00:00:00

  • Quantitative x-ray dark-field computed tomography.

    abstract::The basic principles of x-ray image formation in radiology have remained essentially unchanged since Röntgen first discovered x-rays over a hundred years ago. The conventional approach relies on x-ray attenuation as the sole source of contrast and draws exclusively on ray or geometrical optics to describe and interpre...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/18/017

    authors: Bech M,Bunk O,Donath T,Feidenhans'l R,David C,Pfeiffer F

    更新日期:2010-09-21 00:00:00

  • A theoretical comparison of energy sources--microwave, ultrasound and laser--for interstitial thermal therapy.

    abstract::A number of heating sources are available for minimally invasive thermal therapy of tumours. The purpose of this work was to compare, theoretically, the heating characteristics of interstitial microwave, laser and ultrasound sources in three tissue sites: breast, brain and liver. Using a numerical method, the heating ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/12/011

    authors: Skinner MG,Iizuka MN,Kolios MC,Sherar MD

    更新日期:1998-12-01 00:00:00

  • The dosimetry for a coronary artery stent coated with radioactive 188Re and 32P.

    abstract::Radiation dose distributions have been calculated for 188Re and 32P activity on a coronary artery stent. The doses have been calculated both as a function of position along the stent and of depth into the artery wall. Comparisons of the dose from identical activities of 188Re and 32P on the stent show that the major d...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/12/310

    authors: Fox RA,Henson PW

    更新日期:2000-12-01 00:00:00

  • Pre- and post-natal exposure of children to EMF generated by domestic induction cookers.

    abstract::Induction cookers are a type of cooking appliance that uses an intermediate-frequency magnetic field to heat the cooking vessel. The magnetic flux density produced by an induction cooker during operation was measured according to the EN 62233 standard, and the measured values were below the limits set in the standard....

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/19/001

    authors: Kos B,Valič B,Miklavčič D,Kotnik T,Gajšek P

    更新日期:2011-10-07 00:00:00

  • Benchmarking GATE/Geant4 for 16O ion beam therapy.

    abstract::Oxygen ([Formula: see text]) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of [Formula: see text] ion beams, Monte Carlo (MC) transpo...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa807e

    authors: Resch AF,Fuchs H,Georg D

    更新日期:2017-09-05 00:00:00

  • Transport-based quantitative photoacoustic tomography: simulations and experiments.

    abstract::In this paper we describe a method for quantitative photoacoustic tomography (qPAT) based on the photon radiative transfer equation (RTE) coupled with the Helmholtz photoacoustic wave equation. Considerable simulations and tissue-like phantom experiments are conducted to evaluate transport-based qPAT in comparison wit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/7/009

    authors: Yao L,Sun Y,Jiang H

    更新日期:2010-04-07 00:00:00

  • Prediction of positron emitter distributions for range monitoring in carbon ion therapy: an analytical approach.

    abstract::Range verification is one of the most relevant tasks in ion beam therapy. In the case of carbon ion therapy, positron emission tomography (PET) is the most widely used method for this purpose, which images the [Formula: see text]-activation following nuclear interactions of the ions with the tissue nuclei. Since the p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab17f9

    authors: Hofmann T,Fochi A,Parodi K,Pinto M

    更新日期:2019-05-21 00:00:00

  • Reply to Comment: 'A novel method for fast and robust estimation of fluorescence decay dynamics using constrained least-square deconvolution with Laguerre expansion'.

    abstract::In this response we underscore that the instrumentation described in the original publication (Liu et al 2012 Phys. Med. Biol. 57 843-65) was based on pulse-sampling technique, while the comment by Zhang et al is based on the assumption that a time-correlated single photon counting (TCSPC) instrumentation was used. Th...

    journal_title:Physics in medicine and biology

    pub_type: 评论,杂志文章

    doi:10.1088/1361-6560/aa5231

    authors: Ma D,Liu J,Qi J,Marcu L

    更新日期:2017-02-21 00:00:00