Deep learning on mammary glands distribution for architectural distortion detection in digital breast tomosynthesis.

Abstract:

:Computer aided detection (CADe) for breast lesion can provide an important reference for radiologists in breast cancer screening. Architectural distortion (AD) is a type of breast lesion that is difficult to detect. A majority of CADe methods focus on detecting the radial pattern, which is a main characteristic of typical ADs. However, a few atypical ADs do not exhibit such a pattern. To improve the performance of CADe for typical and atypical ADs, we proposed a deep-learning-based model that used the mammary glands distribution as prior information to detect ADs in digital breast tomosynthesis (DBT). First, information about gland distributions, including Gabor magnitude, Gabor orientation field, and convergence map, were produced using a bank of Gabor filters and convergence measures. Then, this prior information and original slice were input into a Faster-RCNN detection network to obtain the 2-D candidates for each slice. Finally, a 3-D aggregation scheme was employed to fuse these 2-D candidates as 3-D candidates for each DBT volume. Retrospectively, 64 typical AD volumes, 74 atypical AD volumes, and 127 normal volumes were collected. Six-fold cross validation and mean true positive fraction (MTPF) were used to evaluate the model. Compared to an existing convergence-based model, our proposed model achieved an MTPF of 0.53 ± 0.04, 0.61 ± 0.05, and 0.45 ± 0.04 for all DBT volumes, typical + normal volumes, and atypical + normal volumes, respectively. These results were significantly better than those of 0.36 ± 0.03, 0.46 ± 0.04, and 0.28 ± 0.04 for a convergence-based model (p < 0.01). These results indicate that employing the prior information of glands distribution and a deep learning method can improve the performance of CADe for AD.

journal_name

Phys Med Biol

authors

Li Y,He Z,Lu Y,Ma X,Guo Y,Xie Z,Xu Z,Chen W,Chen H

doi

10.1088/1361-6560/ab98d0

subject

Has Abstract

pub_date

2020-06-02 00:00:00

eissn

0031-9155

issn

1361-6560

pub_type

杂志文章
  • Intensity of the flash associated with laser-induced plasma in the eye.

    abstract::A bright flash of light is emitted by the plasma formed at the focus of an ophthalmic Nd: YAG laser. The purpose of this investigation is to determine whether the plasma flash constitutes a hazard to the operator. The intensity of the flash at the slit lamp eyepiece was measured and the experimentally derived value wa...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/32/9/009

    authors: Moseley H,Allan D

    更新日期:1987-09-01 00:00:00

  • Development and comparison of computer methods for organ motion correction in scintigraphy.

    abstract::The process of organ motion correction in scintigraphy is analysed in the frequency domain. The sequence of the chi- and gamma- coordinates registered during scintigraphic recording is converted to a frequency spectrum by a discrete Fourier transform. In the frequency domain motion correction is performed by linear fi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/20/3/010

    authors: Schmidlin P

    更新日期:1975-05-01 00:00:00

  • A depth-encoding PET detector for high resolution PET using 1 mm SiPMs.

    abstract::A dual-ended readout PET detector based on two Hamamatsu 16 × 16 arrays of 1 × 1 mm2 SiPMs coupled to both ends of a 25 × 25 array of 0.69 × 0.69 × 20 mm3 polished LYSOs was evaluated in terms of flood histogram, energy resolution, timing resolution, and DOI resolution. The SiPM arrays have a pitch size of 1.2 mm. Eac...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab9fc9

    authors: Du J,Bai X,Cherry SR

    更新日期:2020-08-19 00:00:00

  • Direct aperture optimization for a variable aperture collimator for intensity-modulated radiation therapy.

    abstract::In this note a technique is described for direct aperture optimization of components deliverable by a variable aperture collimator (VAC) for intensity-modulated radiation therapy. The first key result found was that, provided a large number of VAC components were selected for optimization, the resulting fluence profil...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/5/n02

    authors: Webb S

    更新日期:2004-03-07 00:00:00

  • HeinzelCluster: accelerated reconstruction for FORE and OSEM3D.

    abstract::Using iterative three-dimensional (3D) reconstruction techniques for reconstruction of positron emission tomography (PET) is not feasible on most single-processor machines due to the excessive computing time needed, especially so for the large sinogram sizes of our high-resolution research tomograph (HRRT). In our fir...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/15/307

    authors: Vollmar S,Michel C,Treffert JT,Newport DF,Casey M,Knöss C,Wienhard K,Liu X,Defrise M,Heiss WD

    更新日期:2002-08-07 00:00:00

  • Scan-rescan and intra-observer variability of magnetic resonance imaging of carotid atherosclerosis at 1.5 T and 3.0 T.

    abstract::Carotid atherosclerosis measurements for eight subjects at baseline and 14 +/- 2 days later were examined using 1.5 T and 3.0 T magnetic resonance imaging (MRI). A single observer blinded to field strength, subject and timepoint manually segmented carotid artery wall and lumen boundaries in randomized images in five m...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/23/011

    authors: Vidal A,Bureau Y,Wade T,Spence JD,Rutt BK,Fenster A,Parraga G

    更新日期:2008-12-07 00:00:00

  • Volumetric CT with sparse detector arrays (and application to Si-strip photon counters).

    abstract::Novel x-ray medical imaging sensors, such as photon counting detectors (PCDs) and large area CCD and CMOS cameras can involve irregular and/or sparse sampling of the detector plane. Application of such detectors to CT involves undersampling that is markedly different from the commonly considered case of sparse angular...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/1/90

    authors: Sisniega A,Zbijewski W,Stayman JW,Xu J,Taguchi K,Fredenberg E,Lundqvist M,Siewerdsen JH

    更新日期:2016-01-07 00:00:00

  • Development and validation of a BEAMnrc component module for accurate Monte Carlo modelling of the Varian dynamic Millennium multileaf collimator.

    abstract::A new component module (CM), designated DYNVMLC, was developed to fully model the geometry of the Varian Millennium 120 leaf collimator using the BEAMnrc Monte Carlo code. The model includes details such as the leaf driving screw hole, support railing groove and leaf tips. Further modifications also allow sampling of ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/48/24/004

    authors: Heath E,Seuntjens J

    更新日期:2003-12-21 00:00:00

  • Quantitative evaluation of myocardial function by a volume-normalized map generated from relative blood flow.

    abstract::Our study aimed to quantitatively evaluate blood flow in the left ventricle (LV) of apical hypertrophic cardiomyopathy (APH) by combining wall thickness obtained from cardiac magnetic resonance imaging (MRI) and myocardial perfusion from single-photon emission computed tomography (SPECT). In this study, we considered ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/14/019

    authors: Fukami T,Sato H,Wu J,Lwin TT,Yuasa T,Kawano S,Iida K,Akatsuka T,Hontani H,Takeda T,Tamura M,Yokota H

    更新日期:2007-07-21 00:00:00

  • Adaptive treatment-length optimization in spatiobiologically integrated radiotherapy.

    abstract::Recent theoretical research on spatiobiologically integrated radiotherapy has focused on optimization models that adapt fluence-maps to the evolution of tumor state, for example, cell densities, as observed in quantitative functional images acquired over the treatment course. We propose an optimization model that adap...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aab4b6

    authors: Ajdari A,Ghate A,Kim M

    更新日期:2018-03-27 00:00:00

  • Novel adaptive beam-dependent margins for additional OAR sparing.

    abstract::Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Unfortunately, whilst the use of margins can increase the probability that sufficient dose is delivered to the CTV, it can also result in delivering high dose of r...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aae658

    authors: Tsang HS,Kamerling CP,Ziegenhein P,Nill S,Oelfke U

    更新日期:2018-10-29 00:00:00

  • A complete distortion correction for MR images: II. Rectification of static-field inhomogeneities by similarity-based profile mapping.

    abstract::Radiotherapy treatment planning relies on the use of geometrically correct images. This paper presents a fully automatic tool for correcting MR images for the effects of B(0) inhomogeneities. The post-processing method is based on the gradient-reversal technique of Chang and Fitzpatrick (1992 IEEE Trans. Med. Imaging ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/11/014

    authors: Reinsberg SA,Doran SJ,Charles-Edwards EM,Leach MO

    更新日期:2005-06-07 00:00:00

  • Improving SAR estimations in MRI using subject-specific models.

    abstract::To monitor and strategically control energy deposition in magnetic resonance imaging (MRI), measured as a specific absorption rate (SAR), numerical methods using generic human models have been employed to estimate worst-case values. Radiofrequency (RF) sequences are therefore often designed conservatively with large s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/24/8153

    authors: Jin J,Liu F,Weber E,Crozier S

    更新日期:2012-12-21 00:00:00

  • Measurement of patient entrance surface dose rates for fluoroscopic x-ray units.

    abstract::Measurements of patient entrance surface dose rate provide valuable data for interpreting results from dose-area product studies on fluoroscopic x-ray equipment. Methods for measurement of entrance surface dose rate with backscatter and incident dose rate without backscatter have been investigated. Entrance surface do...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/5/008

    authors: Martin CJ

    更新日期:1995-05-01 00:00:00

  • Experimental validation of Monte Carlo calculations with a voxelized Rando-Alderson phantom: a study on influence parameters.

    abstract::The development and improvement of techniques for an accurate dose assessment in medical physics is an important task. In this study, we focus on the validation of Monte Carlo calculations, by comparing organ doses assessed experimentally with thermoluminescent detectors in the Rando-Alderson phantom with doses calcul...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/20/018

    authors: Struelens L,Vanhavere F,Smans K

    更新日期:2008-10-21 00:00:00

  • A potential method for in vivo range verification in proton therapy treatment.

    abstract::Proton therapy potentially offers excellent dose conformality and reduction in integral dose. The superior dose distribution is, however, much more sensitive to the radiological depth along the beam path than for photon fields. Variations in this depth due to inaccurate planning calculation, setup uncertainty, respira...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/5/016

    authors: Lu HM

    更新日期:2008-03-07 00:00:00

  • SpekCalc: a program to calculate photon spectra from tungsten anode x-ray tubes.

    abstract::A software program, SpekCalc, is presented for the calculation of x-ray spectra from tungsten anode x-ray tubes. SpekCalc was designed primarily for use in a medical physics context, for both research and education purposes, but may also be of interest to those working with x-ray tubes in industry. Noteworthy is the p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/19/N01

    authors: Poludniowski G,Landry G,DeBlois F,Evans PM,Verhaegen F

    更新日期:2009-10-07 00:00:00

  • Additional factors for the estimation of mean glandular breast dose using the UK mammography dosimetry protocol.

    abstract::The UK and European protocols for mammographic dosimetry use conversion factors that relate incident air kerma to the mean glandular dose (MGD) within the breast. The conversion factors currently used were obtained by computer simulation of a model breast with a composition of 50% adipose and 50% glandular tissues by ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/11/308

    authors: Dance DR,Skinner CL,Young KC,Beckett JR,Kotre CJ

    更新日期:2000-11-01 00:00:00

  • Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.

    abstract::This study evaluates the dosimetric performance of the polymer gel dosimeter 'Methacrylic and Ascorbic acid in Gelatin, initiated by Copper' and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/22/017

    authors: Gear JI,Charles-Edwards E,Partridge M,Flux GD

    更新日期:2011-11-21 00:00:00

  • Exact solutions to the multiregion time-dependent bioheat equation. II: Numerical evaluation of the solutions.

    abstract::Analytic solutions to the time-dependent multiregion bioheat equation are evaluated numerically for cartesian and spherical models. Principle and alternate branch contributions to the solutions are examined. The calculations include a parametric investigation and analyses of temperature behaviour in idealised upper th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/35/7/005

    authors: Durkee JW Jr,Antich PP,Lee CE

    更新日期:1990-07-01 00:00:00

  • Automatic T1 bladder tumor detection by using wavelet analysis in cystoscopy images.

    abstract::Correct classification of cystoscopy images depends on the interpreter's experience. Bladder cancer is a common lesion that can only be confirmed by biopsying the tissue, therefore, the automatic identification of tumors plays a significant role in early stage diagnosis and its accuracy. To our best knowledge, the use...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaa3af

    authors: Freitas NR,Vieira PM,Lima E,Lima CS

    更新日期:2018-02-02 00:00:00

  • Comments on 'Calculation of water equivalent thickness of materials of arbitrary density, elemental composition and thickness in proton beam irradiation'.

    abstract::We comment on a previous article by Zhang and Newhauser (2009 Phys. Med. Biol. 54 1383-95) which presents several approximate ways of computing the water equivalent of an arbitrary degrader. First, we present a simple exact method which depends only on the range-energy relation of water and of the degrader material. S...

    journal_title:Physics in medicine and biology

    pub_type: 评论,信件

    doi:10.1088/0031-9155/55/9/L01

    authors: Gottschalk B

    更新日期:2010-05-07 00:00:00

  • An investigation of a PRESAGE® in vivo dosimeter for brachytherapy.

    abstract::Determining accurate in vivo dosimetry in brachytherapy treatment with high dose gradients is challenging. Here we introduce, investigate, and characterize a novel in vivo dosimeter and readout technique with the potential to address this problem. A cylindrical (4 mm × 20 mm) tissue equivalent radiochromic dosimeter P...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/14/3893

    authors: Vidovic AK,Juang T,Meltsner S,Adamovics J,Chino J,Steffey B,Craciunescu O,Oldham M

    更新日期:2014-07-21 00:00:00

  • Characterization of diffraction-enhanced imaging contrast in breast cancer.

    abstract::Diffraction-enhanced imaging (DEI) is a new x-ray imaging modality that has been shown to enhance contrast between normal and cancerous breast tissues. In this study, diffraction-enhanced imaging in computed tomography (DEI-CT) mode was used to quantitatively characterize the refraction contrasts of the organized stru...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/10/019

    authors: Kao T,Connor D,Dilmanian FA,Faulconer L,Liu T,Parham C,Pisano ED,Zhong Z

    更新日期:2009-05-21 00:00:00

  • Volume-selective and spectroscopically resolved NMR investigation of diffusion and relaxation in fertilised hen eggs.

    abstract::A radiofrequency and field-gradient pulse sequence is presented permitting the non-invasive, volume-selective and spectroscopically resolved determination of incoherent transport parameters with the aid of an NMR field-gradient method. With proton NMR, diffusion or (quasi-incoherent) perfusion coefficients as low as 1...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/35/1/007

    authors: Klammler F,Kimmich R

    更新日期:1990-01-01 00:00:00

  • 3D thoracoscopic ultrasound volume measurement validation in an ex vivo and in vivo porcine model of lung tumours.

    abstract::The purpose of this study was to validate the accuracy and reliability of volume measurements obtained using three-dimensional (3D) thoracoscopic ultrasound (US) imaging. Artificial "tumours" were created by injecting a liquid agar mixture into spherical moulds of known volume. Once solidified, the "tumours" were impl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/1/007

    authors: Hornblower VD,Yu E,Fenster A,Battista JJ,Malthaner RA

    更新日期:2007-01-07 00:00:00

  • A model for the accurate computation of the lateral scattering of protons in water.

    abstract::A pencil beam model for the calculation of the lateral scattering in water of protons for any therapeutic energy and depth is presented. It is based on the full Molière theory, taking into account the energy loss and the effects of mixtures and compounds. Concerning the electromagnetic part, the model has no free para...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/4/N102

    authors: Bellinzona EV,Ciocca M,Embriaco A,Ferrari A,Fontana A,Mairani A,Parodi K,Rotondi A,Sala P,Tessonnier T

    更新日期:2016-02-21 00:00:00

  • A novel geometry-dosimetry label fusion method in multi-atlas segmentation for radiotherapy: a proof-of-concept study.

    abstract::Multi-atlas segmentation (MAS) has been widely used to automate the delineation of organs at risk (OARs) for radiotherapy. Label fusion is a crucial step in MAS to cope with the segmentation variabilities among multiple atlases. However, most existing label fusion methods do not consider the potential dosimetric impac...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa5ed9

    authors: Chang J,Tian Z,Lu W,Gu X,Chen M,Jiang SB

    更新日期:2017-05-07 00:00:00

  • Accelerated time-of-flight (TOF) PET image reconstruction using TOF bin subsetization and TOF weighting matrix pre-computation.

    abstract::Time-of-flight (TOF) positron emission tomography (PET) technology has recently regained popularity in clinical PET studies for improving image quality and lesion detectability. Using TOF information, the spatial location of annihilation events is confined to a number of image voxels along each line of response, there...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/3/1309

    authors: Mehranian A,Kotasidis F,Zaidi H

    更新日期:2016-02-07 00:00:00

  • Temporal backward projection of optoacoustic pressure transients using fourier transform methods.

    abstract::In medical imaging different techniques have been developed to gain information from inside a tissue. Optoacoustics is a method to generate tomography pictures of tissue using Q-switched laser pulses. Due to thermal and pressure confinement, a short light pulse generates a pressure distribution inside tissue, which mi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/7/309

    authors: Köstli KP,Frenz M,Bebie H,Weber HP

    更新日期:2001-07-01 00:00:00