Ionization quenching in scintillators used for dosimetry of mixed particle fields.

Abstract:

:Ionization quenching in ion beam dosimetry is often related to the fluence- or dose-averaged linear energy transfer (LET). Both quantities are however averaged over a wide LET range and a mixed field of primary and secondary ions. We propose a novel method to correct the quenched luminescence in scintillators exposed to ion beams. The method uses the energy spectrum of the primaries and accounts for the varying quenched luminescence in heavy, secondary ion tracks through amorphous track structure theory. The new method is assessed against more traditional approaches by correcting the quenched luminescence response from the BCF-12, BCF-60, and 81-0084 plastic scintillators exposed to a 100 MeV pristine proton beam in order to compare the effects of the averaged LET quantities and the secondary ions. Calculations and measurements show that primary protons constitute more than 92% of the energy deposition but account for more than 95% of the luminescence signal in the scintillators. The quenching corrected luminescence signal is in better agreement with the dose measurement when the secondary particles are taken into account. The Birks model provided the overall best quenching corrections, when the quenching corrected signal is adjusted for the number of free model parameters. The quenching parameter kB for the BCF-12 and BCF-60 scintillators is in agreement with literature values and was found to be [Formula: see text] [Formula: see text]m keV-1 for the 81-0084 scintillator. Finally, a fluence threshold for the 100 MeV proton beam was calculated to be of the order of 1010 cm-2, corresponding to 110 Gy, above which the quenching increases non-linearly and the Birks model no longer is applicable.

journal_name

Phys Med Biol

authors

Christensen JB,Almhagen E,Stolarczyk L,Vestergaard A,Bassler N,Andersen CE

doi

10.1088/1361-6560/ab12f2

subject

Has Abstract

pub_date

2019-04-29 00:00:00

pages

095018

issue

9

eissn

0031-9155

issn

1361-6560

journal_volume

64

pub_type

杂志文章
  • Photon detection efficiency of laboratory-based x-ray phase contrast imaging techniques for mammography: a Monte Carlo study.

    abstract::An important challenge in real-world biomedical applications of x-ray phase contrast imaging (XPCI) techniques is the efficient use of the photon flux generated by an incoherent and polychromatic x-ray source. This efficiency can directly influence dose and exposure time and ideally should not affect the superior cont...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa7a92

    authors: Saghamanesh S,Aghamiri SM,Kamali-Asl A,Yashiro W

    更新日期:2017-09-01 00:00:00

  • A comparison of rotation- and blob-based system models for 3D SPECT with depth-dependent detector response.

    abstract::We compare two different implementations of a 3D SPECT system model for iterative reconstruction, both of which compensate for non-uniform photon attenuation and depth-dependent system response. One implementation performs fast rotation of images represented using a basis of rectangular voxels, whereas the other repre...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/11/003

    authors: Yendiki A,Fessler JA

    更新日期:2004-06-07 00:00:00

  • Characterization of the secondary neutron field produced during treatment of an anthropomorphic phantom with x-rays, protons and carbon ions.

    abstract::Short- and long-term side effects following the treatment of cancer with radiation are strongly related to the amount of dose deposited to the healthy tissue surrounding the tumor. The characterization of the radiation field outside the planned target volume is the first step for estimating health risks, such as devel...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/8/2111

    authors: Tessa CL,Berger T,Kaderka R,Schardt D,Burmeister S,Labrenz J,Reitz G,Durante M

    更新日期:2014-04-21 00:00:00

  • Refraction-angle resolution of diffraction enhanced imaging.

    abstract::As a new method, x-ray diffraction enhanced imaging (DEI) has extremely high sensitivity for weakly absorbing low-Z samples in medical and biological fields. Conventional performance parameters, such as spatial resolution and low-contrast resolution, are not enough to describe the characteristics of a DEI system. This...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/12/002

    authors: Huang ZF,Kang KJ,Li Z

    更新日期:2006-06-21 00:00:00

  • Modeling late rectal toxicities based on a parameterized representation of the 3D dose distribution.

    abstract::Many models exist for predicting toxicities based on dose-volume histograms (DVHs) or dose-surface histograms (DSHs). This approach has several drawbacks as firstly the reduction of the dose distribution to a histogram results in the loss of spatial information and secondly the bins of the histograms are highly correl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/7/013

    authors: Buettner F,Gulliford SL,Webb S,Partridge M

    更新日期:2011-04-07 00:00:00

  • The dosimetry for a coronary artery stent coated with radioactive 188Re and 32P.

    abstract::Radiation dose distributions have been calculated for 188Re and 32P activity on a coronary artery stent. The doses have been calculated both as a function of position along the stent and of depth into the artery wall. Comparisons of the dose from identical activities of 188Re and 32P on the stent show that the major d...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/12/310

    authors: Fox RA,Henson PW

    更新日期:2000-12-01 00:00:00

  • Dose measurements in inhomogeneous bone/tissue and lung/tissue phantoms for angiography using synchrotron radiation.

    abstract::For angiography using synchrotron radiation we measured the absorbed dose distribution in inhomogeneous phantoms with thin LiF:Mg, Cu, P, LiF:Mg, Ti thermoluminescent dosimeters (TLDs) in tissue and lung substitutes, and with Mg2SiO4:Tb TLDs in bone substitute for 33.32 keV monoenergetic photons from synchrotron radia...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/3/308

    authors: Nariyama N,Namito Y,Ban S,Hirayama H

    更新日期:2001-03-01 00:00:00

  • Automatic classification of DMSA scans using an artificial neural network.

    abstract::DMSA imaging is carried out in nuclear medicine to assess the level of functional renal tissue in patients. This study investigated the use of an artificial neural network to perform diagnostic classification of these scans. Using the radiological report as the gold standard, the network was trained to classify DMSA s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/7/1789

    authors: Wright JW,Duguid R,McKiddie F,Staff RT

    更新日期:2014-04-07 00:00:00

  • Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique.

    abstract::Subharmonic contrast imaging promises to improve ultrasound-imaging quality by taking advantage of an increased contrast to tissue signal. However, acoustic pressures beyond the subharmonic generation threshold using common ultrasound pulses may induce significant contrast microbubble destruction. In this work, a chir...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/18/005

    authors: Zhang D,Gong Y,Gong X,Liu Z,Tan K,Zheng H

    更新日期:2007-09-21 00:00:00

  • Hidden Markov modelling of spike propagation from interictal MEG data.

    abstract::For patients with partial epilepsy, automatic spike detection techniques applied to interictal MEG data often discover several potentially epileptogenic brain regions. An important determination in treatment planning is which of these detected regions are most likely to be the primary sources of epileptogenic activity...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/14/017

    authors: Ossadtchi A,Mosher JC,Sutherling WW,Greenblatt RE,Leahy RM

    更新日期:2005-07-21 00:00:00

  • Volume estimation of low-contrast lesions with CT: a comparison of performances from a phantom study, simulations and theoretical analysis.

    abstract::Measurements of lung nodule volume with multi-detector computed tomography (MDCT) have been shown to be more accurate and precise compared to conventional lower dimensional measurements. Quantifying the size of lesions is potentially more difficult when the object-to-background contrast is low as with lesions in the l...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/2/671

    authors: Li Q,Gavrielides MA,Zeng R,Myers KJ,Sahiner B,Petrick N

    更新日期:2015-01-21 00:00:00

  • An analytical reconstruction model of the spread-out Bragg peak using laser-accelerated proton beams.

    abstract::With the development of laser technology, laser-driven proton acceleration provides a new method for proton tumor therapy. However, it has not been applied in practice because of the wide and decreasing energy spectrum of laser-accelerated proton beams. In this paper, we propose an analytical model to reconstruct the ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa6fce

    authors: Tao L,Zhu K,Zhu J,Xu X,Lin C,Ma W,Lu H,Zhao Y,Lu Y,Chen JE,Yan X

    更新日期:2017-07-07 00:00:00

  • Directional dependence in film dosimetry: radiographic and radiochromic film.

    abstract::The trend towards conformal, intensity modulated radiotherapy treatments has established the need for a true integrating dosimeter. In traditional radiotherapy, radiographic film dosimetry is commonly used. The accuracy and reproducibility of film optical density as an indicator of dose is influenced by several variab...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/5/305

    authors: Suchowerska N,Hoban P,Butson M,Davison A,Metcalfe P

    更新日期:2001-05-01 00:00:00

  • A static beam delivery device for fast scanning proton arc-therapy.

    abstract::Arc-therapy is a dose delivery technique regularly applied in photon radiation therapy, and is currently subject of great interest for proton therapy as well. In this technique, proton beams are aimed at a tumor from different continuous ranges of incident directions (so called "arcs"). This technique can potentially ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abe02b

    authors: Nesteruk KP,Bolsi A,Lomax AJ,Meer D,van de Water S,Schippers JM

    更新日期:2021-01-26 00:00:00

  • Influence of sulphuric acid contaminants on Fricke dosimetry.

    abstract::The sulphuric acid used for the preparation of the Fricke dosimeter solution may contain trace impurities that can affect the yield of ferric ions. Two methods, pre-irradiation or oxidation with hydrogen peroxide, have been proposed to reduce the influence of these impurities. Fricke users sometimes omit this treatmen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/9/403

    authors: Palm A,Mattsson O

    更新日期:2000-09-01 00:00:00

  • Evaluation of inverse methods and head models for EEG source localization using a human skull phantom.

    abstract::We used a real-skull phantom head to investigate the performances of representative methods for EEG source localization when considering various head models. We describe several experiments using a montage with current sources located at multiple positions and orientations inside a human skull filled with a conductive...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/1/306

    authors: Baillet S,Riera JJ,Marin G,Mangin JF,Aubert J,Garnero L

    更新日期:2001-01-01 00:00:00

  • Investigation of patient, tumour and treatment variables affecting residual motion for respiratory-gated radiotherapy.

    abstract::Respiratory gating can reduce the apparent respiratory motion during imaging and treatment; however, residual motion within the gating window remains. Respiratory training can improve respiratory reproducibility and, therefore, the efficacy of respiratory-gated radiotherapy. This study was conducted to determine wheth...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/20/015

    authors: George R,Ramakrishnan V,Siebers JV,Chung TD,Keall PJ

    更新日期:2006-10-21 00:00:00

  • Accuracy of Monte Carlo photon transport simulation in characterizing brachytherapy dosimeter energy-response artefacts.

    abstract::Practical dosimeters in brachytherapy, such as thermoluminescent dosimeters (TLD) and diodes, are usually calibrated against low-energy megavoltage beams. To measure absolute dose rate near a brachytherapy source, it is necessary to establish the energy response of the detector relative to that of the calibration ener...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/6/004

    authors: Das RK,Li Z,Perera H,Williamson JF

    更新日期:1996-06-01 00:00:00

  • Automated cell cycle analysis with fluorescence microscopy and image analysis.

    abstract::Automatic cell cycle analysis (DNA histograms) is usually performed with flow cytometry. In cases when only few cells are available, the DNA content has to be measured with a fluorescence microscope combined with sensitive camera systems (SIT, MCP, cooled CCDs) and a frame grabber for image analysis. The fluorescent c...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/3/013

    authors: Böcker W,Gantenberg HW,Müller WU,Streffer C

    更新日期:1996-03-01 00:00:00

  • A thin target approach for portal imaging in medical accelerators.

    abstract::A new thin-target method (patent pending) is described for portal imaging with low-energy (tens of keV) photons from a medical linear accelerator operating in a special mode. Low-energy photons are usually produced in the accelerator target, but are absorbed by the target and flattening filter, both made of medium- or...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/8/016

    authors: Tsechanski A,Bielajew AF,Faermann S,Krutman Y

    更新日期:1998-08-01 00:00:00

  • A Monte Carlo study of the variation of electron fluence in water from a 6 MV photon beam outside of the field.

    abstract::Existing studies have suggested some debate on whether the quality of radiation that delivers dose outside of the primary field of a radiotherapy photon beam can be considered the same as that inside the primary field. We used a Monte Carlo approach to simulate the electron fluence differential in energy inside a wate...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/12/015

    authors: Kirkby C,Field C,MacKenzie M,Syme A,Fallone BG

    更新日期:2007-06-21 00:00:00

  • Deep learning networks on chronic liver disease assessment with fine-tuning of shear wave elastography image sequences.

    abstract::Chronic liver disease (CLD) is currently one of the major causes of death worldwide. If not treated, it may lead to cirrhosis, hepatic carcinoma and death. Ultrasound (US) shear wave elastography (SWE) is a relatively new, popular, non-invasive technique among radiologists. Although many studies have been published va...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abae06

    authors: Kagadis GC,Drazinos P,Gatos I,Tsantis S,Papadimitroulas P,Spiliopoulos S,Karnabatidis D,Theotokas I,Zoumpoulis P,Hazle JD

    更新日期:2020-11-05 00:00:00

  • Quenching-free fluorescence signal from plastic-fibres in proton dosimetry: understanding the influence of Čerenkov radiation.

    abstract::The origin of photons emitted in optical fibres under proton irradiation has been attributed to either entirely Čerenkov radiation or light consisting of fluorescence with a substantial amount of Čerenkov radiation. The source of the light emission is assessed in order to understand why the signal from optical fibres ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aaafad

    authors: Brage Christensen J,Almhagen E,Nyström H,Andersen CE

    更新日期:2018-03-09 00:00:00

  • Dose effect of guidewire position in intravascular brachytherapy.

    abstract::It has been reported that the dose effects of metallic guidewires are significant in intravascular brachytherapy (IVBT) using a beta source. The purpose of this work is to investigate the dependence of these dose effects on guidewire position. The EGS4 Monte Carlo codes were used to perform the dose calculations for t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/10/309

    authors: Shih R,Hsu WL,Li XA

    更新日期:2002-05-21 00:00:00

  • Dose distribution to spinal structures from intrathecally administered yttrium-90.

    abstract::Previous treatment of cerebrospinal fluid (CSF) malignancies by intrathecal administration of (131)I-radiolabelled monoclonal antibodies has led to the assumption that more healthy tissue will be spared when a pure beta-emitter such as (90)Y replaces (131)I. The purpose of this study is to compare and quantitatively e...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/1/014

    authors: Mardirossian G,Hall M,Montebello J,Stevens P

    更新日期:2006-01-07 00:00:00

  • A multi-frequency sparse hemispherical ultrasound phased array for microbubble-mediated transcranial therapy and simultaneous cavitation mapping.

    abstract::Focused ultrasound (FUS) phased arrays show promise for non-invasive brain therapy. However, the majority of them are limited to a single transmit/receive frequency and therefore lack the versatility to expose and monitor the treatment volume. Multi-frequency arrays could offer variable transmit focal sizes under a fi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/24/8476

    authors: Deng L,O'Reilly MA,Jones RM,An R,Hynynen K

    更新日期:2016-12-21 00:00:00

  • The ArcCHECK diode array for dosimetric verification of HybridArc.

    abstract::The aim of this work is to evaluate dosimetric accuracy of a new treatment modality, HybridArc, in iPlan RT Dose 4.5 (BrainLAB, Feldkirchen, Germany) using a four-dimensional diode array (ArcCHECK, Sun Nuclear Corporation, Melbourne, USA). HybridArc is able to enhance dynamic conformal arcs with inversely planned elem...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/16/021

    authors: Petoukhova AL,van Egmond J,Eenink MG,Wiggenraad RG,van Santvoort JP

    更新日期:2011-08-21 00:00:00

  • GGEMS-Brachy: GPU GEant4-based Monte Carlo simulation for brachytherapy applications.

    abstract::In brachytherapy, plans are routinely calculated using the AAPM TG43 formalism which considers the patient as a simple water object. An accurate modeling of the physical processes considering patient heterogeneity using Monte Carlo simulation (MCS) methods is currently too time-consuming and computationally demanding ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/13/4987

    authors: Lemaréchal Y,Bert J,Falconnet C,Després P,Valeri A,Schick U,Pradier O,Garcia MP,Boussion N,Visvikis D

    更新日期:2015-07-07 00:00:00

  • Spectral characterization of local magnetic field inhomogeneities.

    abstract::The purpose of this study was the characterization of local magnetic susceptibility deviations by spectral analysis of their induced magnetic field inhomogeneities. Magnetic resonance spectra and related signal decay curves of local susceptibility deviations were simulated for different volume fractions and compositio...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/2/013

    authors: Seppenwoolde JH,van Zijtveld M,Bakker CJ

    更新日期:2005-01-21 00:00:00

  • Alanine dosimetry in strong magnetic fields: use as a transfer standard in MRI-guided radiotherapy.

    abstract::Reference dosimetry in the presence of a strong magnetic field is challenging. Ionisation chambers have shown to be strongly affected by magnetic fields. There is a need for robust and stable detectors in MRI-guided radiotherapy (MRIgRT). This study investigates the behaviour of the alanine dosimeter in magnetic field...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab8148

    authors: Billas I,Bouchard H,Oelfke U,Shipley D,Gouldstone C,Duane S

    更新日期:2020-06-03 00:00:00