Enhancement of subharmonic emission from encapsulated microbubbles by using a chirp excitation technique.

Abstract:

:Subharmonic contrast imaging promises to improve ultrasound-imaging quality by taking advantage of an increased contrast to tissue signal. However, acoustic pressures beyond the subharmonic generation threshold using common ultrasound pulses may induce significant contrast microbubble destruction. In this work, a chirp excitation technique is presented to enhance the subharmonic emission from encapsulated microbubbles. Chirp signals with a center frequency of 5 MHz, variable frequency range and duration time are employed to drive microbubbles in numerical simulation and experimental studies. We provide a theoretical evaluation of the chirp excitation pressure threshold and the acoustic pressure dependence of subharmonic based on Church's model and demonstrate that the amplitude and axial resolution of the subharmonic can be optimized by proper selection of the frequency range and time duration of the chirp signal. Measurements are qualitatively in agreement with the simulation. Moreover, we demonstrate that chirp excitation may be able to improve the amplitude of the subharmonic component up to 22 dB over the pulse excitation. The chirp excitation technique could potentially be used for improving the subharmonic contrast imaging quality.

journal_name

Phys Med Biol

authors

Zhang D,Gong Y,Gong X,Liu Z,Tan K,Zheng H

doi

10.1088/0031-9155/52/18/005

subject

Has Abstract

pub_date

2007-09-21 00:00:00

pages

5531-44

issue

18

eissn

0031-9155

issn

1361-6560

pii

S0031-9155(07)48576-1

journal_volume

52

pub_type

杂志文章
  • Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study.

    abstract::An x-ray fluorescence system with a synchrotron radiation source was used to quantify the levels of iron, copper and zinc in breast tissue specimens. Healthy tissue and breast carcinomas were investigated as an aid to understanding the mechanisms of breast cancer and as a possible complementary diagnostic tool. Eighty...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/13/310

    authors: Geraki K,Farquharson MJ,Bradley DA

    更新日期:2002-07-07 00:00:00

  • Calculation of 10 MV x-ray spectra emitted by a medical linear accelerator using the BFGS quasi-Newton method.

    abstract::To calculate photon spectra for a 10 MV x-ray beam emitted by a medical linear accelerator, we performed numerical analysis using the aluminium transmission data obtained along the central axis of the beam under the narrow beam condition corresponding to a 3x3 cm2 field at a 100 cm distance from the source. We used th...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/2/014

    authors: Shimozato T,Tabushi K,Kitoh S,Shiota Y,Hirayama C,Suzuki S

    更新日期:2007-01-21 00:00:00

  • Direct determination of cone-beam geometric parameters using the helical phantom.

    abstract::Estimation of a set of parameters that describe the geometry of the cone-beam computed tomography system plays an important role in the geometrical calibration. In the calibration process, the helical phantom consisting of spherical markers arranged on a helical trajectory has been widely applied. To directly determin...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/19/5667

    authors: Xu M,Zhang C,Liu X,Li D

    更新日期:2014-10-07 00:00:00

  • Array detection for speckle reduction in optical coherence microscopy.

    abstract::This paper introduces a spatial-diversity method for speckle suppression in optical coherence microscopy. The method is based on combining interference signals from an array of detectors placed in the back focal plane of the objective lens, such that elements receive light backscattered from the sample volume at diffe...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/7/015

    authors: Schmitt JM

    更新日期:1997-07-01 00:00:00

  • MTF evaluation of a phosphor-coated CCD for x-ray imaging.

    abstract::A novel digital x-ray detector has been assembled. The imaging system is based on a phosphor-coated charge-coupled device (CCD) obtained by direct deposition of a gadolinium oxysulphide scintillator onto the detector surface. The modulation transfer function has been measured along the two directions of the digital co...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/12/016

    authors: Gambaccini M,Taibi A,Del Guerra A,Marziani M,Tuffanelli A

    更新日期:1996-12-01 00:00:00

  • Optimal material discrimination using spectral x-ray imaging.

    abstract::Spectral x-ray imaging using novel photon counting x-ray detectors (PCDs) with energy resolving abilities is capable of providing energy-selective images. PCDs have energy thresholds, enabling the classification of photons into multiple energy bins. The extra energy information provided may allow materials such as iod...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/18/012

    authors: Nik SJ,Meyer J,Watts R

    更新日期:2011-09-21 00:00:00

  • The induction of hyperthermia by ultrasound; its value and associated problems: II. Scanned-plane transducer.

    abstract::A system is described in which large superficial areas of tissue may be heated using a single plane ultrasonic transducer scanned in a raster fashion. The shape of the heated area is determined by the movement of a microswitch which is activated when it strikes the rigid edge of a hole of the required shape cut in a p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/30/12/006

    authors: ter Haar G,Hopewell JW

    更新日期:1985-12-01 00:00:00

  • Effect of electron contamination of a 6 MV x-ray beam on near surface diode dosimetry.

    abstract::In critical organ in vivo x-ray dosimetry, the relative contaminating electron contribution to the total dose and total detector response outside the field will be different to the corresponding contributions at the central axis detector calibration position, mainly due to the effects of shielding in the linear accele...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/24/013

    authors: Edwards CR,Mountford PJ,Moloney AJ

    更新日期:2006-12-21 00:00:00

  • Wall effects in plane-parallel ionization chambers.

    abstract::All dosimetry protocols recommend the use of plane-parallel chambers for dose determination in electron beams with energies below 10-15 MeV. The protocols have assumed chamber perturbation effects to be negligible. The new AAPM Protocol (TG39) includes a cavity replacement factor prepl that differs from unity for some...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/4/003

    authors: Nilsson B,Montelius A,Andreo P

    更新日期:1996-04-01 00:00:00

  • Dual-head gamma camera system for intraoperative localization of radioactive seeds.

    abstract::Breast-conserving surgery is a standard option for the treatment of patients with early-stage breast cancer. This form of surgery may result in incomplete excision of the tumor. Iodine-125 labeled titanium seeds are currently used in clinical practice to reduce the number of incomplete excisions. It seems likely that ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/19/7655

    authors: Arsenali B,de Jong HW,Viergever MA,Dickerscheid DB,Beijst C,Gilhuijs KG

    更新日期:2015-10-07 00:00:00

  • Sources of Atomic and Nuclear Data for Biomedical Purposes.

    abstract::Users of nuclear and atomic data for biomedical purposes often have difficulty in identifying the most up-to-date and appropriate sources of such data. The biomedical Subcommittee of the UK Nuclear Data Committee have prepared a list of recommended data sources available at the beginning of 1978 on radioactive decay s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/1/001

    authors: Holt PD

    更新日期:1979-01-01 00:00:00

  • Dose error analysis for a scanned proton beam delivery system.

    abstract::All particle beam scanning systems are subject to dose delivery errors due to errors in position, energy and intensity of the delivered beam. In addition, finite scan speeds, beam spill non-uniformities, and delays in detector, detector electronics and magnet responses will all contribute errors in delivery. In this p...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/23/S09

    authors: Coutrakon G,Wang N,Miller DW,Yang Y

    更新日期:2010-12-07 00:00:00

  • Inverse treatment planning using volume-based objective functions.

    abstract::The results of optimization of inverse treatment plans depend on a choice of the objective function. Even when the optimal solution for a given cost function can be obtained, a better solution may exist for a given clinical scenario and it could be obtained with a revised objective function. In the approach presented ...

    journal_title:Physics in medicine and biology

    pub_type: 临床试验,杂志文章

    doi:10.1088/0031-9155/49/12/003

    authors: Bednarz G,Michalski D,Anne PR,Valicenti RK

    更新日期:2004-06-21 00:00:00

  • The modelling of biological systems in three dimensions using the time domain finite-difference method: I. The implementation of the model.

    abstract::A computer method has been developed which uses the time domain finite-difference (TDFD) algorithm to calculate the deposition of the electromagnetic (EM) field in three-dimensional biological models. This, the first of two papers, describes the algorithm and the computer programs developed. The method is demonstrated...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/31/11/006

    authors: Lau RW,Sheppard RJ

    更新日期:1986-11-01 00:00:00

  • Uncertainties in Monte Carlo-based absorbed dose calculations for an experimental benchmark.

    abstract::There is a need to verify the accuracy of general purpose Monte Carlo codes like EGSnrc, which are commonly employed for investigations of dosimetric problems in radiation therapy. A number of experimental benchmarks have been published to compare calculated values of absorbed dose to experimentally determined values....

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/19/7637

    authors: Renner F,Wulff J,Kapsch RP,Zink K

    更新日期:2015-10-07 00:00:00

  • Automated cell cycle analysis with fluorescence microscopy and image analysis.

    abstract::Automatic cell cycle analysis (DNA histograms) is usually performed with flow cytometry. In cases when only few cells are available, the DNA content has to be measured with a fluorescence microscope combined with sensitive camera systems (SIT, MCP, cooled CCDs) and a frame grabber for image analysis. The fluorescent c...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/3/013

    authors: Böcker W,Gantenberg HW,Müller WU,Streffer C

    更新日期:1996-03-01 00:00:00

  • Relative determination of W-values for alpha particles in tissue-equivalent and other gases.

    abstract::W (the average energy to form an ion pair) for 5.4 MeV 241Am alpha particles in a Rossi-type tissue-equivalent (TE) gas, argon and methane was determined to an accuracy better than 0.2% using a new automated data handling system. A vibrating reed electrometer and current digitiser were used to measure the current prod...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/2/005

    authors: Krieger GL,Baum JW,Varma MN,Beach JL

    更新日期:1979-03-01 00:00:00

  • Application of a CCD linear array camera in the quantification of tissue staining: NBT detection in ischaemic myocardium.

    abstract::A method was developed to quantify the intensity of tissue staining using a CCD (charge-coupled device) camera. Reflection spectra of NBT-stained (nitro-blue tetrazolium-stained) and unstained myocardium were recorded via fibre optics coupled to a CCD camera, connected to a microcomputer. The calculation of the intens...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/36/6/007

    authors: Schröder T,Koch G,Schnabel PA,Hering JP,Bretschneider HJ,Richter J,Hellige G

    更新日期:1991-06-01 00:00:00

  • Effect of temperature on the optical properties of ex vivo human dermis and subdermis.

    abstract::The effect of temperature on the optical properties of human dermis and subdermis as a function of near-infrared wavelength has been studied between 25 degrees C and 40 degrees C. Measurements were performed ex vivo on a total of nine skin samples taken from the abdomen of three individuals. The results show a reprodu...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/43/9/004

    authors: Laufer J,Simpson R,Kohl M,Essenpreis M,Cope M

    更新日期:1998-09-01 00:00:00

  • Impedance magnetocardiogram.

    abstract::We have developed an impedance magnetocardiogram (IMCG) system to detect the change of magnetic field corresponding to changes in blood volume in the heart. A low magnetic field from the electrical activity of the human heart--the so-called magnetocardiogram (MCG)--can be simultaneously detected by using this system. ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/2/403

    authors: Kandori A,Miyashita T,Suzuki D,Yokosawa K,Tsukada K

    更新日期:2001-02-01 00:00:00

  • The consequences of fixed-pattern noise and image movement on electronic portal images.

    abstract::Fixed-pattern noise in electronic portal images (EPIs) is normally eliminated by dividing raw image data by an open-field calibration image (OFCI). However, for successful elimination, there must be exact registration between the two image sets. Any movement within the imaging system, such as that which occurs with ga...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/41/11/007

    authors: Kirby MC

    更新日期:1996-11-01 00:00:00

  • Influence of initial electron beam characteristics on monte carlo calculated absorbed dose distributions for linear accelerator electron beams.

    abstract::The least known parameters in a Monte Carlo simulation of a linear accelerator treatment head are often the properties of the initial electron beam directed onto the exit vacuum window. Several initial beams with different spatial fluence distributions, angular divergences and energy spectra have been transported thro...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/22/308

    authors: Björk P,Knöös T,Nilsson P

    更新日期:2002-11-21 00:00:00

  • Evaluation of quantitative planar 90Y bremsstrahlung whole-body imaging.

    abstract::With high-dose administration of (90)Y labeled antibodies, it is possible to image (90)Y without an admixture of (111)In. We have earlier shown that it is possible to perform quantitative (90)Y bremsstrahlung SPECT for dosimetry purposes with reasonable accuracy. However, whole-body (WB) activity quantification with t...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/54/19/014

    authors: Minarik D,Ljungberg M,Segars P,Gleisner KS

    更新日期:2009-10-07 00:00:00

  • Evaluation of deformable image registration and a motion model in CT images with limited features.

    abstract::Deformable image registration (DIR) is increasingly used in radiotherapy applications and provides the basis for a previously described model of patient-specific respiratory motion. We examine the accuracy of a DIR algorithm and a motion model with respiration-correlated CT (RCCT) images of software phantom with known...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/9/2539

    authors: Liu F,Hu Y,Zhang Q,Kincaid R,Goodman KA,Mageras GS

    更新日期:2012-05-07 00:00:00

  • Linear dimension reduction of sequences of medical images: I. Optimal inner products.

    abstract::A general theory is presented for minimizing noise in linear dimension reduction of sequences of medical images when the factors and the covariance matrix and mean of the noise are given. A dimension reduction is optimal when all diagonal elements in the covariance matrix of the noise in the signal (factor) space are ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/40/11/010

    authors: Hermansen F,Lammertsma AA

    更新日期:1995-11-01 00:00:00

  • Measurement of scattered radiation in a volumetric 64-slice CT scanner using three experimental techniques.

    abstract::Compton scatter poses a significant threat to volumetric x-ray computed tomography, bringing cupping and streak artefacts thus impacting qualitative and quantitative imaging procedures. To perform appropriate scatter compensation, it is necessary to estimate the magnitude and spatial distribution of x-ray scatter. The...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/8/010

    authors: Akbarzadeh A,Ay MR,Ghadiri H,Sarkar S,Zaidi H

    更新日期:2010-04-21 00:00:00

  • Modelling of the dielectric properties of normal and irradiated skin.

    abstract::We have shown that irradiation changes the dielectric properties of human skin at radiofrequencies. Both the dielectric constant and the conductivity of the irradiated skin decrease, especially at low frequencies. The experimental data were analysed using two bioelectric models. Relevant dielectric parameters were det...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/6/001

    authors: Tamura T,Tenhunen M,Lahtinen T,Repo T,Schwan HP

    更新日期:1994-06-01 00:00:00

  • Separating components of variation in measurement series using maximum likelihood estimation. Application to patient position data in radiotherapy.

    abstract::Maximum likelihood estimation (MLE) is presented as a statistical tool to evaluate the contribution of measurement error to any measurement series where the same quantity is measured using different independent methods. The technique was tested against artificial data sets; generated for values of underlying variation...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/20/6019

    authors: Sage JP,Mayles WP,Mayles HM,Syndikus I

    更新日期:2014-10-21 00:00:00

  • The reproducibility of polyacrylamide gel dosimetry applied to stereotactic conformal radiotherapy.

    abstract::The reproducibility of polyacrylamide gel (PAG) dosimetry has been evaluated when used to verify two radiotherapy treatment plans of increasing complexity. The plans investigated were a three-field coplanar arrangement, using the linac jaws for field shaping, and a four-field, conformal, non-coplanar plan using precis...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/45/5/309

    authors: Cosgrove VP,Murphy PS,McJury M,Adams EJ,Warrington AP,Leach MO,Webb S

    更新日期:2000-05-01 00:00:00

  • Mass-energy absorption coefficient and backscatter factor ratios for kilovoltage x-ray beams.

    abstract::For low-energy (up to 150 kV) x-rays, the ratio of mass-energy absorption coefficients for water to air, (mu(en)/rho)w.air, and the backscatter factor B are used in the conversion of air kerma, measured free-in-air, to water kerma on the surface of a water phantom. For clinical radiotherapy, similar conversion factors...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/1/011

    authors: Ma CM,Seuntjens JP

    更新日期:1999-01-01 00:00:00