Concentrations of Fe, Cu and Zn in breast tissue: a synchrotron XRF study.

abstract：:Improving the prevention and detection of preinvasive ductal carcinoma in situ (DCIS) is expected to lower both morbidity and mortality from breast cancer. Transgenic mouse models can be used as a 'test bed' to develop new imaging methods and to evaluate the efficacy of candidate preventive therapies. We hypothesized ...

journal_title：Physics in medicine and biology

authors： Jansen SA,Conzen SD,Fan X,Krausz T,Zamora M,Foxley S,River J,Newstead GM,Karczmar GS

更新日期：2008-10-07 00:00:00

abstract：:Modern effort in radiotherapy to address the challenges of tumor localization and motion has led to the development of MRI guided radiotherapy technologies. Accurate dose calculations must properly account for the effects of the MRI magnetic fields. Previous work has investigated the accuracy of a deterministic linear...

journal_title：Physics in medicine and biology

authors： Zelyak O,Fallone BG,St-Aubin J

更新日期：2017-12-14 00:00:00

abstract：:Corrections for room scatter, [ksc(d, H)]RM, were derived using Monte Carlo methods for rooms of various sizes, including the brachytherapy treatment room, in which primary air kerma strength standardization of a remote afterloading microSelectron 192Ir HDR source was carried out, using a 60 cm3 spherical graphite ion...

journal_title：Physics in medicine and biology

authors： Selvam TP,Rajan KN,Nagarajan PS,Sethulakshmi P,Bhatt BC

更新日期：2001-09-01 00:00:00

abstract：:Radiobiological models for estimating normal tissue complication probability (NTCP) are increasingly used in order to quantify or optimize the clinical outcome of radiation therapy. A good NTCP model should fulfill at least the following two requirements: (a) it should predict the sigmoid shape of the corresponding do...

journal_title：Physics in medicine and biology

authors： Adamus-Górka M,Mavroidis P,Brahme A,Lind BK

更新日期：2008-11-21 00:00:00

abstract：:The aim of this study was to systematically investigate the influence of the inter- and intra-observer segmentation variation of tumors and organs at risk on the simulated temperature coverage of the target. CT scans of six patients with tumors in the pelvic region acquired for radiotherapy treatment planning were use...

journal_title：Physics in medicine and biology

authors： Aklan B,Hartmann J,Zink D,Siavooshhaghighi H,Merten R,Putz F,Ott O,Fietkau R,Bert C

更新日期：2017-05-08 00:00:00

abstract：:Online proton range/dose verification based on measurements of proton-induced positron emitters is a promising strategy for quality assurance in proton therapy. Because of the nonlinear correlation between the dose distribution and the activity distribution of positron emitters, we aim to establish their relationship ...

journal_title：Physics in medicine and biology

authors： Liu C,Li Z,Hu W,Xing L,Peng H

更新日期：2019-09-04 00:00:00

abstract：:Monte Carlo simulation was used to calculate correction factors for output factor (OF), percentage depth-dose (PDD), and off-axis ratio (OAR) measurements with the CyberKnife M6 System. These include the first such data for the InCise MLC. Simulated detectors include diodes, air-filled microchambers, a synthetic micro...

journal_title：Physics in medicine and biology

authors： Francescon P,Kilby W,Noll JM,Masi L,Satariano N,Russo S

更新日期：2017-02-07 00:00:00

abstract：:Radiation dose distributions have been calculated for 188Re and 32P activity on a coronary artery stent. The doses have been calculated both as a function of position along the stent and of depth into the artery wall. Comparisons of the dose from identical activities of 188Re and 32P on the stent show that the major d...

journal_title：Physics in medicine and biology

authors： Fox RA,Henson PW

更新日期：2000-12-01 00:00:00

abstract：PURPOSE:A system for long-length intraoperative imaging is reported based on longitudinal motion of an O-arm gantry featuring a multi-slot collimator. We assess the utility of long-length tomosynthesis and the geometric accuracy of 3D image registration for surgical guidance and evaluation of long spinal constructs. M...

journal_title：Physics in medicine and biology

authors： Zhang X,Uneri A,Wu P,Ketcha MD,Jones C,Huang Y,Lo SL,Helm PA,Siewerdsen JH

更新日期：2021-01-21 00:00:00

abstract：:Cardiac and respiratory motion artefacts in PET imaging have been traditionally resolved by acquiring the data in gated mode. However, gated PET images are usually characterized by high noise content due to their low photon statistics. In this paper, we present a novel 4D model for the PET imaging system, which can in...

journal_title：Physics in medicine and biology

authors： Qiao F,Pan T,Clark JW Jr,Mawlawi OR

更新日期：2006-08-07 00:00:00

abstract：:Due to high levels of noise in pixel-wise time-activity curves, the indirect method that generates kinetic parametric images from dynamic positron emission tomography (PET) images often results in poor parametric image quality. We have demonstrated that the quality of parametric images can be improved by denoising dyn...

journal_title：Physics in medicine and biology

authors： Huang HM

更新日期：2020-11-17 00:00:00

abstract：:Sensing and enumeration of specific types of circulating cells in small animals is an important problem in many areas of biomedical research. Microscopy-based fluorescence in vivo flow cytometry methods have been developed previously, but these are typically limited to sampling of very small blood volumes, so that ver...

journal_title：Physics in medicine and biology

authors： Zettergren E,Swamy T,Runnels J,Lin CP,Niedre M

更新日期：2012-07-21 00:00:00

abstract：:Advanced radiotherapeutical techniques like intensity-modulated radiation therapy (IMRT) are based on an accurate knowledge of the location of the radiation target. An accurate dose delivery, therefore, requires a method to account for the inter- and intrafractional target motion and the target deformation occurring d...

journal_title：Physics in medicine and biology

authors： Tacke M,Nill S,Oelfke U

更新日期：2007-11-21 00:00:00

abstract：:EGSnrc Monte Carlo simulation was used to investigate dose perturbation effects in prostate seed implant brachytherapy using 125I radioactive seeds used in implant brachytherapy. Dose perturbation effects resulting from the seed mutual attenuation in a prostate seed implant consisting of 27 seeds were investigated. Th...

journal_title：Physics in medicine and biology

authors： Mobit P,Badragan I

更新日期：2004-07-21 00:00:00

abstract：:Accurate scatter correction is especially important for high-resolution 3D positron emission tomographies (PETs) such as high-resolution research tomograph (HRRT) due to large scatter fraction in the data. To address this problem, a fully 3D iterative scatter-corrected ordered subset expectation maximization (OSEM) in...

journal_title：Physics in medicine and biology

authors： Kim KS,Ye JC

更新日期：2011-08-07 00:00:00

abstract：:In positron emission tomography (PET) with pixelated detectors, a significant number of annihilation photons interact with scintillation crystals through single or multiple Compton scattering events. When these partial energy depositions occur across multiple crystal elements, we call them inter-crystal scatter (ICS) ...

journal_title：Physics in medicine and biology

authors： Park H,Lee JS

更新日期：2020-10-21 00:00:00

abstract：:K line x-ray fluorescence (KXRF) measurements of bone lead have emerged as a promising new biological marker of internal lead dose in epidemiological studies. Some disagreements exist, however, over the analysis of data at low levels of bone lead concentration. In this study, we performed 30 serial measurements on eac...

journal_title：Physics in medicine and biology

authors： Kim R,Aro A,Rotnitzky A,Amarasiriwardena C,Hu H

更新日期：1995-09-01 00:00:00

abstract：:A software program, SpekCalc, is presented for the calculation of x-ray spectra from tungsten anode x-ray tubes. SpekCalc was designed primarily for use in a medical physics context, for both research and education purposes, but may also be of interest to those working with x-ray tubes in industry. Noteworthy is the p...

journal_title：Physics in medicine and biology

authors： Poludniowski G,Landry G,DeBlois F,Evans PM,Verhaegen F

更新日期：2009-10-07 00:00:00

abstract：:To investigate the profile measurement capabilities of an IBA-Dosimetry scintillation detector and to assess its feasibility for determining the low-intensity tails of pencil-beam scanning spots, the responses of the scintillation detector and Gafchromic EBT2 film to a 115 MeV proton spot were measured in-air at the i...

journal_title：Physics in medicine and biology

authors： Lin L,Ainsley CG,Mertens T,De Wilde O,Talla PT,McDonough JE

更新日期：2013-06-21 00:00:00

abstract：:The reference levels and maximum permissible exposure values for magnetic fields that are currently used have been derived from basic restrictions under the assumption of upright standing body models in a standard posture, i.e. with arms laterally down and without contact with metallic objects. Moreover, if anatomical...

journal_title：Physics in medicine and biology

authors： Schmid G,Hirtl R

更新日期：2016-06-21 00:00:00

abstract：:Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of disease and in situ evaluation of living tissue. The purpose of this article is to review the biological and physical basis of Raman spectroscopy of tissue, to assess the current status of the field and to explore future directions....

journal_title：Physics in medicine and biology

authors： Hanlon EB,Manoharan R,Koo TW,Shafer KE,Motz JT,Fitzmaurice M,Kramer JR,Itzkan I,Dasari RR,Feld MS

更新日期：2000-02-01 00:00:00

abstract：:Short- and long-term side effects following the treatment of cancer with radiation are strongly related to the amount of dose deposited to the healthy tissue surrounding the tumor. The characterization of the radiation field outside the planned target volume is the first step for estimating health risks, such as devel...

journal_title：Physics in medicine and biology

authors： Tessa CL,Berger T,Kaderka R,Schardt D,Burmeister S,Labrenz J,Reitz G,Durante M

更新日期：2014-04-21 00:00:00

abstract：:A micro beam synchrotron x-ray fluorescence (muSRXRF) technique has been used to determine the localization of metals in primary invasive ductal carcinoma of breast. Nine samples were examined, all of which were formalin fixed tissues arranged as micro arrays of 1.0 mm diameter and 10 microm thickness. Cu was the part...

journal_title：Physics in medicine and biology

authors： Farquharson MJ,Al-Ebraheem A,Falkenberg G,Leek R,Harris AL,Bradley DA

更新日期：2008-06-07 00:00:00

abstract：:We report on a radiographic measurement of an ex vivo human knee using a grating-based phase-contrast imaging setup and a medical x-ray tube at a tube voltage of 70 kV. The measurement has been carried out using a Talbot-Lau setup that is suitable to achieve a high visibility in the energy regime of medical imaging. I...

journal_title：Physics in medicine and biology

authors： Horn F,Gelse K,Jabari S,Hauke C,Kaeppler S,Ludwig V,Meyer P,Michel T,Mohr J,Pelzer G,Rieger J,Riess C,Seifert M,Anton G

更新日期：2017-08-01 00:00:00

abstract：:Speed of sound (SOS) measurements, typically made using 1 MHz broadband pulses, are increasingly used in the clinical diagnosis of bone disorders. Previous in vitro studies indicate that broadband ultrasound pulses are susceptible to distortion in cancellous bone, leading to imprecise arrival time and SOS measurements...

journal_title：Physics in medicine and biology

authors： Pollintine P,Haddaway MJ,Davie MW

更新日期：2000-07-01 00:00:00

abstract：:Positron emission tomography is one of the most mature techniques for monitoring the particles range in hadron therapy, aiming to reduce treatment uncertainties and therefore the extent of safety margins in the treatment plan. In-beam PET monitoring has been already performed using inter-spill and post-irradiation dat...

journal_title：Physics in medicine and biology

authors： Kostara E,Sportelli G,Belcari N,Camarlinghi N,Cerello P,Del Guerra A,Ferrero V,Fiorina E,Giraudo G,Morrocchi M,Pennazio F,Pullia M,Rivetti A,Rolo MD,Rosso V,Wheadon R,Bisogni MG

更新日期：2019-01-21 00:00:00

abstract：:In recent codes of practice for reference dosimetry in clinical proton beams using ionization chambers, it is recommended to perform the measurement in a water phantom. However, in situations where the positioning accuracy is very critical, it could be more convenient to perform the measurement in a plastic phantom. I...

journal_title：Physics in medicine and biology

authors： Palmans H,Symons JE,Denis JM,de Kock EA,Jones DT,Vynckier S

更新日期：2002-09-07 00:00:00

abstract：:The intra- and inter-batch accuracy and precision of MRI (polyacrylamide gelatin gel fabricated at atmospheric conditions) polymer gel dosimeters are assessed in full 3D. In the intra-batch study, eight spherical flasks were filled with the same polymer gel along with a set of test tubes that served as calibration pha...

journal_title：Physics in medicine and biology

authors： Vandecasteele J,De Deene Y

更新日期：2013-01-07 00:00:00

abstract：:In proton scanning systems that employ active energy variation for depth modulation, a switch of the particle energy might typically require 1-2 s. For plans comprising many energy slices, these seconds could sum up to a non-negligible fraction of the total treatment duration. We have applied the Nyquist-Shannon sampl...

journal_title：Physics in medicine and biology

authors： Kang JH,Wilkens JJ,Oelfke U

更新日期：2008-05-07 00:00:00

abstract：:The scope of this work was to develop a synthetic single crystal diamond dosimeter (SCDD-Pro) for accurate relative dose measurements of clinical proton beams in water. Monte Carlo simulations were carried out based on the MCNPX code in order to investigate and reduce the dose curve perturbation caused by the SCDD-Pro...

journal_title：Physics in medicine and biology

authors： Moignier C,Tromson D,de Marzi L,Marsolat F,García Hernández JC,Agelou M,Pomorski M,Woo R,Bourbotte JM,Moignau F,Lazaro D,Mazal A

更新日期：2017-07-07 00:00:00