Particle beam microstructure reconstruction and coincidence discrimination in PET monitoring for hadron therapy.

Abstract:

:Positron emission tomography is one of the most mature techniques for monitoring the particles range in hadron therapy, aiming to reduce treatment uncertainties and therefore the extent of safety margins in the treatment plan. In-beam PET monitoring has been already performed using inter-spill and post-irradiation data, i.e. while the particle beam is off or paused. The full beam acquisition procedure is commonly discarded because the particle spills abruptly increase the random coincidence rates and therefore the image noise. This is because random coincidences cannot be separated by annihilation photons originating from radioactive decays and cannot be corrected with standard random coincidence techniques due to the time correlation of the beam-induced background with the ion beam microstructure. The aim of this paper is to provide a new method to recover in-spill data to improve the images obtained with full-beam PET acquisitions. This is done by estimating the temporal microstructure of the beam and thus selecting input PET events that are less likely to be random ones. The PET detector we used was the one developed within the INSIDE project and tested at the CNAO synchrotron-based facility. The data were taken on a PMMA phantom irradiated with 72 MeV proton pencil beams. The obtained results confirm the possibility of improving the acquired PET data without any external signal coming from the synchrotron or ad hoc detectors.

journal_name

Phys Med Biol

authors

Kostara E,Sportelli G,Belcari N,Camarlinghi N,Cerello P,Del Guerra A,Ferrero V,Fiorina E,Giraudo G,Morrocchi M,Pennazio F,Pullia M,Rivetti A,Rolo MD,Rosso V,Wheadon R,Bisogni MG

doi

10.1088/1361-6560/aafa28

subject

Has Abstract

pub_date

2019-01-21 00:00:00

pages

035001

issue

3

eissn

0031-9155

issn

1361-6560

journal_volume

64

pub_type

杂志文章
  • Internal dosimetry with the Monte Carlo code GATE: validation using the ICRP/ICRU female reference computational model.

    abstract::The purpose of this work was to validate GATE-based clinical scale absorbed dose calculations in nuclear medicine dosimetry. GATE (version 6.2) and MCNPX (version 2.7.a) were used to derive dosimetric parameters (absorbed fractions, specific absorbed fractions and S-values) for the reference female computational model...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/62/5/1885

    authors: Villoing D,Marcatili S,Garcia MP,Bardiès M

    更新日期:2017-03-07 00:00:00

  • Magnetic separation of iron oxide nanoparticles to improve their application for magnetic particle imaging.

    abstract::Magnetic Particle Imaging (MPI) is a promising medical imaging technique for visualizing the three-dimensional distribution of tracer materials, specifically iron oxide nanoparticles (IONP). The optimization of magnetic nanoparticles (MNP) plays an essential role to improve the image resolution and sensitivity of imag...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abcd19

    authors: Arsalani S,Loewa N,Kosch O,Radon P,Baffa O,Wiekhorst F

    更新日期:2020-11-23 00:00:00

  • Substituting gelatine with Pluronic F-127 matrix in 3D polymer gel dosimeters can improve nuclear magnetic resonance, thermal and optical properties.

    abstract::This work discusses the substitution of a gelatine physical gel matrix with a matrix made of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127) in five 3D radiotherapy polymer gel dosimeters: MAGAT, PAGAT, NIPAM, VIPARnd (VIP) and VIPARCT (VIC). The current research outcomes s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aad9d5

    authors: Jaszczak M,Wach R,Maras P,Dudek M,Kozicki M

    更新日期:2018-09-06 00:00:00

  • Optical-coherence tomography of a dense tissue: statistics of attenuation and backscattering.

    abstract::This paper addresses fundamental issues that underlie the interpretation of images acquired from turbid tissues by optical-coherence tomography (OCT). The attenuation and backscattering properties of freshly excised rat arteries and their dependence on the focusing and collection optics of the OCT system were measured...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/10/013

    authors: Schmitt JM,Knüttel A,Yadlowsky M,Eckhaus MA

    更新日期:1994-10-01 00:00:00

  • Electron depth-dose dependence on energy spectral quality.

    abstract::Electron depth-dose curves and spectra have been measured from an experimental accelerator on which both energy and spectral shape could be varied independently. The measurements were made at nominal energies of 6 and 12 MeV, with the energy spread (FWHM) varied from 1.7% to over 10% of average energy. Changes in dept...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/28/12/005

    authors: Johnsen SW,LaRiviere PD,Tanabe E

    更新日期:1983-12-01 00:00:00

  • A task-based quality control metric for digital mammography.

    abstract::A reader study was conducted to tune the parameters of an observer model used to predict the detectability index (dʹ ) of test objects as a task-based quality control (QC) metric for digital mammography. A simple test phantom was imaged to measure the model parameters, namely, noise power spectrum,modulation transfer ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/21/6621

    authors: Bloomquist AK,Mainprize JG,Mawdsley GE,Yaffe MJ

    更新日期:2014-11-07 00:00:00

  • Evaluating attenuation correction strategies in a dedicated, single-gantry breast PET-tomosynthesis scanner.

    abstract::We are developing a dedicated, combined breast positron emission tomography (PET)-tomosynthesis scanner. Both the PET and digital breast tomosynthesis (DBT) scanners are integrated in a single gantry to provide spatially co-registered 3D PET-tomosynthesis images. The DBT image will be used to identify the breast bound...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abc5a8

    authors: Krishnamoorthy S,Vent T,Barufaldi B,Maidment ADA,Karp JS,Surti S

    更新日期:2020-10-28 00:00:00

  • Fundamental study on diffuse reflective optical tomography.

    abstract::We report a simulation study on diffuse reflective optical computed tomography, in which continuous-wave sources and detectors are placed on the plane surface of a semi-infinite body. We adopted a simple Tikhonov regularization in the inverse problem and demonstrated the feasibility of three-dimensional reconstruction...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/10/004

    authors: Endoh R,Suzuki A,Fujii M,Nakayama K

    更新日期:2004-05-21 00:00:00

  • FPGA-based distributed coincidence processor for high count-rate online PET coincidence data acquisition.

    abstract::For PET online data acquisition, a centralized coincidence processor (CCP) with a single-thread data processing has been used to select coincidence events for many PET scanners. CCP has the advantage of highly integrated circuit, compact connection between detector front-end and system electronics, and centralized con...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abde85

    authors: Cheng X,Hu K,Yang D,Shao Y

    更新日期:2021-01-21 00:00:00

  • The Akaike information criterion in DCE-MRI: does it improve the haemodynamic parameter estimates?

    abstract::The Akaike information criterion and the associated Akaike weights (AW) rank pharmacokinetic models on the basis of goodness-of-fit and number of parameters. The usefulness of this information for improving the haemodynamic parameter estimates from DCE-MRI was investigated through two examples. In each of these, the e...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/11/3609

    authors: Luypaert R,Ingrisch M,Sourbron S,de Mey J

    更新日期:2012-06-07 00:00:00

  • The use of the Henyey-Greenstein phase function in Monte Carlo simulations in biomedical optics.

    abstract::Monte Carlo (MC) simulations are often at the heart of the testing procedure in biomedical optics. One of the critical points in MC simulations is to define the new photon direction after each scattering event. One of the most popular solutions is to use the Henyey-Greenstein phase function or some linear combinations...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/51/17/N04

    authors: Binzoni T,Leung TS,Gandjbakhche AH,Rüfenacht D,Delpy DT

    更新日期:2006-09-07 00:00:00

  • Impact of free-breathing CT on quantitative measurements of static and quiescent period-gated PET Images.

    abstract::Measurements of standardized uptake values (SUV) can vary due to many causes, including respiratory motion. Various methodologies have been introduced to correct for motion in PET, with quiescent-period-gated (QPG) PET being the most popular approach. QPG has been shown to improve PET image quantification compared to ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab1cdd

    authors: Meier JG,Einstein SA,Diab RH,Erasmus LJ,Xu G,Mawlawi OR

    更新日期:2019-05-16 00:00:00

  • Numerical study of oxygen transport in a carotid bifurcation.

    abstract::This study investigates the oxygen mass transport in the region around the human carotid bifurcation, particularly addressing the effects of bifurcation geometry and pulsatile blood flow on the oxygen transport between the blood flow and artery wall tissue, coupled with the metabolic oxygen consumption and oxygen diff...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/55/14/004

    authors: Tada S

    更新日期:2010-07-21 00:00:00

  • Optimization of the electric field distribution in a large volume tissue-equivalent proportional counter.

    abstract::Large volume tissue-equivalent proportional counters are of interest in radiation protection metrology, as the sensitivity in terms of counts per unit absorbed dose in these devices increases as the square of the counter diameter. Conventional solutions to the problem of maintaining a uniform electric field within a c...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/37/10/002

    authors: Verma PK,Waker AJ

    更新日期:1992-10-01 00:00:00

  • Are phantoms useful for predicting the potential of dose reduction in full-field digital mammography?

    abstract::A phantom study was performed in full-field digital mammography to investigate the opportunity and the magnitude of a possible dose reduction that would leave the image quality above the accepted thresholds associated with some classical phantoms. This preliminary work is intended to lay the groundwork for a future cl...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/8/015

    authors: Gennaro G,Katz L,Souchay H,Alberelli C,di Maggio C

    更新日期:2005-04-21 00:00:00

  • Effect of inter-crystal scatter on estimation methods for random coincidences and subsequent correction.

    abstract::Random coincidences can contribute substantially to the background in positron emission tomography (PET). Several estimation methods are being used for correcting them. The goal of this study was to investigate the validity of techniques for random coincidence estimation, with various low-energy thresholds (LETs). Sim...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/53/9/012

    authors: Torres-Espallardo I,Rafecas M,Spanoudaki V,McElroy DP,Ziegler SI

    更新日期:2008-05-07 00:00:00

  • Volumetric CT with sparse detector arrays (and application to Si-strip photon counters).

    abstract::Novel x-ray medical imaging sensors, such as photon counting detectors (PCDs) and large area CCD and CMOS cameras can involve irregular and/or sparse sampling of the detector plane. Application of such detectors to CT involves undersampling that is markedly different from the commonly considered case of sparse angular...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/1/90

    authors: Sisniega A,Zbijewski W,Stayman JW,Xu J,Taguchi K,Fredenberg E,Lundqvist M,Siewerdsen JH

    更新日期:2016-01-07 00:00:00

  • Calculation of positron range and its effect on the fundamental limit of positron emission tomography system spatial resolution.

    abstract::Developments in positron emission tomography (PET) technology have resulted in systems with finer detector elements designed to further improve spatial resolution. However, there is a limit to what extent reducing detector element size will improve spatial resolution in PET. The spatial resolution of PET imaging is li...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/44/3/019

    authors: Levin CS,Hoffman EJ

    更新日期:1999-03-01 00:00:00

  • Derivation of mean dose tolerances for new fractionation schemes and treatment modalities.

    abstract::Avoiding toxicities in radiotherapy requires the knowledge of tolerable organ doses. For new, experimental fractionation schemes (e.g. hypofractionation) these are typically derived from traditional schedules using the biologically effective dose (BED) model. In this report we investigate the difficulties of establish...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa9836

    authors: Perkó Z,Bortfeld T,Hong T,Wolfgang J,Unkelbach J

    更新日期:2018-02-05 00:00:00

  • Iterative deblurring algorithm for a multiplane tomographic scanner.

    abstract::An iterative algorithm has been developed to reduce blur artefacts in images obtained from the Pho/Con multiplane tomographic scanner. In this technique estimates of the activity distribution are convolved with the detector response function and compared with the original blurred image planes. Successive estimates of ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/30/7/004

    authors: Zenari A,Hooper RH,Osborne N,Scrimger JW

    更新日期:1985-07-01 00:00:00

  • Monte Carlo verification of polymer gel dosimetry applied to radionuclide therapy: a phantom study.

    abstract::This study evaluates the dosimetric performance of the polymer gel dosimeter 'Methacrylic and Ascorbic acid in Gelatin, initiated by Copper' and its suitability for quality assurance and analysis of I-131-targeted radionuclide therapy dosimetry. Four batches of gel were manufactured in-house and sets of calibration vi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/56/22/017

    authors: Gear JI,Charles-Edwards E,Partridge M,Flux GD

    更新日期:2011-11-21 00:00:00

  • Towards a gold standard for quantitative coronary arteriography.

    abstract::Densitometric quantification of coronary artery stenoses in angiographic images can be problematic for two reasons: (i) the x-rays are inadequately oriented with respect to the vessel segments of interest at image acquisition; (ii) non-linear effects due for instance to beam hardening, scattered radiation and veiling ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/12/011

    authors: Doriot PA,Dorsaz PA,Dorsaz L,Bodenmann JJ

    更新日期:1997-12-01 00:00:00

  • Characterization of the secondary neutron field produced during treatment of an anthropomorphic phantom with x-rays, protons and carbon ions.

    abstract::Short- and long-term side effects following the treatment of cancer with radiation are strongly related to the amount of dose deposited to the healthy tissue surrounding the tumor. The characterization of the radiation field outside the planned target volume is the first step for estimating health risks, such as devel...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/8/2111

    authors: Tessa CL,Berger T,Kaderka R,Schardt D,Burmeister S,Labrenz J,Reitz G,Durante M

    更新日期:2014-04-21 00:00:00

  • Radiation damage, repopulation and cell recovery analysis of in vitro tumour cell megacolony culture data using a non-Poissonian cell repopulation TCP model.

    abstract::The effects of radiation damage, tumour repopulation and cell sublethal damage repair and the possibility of extracting information about the model parameters describing them are investigated in this work. Previously published data on two different cultured cell lines were analysed with the help of a tumour control pr...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/13/006

    authors: Stavrev P,Weldon M,Warkentin B,Stavreva N,Fallone BG

    更新日期:2005-07-07 00:00:00

  • A diffusion theory model of spatially resolved fluorescence from depth-dependent fluorophore concentrations.

    abstract::A photon diffusion model has been developed to calculate the steady-state spatially resolved fluorescence from pencil beam excitation in layered tissue. The model allows the calculation of both the excitation reflectance and the fluorescence escape for an arbitrary continuous depth distribution of tissue optical prope...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/46/2/307

    authors: Hyde DE,Farrell TJ,Patterson MS,Wilson BC

    更新日期:2001-02-01 00:00:00

  • A proposal concerning the absorbed dose conversion factor.

    abstract::New definitions of the absorbed dose conversion factors Clambda and CE are proposed. The absorbed dose in water is given by the product of absorbed dose conversion factor, exposure calibration factor, ionisation chamber reading, cap displacement correction factor and perturbation correction factor. At exposure calibra...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/23/2/003

    authors: Shiragai A

    更新日期:1978-03-01 00:00:00

  • Superpixel-based and boundary-sensitive convolutional neural network for automated liver segmentation.

    abstract::Segmentation of liver in abdominal computed tomography (CT) is an important step for radiation therapy planning of hepatocellular carcinoma. Practically, a fully automatic segmentation of liver remains challenging because of low soft tissue contrast between liver and its surrounding organs, and its highly deformable s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aabd19

    authors: Qin W,Wu J,Han F,Yuan Y,Zhao W,Ibragimov B,Gu J,Xing L

    更新日期:2018-05-04 00:00:00

  • Dielectric properties of porcine glands, gonads and body fluids.

    abstract::Dielectric properties of porcine glandular tissues and gonads (in vivo) and body fluids (in vitro) have been obtained in the frequency range of 50 MHz to 20 GHz. The experimental data were fitted to a two term Cole-Cole expression. The data presented complement the available dielectric properties of tissues in the lit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/19/N339

    authors: Peyman A,Gabriel C

    更新日期:2012-10-07 00:00:00

  • Effect on tumour control of time interval between surgery and postoperative radiotherapy: an empirical approach using Monte Carlo simulation.

    abstract::In this work, a procedure, based on Monte Carlo techniques, to analyse the effect on the tumour control probability of the time interval between surgery and postoperative radiotherapy is presented. The approach includes the tumour growth as well as the survival of tumour cells undergoing fractionated radiotherapy. Bot...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/49/13/005

    authors: Al-Dweri FM,Guirado D,Lallena AM,Pedraza V

    更新日期:2004-07-07 00:00:00

  • Arranging optical fibres for the spatial resolution improvement of topographical images.

    abstract::Optical topography is a method for visualization of conical activity. Ways of improving the spatial resolution of the topographical image with three arrangements of optical fibres are discussed. A distribution of sensitivity is obtained from the phantom experiment, and used to reconstruct topographical images of an ac...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/47/18/311

    authors: Yamamoto T,Maki A,Kadoya T,Tanikawa Y,Yamad Y,Okada E,Koizumi H

    更新日期:2002-09-21 00:00:00