Abstract:
:We report on a radiographic measurement of an ex vivo human knee using a grating-based phase-contrast imaging setup and a medical x-ray tube at a tube voltage of 70 kV. The measurement has been carried out using a Talbot-Lau setup that is suitable to achieve a high visibility in the energy regime of medical imaging. In a medical reading by an experienced trauma surgeon signatures of chondrocalcinosis in the medial meniscus have been identified more evidently using the dark-field image in comparison to the conventional attenuation image. The analysis has been carried out at various dose levels down to 0.14 mGy measured as air kerma, which is a dose comparable to clinically used radiographic devices. The diagnosis has been confirmed by a histological analysis of the meniscus tissue. In the introduced high-frequency filtered phase-contrast image the anterior and posterior horn of the medial meniscus and the posterior cruciate ligament have also been visible. Furthermore, atherosclerotic plaque is visible in both imaging modalities, attenuation and dark-field, despite the presence of overlaying bone. This measurement, for the first time, proves the feasibility of Talbot-Lau x-ray imaging at high-energy spectra above 40 kVp and reasonable dose levels with regard to spacious and dense objects.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Horn F,Gelse K,Jabari S,Hauke C,Kaeppler S,Ludwig V,Meyer P,Michel T,Mohr J,Pelzer G,Rieger J,Riess C,Seifert M,Anton Gdoi
10.1088/1361-6560/aa7721subject
Has Abstractpub_date
2017-08-01 00:00:00pages
6729-6745issue
16eissn
0031-9155issn
1361-6560journal_volume
62pub_type
杂志文章abstract::For low-energy (up to 150 kV) x-rays, the ratio of mass-energy absorption coefficients for water to air, (mu(en)/rho)w.air, and the backscatter factor B are used in the conversion of air kerma, measured free-in-air, to water kerma on the surface of a water phantom. For clinical radiotherapy, similar conversion factors...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/44/1/011
更新日期:1999-01-01 00:00:00
abstract::Sparse-view CT reconstruction algorithms via total variation (TV) optimize the data iteratively on the basis of a noise- and artifact-reducing model, resulting in significant radiation dose reduction while maintaining image quality. However, the piecewise constant assumption of TV minimization often leads to the appea...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/59/12/2997
更新日期:2014-06-21 00:00:00
abstract::This study investigated the relationship between the specific absorption rate and temperature elevation in an anatomically-based model named NORMAN for exposure to radio-frequency far fields in the ICNIRP guidelines (1998 Health Phys. 74 494-522). The finite-difference time-domain method is used for analyzing the elec...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/52/16/020
更新日期:2007-08-21 00:00:00
abstract::The dose-calculation accuracy of the tomotherapy Hi-Art II(R) (Tomotherapy, Inc., Madison, WI) treatment planning system (TPS) in the presence of low-density lung media was investigated. In this evaluation, a custom-designed heterogeneous phantom mimicking the mediastinum geometry was used. Gammex LN300 and balsa wood...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/54/8/004
更新日期:2009-04-21 00:00:00
abstract::Diffusion tensor - magnetic resonance electrical impedance tomography (DT-MREIT) is an imaging modality to obtain low-frequency anisotropic conductivity distribution employing diffusion tensor imaging (DTI) and magnetic resonance electrical impedance tomography (MREIT) techniques. DT-MREIT is based on the linear relat...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/abddcf
更新日期:2021-01-20 00:00:00
abstract::The relative biological effectiveness (RBE) of protons varies with multiple physical and biological factors. Phenomenological RBE models have been developed to include such factors in the estimation of a variable RBE, in contrast to the clinically applied constant RBE of 1.1. In this study, eleven published phenomenol...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aad9db
更新日期:2018-09-13 00:00:00
abstract::Recent developments in the technique of constant infusion and in emission computed tomography have provided a new method for quantitative regional flow measurements. This paper re-examines critically the theoretical relationship between flow and radioactivity during constant infusion of short-lived isotopes. Sensitivi...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/24/6/005
更新日期:1979-11-01 00:00:00
abstract::A step and shoot sequencer was developed that can be integrated into an IMRT optimization algorithm. The method uses non-uniform fluence steps and is adopted to the constraints of an MLC. It consists of a clustering, a smoothing and a segmentation routine. The performance of the algorithm is demonstrated for eight mat...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/46/7/319
更新日期:2001-07-01 00:00:00
abstract::While megavoltage cone-beam computed tomography (CBCT) using an electronic portal imaging device (EPID) provides many advantages over kilovoltage (kV) CBCT, clinical adoption is limited by its high doses. Multi-layer imager (MLI) EPIDs increase DQE(0) while maintaining high resolution. However, even well-designed, hig...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aaa160
更新日期:2018-01-30 00:00:00
abstract::A multicentre phase II trial of stereotactic body radiotherapy for T1N0M0 non-small cell lung cancer was initiated in Japan as the Japan Clinical Oncology Group trial (JCOG0403). Before starting the trial, a decision was made to evaluate the treatment machine and treatment planning in participating institutions to min...
journal_title:Physics in medicine and biology
pub_type: 杂志文章,多中心研究
doi:10.1088/0031-9155/51/21/002
更新日期:2006-11-07 00:00:00
abstract::A photon diffusion model has been developed to calculate the steady-state spatially resolved fluorescence from pencil beam excitation in layered tissue. The model allows the calculation of both the excitation reflectance and the fluorescence escape for an arbitrary continuous depth distribution of tissue optical prope...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/46/2/307
更新日期:2001-02-01 00:00:00
abstract::IMRT optimization is an iterative process in which many dose calculations may be necessary. A fast and accurate dose calculation engine is essential for the optimization program to converge to a reliable solution in a reasonable time. Previously we developed a fast dose calculation method for IMRT optimization based o...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/49/19/011
更新日期:2004-10-07 00:00:00
abstract::The rationale for multi-modality imaging is to integrate the strengths of different imaging technologies while reducing the shortcomings of an individual modality. The work presented here proposes a limited-field-of-view (LFOV) SPECT reconstruction technique that can be implemented on a multi-modality MR/SPECT system ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/56/3/010
更新日期:2011-02-07 00:00:00
abstract::We present a new version of STIR (Software for Tomographic Image Reconstruction), an open source object-oriented library implemented in C++ for 3D positron emission tomography reconstruction. This library has been designed such that it can be used for many algorithms and scanner geometries, while being portable to var...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/57/4/867
更新日期:2012-02-21 00:00:00
abstract::The aim of this study is to calculate realistic dose distributions that include the continuous deformation of organs and continuous motion of machine using 4D Monte Carlo methods for both volumetric modulated arc therapy and helical tomotherapy treatments. As part of a previous study, we presented a method to perform ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/9/2807
更新日期:2013-05-07 00:00:00
abstract::We present a method to include robustness in a multi-criteria optimization (MCO) framework for intensity-modulated proton therapy (IMPT). The approach allows one to simultaneously explore the trade-off between different objectives as well as the trade-off between robustness and nominal plan quality. In MCO, a database...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/57/3/591
更新日期:2012-02-07 00:00:00
abstract::A motorized electron multileaf collimator (eMLC) was developed as an add-on device to the Varian linac for delivery of advanced electron beam therapy. It has previously been shown that electron beams collimated by an eMLC have very similar penumbra to those collimated by applicators and cutouts. Thus, manufacturing pa...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/16/5653
更新日期:2013-08-21 00:00:00
abstract::Computational modeling is an important tool in ultrasound imaging research, but realistic three-dimensional (3D) simulations can exceed the capabilities of serial computers. This paper uses a 3D simulator based on a k-space method that incorporates relaxation absorption and nonreflecting boundary conditions. The simul...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/54/17/007
更新日期:2009-09-07 00:00:00
abstract::The development of new biological imaging technologies offers the opportunity to further individualize radiotherapy. Biologically conformal radiation therapy (BCRT) implies the use of the spatial distribution of one or more radiobiological parameters to guide the IMRT dose prescription. Our aim was to implement BCRT i...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/51/16/N02
更新日期:2006-08-21 00:00:00
abstract::Depth-dose distributions were calculated for thermal and epithermal neutron fluence and capture gamma ray dose rates using a two-dimensional neutron-coupled gamma-ray transport code (DOT 3.5) for gadolinium neutron capture therapy. The results show that (i) a capture gamma-ray dose rate of 10 Gy h-1 was obtained with ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/37/1/010
更新日期:1992-01-01 00:00:00
abstract::The anisotropic mechanical properties (mechanical anisotropy) and view-dependent ultrasonic backscattering (acoustic anisotropy) of striated muscle due to the underlying myofiber arrangement have been well documented, but whether they impact on ultrasound strain imaging (USI) techniques remains unclear. The aim of thi...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa530b
更新日期:2017-02-21 00:00:00
abstract::Two complementary approaches to the noise suppression problem in on-line portal imaging have been analysed. Temporal filtering by image summation can substantially reduce the amount of noise in an image. In many cases, however, movements of the patient or the radiation source limit the time period over which the avera...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/35/3/011
更新日期:1990-03-01 00:00:00
abstract::Dynamic contrast-enhanced computed tomography (DCE-CT) is an imaging tool that aids in evaluating functional characteristics of tissue at different stages of disease management: diagnostic, radiation treatment planning, treatment effectiveness, and monitoring. Clinical validation of DCE-derived perfusion parameters re...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/17/6111
更新日期:2013-09-07 00:00:00
abstract::A silicon semiconductor photodiode was used to measure the TL-signal of TLD-300 (CaF2:Tm) detectors irradiated with 60Co gamma rays and 226Ra alpha particles. The applied dose values varied from 0.12 to 14.3 Gy for gamma rays and from about 50 to 300 Gy for alpha particles. Because of the infrared sensitivity of the p...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/33/12/006
更新日期:1988-12-01 00:00:00
abstract::Respiratory gating based on external surrogates is performed in many clinics. We have developed a new technique for treatment verification using an electronic portal imaging device (EPID) in cine mode for gated 3D conformal therapy. Implanted radiopaque fiducial markers inside or near the target are required for this ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/50/16/002
更新日期:2005-08-21 00:00:00
abstract::3D breast modelling for 2D and 3D breast x-ray imaging would benefit from the availability of digital and physical phantoms that reproduce accurately the complexity of the breast anatomy. While a number of groups have produced digital phantoms with increasing level of complexity, physical phantoms reproducing that sof...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab0670
更新日期:2019-03-27 00:00:00
abstract::Deformable image registration is widely used in various radiation therapy applications including daily treatment planning adaptation to map planned tissue or dose to changing anatomy. In this work, a simple and efficient inverse consistency deformable registration method is proposed with aims of higher registration ac...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/53/21/017
更新日期:2008-11-07 00:00:00
abstract::In elastography we have previously developed a tracking and correction method that estimates the axial and lateral strain components along and perpendicular to the compressor/scanning axis following an externally applied compression. However, the resulting motion is a three-dimensional problem. Therefore, in order to ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/45/6/311
更新日期:2000-06-01 00:00:00
abstract::The electromagnetic spectrum contains different frequency bands useful for medical imaging and therapy. Short wavelengths (ionizing radiation) are commonly used for radiological and radionuclide imaging and for cancer radiation therapy. Intermediate wavelengths (optical radiation) are useful for more localized imaging...
journal_title:Physics in medicine and biology
pub_type: 杂志文章,评审
doi:10.1088/1361-6560/aaf4de
更新日期:2019-02-06 00:00:00
abstract::X-ray fluorescence computed tomography (XFCT) is a relatively new synchrotron-based imaging modality aiming at reconstructing the distribution of nonradiative elements within a sample irradiated with high-intensity monochromatic x-rays. In a recent paper La Rivière (2004 Phys. Med. Biol. 49 2391-405) presented an appr...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/55/4/007
更新日期:2010-02-21 00:00:00