Abstract:
:Existing studies have suggested some debate on whether the quality of radiation that delivers dose outside of the primary field of a radiotherapy photon beam can be considered the same as that inside the primary field. We used a Monte Carlo approach to simulate the electron fluence differential in energy inside a water phantom in response to irradiation by a 6 MV photon beam. The goal was to quantify how significantly the electron fluence changes when moving from a volume exposed to the primary field to one outside of the primary field, and understand any potential biological implications. We scored the electron fluence outwards in annular volumes in response to a 5 cm radius 6 MV beam and at the central axis in response to a rectangular 6 MV beam partially blocked by an MLC. The resulting fluence spectra were compared to different low-LET sources for which biological response in the form of chromosomal aberrations has been published. Our results show a significant increase in the low energy component of the fluence spectra outside of the primary field, which increases the mean LET to values similar to that seen in response to a 137Cs photon source. In turn, it is shown that this has the potential to increase the RBE.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Kirkby C,Field C,MacKenzie M,Syme A,Fallone BGdoi
10.1088/0031-9155/52/12/015subject
Has Abstractpub_date
2007-06-21 00:00:00pages
3563-78issue
12eissn
0031-9155issn
1361-6560pii
S0031-9155(07)43378-4journal_volume
52pub_type
杂志文章abstract::Analytic solutions to the time-dependent multiregion bioheat equation are evaluated numerically for cartesian and spherical models. Principle and alternate branch contributions to the solutions are examined. The calculations include a parametric investigation and analyses of temperature behaviour in idealised upper th...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/35/7/005
更新日期:1990-07-01 00:00:00
abstract::The total ionisation produced by ions stopped in nitrogen, methane and carbon dioxide has been measured in the energy range 25-375 keV using a chamber described previously. The chamber was operated alternately as a proportional counter and as an ionisation chamber to measure respectively the particle rate and the tota...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/25/3/010
更新日期:1980-05-01 00:00:00
abstract::Uncemented prosthetic joint implants used in orthopaedic surgery are usually coated with a porous surface to encourage bone ingrowth. Better contact between the endosteal bone and the porous surface improves ingrowth, and such contact may be increased if the joint further subsides into position in the first weeks foll...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/38/2/009
更新日期:1993-02-01 00:00:00
abstract::Large volume tissue-equivalent proportional counters are of interest in radiation protection metrology, as the sensitivity in terms of counts per unit absorbed dose in these devices increases as the square of the counter diameter. Conventional solutions to the problem of maintaining a uniform electric field within a c...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/37/10/002
更新日期:1992-10-01 00:00:00
abstract::Induction cookers are a type of cooking appliance that uses an intermediate-frequency magnetic field to heat the cooking vessel. The magnetic flux density produced by an induction cooker during operation was measured according to the EN 62233 standard, and the measured values were below the limits set in the standard....
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/56/19/001
更新日期:2011-10-07 00:00:00
abstract::Source anisotropy is a very important factor in the brachytherapy quality assurance of high-dose rate (HDR) 192Ir afterloading stepping sources. If anisotropy is not taken into account then doses received by a brachytherapy patient in certain directions can be in error by a clinically significant amount. Experimental ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/43/6/029
更新日期:1998-06-01 00:00:00
abstract::The purpose of this work was to validate GATE-based clinical scale absorbed dose calculations in nuclear medicine dosimetry. GATE (version 6.2) and MCNPX (version 2.7.a) were used to derive dosimetric parameters (absorbed fractions, specific absorbed fractions and S-values) for the reference female computational model...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/62/5/1885
更新日期:2017-03-07 00:00:00
abstract::In charged particle therapy with pencil beam scanning (PBS), localization of the dose in the Bragg peak makes dose distributions sensitive to lateral tissue heterogeneities. The sensitivity of a PBS plan to lateral tissue heterogeneities can be reduced by selecting appropriate beam angles. The purpose of this study is...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/61/24/8664
更新日期:2016-12-21 00:00:00
abstract::Radiochromic films are useful as dosimeters in high-precision radiotherapy owing to their high spatial resolution. However, when a particle beam is measured using a radiochromic film, the dose cannot be estimated accurately because the film darkness varies with variations in linear energy transfer (LET). This paper pr...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab8bf3
更新日期:2020-06-15 00:00:00
abstract::Ion beam therapy offers the possibility of a highly conformal tumor-dose distribution; however, this technique is extremely sensitive to inaccuracies in the treatment procedures. Ambiguities in the conversion of Hounsfield units of the treatment planning x-ray CT to relative stopping power (RSP) can cause uncertaintie...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa5602
更新日期:2017-02-07 00:00:00
abstract::In this paper we present a generalized Deep Learning-based approach for solving ill-posed large-scale inverse problems occuring in medical image reconstruction. Recently, Deep Learning methods using iterative neural networks (NNs) and cascaded NNs have been reported to achieve state-of-the-art results with respect to ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/ab990e
更新日期:2020-07-06 00:00:00
abstract::The exponential edge-gradient effect must arise in any x-ray transmission CT scanner whenever long sharp edges of high contrast are encountered. The effect is non-linear and is due to the interaction of the exponential law of x-ray attenuation and the finite width of the scanning beam in the x-y plane. The error induc...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/26/3/010
更新日期:1981-05-01 00:00:00
abstract::In previous work we demonstrated the potential of positron emission tomography (PET) detectors with depth-of-interaction (DOI) encoding capability based on phosphor-coated crystals. A DOI resolution of 8 mm full-width at half-maximum was obtained for 20 mm long scintillator crystals using a delayed charge integration ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/57/20/6571
更新日期:2012-10-21 00:00:00
abstract::Gel dosimetry based on magnetic resonance imaging (MRI) has previously been shown to provide verification of calculated dose distributions in soft tissue equivalent homogeneous phantoms. This study demonstrates how measurements of dose distribution can also be achieved in a phantom containing porous, lung-equivalent, ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/45/10/303
更新日期:2000-10-01 00:00:00
abstract::While megavoltage cone-beam computed tomography (CBCT) using an electronic portal imaging device (EPID) provides many advantages over kilovoltage (kV) CBCT, clinical adoption is limited by its high doses. Multi-layer imager (MLI) EPIDs increase DQE(0) while maintaining high resolution. However, even well-designed, hig...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aaa160
更新日期:2018-01-30 00:00:00
abstract::This study investigated the temperature elevation in the eye of anatomically based human head models for plane-wave exposures. The finite-difference time-domain method is used for analyzing electromagnetic absorption and temperature elevation. The eyes in the anatomic models have average dimensions and weight. Computa...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/52/21/003
更新日期:2007-11-07 00:00:00
abstract::The (83)Kr magnetic resonance (MR) relaxation time T(1) of krypton gas in contact with model surfaces was previously found to be highly sensitive to surface composition, surface-to-volume ratio, and surface temperature. The work presented here explored aspects of pulmonary (83)Kr T(1) relaxation measurements in excise...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/56/13/001
更新日期:2011-07-07 00:00:00
abstract::Usually, Monte Carlo models are validated against experimental data. However, models of multiple Coulomb scattering (MCS) in the Gaussian approximation are exceptional in that we have theories which are probably more accurate than the experiments which have, so far, been done to test them. In problems directly sensiti...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aa6ce3
更新日期:2017-07-06 00:00:00
abstract::The device developed by the authors and described here enables the user to measure the depth from the water surface to the point of measurement for a cylindrical ion chamber with a waterproof plastic cap in a water phantom, free of surface-tension error with a high precision. The device seeks vertical orientation and ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/40/8/007
更新日期:1995-08-01 00:00:00
abstract::A stable cryogel dosimeter was prepared using ferrous benzoic xylenol orange (FBX) in a transparent poly-(vinyl alcohol) (PVA) cryogel matrix. Dose response was evaluated for different numbers of freeze-thaw cycles (FTCs), different concentrations of PVA, and ratios of water/dimethyl sulfoxide. Linear relationships be...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/59/7/1773
更新日期:2014-04-07 00:00:00
abstract::In medical imaging different techniques have been developed to gain information from inside a tissue. Optoacoustics is a method to generate tomography pictures of tissue using Q-switched laser pulses. Due to thermal and pressure confinement, a short light pulse generates a pressure distribution inside tissue, which mi...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/46/7/309
更新日期:2001-07-01 00:00:00
abstract::Intensity modulated proton radiotherapy (IMPT) can reduce the dose to critical structures by optimizing the distribution and intensity of individual pencil beams. The IMPT can be delivered by dynamically scanning a pencil beam with variable intensity and energy across the tumor target volume. The lateral penumbra of a...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/53/6/016
更新日期:2008-03-21 00:00:00
abstract::In brachytherapy, plans are routinely calculated using the AAPM TG43 formalism which considers the patient as a simple water object. An accurate modeling of the physical processes considering patient heterogeneity using Monte Carlo simulation (MCS) methods is currently too time-consuming and computationally demanding ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/60/13/4987
更新日期:2015-07-07 00:00:00
abstract::Projection and backprojection are operations that arise frequently in tomographic imaging. Recently, we proposed a new method for projection and backprojection, which we call distance-driven, and that offers low arithmetic cost and a highly sequential memory access pattern. Furthermore, distance-driven projection and ...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/49/11/024
更新日期:2004-06-07 00:00:00
abstract::Positron emission tomography (PET) has been suggested as an imaging technique for in vivo proton dose and range verification after proton induced-tissue activation. During proton treatment, irradiated tissue is activated and decays while emitting positrons. In this paper, we assessed the feasibility of using PET imagi...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/11/3815
更新日期:2013-06-07 00:00:00
abstract::Stroke lesion volume is a key radiologic measurement in assessing prognosis of acute ischemic stroke (AIS) patients. The aim of this paper is to develop an automated segmentation method for accurately segmenting follow-up ischemic and hemorrhagic lesion from multislice non-contrast CT (NCCT) volumes of AIS patients. T...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/1361-6560/aba166
更新日期:2020-11-05 00:00:00
abstract::This paper describes a neural network (NN) regression model for relative dose computation. The input signal of the NN model includes depths and field sizes and the output is the relative dose, for example, percentage depth dose (%DD) or tissue-air ratio (TAR) in this paper. After a functional link has been created, th...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/45/4/307
更新日期:2000-04-01 00:00:00
abstract::This study presents the computational dosimetry of contact currents for grounded and ungrounded human models. The uncertainty of the quasi-static (QS) approximation of the in situ electric field induced in a grounded/ungrounded human body due to the contact current is first estimated. Different scenarios of cylindrica...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/58/15/5153
更新日期:2013-08-07 00:00:00
abstract::We propose a retrospective respiratory gating algorithm to generate dynamic CT studies. To this end, we compared three different methods of extracting the respiratory signal from the projections of small-animal cone-beam computed tomography (CBCT) scanners. Given a set of frames acquired from a certain axial angle, su...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/53/17/015
更新日期:2008-09-07 00:00:00
abstract::Optical topography is a method for visualization of conical activity. Ways of improving the spatial resolution of the topographical image with three arrangements of optical fibres are discussed. A distribution of sensitivity is obtained from the phantom experiment, and used to reconstruct topographical images of an ac...
journal_title:Physics in medicine and biology
pub_type: 杂志文章
doi:10.1088/0031-9155/47/18/311
更新日期:2002-09-21 00:00:00