Quenching-free fluorescence signal from plastic-fibres in proton dosimetry: understanding the influence of Čerenkov radiation.

Abstract:

:The origin of photons emitted in optical fibres under proton irradiation has been attributed to either entirely Čerenkov radiation or light consisting of fluorescence with a substantial amount of Čerenkov radiation. The source of the light emission is assessed in order to understand why the signal from optical fibres irradiated with protons is reportedly quenching-free. The present study uses the directional emittance of Čerenkov photons in 12 MeV and 20 MeV electron beams to validate a Monte Carlo model for simulating the emittance and transmission of Čerenkov radiation in optical fibres. We show that fewer than 0.01 Čerenkov photons are emitted and guided per 225 MeV proton penetrating the optical fibre, and that the Čerenkov signal in the optical fibre is completely negligible at the Bragg peak. Furthermore, on taking the emittance and guidance of both fluorescence and Čerenkov photons into account, it becomes evident that the reported quenching-free signal in PMMA-based optical fibres during proton irradiation is due to fluorescence.

journal_name

Phys Med Biol

authors

Brage Christensen J,Almhagen E,Nyström H,Andersen CE

doi

10.1088/1361-6560/aaafad

subject

Has Abstract

pub_date

2018-03-09 00:00:00

pages

065001

issue

6

eissn

0031-9155

issn

1361-6560

journal_volume

63

pub_type

杂志文章
  • A new extended-length parallel-plate ionization chamber.

    abstract::A special parallel-plate ionization chamber was developed. The motivation for the construction of this new chamber was mainly to fulfil the need of a reference system for computed tomography standard beams in the Calibration Laboratory of IPEN. However, the chamber was tested also in standard radiation beams of mammog...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/16/012

    authors: Maia AF,Caldas LV

    更新日期:2005-08-21 00:00:00

  • Reference dosimetry on TomoTherapy: an addendum to the 1990 UK MV dosimetry code of practice.

    abstract::The current UK code of practice for high-energy photon therapy dosimetry (Lillicrap et al 1990 Phys. Med. Biol. 35 1355-60) gives instructions for measuring absorbed dose to water under reference conditions for megavoltage photons. The reference conditions and the index used to specify beam quality require that a mach...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/6/1339

    authors: Thomas SJ,Aspradakis MM,Byrne JP,Chalmers G,Duane S,Rogers J,Thomas RA,Tudor GS,Twyman N,IPEM Working Party.

    更新日期:2014-03-21 00:00:00

  • CT reconstruction algorithm for a dental panoramic x-ray unit.

    abstract::A variable Jacobian and weighted backprojection algorithm, used for medical CT, was adapted to perform CT reconstructions on data obtained with a dental panoramic x-ray unit. A detector array, fitted to the unit for the purpose of acquiring digital panoramic radiographs, was used to collect the data. Compensations wer...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/37/12/001

    authors: Lee MD,Waggener RG,McDavid WD,Dove SB,Welander U,Tronje G

    更新日期:1992-12-01 00:00:00

  • Brachytherapy technology and physics practice since 1950: a half-century of progress.

    abstract::The 50-year tenure of Physics in Medicine and Biology has coincided with some of the most important developments in radiological science, including the introduction of artificial radioactivity, computers and 3D imaging into medicine. These events have profoundly influenced the development of brachytherapy. Although it...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/0031-9155/51/13/R18

    authors: Williamson JF

    更新日期:2006-07-07 00:00:00

  • In vivo electric conductivity of cervical cancer patients based on B₁⁺ maps at 3T MRI.

    abstract::The in vivo electric conductivity (σ) values of tissue are essential for accurate electromagnetic simulations and specific absorption rate (SAR) assessment for applications such as thermal dose computations in hyperthermia. Currently used σ-values are mostly based on ex vivo measurements. In this study the conductivit...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/4/1596

    authors: Balidemaj E,de Boer P,van Lier AL,Remis RF,Stalpers LJ,Westerveld GH,Nederveen AJ,van den Berg CA,Crezee J

    更新日期:2016-02-21 00:00:00

  • Use of an amorphous silicon electronic portal imaging device for multileaf collimator quality control and calibration.

    abstract::Multileaf collimator (MLC) calibration and quality control is a time-consuming procedure typically involving the processing, scanning and analysis of films to measure leaf and collimator positions. Faster and more reliable calibration procedures are required for these tasks, especially with the introduction of intensi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/7/003

    authors: Baker SJ,Budgell GJ,MacKay RI

    更新日期:2005-04-07 00:00:00

  • High intensity focused ultrasound for the treatment of rat tumours.

    abstract::Discrete implanted liver tumours in the rat have been exposed to arrays of 1.7 MHz ultrasound lesions. Focal peak intensities in the range 1.4-3.5 k Wcm-2 were used for an exposure time of 10 s. It has been demonstrated that where the whole tumour volume was exposed to the focused ultrasound beam, no evidence of tumou...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/36/11/009

    authors: ter Haar G,Rivens I,Chen L,Riddler S

    更新日期:1991-11-01 00:00:00

  • Substituting gelatine with Pluronic F-127 matrix in 3D polymer gel dosimeters can improve nuclear magnetic resonance, thermal and optical properties.

    abstract::This work discusses the substitution of a gelatine physical gel matrix with a matrix made of poly(ethylene oxide)-block-poly(propylene oxide)-block-poly(ethylene oxide) (Pluronic F-127) in five 3D radiotherapy polymer gel dosimeters: MAGAT, PAGAT, NIPAM, VIPARnd (VIP) and VIPARCT (VIC). The current research outcomes s...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aad9d5

    authors: Jaszczak M,Wach R,Maras P,Dudek M,Kozicki M

    更新日期:2018-09-06 00:00:00

  • Optimization of the accuracy of retention and washout measurements of 99mTc-Sestamibi from breast tumours using an anthropomorphic phantom.

    abstract::Quantifying the retention or washout of (99m)Tc-Sestamibi (MIBI) in breast tumours in vivo may provide a basis for predicting the chemotherapy response. The aim of this study is to investigate the variations and limitations of the different methods used to quantify these parameters. A phantom was developed that allowe...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/9/013

    authors: Marshall C,Griffiths PA

    更新日期:2005-05-07 00:00:00

  • A novel microbubble construct for intracardiac or intravascular MR manometry: a theoretical study.

    abstract::It has been demonstrated that gas-filled microbubble contrast agents, based on their volume changes, can serve as pressure probes in an MR field. It was recently reported that such an MR-based pressure measurement with microbubbles at 1.5 T must make use of microbubbles that have a volumetric magnetic susceptibility d...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/50/20/001

    authors: Dharmakumar R,Plewes DB,Wright GA

    更新日期:2005-10-21 00:00:00

  • An automated, fast and accurate registration method to link stranded seeds in permanent prostate implants.

    abstract::The geometry of a permanent prostate implant varies over time. Seeds can migrate and edema of the prostate affects the position of seeds. Seed movements directly influence dosimetry which relates to treatment quality. We present a method that tracks all individual seeds over time allowing quantification of seed moveme...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/60/20/N391

    authors: Westendorp H,Nuver TT,Moerland MA,Minken AW

    更新日期:2015-10-21 00:00:00

  • Characterization of noise and background signals in a magnetic particle imaging system.

    abstract::Magnetic Particle Imaging (MPI) is a novel technology, which opens new possibilities for promising biomedical applications. MPI uses magnetic fields to generate a specific response from magnetic nanoparticles (MNPs), to determine their spatial location non-invasively and without using ionizing radiation. One open chal...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abc364

    authors: Paysen H,Kosch O,Wells J,Loewa N,Wiekhorst F

    更新日期:2020-10-21 00:00:00

  • Benchmarking GATE/Geant4 for 16O ion beam therapy.

    abstract::Oxygen ([Formula: see text]) ions are a potential alternative to carbon ions in ion beam therapy. Their enhanced linear energy transfer indicates a higher relative biological effectiveness and a reduced oxygen enhancement ratio. Due to the limited availability of [Formula: see text] ion beams, Monte Carlo (MC) transpo...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/aa807e

    authors: Resch AF,Fuchs H,Georg D

    更新日期:2017-09-05 00:00:00

  • Ultraviolet and visible spectroscopies for tissue diagnostics: fluorescence spectroscopy and elastic-scattering spectroscopy.

    abstract::We review the application of fluorescence spectroscopy and elastic-scattering spectroscopy, over the ultraviolet-to-visible wavelength range, to minimally invasive medical diagnostics. The promises and hopes, as well as the difficulties, of these developing techniques are discussed. ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/0031-9155/42/5/005

    authors: Bigio IJ,Mourant JR

    更新日期:1997-05-01 00:00:00

  • The gastrointestinal absorption of plutonium and americium in the hamster.

    abstract::Plutonium-239 and americium-241 were administered to adult hamsters in various chemical forms and their absorption from the gut was measured. The results have been compared with published data on other species in order to derive values for the estimated absorption of these actinides in man. On the basis of current kno...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/24/2/015

    authors: Stather JW,Harrison JD,Rodwell P,David AJ

    更新日期:1979-03-01 00:00:00

  • Estimation of tissue resistivities from multiple-electrode impedance measurements.

    abstract::In order to measure in vivo resistivity of tissues in the thorax, the possibility of combining anatomical data extracted from high-resolution images with multiple-electrode impedance measurements, a priori knowledge of the range of tissue resistivities, and a priori data on the instrumentation noise is assessed in thi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/39/1/001

    authors: Eyüboğlu BM,Pilkington TC,Wolf PD

    更新日期:1994-01-01 00:00:00

  • Mapping initial and general recombination in scanning proton pencil beams.

    abstract::The ion recombination is examined in parallel-plate ionization chambers in scanning proton beams at the Danish Centre for Particle Therapy and the Skandion Clinic. The recombination correction factor k s is investigated for clinically relevant energies between 70 MeV and 244 MeV for dose rates below 400 Gy min-1 in ai...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/ab8579

    authors: Christensen JB,Almhagen E,Stolarczyk L,Liszka M,Hernandez GG,Bassler N,Nørrevang O,Vestergaard A

    更新日期:2020-06-05 00:00:00

  • Time-invariant component-based normalization for a simultaneous PET-MR scanner.

    abstract::Component-based normalization is a method used to compensate for the sensitivity of each of the lines of response acquired in positron emission tomography. This method consists of modelling the sensitivity of each line of response as a product of multiple factors, which can be classified as time-invariant, time-varian...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/9/3554

    authors: Belzunce MA,Reader AJ

    更新日期:2016-05-07 00:00:00

  • Head scatter modelling for irregular field shaping and beam intensity modulation.

    abstract::Scattered radiation from within the treatment head can contribute significant dose to all parts of a radiotherapy treatment field. A multileaf collimator may be used to create an arbitrarily shaped field, and may also be used, under dynamic control, to modulate the beam intensity over the field. This method of intensi...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/42/9/006

    authors: Hounsell AR,Wilkinson JM

    更新日期:1997-09-01 00:00:00

  • Direct detection of 6 MV x-rays from a medical linear accelerator using a semiconducting polymer diode.

    abstract::Recently, a new family of low-cost x-radiation detectors have been developed, based on semiconducting polymer diodes, which are easy to process, mechanically flexible, relatively inexpensive, and able to cover large areas. To test their potential for radiotherapy applications such as beam monitors or dosimeters, as an...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/58/13/4471

    authors: Mills CA,Chan YF,Intaniwet A,Shkunov M,Nisbet A,Keddie JL,Sellin PJ

    更新日期:2013-07-07 00:00:00

  • Detector arrangement and sampling characteristics in rotary positron-emission computed tomography.

    abstract::A rotary positron-emission computed tomography system has been proposed in which detectors are mounted unequally spaced on a ring, so as to provide fine and uniform linear sampling during a 360 degree rotation of the ring around its centre. The usefulness of a simple iterative method for searching for a suitable arran...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/26/3/011

    authors: Yamamoto M

    更新日期:1981-05-01 00:00:00

  • ALGEBRA: ALgorithm for the heterogeneous dosimetry based on GEANT4 for BRAchytherapy.

    abstract::Task group 43 (TG43)-based dosimetry algorithms are efficient for brachytherapy dose calculation in water. However, human tissues have chemical compositions and densities different than water. Moreover, the mutual shielding effect of seeds on each other (interseed attenuation) is neglected in the TG43-based dosimetry ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/57/11/3273

    authors: Afsharpour H,Landry G,D'Amours M,Enger S,Reniers B,Poon E,Carrier JF,Verhaegen F,Beaulieu L

    更新日期:2012-06-07 00:00:00

  • An investigation and explanation of the fall-off of x-ray tube current during an exposure.

    abstract::It was observed that the radiation output of x-ray tubes falls off exponentially during an exposure with a time constant of about 120 ms. The equilibrium value is approximately 15% lower than that at the beginning of the exposure. The clinically noticeable consequences are discrepancies in x-ray generator calibration,...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/25/2/004

    authors: Brezovich IA,Barnes GT

    更新日期:1980-03-01 00:00:00

  • Integral equations and boundary-element solution for static potential in a general piece-wise homogeneous volume conductor.

    abstract::Boundary element methods (BEM) are used for forward computation of bioelectromagnetic fields in multi-compartment volume conductor models. Most BEM approaches assume that each compartment is in contact with at most one external compartment. In this work, I present a general surface integral equation and BEM discretiza...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/61/22/N606

    authors: Stenroos M

    更新日期:2016-11-21 00:00:00

  • Comment on 'Proton beam monitor chamber calibration'.

    abstract::We comment on a recent article (Gomà et al 2014 Phys. Med. Biol. 59 4961-71) which compares different routes of reference dosimetry for the energy dependent beam monitor calibration in scanned proton beams. In this article, a 3% discrepancy is reported between a Faraday cup and a plane-parallel ionization chamber in t...

    journal_title:Physics in medicine and biology

    pub_type: 评论,杂志文章

    doi:10.1088/0031-9155/61/17/6585

    authors: Palmans H,Vatnitsky SM

    更新日期:2016-09-07 00:00:00

  • Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry.

    abstract::Polymer gel dosimetry aims to provide three-dimensional images of radiation therapy dose distributions in irradiated aqueous gels. The first gels required manufacture in an oxygen-free environment, but later the MAGIC formulation was introduced, which could be made in normal atmospheric conditions. Here we report our ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/52/10/N03

    authors: Luci JJ,Whitney HM,Gore JC

    更新日期:2007-05-21 00:00:00

  • Review of photon interaction cross section data in the medical and biological context.

    abstract::The probability of a photon (x-ray, gamma-ray, bremsstrahlung, etc) of a given energy E undergoing absorption or scattering when traversing a layer of material Z can be expressed quantitatively in terms of a linear attenuation coefficient mu (cm(-1)). Since mu is dependent on the material's density, rho (g cm(-3)), wh...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章,评审

    doi:10.1088/0031-9155/44/1/001

    authors: Hubbell JH

    更新日期:1999-01-01 00:00:00

  • Fast calculation of 3D radiofrequency ablation zone based on a closed-form solution of heat conduction equation fitted by ex vivo measurements.

    abstract::Fast calculation or simulation of the ablation zone induced by radiofrequency ablation (RFA) has a critical role in hepatic RFA planning and therapy. However, it remains challenging to approximate the ablation zone in real time, especially when more than one probe is involved in one ablation session. This paper presen...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/1361-6560/abe052

    authors: Chen R,Zhang J,Kong D,Lou Q,Lu F

    更新日期:2021-01-27 00:00:00

  • An investigation of automatic exposure control calibration for chest imaging with a computed radiography system.

    abstract::The purpose of this study was to examine the use of three physical image quality metrics in the calibration of an automatic exposure control (AEC) device for chest radiography with a computed radiography (CR) imaging system. The metrics assessed were signal-to-noise ratio (SNR), contrast-to-noise ratio (CNR) and mean ...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/59/9/2307

    authors: Moore CS,Wood TJ,Avery G,Balcam S,Needler L,Beavis AW,Saunderson JR

    更新日期:2014-05-07 00:00:00

  • Radiation dose factors for alpha-emitters in osteons and some considerations on dose non-uniformity ratios and relative distribution factors.

    abstract::Dose factors for locations within a tissue-filled cylindrical cavity bounded by an infinite medium of bone labelled with an alpha-emitter are calculated by means of a Monte Carlo procedure. The calculational approach is general and allows us to determine dose factors for specific distances or target volumes defined by...

    journal_title:Physics in medicine and biology

    pub_type: 杂志文章

    doi:10.1088/0031-9155/34/3/007

    authors: Polig E

    更新日期:1989-03-01 00:00:00