当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > A role for the segment polarity gene shaggy-zeste white 3 in the specification of regional identity in the developing wing of Drosophila.

A role for the segment polarity gene shaggy-zeste white 3 in the specification of regional identity in the developing wing of Drosophila.

Abstract：

:The Drosophila segment polarity gene known as shaggy or zeste white 3 encodes a ubiquitously expressed serine-threonine protein kinase which is critical for a number of important developmental processes. In the developing wing blade, clones of cells lacking the normal shaggy-zeste white 3 product form dense tufts of margin-like bristles and bristle precursors. In a previous study I hypothesized that this phenotype could be best explained as a transformation in the regional identity of wing blade cells to one resembling that found along the normal wing margin. A number of genes have recently been identified which are expressed exclusively or at higher levels along the normal wing margin; in this study I will show that two of these genes, vestigial and scalloped, are overexpressed at margin-like levels in shaggy-zeste white 3 clones. This phenotype does not depend upon the formation of ectopic bristle precursors and occurs in clones lacking both shaggy-zeste white 3 and the entire achaete-scute complex. As vestigial and scalloped are both involved in early patterning events prior to the stages of bristle specification, these results strongly suggest that shaggy-zeste white 3 is required for the normal specification or maintenance of regional identity in the developing wing blade. The margin-like transformation is, however, partial, since the expression of apterous (in pupal wings) and wingless and cut (at late third instar) was not reliably altered in shaggy-zeste white 3 clones. It has been suggested that shaggy-zeste white 3 is involved in a wingless signaling pathway in the embryo; a model is discussed in which shaggy-zeste white 3 acts downstream of localized apterous and wingless expression to specify or maintain margin identity in the wing.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Blair SS

doi

10.1006/dbio.1994.1081

subject

Has Abstract

pub_date

1994-03-01 00:00:00

pages

229-44

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(84)71081-5

journal_volume

162

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Ascidian notochord elongation.

    abstract：:The elongation of embryo and tissue is a key morphogenetic event in embryogenesis and organogenesis. Notochord, a typical chordate organ, undergoes elongation to perform its regulatory roles and to form the structural support in the embryo. Notochord elongation is morphologically similar across all chordates, but asci...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.11.009

    authors： Lu Q,Bhattachan P,Dong B

    更新日期：2019-04-15 00:00:00

  • alphaSU2, an epithelial integrin that binds laminin in the sea urchin embryo.

    abstract：:At gastrulation in the sea urchin embryo dramatic cell adhesion changes contribute to primary mesenchyme cell ingression movements and to cell rearrangements during archenteron invagination. At ingression, quantitative adhesion assays demonstrated previously that primary mesenchyme cells (PMCs) change their affinity f...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9165

    authors： Hertzler PL,McClay DR

    更新日期：1999-03-01 00:00:00

  • The direction of neurite growth in a weak DC electric field depends on the substratum: contributions of adhesivity and net surface charge.

    abstract：:We investigated the influence of the growth surface on the direction of Xenopus spinal neurite growth in the presence of a dc electric field of physiological magnitude. The direction of galvanotropism was determined by the substratum; neurites grew toward the negative electrode (cathode) on untreated Falcon tissue cul...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9039

    authors： Rajnicek AM,Robinson KR,McCaig CD

    更新日期：1998-11-15 00:00:00

  • Embryonic origin of gustatory cranial sensory neurons.

    abstract：:Cranial nerves VII, IX and X provide both gustatory (taste) and non-gustatory (touch, pain, temperature) innervation to the oral cavity of vertebrates. Gustatory neurons innervate taste buds and project centrally to the rostral nucleus of the solitary tract (NTS), whereas neurons providing general epithelial innervati...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.07.042

    authors： Harlow DE,Barlow LA

    更新日期：2007-10-15 00:00:00

  • Contacts between the commissural axons and the floor plate cells are mediated by nectins.

    abstract：:During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.05.034

    authors： Okabe N,Shimizu K,Ozaki-Kuroda K,Nakanishi H,Morimoto K,Takeuchi M,Katsumaru H,Murakami F,Takai Y

    更新日期：2004-09-15 00:00:00

  • The Drosophila IMP-E2 gene encodes an apically secreted protein expressed during imaginal disc morphogenesis.

    abstract：:During metamorphosis, the steroid hormone 20-hydroxyecdysone induces morphogenesis of imaginal discs, including the formation of appendages. IMP-E2 is an ecdysone-dependent, single-copy Drosophila gene, whose transcripts accumulate rapidly in imaginal discs in response to the hormone. The IMP-E2 product is secreted at...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90084-v

    authors： Paine-Saunders S,Fristrom D,Fristrom JW

    更新日期：1990-08-01 00:00:00

  • Retinoic acid-metabolizing enzyme Cyp26a1 is essential for determining territories of hindbrain and spinal cord in zebrafish.

    abstract：:Retinoic acid (RA) plays a critical role in neural patterning and organogenesis in the vertebrate embryo. Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated. The gir mutant displayed patterning defects in multiple organs including the com...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.11.023

    authors： Emoto Y,Wada H,Okamoto H,Kudo A,Imai Y

    更新日期：2005-02-15 00:00:00

  • Involvement of the cytoskeleton in the movement of cortical granules during oocyte maturation, and cortical granule anchoring in mouse eggs.

    abstract：:Exocytosis of cortical granules in mouse eggs is required to produce the zona pellucida block to polyspermy. In this study, we examined the role of microfilaments and microtubules in the regulation of cortical granule movement toward the cortex during oocyte maturation and anchoring of cortical granules in the cortex....

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8945

    authors： Connors SA,Kanatsu-Shinohara M,Schultz RM,Kopf GS

    更新日期：1998-08-01 00:00:00

  • SpGCF1, a sea urchin embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.

    abstract：:Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1181

    authors： Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

    更新日期：1995-06-01 00:00:00

  • Kif18a is specifically required for mitotic progression during germ line development.

    abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.03.011

    authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

    更新日期：2015-06-15 00:00:00

  • Major protein changes during vitellogenesis and maturation of Fundulus oocytes.

    abstract：:The protein content of various size follicles was measured in Fundulus heteroclitus and indicated four phases of increase relative to follicle volume: Phases I (previtellogenic; estimated to be less than 0.01 mg/mm3), II (vitellogenic; 0.20 mg/mm3), III (early maturation; 0.03 mg/mm3), and IV (late maturation; 0 mg/mm...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90106-x

    authors： Wallace RA,Selman K

    更新日期：1985-08-01 00:00:00

  • Maternal and zygotic expression of the endoderm-specific alkaline phosphatase gene in embryos of the ascidian, Halocynthia roretzi.

    abstract：:Alkaline phosphatase (AP) activity is expressed by endodermal cells of ascidian larvae. It was reported previously that the expression of AP activity is resistant to treatment with actinomycin D, a transcription inhibitor that inhibits the appearance of several other tissue-specific molecules and morphological markers...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：

    authors： Kumano G,Nishida H

    更新日期：1998-06-15 00:00:00

  • Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.

    abstract：:Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8670

    authors： Yoon JK,Olson EN,Arnold HH,Wold BJ

    更新日期：1997-08-15 00:00:00

  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart.

    abstract：:The arterial pole of the heart is the region where the ventricular myocardium continues as the vascular smooth muscle tunics of the aorta and pulmonary trunk. It has been shown that the arterial pole myocardium derives from the secondary heart field and the smooth muscle tunic of the aorta and pulmonary trunk derives ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.02.012

    authors： Waldo KL,Hutson MR,Ward CC,Zdanowicz M,Stadt HA,Kumiski D,Abu-Issa R,Kirby ML

    更新日期：2005-05-01 00:00:00

  • Dynamic expression of broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis.

    abstract：:Metamorphosis in Drosophila melanogaster is orchestrated by the steroid hormone ecdysone, which triggers a cascade of primary-response transcriptional regulators and secondary effector genes during the third larval instar and prepupal periods of development. The early ecdysone-response Broad-Complex (BR-C) gene, a key...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9879

    authors： Mugat B,Brodu V,Kejzlarova-Lepesant J,Antoniewski C,Bayer CA,Fristrom JW,Lepesant JA

    更新日期：2000-11-01 00:00:00

  • Changes in the synthesis and intracellular localization of nuclear proteins during embryogenesis in the sea urchin Strongylocentrotus purpuratus.

    abstract：:A rapid, gentle technique is described for the isolation of nuclei from sea urchin embryos. Using this technique, we have analyzed the synthesis and accumulation of nonhistone nuclear proteins during sea urchin development by two-dimensional gel electrophoresis. Most nuclear proteins fall into one of three patterns of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90445-3

    authors： Servetnick MD,Wilt FH

    更新日期：1987-09-01 00:00:00

  • The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm.

    abstract：:Understanding the regulatory circuitry controlling myogenesis is critical to understanding developmental mechanisms and developmentally-derived diseases. We analyzed the transcriptional regulation of a Drosophila myogenic repressor gene, Holes in muscles (Him). Previously, Him was shown to inhibit Myocyte enhancer fac...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.02.005

    authors： Elwell JA,Lovato TL,Adams MM,Baca EM,Lee T,Cripps RM

    更新日期：2015-04-15 00:00:00

  • Tissue-specific functions of the Caenorhabditis elegans p120 Ras GTPase activating protein GAP-3.

    abstract：:All metazoan genomes encode multiple RAS GTPase activating proteins (RasGAPs) that negatively regulate the conserved RAS/MAPK signaling pathway. In mammals, several RasGAPs exhibit tumor suppressor activity by preventing excess RAS signal transduction. We have identified gap-3 as the to date missing Caenorhabditiseleg...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.08.026

    authors： Stetak A,Gutierrez P,Hajnal A

    更新日期：2008-11-15 00:00:00

  • Differential effect of activators of protein kinase C on cytoskeletal changes in mouse and hamster eggs.

    abstract：:Treatment of metaphase II-arrested hamster eggs with activators of protein kinase C has been reported to promote resumption of the cell cycle, second polar body emission, and pronucleus formation (G.I. Gallicano, S.M. Schwarz, R.W. McGaughey, and D.G. Capco, 1993, Dev. Biol. 156, 94-106). In contrast, we have not obse...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1233

    authors： Moore GD,Kopf GS,Schultz RM

    更新日期：1995-08-01 00:00:00

  • Identification of DNA-binding protein(s) in the developing heart.

    abstract：:An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1088

    authors： Litvin J,Montgomery MO,Goldhamer DJ,Emerson CP Jr,Bader DM

    更新日期：1993-04-01 00:00:00

  • Developmental clustering of ion channels at and near the node of Ranvier.

    abstract：:Voltage-gated Na(+) and K(+) channels are localized to distinct subcellular domains in mammalian myelinated nerve fibers. Specifically, Na(+) channels are clustered in high densities at nodes of Ranvier, while K(+) channels are found in juxtaparanodal zones just beyond regions of axoglial contact where sequential laye...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1006/dbio.2001.0326

    authors： Rasband MN,Trimmer JS

    更新日期：2001-08-01 00:00:00

  • The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.

    abstract：:Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.03.012

    authors： Anderson AM,Weasner BP,Weasner BM,Kumar JP

    更新日期：2014-06-15 00:00:00

  • Role of RB1 in human embryonic stem cell-derived retinal organoids.

    abstract：:Three-dimensional (3D) organoid models derived from human pluripotent stem cells provide a platform for studying human development and understanding disease mechanisms. Most studies that examine biallelic inactivation of the cell cycle regulator Retinoblastoma 1 (RB1) and the link to retinoblastoma is in mice, however...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2020.03.011

    authors： Zheng C,Schneider JW,Hsieh J

    更新日期：2020-06-15 00:00:00

  • A novel cyclic AMP metabolism exhibited by giant cells and its possible role in the sexual development of Dictyostelium discoideum.

    abstract：:In Dictyostelium discoideum cyclic AMP (cAMP) metabolism during macrocyst development, i.e., the sexual cycle of this organism, and in giant cells, i.e., fusion products from opposite mating-type cells, was investigated. The pattern of change in cAMP levels during macrocyst development differed considerably from that ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90104-0

    authors： Abe K,Orii H,Okada Y,Saga Y,Yanagisawa K

    更新日期：1984-08-01 00:00:00

  • Tbl3 regulates cell cycle length during zebrafish development.

    abstract：:The regulation of cell cycle rate is essential for the correct timing of proliferation and differentiation during development. Changes to cell cycle rate can have profound effects on the size, shape and cell types of a developing organ. We previously identified a zebrafish mutant ceylon (cey) that has a severe reducti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.05.024

    authors： Hutchinson SA,Tooke-Locke E,Wang J,Tsai S,Katz T,Trede NS

    更新日期：2012-08-15 00:00:00

  • The initial expression and patterned appearance of tenascin in scutate scales is absent from the dermis of the scaleless (sc/sc) chicken.

    abstract：:Morphogenesis of the anterior metatarsal skin (scutate scale region), from 9.5 to 12 days of development, results in the formation of orderly patterned scale ridges. It is after the initial formation of the Definitive Scale Ridge that the characteristic outer and inner epidermal surfaces differentiate. The hard, plate...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(05)80016-8

    authors： Shames RB,Jennings AG,Sawyer RH

    更新日期：1991-09-01 00:00:00

  • Coordinated activity of Spry1 and Spry2 is required for normal development of the external genitalia.

    abstract：:Development of the mammalian external genitalia is controlled by a network of signaling molecules and transcription factors. Because FGF signaling plays a central role in this complicated morphogenetic process, we investigated the role of Sprouty genes, which are important intracellular modulators of FGF signaling, du...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.12.014

    authors： Ching ST,Cunha GR,Baskin LS,Basson MA,Klein OD

    更新日期：2014-02-01 00:00:00

  • The biology of the extracorporeal vasculature of Botryllus schlosseri.

    abstract：:The extracorporeal vasculature of the colonial ascidian Botryllus schlosseri plays a key role in several biological processes: transporting blood, angiogenesis, regeneration, self-nonself recognition, and parabiosis. The vasculature also interconnects all individuals in a colony and is composed of a single layer of ec...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.10.013

    authors： Rodriguez D,Nourizadeh S,De Tomaso AW

    更新日期：2019-04-15 00:00:00

  • APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

    abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0486

    authors： Levitan D,Yu G,St George Hyslop P,Goutte C

    更新日期：2001-12-15 00:00:00

  • Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.

    abstract：:Hand proteins are evolutionally conserved basic helix-loop-helix (bHLH) transcription factors implicated in development of neural crest-derived tissues, heart and limb. Hand1 is expressed in the distal (ventral) zone of the branchial arches, whereas the Hand2 expression domain extends ventrolaterally to occupy two-thi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.07.036

    authors： Barbosa AC,Funato N,Chapman S,McKee MD,Richardson JA,Olson EN,Yanagisawa H

    更新日期：2007-10-01 00:00:00