Pediatric pharmacokinetic data: implications for environmental risk assessment for children.

Abstract:

:Pharmacology and toxicology share a common interest in pharmacokinetic data, especially as it is available in pediatric populations. These data have been critical to the clinical pharmacologist for many years in designing age-specific dosing regimens. Now they are being used increasingly by toxicologists to understand the ontogeny of physiologic parameters that may affect the metabolism and clearance of environmental toxicants. This article reviews a wide range of physiologic and metabolic factors that are present in utero and in early postnatal life and that can affect the internal dose of an absorbed chemical and its metabolites. It also presents a child/adult pharmacokinetic database that includes data for 45 therapeutic drugs organized into specific children's age groupings and clearance pathways. Analysis of these data suggests that substantial child/adult differences in metabolism and clearance are likely for a variety of drugs and environmental chemicals in the early postnatal period. These results are also relevant to in utero exposures, where metabolic systems are even more immature, but exposures are greatly modified by the maternal system and placental metabolism. The implications of these child/adult differences for assessing children's risks from environmental toxicants is discussed with special focus on physiologically based pharmacokinetic modeling strategies that could simulate children's abilities to metabolize and eliminate chemicals at various developmental stages.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Ginsberg G,Hattis D,Miller R,Sonawane B

subject

Has Abstract

pub_date

2004-04-01 00:00:00

pages

973-83

issue

4 Suppl

eissn

0031-4005

issn

1098-4275

journal_volume

113

pub_type

杂志文章
  • Acute poststreptococcal glomerulonephritis: a manifestation of immune reconstitution inflammatory syndrome.

    abstract::Immune reconstitution inflammatory syndrome (IRIS) is a well-described complication of initiation of highly active antiretroviral therapy in HIV-infected patients. As the immune system recovers, an inappropriate inflammatory response often occurs that causes significant disease. It is most commonly seen in patients na...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1246

    authors: Martin J,Kaul A,Schacht R

    更新日期:2012-09-01 00:00:00

  • Use of a visual aid to improve counseling at the threshold of viability.

    abstract:OBJECTIVES:To pilot-test a visual aid developed to help counsel pregnant women. METHODS:After agreeing to participate, pregnant women at >28 weeks of gestation were assigned randomly to counseling with or without a visual aid. The visual aid contained pictures, graphics, and short messages about delivery room resuscit...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-0597

    authors: Kakkilaya V,Groome LJ,Platt D,Kurepa D,Pramanik A,Caldito G,Conrad L,Bocchini JA Jr,Davis TC

    更新日期:2011-12-01 00:00:00

  • Effect of donor-specific transfusions on renal transplantation in children.

    abstract::Most family members who are evaluated as kidney donors for children have high reactivity in a mixed lymphocyte culture test and are thus excluded from donation. Fifty children, most of whom had highly reactive mixed lymphocyte cultures with their donors, were challenged with three blood transfusions from their donors ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Potter D,Garovoy M,Hopper S,Terasaki P,Salvatierra O Jr

    更新日期:1985-09-01 00:00:00

  • Preparedness for pediatric emergencies encountered in the practitioner's office.

    abstract::Pediatricians in the Washington, DC, metropolitan area were surveyed to assess their readiness to deal with life-threatening emergencies in their offices. Information about emergency equipment, prearranged emergency plans, advanced life support training, and emergency medical services assistance was elicited. Recommen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Altieri M,Bellet J,Scott H

    更新日期:1990-05-01 00:00:00

  • Involving Youth With a Chronic Illness in Decision-making: Highlighting the Role of Providers.

    abstract::Decision-making is important in the context of pediatric chronic illness because children and families need to make decisions about burdensome and complex treatments on a regular basis, and children must eventually learn how to make such decisions independently. Research related to children's decision-making in medica...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0516D

    authors: Miller VA

    更新日期:2018-11-01 00:00:00

  • Overweight among low-income preschool children associated with the consumption of sweet drinks: Missouri, 1999-2002.

    abstract:OBJECTIVE:To examine the association between sweet drink consumption and overweight among preschool children. METHODS:A retrospective cohort design was used to examine the association between sweet drink consumption and overweight at follow-up among 10904 children who were aged 2 and 3 years and had height, weight, an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1148

    authors: Welsh JA,Cogswell ME,Rogers S,Rockett H,Mei Z,Grummer-Strawn LM

    更新日期:2005-02-01 00:00:00

  • Screening for Speech and Language Delay and Disorders in Children Aged 5 Years or Younger: US Preventive Services Task Force Recommendation Statement.

    abstract:BACKGROUND:This report is an update of the US Preventive Services Task Force (USPSTF) 2006 recommendation on screening for speech and language delay in preschool-aged children. METHODS:The USPSTF reviewed the evidence on screening for speech and language delay and disorders in children aged 5 years or younger, includi...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2015-1711

    authors: Siu AL,US Preventive Services Task Force.

    更新日期:2015-08-01 00:00:00

  • Vitamin D status of exclusively breastfed 4-month-old infants supplemented during different seasons.

    abstract:OBJECTIVE:To examine the vitamin D status of 4-month-old exclusively breastfed infants supplemented with 400 IU daily of vitamin D and to determine whether there was any seasonal variation in serum 25-hydroxyvitamin D (25(OH)D) levels of infants. METHODS:In this cross-sectional study, serum calcium, phosphorus, alkali...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0017

    authors: Halicioglu O,Sutcuoglu S,Koc F,Yildiz O,Akman SA,Aksit S

    更新日期:2012-10-01 00:00:00

  • Prospective longitudinal study of children with tic disorders and/or obsessive-compulsive disorder: relationship of symptom exacerbations to newly acquired streptococcal infections.

    abstract:BACKGROUND:It has been proposed that infection by group A beta-hemolytic streptococci (GABHS) can trigger acute symptom exacerbations among patients with Tourette's syndrome (TS) or obsessive-compulsive disorder (OCD), via autoimmune mechanisms. OBJECTIVE:To examine the temporal relationship between newly acquired GAB...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.6.e578

    authors: Luo F,Leckman JF,Katsovich L,Findley D,Grantz H,Tucker DM,Lombroso PJ,King RA,Bessen DE

    更新日期:2004-06-01 00:00:00

  • Yield of chest radiography after removal of esophageal foreign bodies.

    abstract:OBJECTIVES:The aim of this study was to determine the benefit of routine postoperative chest radiography after removal of esophageal foreign bodies in children. METHODS:Medical records were reviewed of all patients evaluated with an esophageal foreign body at a single children's hospital over 10 years. Operative recor...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3676

    authors: Fisher J,Mittal R,Hill S,Wulkan ML,Clifton MS

    更新日期:2013-05-01 00:00:00

  • An evaluation of information-seeking behaviors of general pediatricians.

    abstract:OBJECTIVE:Usage of computer resources at the point of care has a positive effect on physician decision making. Pediatricians' information-seeking behaviors are not well characterized. The goal of this study was to characterize quantitatively the information-seeking behaviors of general pediatricians and specifically co...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.113.1.64

    authors: D'Alessandro DM,Kreiter CD,Peterson MW

    更新日期:2004-01-01 00:00:00

  • Serious air rifle injuries in children.

    abstract::Seven potentially lethal air gun injuries in children are reported. Multiple-pump action air rifles have penetration velocities far in excess of the classic Daisy "BB" guns. However, these lethal weapons are sold to be used by children. Lack of effective regulatory legislation coupled with parental ignorance will cont...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Blocker S,Coln D,Chang JH

    更新日期:1982-06-01 00:00:00

  • Use of wireless capsule endoscopy in the management of severe Henoch-Schonlein purpura.

    abstract::Henoch-Schonlein purpura is a multisystem vasculitis that primarily affects children. Characteristic symptoms include purpura of the lower extremities and buttocks, abdominal pain, arthralgias, and hematuria. Gastrointestinal bleeding occurs in approximately 50% of children and, although often self-limiting, can be si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-3111

    authors: Preud'Homme DL,Michail S,Hodges C,Milliken T,Mezoff AG

    更新日期:2006-09-01 00:00:00

  • Safe transportation of preterm and low birth weight infants at hospital discharge.

    abstract::Safe transportation of preterm and low birth weight infants requires special considerations. Both physiologic immaturity and low birth weight must be taken into account to properly position such infants. This clinical report provides guidelines for pediatricians and other caregivers who counsel parents of preterm and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0559

    authors: Bull MJ,Engle WA,Committee on Injury, Violence, and Poison Prevention and Committee on Fetus and Newborn.,American Academy of Pediatrics.

    更新日期:2009-05-01 00:00:00

  • Premedication for nonemergent neonatal intubations: a randomized, controlled trial comparing atropine and fentanyl to atropine, fentanyl, and mivacurium.

    abstract:OBJECTIVE:The purpose of this work was to investigate whether using a muscle relaxant would improve intubation conditions in infants, thereby decreasing the incidence and duration of hypoxia and time and number of attempts needed to successfully complete the intubation procedure. PATIENTS/METHODS:This was a prospectiv...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2006-0590

    authors: Roberts KD,Leone TA,Edwards WH,Rich WD,Finer NN

    更新日期:2006-10-01 00:00:00

  • Sustaining and spreading the reduction of adverse drug events in a multicenter collaborative.

    abstract:OBJECTIVES:Adverse drug events (ADEs) occur more frequently in pediatric patients than adults. ADEs frequently cause serious harm to children and increase the cost of care. The purpose of this study was to decrease ADEs by targeting the entire medication-delivery system for all high-risk medications. METHODS:Thirteen ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-3772

    authors: Tham E,Calmes HM,Poppy A,Eliades AB,Schlafly SM,Namtu KC,Smith DM,Vitaska MC,McConnell C,Potts AL,Jastrzembski J,Logsdon TR,Hall M,Takata GS

    更新日期:2011-08-01 00:00:00

  • Long-term reduction in adverse drug events: an evidence-based improvement model.

    abstract:OBJECTIVES:To develop and test an evidence-based model for reducing medication errors and harm in hospitalized children. METHODS:Prospective interrupted time series study evaluating the effectiveness of a multifaceted, staged intervention over 4 years in a major urban pediatric referral hospital. Guidelines for safe p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1902

    authors: Gazarian M,Graudins LV

    更新日期:2012-05-01 00:00:00

  • Developmental Outcomes in Duarte Galactosemia.

    abstract::: media-1vid110.1542/5849572227001PEDS-VA_2018-2516Video Abstract OBJECTIVES: For decades, infants with Duarte galactosemia (DG) have been identified by newborn screening (NBS), but whether they should be treated with dietary restrictions of galactose has remained unknown. To clarify, we conducted a study of dietary a...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-2516

    authors: Carlock G,Fischer ST,Lynch ME,Potter NL,Coles CD,Epstein MP,Mulle JG,Kable JA,Barrett CE,Edwards SM,Wilson E,Fridovich-Keil JL

    更新日期:2019-01-01 00:00:00

  • Adverse effects in children after unintentional buprenorphine exposure.

    abstract::Buprenorphine in sublingual formulation was recently introduced to the American market for treatment of opioid dependence. We report a series of 5 toddlers with respiratory and mental-status depression after unintentional buprenorphine exposure. Despite buprenorphine's partial agonist activity and ceiling effect on re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0948

    authors: Geib AJ,Babu K,Ewald MB,Boyer EW

    更新日期:2006-10-01 00:00:00

  • Medicaid policy statement.

    abstract::Medicaid is a vital safety net for children that must be maintained. It is the largest single insurer of children, yet millions of children who are eligible remain unenrolled. Every effort should be made to implement expanded eligibility and streamlined enrollment procedures. Early and Periodic Screening, Diagnosis, a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0891

    authors: American Academy of Pediatrics Committee on Child Health Financing.

    更新日期:2005-07-01 00:00:00

  • Prevalence of Autism Spectrum Disorder in Preterm Infants: A Meta-analysis.

    abstract:CONTEXT:Evidence is emerging that preterm infants are at risk for autism spectrum disorder (ASD). OBJECTIVES:To conduct a systematic review and meta-analysis to estimate the prevalence of ASD in preterm infants. DATA SOURCES:Medline (via PubMed and Ovid), Embase, PsycINFO, and relevant conference proceedings were sea...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2018-0134

    authors: Agrawal S,Rao SC,Bulsara MK,Patole SK

    更新日期:2018-09-01 00:00:00

  • Can school income and racial/ethnic composition explain the racial/ethnic disparity in adolescent physical activity participation?

    abstract:OBJECTIVE:Our goal was to determine if racial/ethnic disparities in adolescent boys' and girls' physical activity participation exist and persist once the school attended is considered. METHODS:We performed a cross-sectional analysis of 17,007 teens in the National Longitudinal Study of Adolescent Health. Using multiv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1920

    authors: Richmond TK,Hayward RA,Gahagan S,Field AE,Heisler M

    更新日期:2006-06-01 00:00:00

  • Menstruation in girls and adolescents: using the menstrual cycle as a vital sign.

    abstract::Young patients and their parents often are unsure about what represents normal menstrual patterns, and clinicians also may be unsure about normal ranges for menstrual cycle length and amount and duration of flow through adolescence. It is important to be able to educate young patients and their parents regarding what ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2006-2481

    authors: American Academy of Pediatrics Committee on Adolescence.,American College of Obstetricians and Gynecologists Committee on Adolescent Health Care.,Diaz A,Laufer MR,Breech LL

    更新日期:2006-11-01 00:00:00

  • Clinical comparison of localized intestinal perforation and necrotizing enterocolitis in neonates.

    abstract:OBJECTIVE:To better define the prognosis of neonates with gastrointestinal perforation and improve their management. METHODS:We reviewed the results of physical examinations, laboratory results, and radiographic tests of 42 patients in whom gastrointestinal perforation was diagnosed in our neonatal intensive care unit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Buchheit JQ,Stewart DL

    更新日期:1994-01-01 00:00:00

  • Trends in Access to Health Care Services for US Children: 2000-2014.

    abstract:BACKGROUND AND OBJECTIVE:Recent years have witnessed substantial gains in health insurance coverage for children, but few studies have examined trends across a diverse set of access indicators. We examine US children's access to health services and whether trends vary by race/ethnicity and income. METHODS:Analysis of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2176

    authors: Larson K,Cull WL,Racine AD,Olson LM

    更新日期:2016-12-01 00:00:00

  • Complications associated with image-guided gastrostomy and gastrojejunostomy tubes in children.

    abstract:OBJECTIVE:To evaluate the complications associated with the image-guided insertion of gastrostomy (G) and gastrojejunostomy (GJ) tubes in children, performed by the retrograde percutaneous route. METHODS:A convenience sample of 208 charts of 840 patients recorded as having G and/or GJ tubes placed by the interventiona...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.2.458

    authors: Friedman JN,Ahmed S,Connolly B,Chait P,Mahant S

    更新日期:2004-08-01 00:00:00

  • Isolation of toxin producing Clostridium difficile from two children with oxacillin- and dicloxacillin-associated diarrhea.

    abstract::Clostridium difficile was isolated from the feces of two infants who had developed watery diarrhea with blood-tinged stain. One child suffered from diarrhea after five days of parenteral oxacillin therapy; the diarrhea subsided within three days of cessation of therapy. The other infant developed diarrhea following fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Brook I

    更新日期:1980-06-01 00:00:00

  • Accuracy of infant admission lengths.

    abstract:OBJECTIVE:A variety of methods are used to assess the length of infants at hospital admission. A tape-measure technique is commonly used; however, this measure is potentially inaccurate. We aimed to assess accuracy of tape measurement of infant lengths by comparison with the more accurate length-board technique. METHO...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.6.1108

    authors: Corkins MR,Lewis P,Cruse W,Gupta S,Fitzgerald J

    更新日期:2002-06-01 00:00:00

  • Congenital left paraduodenal hernia causing chronic abdominal pain and abdominal catastrophe.

    abstract::Paraduodenal hernias are the most common type of congenital internal hernia. Because of its overall rare incidence, this entity is often overlooked during initial assessment of the patient. Lack of specific diagnostic criteria also makes diagnosis exceedingly difficult, and the resulting diagnostic delays can lead to ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-3701

    authors: Shi Y,Felsted AE,Masand PM,Mothner BA,Nuchtern JG,Rodriguez JR,Vasudevan SA

    更新日期:2015-04-01 00:00:00

  • Pediatric generalized joint hypermobility with and without musculoskeletal complaints: a localized or systemic disorder?

    abstract:OBJECTIVES:Children with generalized hypermobility of the joints and musculoskeletal complaints frequently visit pediatric clinics, but many show no currently known collagen or other possibly related diseases. Whether the symptoms are confined to the musculoskeletal system is unknown. We assessed whether such children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.3.e248

    authors: Engelbert RH,Bank RA,Sakkers RJ,Helders PJ,Beemer FA,Uiterwaal CS

    更新日期:2003-03-01 00:00:00