Effect of donor-specific transfusions on renal transplantation in children.

Abstract:

:Most family members who are evaluated as kidney donors for children have high reactivity in a mixed lymphocyte culture test and are thus excluded from donation. Fifty children, most of whom had highly reactive mixed lymphocyte cultures with their donors, were challenged with three blood transfusions from their donors before transplantation and were tested for the development of lymphocytotoxic antibodies. Ten children (20%) became sensitized and had a positive T-cell or B-cell crossmatch. Sensitization occurred less frequently in children treated with azathioprine during donor-specific transfusions (11%) than in those not treated (26%), but the difference was not significant. Thirty-seven children received renal transplants from their blood donors after the donor-specific transfusions. There were no deaths, and only two patients had kidney failure. Actuarial kidney survival was 93% after 6 years. The use of donor-specific transfusion has increased the number of related-donor transplants performed and the results have been highly successful.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Potter D,Garovoy M,Hopper S,Terasaki P,Salvatierra O Jr

subject

Has Abstract

pub_date

1985-09-01 00:00:00

pages

402-5

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

76

pub_type

杂志文章
  • The school nurse practitioner: providing improved health care to children.

    abstract::School nurse practitioners have the competence to participate in providing a broad range of direct primary health care and services to the school-age child. Greater utilization of these specially prepared and highly qualified nurse practitioners as providers of health care in the school is a practical and effective me...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Silver HK,Igoe JB,McAtee PR

    更新日期:1976-10-01 00:00:00

  • Trends in multiple births conceived using assisted reproductive technology, United States, 1997-2000.

    abstract:OBJECTIVE:To examine trends in multiple births conceived using assisted reproductive technology (ART) in the United States between 1997 and 2000 and to estimate the proportion of all US multiple births attributable to ART use. METHODS:We analyzed population-based data of 109 519 live-born infants who were conceived in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Reynolds MA,Schieve LA,Martin JA,Jeng G,Macaluso M

    更新日期:2003-05-01 00:00:00

  • Helping Children and Families Deal With Divorce and Separation.

    abstract::For the past several years in the United States, there have been more than 800 000 divorces and parent separations annually, with over 1 million children affected. Children and their parents can experience emotional trauma before, during, and after a separation or divorce. Pediatricians can be aware of their patients'...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-3020

    authors: Cohen GJ,Weitzman CC,COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH.,SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS.

    更新日期:2016-12-01 00:00:00

  • Executive and memory function in adolescents born very preterm.

    abstract:BACKGROUND:Many preterm children display school difficulties, which may be mediated by impairment in executive function and memory. OBJECTIVE:To evaluate executive and memory function among adolescents born preterm compared with term controls at 16 years. METHODS:A total of 337 of 437 (77%) adolescents born in 1989 t...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-1421

    authors: Luu TM,Ment L,Allan W,Schneider K,Vohr BR

    更新日期:2011-03-01 00:00:00

  • Prevalence of household firearms and firearm-storage practices in the 50 states and the District of Columbia: findings from the Behavioral Risk Factor Surveillance System, 2002.

    abstract:OBJECTIVES:To examine the prevalence of household firearms and firearm-storage practices in the 50 states and the District of Columbia and estimate the number of children exposed to unsafe storage practices. METHODS:We analyzed data from the 2002 cross-sectional Behavioral Risk Factor Surveillance System survey of 240...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0300

    authors: Okoro CA,Nelson DE,Mercy JA,Balluz LS,Crosby AE,Mokdad AH

    更新日期:2005-09-01 00:00:00

  • Management of congenital adrenal hyperplasia using serum dehydroepiandrosterone sulfate and 17-hydroxyprogesterone concentrations.

    abstract::Simultaneous serum concentrations of dehydroepiandrosterone sulfate (DHEA-S) and 17-hydroxyprogesterone (17-OHP) were compared with urinary 17-ketosteroid (17-KS) and pregnanetriol (PT) excretion during therapy in 18 prepubertal patients with the 21-hydroxylase deficiency form of congenital adrenal hyperplasia (CAH). ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Golden MP,Lippe BM,Kaplan SA,Lavin N,Slavin J

    更新日期:1978-06-01 00:00:00

  • Effect of honey on nocturnal cough and sleep quality: a double-blind, randomized, placebo-controlled study.

    abstract:OBJECTIVES:To compare the effects of a single nocturnal dose of 3 honey products (eucalyptus honey, citrus honey, or labiatae honey) to placebo (silan date extract) on nocturnal cough and difficulty sleeping associated with childhood upper respiratory tract infections (URIs). METHODS:A survey was administered to paren...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2011-3075

    authors: Cohen HA,Rozen J,Kristal H,Laks Y,Berkovitch M,Uziel Y,Kozer E,Pomeranz A,Efrat H

    更新日期:2012-09-01 00:00:00

  • Effects of negative life events on immune suppression in children and youth infected with human immunodeficiency virus type 1.

    abstract:OBJECTIVES:To evaluate the association of negative stressful life events experienced over 12 months and the risk of moderate to severe immune suppression among children and youth infected with human immunodeficiency virus type 1 (HIV-1). METHODS:Longitudinal study of 618 HIV-1-infected children, baseline ages 1 to 20 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.540

    authors: Howland LC,Gortmaker SL,Mofenson LM,Spino C,Gardner JD,Gorski H,Fowler MG,Oleske J

    更新日期:2000-09-01 00:00:00

  • Enzymatic defect in a child with hereditary hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency: immunochemical studies.

    abstract::Immunochemical studies of the enzyme defect in the first reported child with acute hepatic porphyria due to homozygous delta-aminolevulinic acid dehydratase deficiency are described. This enzyme activity was markedly decreased (approximately 2% of the normal control level) in the proband, a 3-year-old boy, and interme...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fujita H,Sassa S,Lundgren J,Holmberg L,Thunell S,Kappas A

    更新日期:1987-12-01 00:00:00

  • Successful treatment of type 1 diabetes and seizures with combined ketogenic diet and insulin.

    abstract::Diabetic ketoacidosis (DKA) is a life-threatening condition and a major cause of morbidity and mortality in children with type 1 diabetes mellitus. The deficiency of insulin leads to metabolic decompensation, causing hyperglycemia and ketosis that resolves with the administration of insulin and fluids. However, an ind...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0741

    authors: Aguirre Castaneda RL,Mack KJ,Lteif A

    更新日期:2012-02-01 00:00:00

  • A perimortem protocol for suspected genetic disease.

    abstract::A considerable portion of pediatric deaths represent disease with risk of recurrence in subsequent family members. Procedures to obtain samples of body fluids and tissues suitable for diagnosis of mendelian and chromosomal disorders are described. These procedures, the "perimortem protocol," are used in studying child...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kronick JB,Scriver CR,Goodyer PR,Kaplan PB

    更新日期:1983-06-01 00:00:00

  • Helping Babies Survive Programs as an Impetus for Quality Improvement.

    abstract::Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-016915J

    authors: Ehret DEY,Patterson JK,Kc A,Worku B,Kamath-Rayne BD,Bose CL

    更新日期:2020-10-01 00:00:00

  • Exemplar pediatric collaborative improvement networks: achieving results.

    abstract::A number of pediatric collaborative improvement networks have demonstrated improved care and outcomes for children. Regionally, Cincinnati Children's Hospital Medical Center Physician Hospital Organization has sustained key asthma processes, substantially increased the percentage of their asthma population receiving "...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3786F

    authors: Billett AL,Colletti RB,Mandel KE,Miller M,Muething SE,Sharek PJ,Lannon CM

    更新日期:2013-06-01 00:00:00

  • The effects of multisystemic therapy on diabetes stress among adolescents with chronically poorly controlled type 1 diabetes: findings from a randomized, controlled trial.

    abstract:OBJECTIVE:The goal of this study was to determine whether multisystemic therapy (MST), an intensive, home-based psychotherapy, could decrease diabetes-related stress among adolescents with chronically poorly controlled type 1 diabetes. Stress was also evaluated as a mediator of the effect of MST on adherence and metabo...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-0638

    authors: Ellis DA,Frey MA,Naar-King S,Templin T,Cunningham PB,Cakan N

    更新日期:2005-12-01 00:00:00

  • The effectiveness of baby books for providing pediatric anticipatory guidance to new mothers.

    abstract:OBJECTIVE:To assess whether embedding pediatric anticipatory guidance into books read to infants is an effective way to educate low-income, first-time mothers about injury-prevention and health-promotion practices. PATIENTS AND METHODS:Primiparous women (N = 168) were randomly assigned to 1 of 3 groups: an educational...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-2728

    authors: Reich SM,Bickman L,Saville BR,Alvarez J

    更新日期:2010-05-01 00:00:00

  • Intentions to use violence among young adolescents.

    abstract:OBJECTIVE:Frequent violent behavior among adolescents has been found to be associated with previous exposure to violence, personal victimization, depression, hopelessness, and older age. Although young adolescents engage in less severe violent behavior than older adolescents, their perceived normative expectations to u...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: DuRant RH,Treiber F,Goodman E,Woods ER

    更新日期:1996-12-01 00:00:00

  • Primary varicella and herpes zoster among HIV-infected children from 1989 to 2006.

    abstract:OBJECTIVES:The primary objective of this study was to determine the incidence of herpes zoster in perinatally HIV-infected children. Secondary objectives included assessing the impact of highly active antiretroviral therapy and varicella zoster virus immunization on primary varicella and herpes zoster incidence and ide...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0564

    authors: Wood SM,Shah SS,Steenhoff AP,Rutstein RM

    更新日期:2008-01-01 00:00:00

  • MIS-C and Cardiac Conduction Abnormalities.

    abstract:OBJECTIVES:Multisystem inflammatory syndrome in children (MIS-C) has spread through the pediatric population during the coronavirus disease 2019 pandemic. Our objective for the study was to report the prevalence of conduction anomalies in MIS-C and identify predictive factors for the conduction abnormalities. METHODS:...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-009738

    authors: Choi NH,Fremed M,Starc T,Weller R,Cheung E,Ferris A,Silver ES,Liberman L

    更新日期:2020-12-01 00:00:00

  • Gabapentin successfully manages chronic unexplained irritability in children with severe neurologic impairment.

    abstract::Neurologically impaired children have an increased frequency of recurrent pain and irritability that persist in some despite comprehensive evaluation and management of possible pain sources. We hypothesized that visceral hyperalgesia was a source of chronic unexplained irritability and report the outcome of gabapentin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1609

    authors: Hauer JM,Wical BS,Charnas L

    更新日期:2007-02-01 00:00:00

  • Risk stratification of children being evaluated for intussusception.

    abstract:CONTEXT:Intussusception is the most common cause of intestinal obstruction in young children, and delayed diagnosis may lead to bowel perforation. OBJECTIVE:To determine predictive clinical criteria and develop a decision tree to risk-stratify children with possible intussusception. DESIGN/METHODS:This is a prospecti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-2432

    authors: Weihmiller SN,Buonomo C,Bachur R

    更新日期:2011-02-01 00:00:00

  • High-flow nasal cannulae in the management of apnea of prematurity: a comparison with conventional nasal continuous positive airway pressure.

    abstract::Apnea of prematurity (AOP) is frequently managed with nasal continuous positive airway pressure (NCPAP). Nasal cannula (NC) are used at low flows (<0.5 L/min) to deliver supplemental oxygen to neonates. A number of centers use high-flow nasal cannula (HFNC) in the management of AOP without measuring the positive diste...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.107.5.1081

    authors: Sreenan C,Lemke RP,Hudson-Mason A,Osiovich H

    更新日期:2001-05-01 00:00:00

  • Negative Chest Radiography and Risk of Pneumonia.

    abstract::: media-1vid110.1542/5804413949001PEDS-VA_2018-0236Video Abstract BACKGROUND AND OBJECTIVES: The ability of the chest radiograph (CXR) to exclude the diagnosis of pneumonia in children is unclear. We sought to determine the negative predictive value of CXR in children with suspected pneumonia. METHODS:Children 3 mont...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0236

    authors: Lipsett SC,Monuteaux MC,Bachur RG,Finn N,Neuman MI

    更新日期:2018-09-01 00:00:00

  • Which children benefit the most from early intervention?

    abstract::Recent findings from three separate studies support and extend a large and growing body of early-intervention research literature spanning 30 years. The literature is consistent in demonstrating positive developmental outcomes as a result of intensive early intervention for children of low-income and undereducated fam...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ramey CT,Ramey SL

    更新日期:1994-12-01 00:00:00

  • Neuroprotection with prolonged head cooling started before postischemic seizures in fetal sheep.

    abstract:OBJECTIVE:Cerebral hypothermia has been shown to reduce damage from experimental hy-poxia-ischemia if started shortly after reperfusion. However, in the newborn infant it may not be feasible to determine prognosis so soon after exposure to asphyxia. The aim of this study was to determine whether head cooling, delayed u...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.5.1098

    authors: Gunn AJ,Gunn TR,Gunning MI,Williams CE,Gluckman PD

    更新日期:1998-11-01 00:00:00

  • Toppled television sets cause significant pediatric morbidity and mortality.

    abstract:OBJECTIVE:To quantify pediatric injuries and deaths that result from toppled television sets. DESIGN:Retrospective analysis of incident files compiled by the US Consumer Product Safety Commission (CPSC) data systems and The Children's Hospital of Alabama (TCHA) inpatient medical records. SETTING:United States, Januar...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.3.e32

    authors: Bernard PA,Johnston C,Curtis SE,King WD

    更新日期:1998-09-01 00:00:00

  • Mycoplasma pneumoniae and atypical Stevens-Johnson syndrome: a case series.

    abstract::Mycoplasma pneumoniae is a common cause of community-acquired respiratory illness in the adolescent population. Stevens-Johnson syndrome is an extrapulmonary manifestation that has been associated with M. pneumoniae infections. Three adolescent males presented within a 1-month period with M. pneumoniae respiratory ill...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2401

    authors: Ravin KA,Rappaport LD,Zuckerbraun NS,Wadowsky RM,Wald ER,Michaels MM

    更新日期:2007-04-01 00:00:00

  • Case Report: When an Induced Illness Looks Like a Rare Disease.

    abstract::The recognition of fabricated illness (FI) in a child represents a diagnostic challenge. The suspicion of FI often arises from the discrepancy between laboratory tests and clinical history. For instance, (unnecessary) insulin injections by caregivers has been widely described as a common cause of factitious hypoglycem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-4165

    authors: Rabbone I,Galderisi A,Tinti D,Ignaccolo MG,Barbetti F,Cerutti F

    更新日期:2015-11-01 00:00:00

  • Pharmacokinetic comparison of intravenous and oral chloramphenicol in patients with Haemophilus influenzae meningitis.

    abstract::The pharmacokinetics of chloramphenicol following intravenous and oral administration were studied in 14 infants with Haemophilus influenzae meningitis. Following five days of treatment with intravenous chloramphenicol (100 mg/kg/day every six hours), oral chloramphenicol was substituted at the same dose. Multiple ser...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Yogev R,Kolling WM,Williams T

    更新日期:1981-05-01 00:00:00

  • Echocardiographic characteristics of premature infants with patient ductus arteriosus.

    abstract::As part of a multicenter collaborative study, M-mode echocardiograms were obtained shortly after birth on 3,559 premature infants with birth weight less than or equal to 1,750 g. Of these infants, 1,496 did not develop a cardiac murmur or other signs of a "hemodynamically significant" patent ductus arteriosus (PDA). E...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Johnson GL,Breart GL,Gewitz MH,Brenner JI,Lang P,Dooley KJ,Ellison RC

    更新日期:1983-12-01 00:00:00

  • Assessment of stress in mothers of children with severe breath-holding spells.

    abstract:BACKGROUND:Severe breath-holding spells (BHS) in children consist of a stereotypical sequence of provocation to cry, noiseless expiration, color change, and loss of consciousness. Parenting a child who exhibits BHS is likely more stressful than parenting a healthy child, owing to this additional medical concern. It is ...

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    pub_type: 杂志文章

    doi:10.1542/peds.106.1.1

    authors: Mattie-Luksic M,Javornisky G,DiMario FJ

    更新日期:2000-07-01 00:00:00