Sustaining and spreading the reduction of adverse drug events in a multicenter collaborative.

Abstract:

OBJECTIVES:Adverse drug events (ADEs) occur more frequently in pediatric patients than adults. ADEs frequently cause serious harm to children and increase the cost of care. The purpose of this study was to decrease ADEs by targeting the entire medication-delivery system for all high-risk medications. METHODS:Thirteen freestanding children's hospitals participated in this ADE collaborative. An advisory panel developed a change package of interventions that consisted of standardization of medication-ordering (eg, consensus-based protocols and order sets and high-alert medication protocols), reliable medication-dispensing processes (eg, automated dispensing cabinets and redesign of floor stock procedures), reliable medication-administration processes (eg, safe pump use and reducing interruptions), improvement of patient safety culture (eg, safety-culture changes and reduction of staff intimidation), and clinical decision support (eg, increase ADE detection and redesign care systems). ADE rates were compared from the 3-month baseline period to quarters of the 12-month intervention phase. ADE rates were categorized further as opioid related and other medication related. RESULTS:From baseline to the final quarter, the collaborative resulted in a 42% decrease in total ADEs, a 51% decrease in opioid-related ADEs, and a 41% decrease in other medication ADEs. CONCLUSION:A pediatric collaborative that targeted the medication-delivery system decreased the rate of ADEs at participating institutions.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Tham E,Calmes HM,Poppy A,Eliades AB,Schlafly SM,Namtu KC,Smith DM,Vitaska MC,McConnell C,Potts AL,Jastrzembski J,Logsdon TR,Hall M,Takata GS

doi

10.1542/peds.2010-3772

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

e438-45

issue

2

eissn

0031-4005

issn

1098-4275

pii

peds.2010-3772

journal_volume

128

pub_type

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