Abstract:
OBJECTIVES:Adverse drug events (ADEs) occur more frequently in pediatric patients than adults. ADEs frequently cause serious harm to children and increase the cost of care. The purpose of this study was to decrease ADEs by targeting the entire medication-delivery system for all high-risk medications. METHODS:Thirteen freestanding children's hospitals participated in this ADE collaborative. An advisory panel developed a change package of interventions that consisted of standardization of medication-ordering (eg, consensus-based protocols and order sets and high-alert medication protocols), reliable medication-dispensing processes (eg, automated dispensing cabinets and redesign of floor stock procedures), reliable medication-administration processes (eg, safe pump use and reducing interruptions), improvement of patient safety culture (eg, safety-culture changes and reduction of staff intimidation), and clinical decision support (eg, increase ADE detection and redesign care systems). ADE rates were compared from the 3-month baseline period to quarters of the 12-month intervention phase. ADE rates were categorized further as opioid related and other medication related. RESULTS:From baseline to the final quarter, the collaborative resulted in a 42% decrease in total ADEs, a 51% decrease in opioid-related ADEs, and a 41% decrease in other medication ADEs. CONCLUSION:A pediatric collaborative that targeted the medication-delivery system decreased the rate of ADEs at participating institutions.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Tham E,Calmes HM,Poppy A,Eliades AB,Schlafly SM,Namtu KC,Smith DM,Vitaska MC,McConnell C,Potts AL,Jastrzembski J,Logsdon TR,Hall M,Takata GSdoi
10.1542/peds.2010-3772subject
Has Abstractpub_date
2011-08-01 00:00:00pages
e438-45issue
2eissn
0031-4005issn
1098-4275pii
peds.2010-3772journal_volume
128pub_type
杂志文章,多中心研究,随机对照试验相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:To study late side effects of antenatal corticosteroid treatment on health and sexual development in subjects 20 to 22 years old. METHODS:A follow-up study among young adults whose mothers had, because of a threatening delivery, participated in a randomized, double-blind, placebo- controlled trial of betamet...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.105.6.e77
更新日期:2000-06-01 00:00:00
abstract::A physician faces many challenges in making a definitive diagnosis of asthma in young children. Although there are clinical and historical features consistent with asthma, identical features are present in many other diseases. Furthermore, there is no specific test for asthma. Other diseases must always be ruled out b...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract:OBJECTIVES:To develop a practical, readily applied algorithm for primary health care providers to identify, evaluate, and manage constipation in children with autism spectrum disorders (ASDs). METHODS:The Gastroenterology Committee of the Autism Speaks Autism Treatment Network (ATN), a multisite consortium of centers ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2012-0900H
更新日期:2012-11-01 00:00:00
abstract::The bilirubin titration point--the lowest bilirubin concentration at which loosely bound bilirubin could be demonstrated by Sephadex gel filtration--was determined in samples collected before, during, and on completion of 17 exchange transfusions as well as in the discarded and donor blood. The bilirubin titration poi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract:BACKGROUND:In ice hockey and soccer, age restrictions exist for body checking and heading because of injury risk. There are currently no age restrictions for tackling in youth football. METHODS:We surveyed a nationally representative sample of US parents regarding their support for age restrictions on tackling in foot...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-2402
更新日期:2019-05-01 00:00:00
abstract::Long-term growth and developmental data are presented for the smallest and third smallest surviving newborns in the world literature to 5 and 20 years of age, respectively. Both patients exhibited normal motor and language development. Although head circumference for both newborns demonstrated catchup growth, signific...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0039
更新日期:2012-01-01 00:00:00
abstract::During a 3-month period, 1,062 mother-infant pairs were studied for infections following internal fetal monitoring during labor. Six infants (0.56%) developed septic scalp dermatitis at the site of the spiral electrode application. Factors associated with septic scalp dermatitis included the number of vaginal examinat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-07-01 00:00:00
abstract::Today clinical information is used for a multitude of purposes beyond patient care documentation including quality review and improvement processes, allocation of resources, budgetary and long-term planning, productivity measurement, and justification to payers for services provided. Providers in perinatal medicine ar...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Prelicensure studies of diphtheria, tetanus, acellular pertussis, hepatitis B, inactivated polio virus vaccine suggested that there were higher rates of fever after its administration than when its component antigens were given separately. METHODS:We conducted an open, controlled, cohort study to evaluate s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-1977
更新日期:2008-12-01 00:00:00
abstract:CONTEXT:Breastfeeding duration and exclusivity among Latinas fall below recommended levels, indicating a need for targeted interventions. The effectiveness of clinical breastfeeding interventions for Latinas remains unclear. OBJECTIVE:To systematically review the documented effectiveness of clinical breastfeeding inte...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析,评审
doi:10.1542/peds.2015-2423
更新日期:2016-01-01 00:00:00
abstract:OBJECTIVES:The primary objectives were to evaluate the quality of development and reporting of American Academy of Pediatrics (AAP) guidelines and to determine the level of evidence underlying the recommendations. METHODS:Two reviewers scored each guideline by using the Appraisal of Guidelines for Research and Evaluat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-2027
更新日期:2013-04-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Hypothalamic-pituitary-adrenal axis suppression (HPAS) when treating children with corticosteroids is thought to be rare. Our objective was to determine the prevalence of and predictive factors for various degrees of HPAS. METHODS:Clinical features of HPAS, doses, adherence, asthma score, and ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1147
更新日期:2012-12-01 00:00:00
abstract::The appropriate determination of adequate tissue perfusion and the best approach to treatment of perceived abnormalities in blood pressure in the neonate remain controversial. There is no consensus regarding the actual definition of hypotension in the neonate or how best to raise perceived low blood pressure. In addit...
journal_title:Pediatrics
pub_type:
doi:10.1542/peds.2005-0620F
更新日期:2006-03-01 00:00:00
abstract:OBJECTIVES:We aim to describe the demographics, clinical presentation, hospital course, and severity of pediatric inpatients with coronavirus disease 2019 (COVID-19), with an emphasis on healthy, immunocompromised, and chronically ill children. METHODS:We conducted a single-center retrospective cohort study of hospita...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-003186
更新日期:2020-10-01 00:00:00
abstract::The pharmacokinetics of chloramphenicol following intravenous and oral administration were studied in 14 infants with Haemophilus influenzae meningitis. Following five days of treatment with intravenous chloramphenicol (100 mg/kg/day every six hours), oral chloramphenicol was substituted at the same dose. Multiple ser...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-05-01 00:00:00
abstract::This article provides background information on acoustic impedance testing and illustrates utilization of test results in pediatric clinical practice. Acoustic impedance measurement devices are presently being used successfully by hearing screening programs and by otorhinolaryngologists in clinical and hospital setti...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-05-01 00:00:00
abstract::Recent findings from three separate studies support and extend a large and growing body of early-intervention research literature spanning 30 years. The literature is consistent in demonstrating positive developmental outcomes as a result of intensive early intervention for children of low-income and undereducated fam...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract:BACKGROUND:The "Guide to Community Preventive Services" strongly recommends reducing out-of-pocket costs to increase vaccination rates among children. Nevertheless, out-of-pocket expenses are still incurred during the receipt of childhood vaccines, vaccine administration, and associated well-child visits. OBJECTIVE:Ou...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-3654
更新日期:2007-11-01 00:00:00
abstract:OBJECTIVE:We hypothesized that patients with cystic fibrosis (CF) have higher rates of protein breakdown than normal volunteers and that the infusion of insulin would result in less suppression of proteolysis. Methods. Using [1-C]leucine and a three-step hyperinsulinemic euglycemic clamp, we measured rates of leucine a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.101.3.433
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVE:To evaluate a secondary liver iron overload and its fate in children who are treated conventionally for acute lymphoblastic leukemia and to assess whether serum soluble transferrin receptor (sTfR) is useful in detecting iron load. METHODS:Liver siderosis was estimated histologically from liver biopsy specime...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:10.1542/peds.111.1.91
更新日期:2003-01-01 00:00:00
abstract::The response of 23 children with attention deficit disorder (ADD) with hyperactivity (+H) and 17 children with ADD without hyperactivity (-H) to three doses of methylphenidate (5, 10, and 15 mg twice a day) was evaluated in a triple-blind, placebo-controlled cross-over design using parent and teacher ratings of behavi...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章
doi:
更新日期:1991-04-01 00:00:00
abstract:OBJECTIVE:With male gender as a strong predictor of cardiovascular instability, we hypothesized that gender-specific differences in circulating carbon monoxide levels contributed to dysregulated microvascular function in preterm male infants. METHODS:Infants born at 24 to 34 weeks of gestation (N = 84) were studied in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0877
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this controlled study was to provide a description of children's postoperative pain, including pain intensity and analgesic consumption. METHODS:Participants included 261 children, 2 to 12 years of age, undergoing routine tonsillectomy and adenoidectomy surgery. Baseline and demographic data w...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3529
更新日期:2009-10-01 00:00:00
abstract::The place of causal inference in clinical practice is considered. One function relates to the validation of existing knowledge, as in the evaluation of the medical literature, and is exemplified by the process of editorial selection. A second function relates to the validation of potential knowledge, as in the testing...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Neutropenia, defined as absolute neutrophil count (ANC) <1500/mm(3), affects 6% to 58% of premature infants in the first week of life. This early-onset neutropenia in premature infants has previously been correlated with sepsis, maternal hypertension, severe asphyxia, and periventricular hemorrhage. Late-ons...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.4.e55
更新日期:2000-10-01 00:00:00
abstract::The effect of body position (supine v prone) on energy expenditure and behavior of 42 healthy low birth weight (920 to 1,760 g) infants was evaluated in 66 studies. Each infant was randomly assigned to the supine or prone position for the first three-hour epoch; the position was reversed for the second three-hour epoc...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:Not enough is known about the national prevalence of racial/ethnic disparities in children's medical and dental care. OBJECTIVE:The purpose of this work was to examine racial/ethnic disparities in medical and oral health, access to care, and use of services in a national sample. METHODS:The National Survey...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1243
更新日期:2008-02-01 00:00:00
abstract:OBJECTIVE:Incorporating Healthy Steps for Young Children into pediatric practice has been shown to have positive effects for children and families. Although this model of care has also been integrated into several pediatric and family medicine training programs, published reports to date have focused only on residents'...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-3090
更新日期:2007-09-01 00:00:00
abstract:OBJECTIVE:Newborn infants are vitamin K deficient. Vitamin K status in full-term infants after intramuscular vitamin K supplementation at birth has been described. Similar information in growing premature infants has not been reported. The objective of this study was to assess vitamin K status in premature infants by m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.5.1117
更新日期:2001-11-01 00:00:00
abstract::Early sexual intercourse among American adolescents represents a major public health problem. Although early sexual activity may be caused by a variety of factors, the media are believed to play a significant role. In film, television, and music, sexual messages are becoming more explicit in dialogue, lyrics, and beha...
journal_title:Pediatrics
pub_type: 指南,杂志文章
doi:10.1542/peds.107.1.191
更新日期:2001-01-01 00:00:00