Attention deficit disorder with and without hyperactivity: clinical response to three dose levels of methylphenidate.

Abstract:

:The response of 23 children with attention deficit disorder (ADD) with hyperactivity (+H) and 17 children with ADD without hyperactivity (-H) to three doses of methylphenidate (5, 10, and 15 mg twice a day) was evaluated in a triple-blind, placebo-controlled cross-over design using parent and teacher ratings of behavior, laboratory tests of ADD symptoms, and behavioral observations during academic performance. Results indicated that the children with ADD+H were rated as having more pervasive behavioral problems at home and more pervasive and severe conduct problems at school than the children with ADD-H. Laboratory tests found the children with ADD+H to be impaired in behavioral inhibition and vigilance whereas children with ADD-H were more impaired in the consistent retrieval of verbally learned material Drug effects were noted on the parent and teacher ratings and on most laboratory measures, with all three doses typically producing significant changes but rarely differing among themselves in effectiveness. The groups were not found to differ significantly on any measures in their response to methylphenidate. However, more children with ADD-H were clinically judged as having either no clinical response (24%) or responding best to the low dose (35%) of medication. In contrast, most ADD+H (95%) children were judged to be positive responders and most were recommended to receive the moderate to high dose (71%).

journal_name

Pediatrics

journal_title

Pediatrics

authors

Barkley RA,DuPaul GJ,McMurray MB

subject

Has Abstract

pub_date

1991-04-01 00:00:00

pages

519-31

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

87

pub_type

临床试验,杂志文章
  • Prevention of influenza: recommendations for influenza immunization of children, 2007-2008.

    abstract::The American Academy of Pediatrics recommends annual influenza immunization for all children with high-risk conditions who are 6 months of age and older, for all healthy children ages 6 through 59 months, for all household contacts and out-of-home caregivers of children with high-risk conditions and of healthy childre...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-0160

    authors: American Academy of Pediatrics Committee on Infectious Diseases.

    更新日期:2008-04-01 00:00:00

  • Ten-year follow-up of children born at

    abstract:BACKGROUND:Thyroid hormones are essential for brain development. We conducted a randomized, controlled trial with thyroxine (T4) supplementation in infants <30 weeks' gestation and with the last neurodevelopmental follow-up moment at the age of 5.5 years. T4 supplementation was associated with improved outcome of infan...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-0876

    authors: van Wassenaer AG,Westera J,Houtzager BA,Kok JH

    更新日期:2005-11-01 00:00:00

  • Erythromelalgia.

    abstract::Erythromelalgia is an extraordinary disease which remains elusive in its pathophysiology and management. Victims suffer intense burning and redness of the hands and feet. In what appears to be the antithesis of Raynaud's disease, the pain is relieved by emersion in cold. A child with erythromelalgia is described whose...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mandell F,Folkman J,Matsumoto S

    更新日期:1977-01-01 00:00:00

  • The well-being of the health care environment for CSHCN and their families: a latent variable approach.

    abstract:OBJECTIVE:Using structural equation modeling, we sought to assess the system of services for children with special health care needs (CSHCN) and their families by using 14 key indicators of functional abilities of CSHCN, health insurance coverage, access to care, and the impact of their conditions on their families. M...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1255F

    authors: Blumberg SJ,Carle AC

    更新日期:2009-12-01 00:00:00

  • A cluster of children with seizures caused by camphor poisoning.

    abstract:BACKGROUND:Isolated cases of camphor-induced seizures have been reported in young children after gastrointestinal, dermal, and inhalation exposure. In 1982, after a series of unintentional ingestions of camphor products, the US Food and Drug Administration restricted the camphor content to <11% in some products intende...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2097

    authors: Khine H,Weiss D,Graber N,Hoffman RS,Esteban-Cruciani N,Avner JR

    更新日期:2009-05-01 00:00:00

  • Obesity development during adolescence in a biracial cohort: the NHLBI Growth and Health Study.

    abstract:OBJECTIVE:The National Heart, Lung, and Blood Institute Growth and Health Study (NGHS) is a 10-year study to investigate the development of obesity in black and white girls during adolescence and its environmental and psychosocial correlates. The purpose of this report was to examine changes in the annual prevalence ra...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.110.5.e54

    authors: Kimm SY,Barton BA,Obarzanek E,McMahon RP,Kronsberg SS,Waclawiw MA,Morrison JA,Schreiber GB,Sabry ZI,Daniels SR,NHLBI Growth and Health Study.

    更新日期:2002-11-01 00:00:00

  • Booster seat laws and fatalities in children 4 to 7 years of age.

    abstract:OBJECTIVE:To determine whether state booster seat laws were associated with decreased fatality rates in children 4 to 7 years of age in the United States. METHODS:Retrospective, longitudinal analysis of all motor vehicle occupant crashes involving children 4 to 7 years of age identified in the Fatality Analysis Report...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1058

    authors: Mannix R,Fleegler E,Meehan WP 3rd,Schutzman SA,Hennelly K,Nigrovic L,Lee LK

    更新日期:2012-12-01 00:00:00

  • Risk Stratification to Decrease Unnecessary Diagnostic Imaging for Acute Appendicitis.

    abstract:BACKGROUND:There has been an increase in the use of imaging modalities to diagnose appendicitis despite evidence that can help identify children at especially high or low risk of appendicitis who may not benefit. We hypothesized that the passive diffusion of a standardized care pathway (including diagnostic imaging rec...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.2015-4031

    authors: Depinet H,von Allmen D,Towbin A,Hornung R,Ho M,Alessandrini E

    更新日期:2016-09-01 00:00:00

  • An overview of the effects of dietary fiber on gastrointestinal transit.

    abstract::This article is a review of the effects that ingested dietary fiber has on gastrointestinal transit time. The various phases of gastrointestinal motility are considered, and the effect of fiber on these various components is explored. Fiber affects each phase of gastrointestinal motility differently; however, the most...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Hillemeier C

    更新日期:1995-11-01 00:00:00

  • Slow-release terbutaline and theophylline for the long-term therapy of children with asthma: a Latin square and factorial study of drug effects and interactions.

    abstract::To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind cross-over study. The patients and the treatments were ran...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Chow OK,Fung KP

    更新日期:1989-07-01 00:00:00

  • Role of nutrition in pregnancy with phenylketonuria and birth defects.

    abstract:OBJECTIVE:The maternal phenylketonuria (PKU) syndrome is caused by high blood phenylalanine (Phe) levels during pregnancy, leading to a host of birth defects, especially microcephaly and congenital heart disease (CHD). For finding whether the maternal PKU syndrome could be prevented, an international collaborative stud...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Matalon KM,Acosta PB,Azen C

    更新日期:2003-12-01 00:00:00

  • The changing role and responsibilities of chairmen in clinical academic departments: the transition from autocracy.

    abstract::There is considerable literature dealing with the responsibilities of clinical department chairmen, which primarily emphasizes the importance of developing a sound and facilitating administration. This is dependent on the hiring of appropriate support personnel, developing a representative committee structure, being a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Brent RL

    更新日期:1992-07-01 00:00:00

  • Incidence of and risk factors for neonatal respiratory depression and encephalopathy in rural Sarlahi, Nepal.

    abstract:OBJECTIVES:To characterize the incidence of, risk factors for, and neonatal morbidity and mortality associated with respiratory depression at birth and neonatal encephalopathy (NE) among term infants in a developing country. METHODS:Data were collected prospectively in 2002-2006 during a community-based trial that enr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3590

    authors: Lee AC,Mullany LC,Tielsch JM,Katz J,Khatry SK,LeClerq SC,Adhikari RK,Darmstadt GL

    更新日期:2011-10-01 00:00:00

  • Maternal mosaicism confounds the neonatal diagnosis of type 1 Timothy syndrome.

    abstract::The presence of 2 distinct populations of somatic or germline cells within a single individual harboring different genotypes is termed mosaicism. Recent reports suggest that parental mosaicism is involved in the heritability of type 1 Timothy syndrome (TS1), an extremely rare and life-threatening multisystem disorder ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2941

    authors: Dufendach KA,Giudicessi JR,Boczek NJ,Ackerman MJ

    更新日期:2013-06-01 00:00:00

  • Serum transaminase levels in boys with Duchenne and Becker muscular dystrophy.

    abstract:OBJECTIVE:Serum alanine transaminase (ALT) and aspartate transaminase (AST) levels are commonly used as biochemical indicators of hepatocellular injury but can also detect occult muscle disease. High concomitant serum creatine phosphokinase (CPK) levels can point to muscle as the source of high transaminase levels. Nev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0929

    authors: McMillan HJ,Gregas M,Darras BT,Kang PB

    更新日期:2011-01-01 00:00:00

  • Parenting and early development among children of drug-abusing women: effects of home intervention.

    abstract:OBJECTIVE:To evaluate the efficacy of home intervention with drug-abusing women on parenting behavior and attitudes, and on children's development. DESIGN:A randomized, clinical trial of 60 drug-abusing women recruited prenatally and randomized into an intervention (n = 31) or comparison (n = 29) group. There were no ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Black MM,Nair P,Kight C,Wachtel R,Roby P,Schuler M

    更新日期:1994-10-01 00:00:00

  • Evaluation of a type 2 diabetes screening protocol in an urban pediatric clinic.

    abstract:BACKGROUND:In 2000, the American Diabetes Association issued recommendations for type 2 diabetes mellitus screening among children. They recommended testing children > or =10 years of age who have a body mass index (BMI) of >85th percentile for age and at least 2 other risk factors (family history of type 2 diabetes, h...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.1.141

    authors: Drobac S,Brickman W,Smith T,Binns HJ

    更新日期:2004-07-01 00:00:00

  • Maternal prenatal lifestyle factors and infectious disease in early childhood: a follow-up study of hospitalization within a Danish birth cohort.

    abstract:OBJECTIVES:To examine whether maternal prenatal lifestyle factors were associated with the risk of hospitalization with infectious disease during early childhood and whether a possible association was modified by fetal growth reduction. METHODS:The study was based on a birth cohort of 10 400 newborns whose mothers att...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.107.2.357

    authors: Yuan W,Basso O,Sørensen HT,Olsen J

    更新日期:2001-02-01 00:00:00

  • Cumulative social disadvantage and child health.

    abstract:CONTEXT:Disparities in child health are a major public health concern. However, it is unclear whether these are predominantly the result of low income, race, or other social risk factors that may contribute to their health disadvantage. Although others have examined the effects of the accumulation of risk factors, this...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1647

    authors: Bauman LJ,Silver EJ,Stein RE

    更新日期:2006-04-01 00:00:00

  • The cause of infant and toddler subdural hemorrhage: a prospective study.

    abstract:OBJECTIVE:To determine the frequency of child abuse and unintentional injury as a cause of infant and toddler subdural hemorrhage (SDH). METHODS:A prospective case series of a level I regional trauma center, regional children's hospital, and county medical examiner's office assessed consecutive children who were

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.3.636

    authors: Feldman KW,Bethel R,Shugerman RP,Grossman DC,Grady MS,Ellenbogen RG

    更新日期:2001-09-01 00:00:00

  • Growth and neurodevelopmental outcomes after early low-dose hydrocortisone treatment in extremely low birth weight infants.

    abstract:BACKGROUND:Low cortisol concentrations in premature infants have been correlated with increased severity of illness, hypotension, mortality, and development of bronchopulmonary dysplasia. A total of 360 mechanically ventilated infants with a birth weight of 500 to 999 g were enrolled in a randomized, multicenter trial ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2006-3158

    authors: Watterberg KL,Shaffer ML,Mishefske MJ,Leach CL,Mammel MC,Couser RJ,Abbasi S,Cole CH,Aucott SW,Thilo EH,Rozycki HJ,Lacy CB

    更新日期:2007-07-01 00:00:00

  • Use of hymenal measurements in the diagnosis of previous penetration.

    abstract:OBJECTIVE:To determine the usefulness of measurements of the vaginal opening and amount of hymenal tissue present inferiorly and laterally in the diagnosis of vaginal penetration. METHODS:The transhymenal diameters and the amount of tissue present between the hymenal edge and vestibule inferiorly at 6 o'clock and late...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.2.228

    authors: Berenson AB,Chacko MR,Wiemann CM,Mishaw CO,Friedrich WN,Grady JJ

    更新日期:2002-02-01 00:00:00

  • INSIGHT Responsive Parenting Intervention and Infant Sleep.

    abstract:OBJECTIVES:Inadequate sleep during infancy is associated with adverse outcomes for infants and families. We sought to improve sleep behaviors and duration through a responsive parenting (RP) intervention designed for obesity prevention. METHODS:The Intervention Nurses Start Infants Growing on Healthy Trajectories (INS...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2016-0762

    authors: Paul IM,Savage JS,Anzman-Frasca S,Marini ME,Mindell JA,Birch LL

    更新日期:2016-07-01 00:00:00

  • Intestinal parasite screening in internationally adopted children: importance of multiple stool specimens.

    abstract:OBJECTIVE:Our goal was to determine the prevalence of intestinal parasites in internationally adopted children, to examine factors associated with infection, and to determine if evaluating multiple stool specimens increases the yield of parasite identification. METHODS:We evaluated internationally adopted children wit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3032

    authors: Staat MA,Rice M,Donauer S,Mukkada S,Holloway M,Cassedy A,Kelley J,Salisbury S

    更新日期:2011-09-01 00:00:00

  • Treatment of apnea of prematurity with aminophylline.

    abstract::The effectiveness of aminophylline in the treatment of apnea of prematurity was evaluated in 13 premature infants (mean birthweight, 1.13 kg; mean gestational age, 29 weeks). Apnea was recorded by direct observation in combination with impedance monitoring. Rectal suppositories of aminophylline (5 mg) were given at si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bednarek FJ,Roloff DW

    更新日期:1976-09-01 00:00:00

  • Advanced Ultrasound Techniques for Pediatric Imaging.

    abstract::Ultrasound has become a useful tool in the workup of pediatric patients because of the highly convenient, cost-effective, and safe nature of the examination. With rapid advancements in anatomic and functional ultrasound techniques over the recent years, the diagnostic and interventional utility of ultrasound has risen...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2018-2609

    authors: Hwang M,Piskunowicz M,Darge K

    更新日期:2019-03-01 00:00:00

  • Assent observed: children's involvement in leukemia treatment and research discussions.

    abstract:OBJECTIVE:Assent is a critical issue in pediatric ethics that has not been well-studied. We examined the role of older children in discussing a recent diagnosis of acute leukemia and treatment options, including participation in a randomized, clinical trial (RCT). DESIGN:Our sample was drawn from data collected as par...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.109.5.806

    authors: Olechnowicz JQ,Eder M,Simon C,Zyzanski S,Kodish E

    更新日期:2002-05-01 00:00:00

  • Effects of environmental exposures on the cardiovascular system: prenatal period through adolescence.

    abstract::Exposures to drugs, chemical and biological agents, therapeutic radiation, and other factors before and after birth can lead to pediatric or adult cardiovascular anomalies. Furthermore, nutritional deficiencies in the perinatal period can cause cardiovascular anomalies. These anomalies may affect heart structure, the ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Mone SM,Gillman MW,Miller TL,Herman EH,Lipshultz SE

    更新日期:2004-04-01 00:00:00

  • Screening for congenital adrenal hyperplasia: the Delfia Screening Test overestimates serum 17-hydroxyprogesterone in preterm infants.

    abstract:OBJECTIVE:To compare 17-hydroxyprogesterone (17-OHP) levels measured by quantitative serum radioimmunoassay (RIA), including an extraction step, and by screening fluoroimmunoassay (FIA) on blood spots in preterm infants. METHODS:Subjects were 39 healthy infants born at less than 31 weeks' gestational age. Each infant ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: al Saedi S,Dean H,Dent W,Stockl E,Cronin C

    更新日期:1996-01-01 00:00:00

  • Early or delayed enteral feeding for preterm growth-restricted infants: a randomized trial.

    abstract:BACKGROUND:Growth-restricted preterm infants are at increased risk of developing necrotizing enterocolitis (NEC) and initiation of enteral feeding is frequently delayed. There is no evidence that this delay is beneficial and it might further compromise nutrition and growth. METHODS:Infants with gestation below 35 week...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2011-2379

    authors: Leaf A,Dorling J,Kempley S,McCormick K,Mannix P,Linsell L,Juszczak E,Brocklehurst P,Abnormal Doppler Enteral Prescription Trial Collaborative Group.

    更新日期:2012-05-01 00:00:00