Screening for congenital adrenal hyperplasia: the Delfia Screening Test overestimates serum 17-hydroxyprogesterone in preterm infants.

Abstract:

OBJECTIVE:To compare 17-hydroxyprogesterone (17-OHP) levels measured by quantitative serum radioimmunoassay (RIA), including an extraction step, and by screening fluoroimmunoassay (FIA) on blood spots in preterm infants. METHODS:Subjects were 39 healthy infants born at less than 31 weeks' gestational age. Each infant had weekly blood sampling, and RIA and FIA were performed on each sample. RESULTS:Two hundred twenty-seven samples were taken at 28 to 41 weeks' postconceptional age. Mean +/- SD 17-OHP measured by RIA was 11.4 +/- 11.1 nmol/L (0.4 +/- 0.4 micrograms/dL), and decreased over time. Mean +/- SD 17-OHP measured by FIA was 38.96 +/- 37.3 nmol/L, greater than 17-OHP (RIA). Log(delta FIA-RIA) was inversely related to postconceptional age (R2 = .39). CONCLUSION:Screening FIA of blood spots overestimates levels of 17-OHP in preterm infants and should not be used to determine the likelihood of congenital adrenal hyperplasia in this population. We have abandoned FIA screening for congenital adrenal hyperplasia in infants weighing less than 1500 g.

journal_name

Pediatrics

journal_title

Pediatrics

authors

al Saedi S,Dean H,Dent W,Stockl E,Cronin C

subject

Has Abstract

pub_date

1996-01-01 00:00:00

pages

100-2

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

97

pub_type

临床试验,杂志文章
  • A Quality Improvement Initiative: Improving the Frequency of Inpatient Electronic Prescribing.

    abstract:OBJECTIVE:To improve the frequency of electronic prescribing (e-prescribing) of discharge prescriptions at a children's hospital via a bundle of quality improvement interventions. METHODS:Surveys and focus groups were conducted with patient families and pediatric residents to identify barriers and propose solutions to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-0760

    authors: Fuchs J,Lo HY,Peterman A,Camp E,Chase L

    更新日期:2016-11-01 00:00:00

  • Poverty, Transportation Access, and Medication Nonadherence.

    abstract:BACKGROUND AND OBJECTIVES:Variability in primary medication nonadherence (PMN), or failure to fill a new prescription, influences disparities and widens equity gaps. This study sought to evaluate PMN across 1 metropolitan area and assess relationships with underlying zip code-level measures. METHODS:This was a retrosp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-3402

    authors: Hensley C,Heaton PC,Kahn RS,Luder HR,Frede SM,Beck AF

    更新日期:2018-04-01 00:00:00

  • Safety of live viral vaccines in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome).

    abstract::The package inserts of live viral vaccines include immunodeficiency as a contraindication. Nevertheless, patients with mild forms of immunodeficiency may benefit from vaccination. No published guidelines exist for the administration of these vaccines specifically to patients with chromosome 22q11.2 deletion syndrome. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.4.e325

    authors: Perez EE,Bokszczanin A,McDonald-McGinn D,Zackai EH,Sullivan KE

    更新日期:2003-10-01 00:00:00

  • Prospective diagnosis of 2-methylbutyryl-CoA dehydrogenase deficiency in the Hmong population by newborn screening using tandem mass spectrometry.

    abstract:OBJECTIVE:2-methylbutyryl-CoA dehydrogenase deficiency, also known as short/branched-chain acyl-CoA dehydrogenase (SBCAD) deficiency, is a recently described autosomal recessive disorder of L-isoleucine metabolism. Only 4 affected individuals in 2 families have been described. One patient developed athetoid cerebral pa...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.112.1.74

    authors: Matern D,He M,Berry SA,Rinaldo P,Whitley CB,Madsen PP,van Calcar SC,Lussky RC,Andresen BS,Wolff JA,Vockley J

    更新日期:2003-07-01 00:00:00

  • Preoperative anxiety, postoperative pain, and behavioral recovery in young children undergoing surgery.

    abstract:OBJECTIVE:Findings from published studies suggest that the postoperative recovery process is more painful, slower, and more complicated in adult patients who had high levels of preoperative anxiety. To date, no similar investigation has ever been conducted in young children. METHODS:We recruited 241 children aged 5 to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2920

    authors: Kain ZN,Mayes LC,Caldwell-Andrews AA,Karas DE,McClain BC

    更新日期:2006-08-01 00:00:00

  • Dating of bruises in children: an assessment of physician accuracy.

    abstract:OBJECTIVE:To determine whether physicians can estimate accurately the age of an accidental bruise on direct physical examination. METHODS:Children who presented to the emergency department of a children's hospital with accidental bruises of known age and origin had demographic data and information about their injury r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.4.804

    authors: Bariciak ED,Plint AC,Gaboury I,Bennett S

    更新日期:2003-10-01 00:00:00

  • A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants.

    abstract:BACKGROUND AND OBJECTIVE:Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce the potential risk...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2004-2183

    authors: Moya FR,Gadzinowski J,Bancalari E,Salinas V,Kopelman B,Bancalari A,Kornacka MK,Merritt TA,Segal R,Schaber CJ,Tsai H,Massaro J,d'Agostino R,International Surfaxin Collaborative Study Group.

    更新日期:2005-04-01 00:00:00

  • Toe tourniquet syndrome in association with maternal hair loss.

    abstract::Increased hair loss a few months after delivering an infant is a common postpartum condition known as telogen effluvium. A much less common condition involving young infants is the hair-thread tourniquet syndrome, or toe tourniquet syndrome, which involves hair or thread becoming so tightly wrapped around an appendage...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.3.685

    authors: Strahlman RS

    更新日期:2003-03-01 00:00:00

  • Egg Freezing in Childhood and Young Adult Cancer Survivors.

    abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-0291

    authors: Filippi F,Meazza C,Paffoni A,Raspagliesi F,Terenziani M,Somigliana E

    更新日期:2016-10-01 00:00:00

  • Population case-control study of cerebral palsy: neonatal predictors for low-risk term singletons.

    abstract:OBJECTIVES:For singletons with cerebral palsy (CP) who were born at term, the goals were (1) to determine the proportion not admitted to a Special Care Unit/NICU (NICU), (2) to compare clinical descriptions of those admitted to NICUs and those not admitted, and (3) to identify neonatal predictors of CP among those not ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1894

    authors: McIntyre S,Badawi N,Brown C,Blair E

    更新日期:2011-03-01 00:00:00

  • An explosive outbreak of Mycoplasma pneumoniae infection in a summer camp.

    abstract::An outbreak of Mycoplasma pneumoniae infection occurred in the summer of 1978 in a boys' camp in northern Wisconsin and affected 139 of 196 persons (71%); 115 (59%) had laboratory evidence of infection. In 77% of the cases, onset of disease occurred within three weeks after arrival at camp, in contrast to the usually ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Broome CV,LaVenture M,Kaye HS,Davis AT,White H,Plikaytis BD,Fraser DW

    更新日期:1980-12-01 00:00:00

  • The safe environment for every kid model: impact on pediatric primary care professionals.

    abstract:OBJECTIVE:To examine whether the Safe Environment for Every Kid (SEEK) model of enhanced primary care would improve the attitudes, knowledge, comfort, competence, and behavior of child health care professionals (HPs) regarding addressing major risk factors for child maltreatment (CM). METHODS:In a cluster randomized c...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2010-1845

    authors: Dubowitz H,Lane WG,Semiatin JN,Magder LS,Venepally M,Jans M

    更新日期:2011-04-01 00:00:00

  • Parents' Perspectives Regarding Age Restrictions for Tackling in Youth Football.

    abstract:BACKGROUND:In ice hockey and soccer, age restrictions exist for body checking and heading because of injury risk. There are currently no age restrictions for tackling in youth football. METHODS:We surveyed a nationally representative sample of US parents regarding their support for age restrictions on tackling in foot...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2402

    authors: Chrisman SPD,Whitlock KB,Kroshus E,Schwien C,Herring SA,Rivara FP

    更新日期:2019-05-01 00:00:00

  • Aminoglycoside-based triple-antibiotic therapy versus monotherapy for children with ruptured appendicitis.

    abstract:OBJECTIVE:We conducted a retrospective cohort study to compare the use of triple therapy versus monotherapy for children and adolescents with perforated appendicitis and to determine whether there has been a transition to monotherapy within the freestanding children's hospitals that contribute to the Pediatric Health I...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2006-2040

    authors: Goldin AB,Sawin RS,Garrison MM,Zerr DM,Christakis DA

    更新日期:2007-05-01 00:00:00

  • Biphasic anaphylactic reactions in pediatrics.

    abstract:OBJECTIVES:The objectives of this study were to: 1) determine the incidence of biphasic reactions in children with anaphylaxis; 2) establish what risk factors can predict progression to a biphasic reaction; and 3) assess the utility of inpatient observation for patients whose anaphylaxis appears to have resolved. METH...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.4.762

    authors: Lee JM,Greenes DS

    更新日期:2000-10-01 00:00:00

  • Corneal abrasions in young infants.

    abstract:OBJECTIVES:We sought to determine the prevalence of corneal abrasions and possible associations with fingernail length, demographic information, sleeping, and crying among young infants. METHODS:Parents of 1- to 12-week-old infants without symptoms who were presenting for well-child visits completed a brief questionna...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2023

    authors: Shope TR,Rieg TS,Kathiria NN

    更新日期:2010-03-01 00:00:00

  • Neisseria meningitidis bacteremia in children: quantitation of bacteremia and spontaneous clinical recovery without antibiotic therapy.

    abstract::The relationship between the magnitude of bacteremia due to Neisseria meningitidis and the clinical diagnosis was determined for 43 children who had fever in the presence or absence of focal signs of infection. Bacteremia was quantitated by the previously described procedure using heparinized blood (0.2 to 1.0 mL). Ad...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sullivan TD,LaScolea LJ Jr

    更新日期:1987-07-01 00:00:00

  • Asthma as a barrier to children's physical activity: implications for body mass index and mental health.

    abstract:OBJECTIVES:The purpose of this work was to identify barriers to physical activity in children with asthma and to compare their customary activity levels, BMI and emotional well-being with that of children with other medical conditions. It was hypothesized that children with asthma would have higher BMI and lower levels...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-1846

    authors: Glazebrook C,McPherson AC,Macdonald IA,Swift JA,Ramsay C,Newbould R,Smyth A

    更新日期:2006-12-01 00:00:00

  • Providing Care for Children in Immigrant Families.

    abstract::Children in immigrant families (CIF), who represent 1 in 4 children in the United States, represent a growing and ever more diverse US demographic that pediatric medical providers nationwide will increasingly encounter in clinical care. Immigrant children are those born outside the United States to non-US citizen pare...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-2077

    authors: Linton JM,Green A,COUNCIL ON COMMUNITY PEDIATRICS.

    更新日期:2019-09-01 00:00:00

  • Early developmental outcomes of children with congenital HHV-6 infection.

    abstract:OBJECTIVE:The goal of this study was to determine if congenital human herpesvirus-6 (HHV-6) infection influences early neurodevelopment. METHODS:We enrolled 57 newborns with HHV-6 congenital infection and 242 control newborns without congenital infection into a prospective, double-blind study with 4 visits between 4 a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0886

    authors: Caserta MT,Hall CB,Canfield RL,Davidson P,Lofthus G,Schnabel K,Carnahan J,Shelley L,Wang H

    更新日期:2014-12-01 00:00:00

  • Adenovirus meningoencephalitis.

    abstract::Central nervous system manifestations in association with adenovirus infections have rarely been documented. In this report, four children, ages 4, 5, 6, and 10 years, with adenoviral meningoencephalitis are described. Adenoviruses were recovered from CSF specimens in all four patients. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kelsey DS

    更新日期:1978-02-01 00:00:00

  • Adiposity and different types of screen time.

    abstract:OBJECTIVE:Few prospective studies have examined separate forms of screen time in relation to adiposity. Our objective was to assess independent relations of television, electronic games (video/computer), and digital versatile disc (DVD)/videos and total screen time with change in adolescent BMI. METHODS:Using data fro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0887

    authors: Falbe J,Rosner B,Willett WC,Sonneville KR,Hu FB,Field AE

    更新日期:2013-12-01 00:00:00

  • A pacifier increases the risk of recurrent acute otitis media in children in day care centers.

    abstract:OBJECTIVE:To follow up a previous retrospective analysis in which we found the use of a pacifier to be a risk factor for recurrent acute otitis media (AOM). METHOD:In the present prospective study, the occurrence of AOM and the use of a pacifier were recorded in 845 children attending day care centers during a 15-mont...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Niemelä M,Uhari M,Möttönen M

    更新日期:1995-11-01 00:00:00

  • Prescription opioid epidemic and infant outcomes.

    abstract:BACKGROUND AND OBJECTIVES:Although opioid pain relievers are commonly prescribed in pregnancy, their association with neonatal outcomes is poorly described. Our objectives were to identify neonatal complications associated with antenatal opioid pain reliever exposure and to establish predictors of neonatal abstinence s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-3299

    authors: Patrick SW,Dudley J,Martin PR,Harrell FE,Warren MD,Hartmann KE,Ely EW,Grijalva CG,Cooper WO

    更新日期:2015-05-01 00:00:00

  • Management of childhood onset nephrotic syndrome.

    abstract::The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study of Kidney Disease in Children in 1967. The characteristics of children presenting with nephrotic syndrome have changed over recent decades ...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2008-1559

    authors: Gipson DS,Massengill SF,Yao L,Nagaraj S,Smoyer WE,Mahan JD,Wigfall D,Miles P,Powell L,Lin JJ,Trachtman H,Greenbaum LA

    更新日期:2009-08-01 00:00:00

  • Cardiometabolic risk factors among US adolescents and young adults and risk of early mortality.

    abstract:OBJECTIVE:To determine the risk of mortality associated with cardiometabolic risk factors in a national sample of adolescents and young adults. METHODS:Prospective study of participants in the third NHANES (1988-1994), aged 12 to 39 years at the time of the survey (n = 9245). Risk factors included 3 measures of adipos...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2583

    authors: Saydah S,Bullard KM,Imperatore G,Geiss L,Gregg EW

    更新日期:2013-03-01 00:00:00

  • Physical education class injuries treated in emergency departments in the US in 1997-2007.

    abstract:OBJECTIVE:The goal was to describe the epidemiological features of physical education (PE)-related injuries treated in US emergency departments. METHODS:A retrospective analysis was conducted with data for children and adolescents (5-18 years of age) from the National Electronic Injury Surveillance Study of the US Con...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3843

    authors: Nelson NG,Alhajj M,Yard E,Comstock D,McKenzie LB

    更新日期:2009-09-01 00:00:00

  • Fibromyalgia syndrome in children and adolescents: clinical features at presentation and status at follow-up.

    abstract:OBJECTIVES:To 1) describe the characteristic features of fibromyalgia syndrome (FS) in a pediatric population, 2) note similarities and differences with FS in adults, and 3) determine outcome after treatment. SETTING AND DESIGN:The Pediatric Rheumatology Clinic at the University of Rochester Medical Center is staffed ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.3.377

    authors: Siegel DM,Janeway D,Baum J

    更新日期:1998-03-01 00:00:00

  • Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health.

    abstract::Approximately 25% of the world's children aged <5 years have stunted growth, which is associated with increased mortality, cognitive dysfunction, and loss of productivity. Reducing by 40% the number of stunted children is a global target for 2030. The pathogenesis of stunting is poorly understood. Prenatal and postnat...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-0641

    authors: Owino V,Ahmed T,Freemark M,Kelly P,Loy A,Manary M,Loechl C

    更新日期:2016-12-01 00:00:00

  • Trends in otitis media treatment failure and relapse.

    abstract:OBJECTIVES:The goals were to describe trends in acute otitis media, treatment failure, and relapse and in high-dose amoxicillin use and to determine whether treatment of acute otitis media with high-dose amoxicillin was associated with treatment failure or relapse. METHODS:We conducted a retrospective study of acute o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1565

    authors: Sox CM,Finkelstein JA,Yin R,Kleinman K,Lieu TA

    更新日期:2008-04-01 00:00:00