Slow-release terbutaline and theophylline for the long-term therapy of children with asthma: a Latin square and factorial study of drug effects and interactions.

Abstract:

:To evaluate the long-term effects of slow-release formulations of theophylline and terbutaline on pulmonary function, clinical symptoms, and side effects, 24 children with stable and moderately severe perennial asthma participated in a prospective double-blind cross-over study. The patients and the treatments were randomized according to the Latin square design to eliminate all possible period/climate biases throughout the protracted study period. The treatments consisted of terbutaline, 5 mg, theophylline, 200 mg, the combination, and placebo, given twice daily orally and crossing over every 28 days. The two drugs, administered alone or in combination, improved lung function and symptoms when compared with placebo. The interaction of theophylline and terbutaline was quantitatively shown by 2 x 2 factorial statistical design to be essentially additive rather than synergistic in the control of asthma. No increase in side effects was noted when the combined therapy was used. These findings suggest therapeutic advantages to combining submaximal oral doses of sustained-release theophylline and terbutaline for the long-term treatment of children with asthma.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Chow OK,Fung KP

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

119-25

issue

1

eissn

0031-4005

issn

1098-4275

journal_volume

84

pub_type

临床试验,杂志文章,随机对照试验
  • Standardizing the Evaluation of Nonaccidental Trauma in a Large Pediatric Emergency Department.

    abstract:BACKGROUND AND OBJECTIVES:Variability exists in the evaluation of nonaccidental trauma (NAT) in the pediatric emergency department because of misconceptions and individual bias of clinicians. Further maltreatment, injury, and death can ensue if these children are not evaluated appropriately. The implementation of guide...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1994

    authors: Riney LC,Frey TM,Fain ET,Duma EM,Bennett BL,Murtagh Kurowski E

    更新日期:2018-01-01 00:00:00

  • Medication errors in pediatric inpatients: prevalence and results of a prevention program.

    abstract:OBJECTIVE:The objective of this study was to assess the prevalence and characteristics of medication errors in pediatric and neonatal inpatients and to measure the impact of interventions to reduce medication errors. METHODS:A preintervention and postintervention cross-sectional study was conducted of a sample of pres...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2008-0014

    authors: Otero P,Leyton A,Mariani G,Ceriani Cernadas JM,Patient Safety Committee.

    更新日期:2008-09-01 00:00:00

  • The benefit of pimecrolimus (Elidel, SDZ ASM 981) on parents' quality of life in the treatment of pediatric atopic dermatitis.

    abstract:OBJECTIVE:Two 26-week US clinical trials of identical design were conducted to evaluate the efficacy and safety of pimecrolimus (Elidel, SDZ ASM 981) cream 1% in pediatric atopic dermatitis (AD). A secondary aim of both trials, and the focus of this article, was to evaluate the quality-of-life (QoL) impact of pimecroli...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.110.6.1133

    authors: Whalley D,Huels J,McKenna SP,Van Assche D

    更新日期:2002-12-01 00:00:00

  • Readmissions among children previously hospitalized with pneumonia.

    abstract:BACKGROUND AND OBJECTIVES:Pneumonia is a leading cause of hospitalization and readmission in children. Understanding the patient characteristics associated with pneumonia readmissions is necessary to inform interventions to reduce avoidable hospitalizations and related costs. The objective of this study was to characte...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2014-0331

    authors: Neuman MI,Hall M,Gay JC,Blaschke AJ,Williams DJ,Parikh K,Hersh AL,Brogan TV,Gerber JS,Grijalva CG,Shah SS

    更新日期:2014-07-01 00:00:00

  • Cerebral arteriopathy in children with neurofibromatosis type 1.

    abstract:OBJECTIVE:Cerebrovascular abnormalities are serious but underrecognized complications of neurofibromatosis type 1 (NF1). The aim of this study was to investigate the prevalence, clinical presentation, imaging findings, and prognosis of cerebral arteriopathies in childhood NF1. METHODS:Patients followed at the NF1 clin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0152

    authors: Rea D,Brandsema JF,Armstrong D,Parkin PC,deVeber G,MacGregor D,Logan WJ,Askalan R

    更新日期:2009-09-01 00:00:00

  • Adult outcomes of pediatric recurrent abdominal pain: do they just grow out of it?

    abstract:OBJECTIVE:To determine whether medically unexplained recurrent abdominal pain (RAP) in childhood predicts abdominal pain, irritable bowel syndrome (IBS), other somatic complaints, and psychiatric symptoms and disorders in young adulthood. METHODS:A sample of 28 young adults evaluated for RAP between the ages of 6 and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.1.e1

    authors: Campo JV,Di Lorenzo C,Chiappetta L,Bridge J,Colborn DK,Gartner JC Jr,Gaffney P,Kocoshis S,Brent D

    更新日期:2001-07-01 00:00:00

  • A practical clinical approach to diagnosis of fetal alcohol spectrum disorders: clarification of the 1996 institute of medicine criteria.

    abstract:BACKGROUND:The adverse effects of alcohol on the developing human represent a spectrum of structural anomalies and behavioral and neurocognitive disabilities, most accurately termed fetal alcohol spectrum disorders (FASD). The first descriptions in the modern medical literature of a distinctly recognizable pattern of m...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0259

    authors: Hoyme HE,May PA,Kalberg WO,Kodituwakku P,Gossage JP,Trujillo PM,Buckley DG,Miller JH,Aragon AS,Khaole N,Viljoen DL,Jones KL,Robinson LK

    更新日期:2005-01-01 00:00:00

  • Improving growth of very low birth weight infants in the first 28 days.

    abstract:OBJECTIVE:To increase weight gain in the first 28 days after birth for very low birth weight (VLBW) infants by isolating and sharing meaningful process differences between high- and low-weight-gain centers within a neonatal network. DESIGN/METHODS:We identified weight gain as an important target for improvement in 199...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.112.1.8

    authors: Bloom BT,Mulligan J,Arnold C,Ellis S,Moffitt S,Rivera A,Kunamneni S,Thomas P,Clark RH,Peabody J

    更新日期:2003-07-01 00:00:00

  • Neurodevelopmental outcomes of extremely low birth weight infants

    abstract:OBJECTIVE:This study evaluated the impact of changes in perinatal management on neurodevelopmental impairment (NDI) at 18 to 22 months' corrected age of low gestation (22-26 weeks) and higher gestation (27-32 weeks) extremely low birth weight infants (401-1000 g birth weight) who were cared for in the National Institut...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2247

    authors: Vohr BR,Wright LL,Poole WK,McDonald SA

    更新日期:2005-09-01 00:00:00

  • Etiology of childhood bacteremia and timely antibiotics administration in the emergency department.

    abstract:BACKGROUND:Bacteremia is now an uncommon presentation to the children's emergency department (ED) but is associated with significant morbidity and mortality. Its evolving etiology may affect the ability of clinicians to initiate timely, appropriate antimicrobial therapy. METHODS:A retrospective time series analysis of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2061

    authors: Irwin AD,Drew RJ,Marshall P,Nguyen K,Hoyle E,Macfarlane KA,Wong HF,Mekonnen E,Hicks M,Steele T,Gerrard C,Hardiman F,McNamara PS,Diggle PJ,Carrol ED

    更新日期:2015-04-01 00:00:00

  • Intellectual development and familial dysautonomia.

    abstract::The study examined adaptive trends in cognitive development among individuals with familial dysautonomia and sought to establish new base rates of intelligence for the dysautonomic population. Fifty-two subjects, aged 6 to 28 years, were administered the Wechsler scales of intelligence. The results indicate that there...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Welton W,Clayson D,Axelrod FB,Levine DB

    更新日期:1979-05-01 00:00:00

  • Left atrial myxoma: association with acute coronary embolization in an 11-year-old boy.

    abstract::An 11-year-old boy had clinical signs of an acute inferior wall myocardial infarction. On echocardiography, a left atrial myxoma was demonstrated. Coronary artery embolization from myxoma was confirmed by selective coronary arteriography. The tumor was removed 12 days after acute coronary embolization. The clinical va...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Tanabe J,Williams RL,Diethrich EB

    更新日期:1979-05-01 00:00:00

  • Blood alcohol levels for American Indian mothers and newborns.

    abstract::Very little is known about the alcohol elimination rates of newborns who have had chronic alcohol exposure in utero. In these case reports, blood alcohol levels were taken immediately before delivery, at delivery, and postdelivery for 2 mothers who drank alcohol during their pregnancies and 3 single-birth newborns. Ne...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1400

    authors: Kvigne VL,Randall B,Simanton EG,Brenneman G,Welty TK

    更新日期:2012-10-01 00:00:00

  • Cardiovascular reactivity and adolescent boys' physical health.

    abstract:OBJECTIVE:Minor illnesses and major diseases are affected by individual, environmental, and social factors. The purpose of the study was to determine if cardiovascular reactivity, an individual characteristic, was related to adolescent boys' health status and behaviors. METHODS:A total of 89 low socioeconomic status 1...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.3.e11

    authors: Dobkin PL,Tremblay RE,Treiber FA

    更新日期:1998-03-01 00:00:00

  • Initial neurologic presentation in young children sustaining inflicted and unintentional fatal head injuries.

    abstract:BACKGROUND:It remains unclear if fatal brain injuries in young children are characterized by immediate rapid deterioration or can present after an initial period of lucidity. This issue has legal implications in child abuse, for which understanding the clinical course affects perpetrator identification. OBJECTIVE:To d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2671

    authors: Arbogast KB,Margulies SS,Christian CW

    更新日期:2005-07-01 00:00:00

  • Disparities in Service Use Among Children With Autism: A Systematic Review.

    abstract:CONTEXT:Research reveals racial, ethnic, and socioeconomic disparities in autism diagnosis; there is limited information on potential disparities related to other dimensions of services. OBJECTIVE:We reviewed evidence related to disparities in service use, intervention effectiveness, and quality of care provided to ch...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-1895G

    authors: Smith KA,Gehricke JG,Iadarola S,Wolfe A,Kuhlthau KA

    更新日期:2020-04-01 00:00:00

  • Fatal myocardial infarction following therapy with prothrombin complex concentrates in a young man with hemophilia A.

    abstract::A fatal myocardial infarction in a 22-year-old man with hemophilia A and a factor VIII inhibitor is described. The catastrophic event occurred while the patient was receiving high doses of unactivated prothrombin complex concentrates. Autopsy examination revealed myocardial hemorrhage with no evidence of coronary arte...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sullivan DW,Purdy LJ,Billingham M,Glader BE

    更新日期:1984-08-01 00:00:00

  • Minimizing false-positives in universal newborn hearing screening: a simple solution.

    abstract:BACKGROUND AND OBJECTIVES:The false-positive rates of previously reported universal newborn hearing screening (UNHS) programs range between 2.5% and 8%. Critics of UNHS programs have claimed that this rate is too high and might lead to a number of the negative effects produced by false-positive screening tests, namely ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.3.e29

    authors: Clemens CJ,Davis SA

    更新日期:2001-03-01 00:00:00

  • Renal ultrasound evaluation of urinary tract infections in children.

    abstract::Ultrasonography of the kidney may replace the intravenous pyelogram as the study of choice in identifying treatable abnormalities in children with urinary tract infection. In a series of 64 consecutive children with urinary tract infection in whom an intravenous pyelogram, renal ultrasound, and voiding cystogram were ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Johnson CE,DeBaz BP,Shurin PA,DeBartolomeo R

    更新日期:1986-11-01 00:00:00

  • The effects of stimulant medication on the growth of hyperkinetic children.

    abstract::This article reviews the literature on possible growth-suppressing effects of stimulant medications in the long-term treatment of children with the hyperkinetic behavior syndrome. The evidence clearly indicates a temporary retardation in the rate of growth in weight and suggests a temporary slowing of growth in statur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roche AF,Lipman RS,Overall JE,Hung W

    更新日期:1979-06-01 00:00:00

  • Parental separation and pediatric cancer: a Danish cohort study.

    abstract:OBJECTIVE:The purpose of this study was to determine the risk for separation (ending cohabitation) of the parents of a child with a diagnosis of cancer. METHODS:In a nationwide cohort, we compared the risk for ending cohabitation of the parents of 2450 children (aged 0-20 years) given a diagnosis of cancer with the ri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-2657

    authors: Grant S,Carlsen K,Bidstrup PE,Bastian GS,Lund LW,Dalton SO,Johansen C

    更新日期:2012-05-01 00:00:00

  • Hypertrophic obstructive cardiomyopathy in an infant with an adrenocortical tumor.

    abstract::Nonfamilial cardiomyopathies in childhood have been only sporadically ascribed to endocrine disorders. We report on a 4-month-old male infant presenting with Cushing's syndrome associated with excessive body weight (8.9 kg; >97th percentile) and features of virilization (Tanner stage 2 for pubic hair development). Abd...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2692

    authors: Hauser J,Riedl S,Michel-Behnke I,Minkov M,Perneczky E,Horcher E

    更新日期:2013-08-01 00:00:00

  • Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?

    abstract:OBJECTIVE:The goal was to estimate the level of delivered continuous positive airway pressure by measuring oral cavity pressure with the mouth closed in infants of various weights and ages treated with heated, humidified high-flow nasal cannula at flow rates of 1-5 L/minute. We hypothesized that clinically relevant lev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0957

    authors: Kubicka ZJ,Limauro J,Darnall RA

    更新日期:2008-01-01 00:00:00

  • Skin lesions in a boy with X-linked lymphoproliferative disorder: comparison of 5 SH2D1A deletion cases.

    abstract::SH2D1A gene defects are the cause of X-linked lymphoproliferative disorder (XLP-1), a rare condition characterized by severe immune dysregulation. We present a patient lacking the typical symptoms of XLP-1, but experiencing a severe unusual skin condition encompassing features of dermatosclerosis and vesiculobullous s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0870

    authors: Mejstríková E,Janda A,Hrusák O,Bucková H,Vlcková M,Hancárová M,Freiberger T,Ravcuková B,Vesely K,Fajkusová L,Kopecková L,Sumerauer D,Kabícková E,Sedivá A,Stary J,Sedlácek Z

    更新日期:2012-02-01 00:00:00

  • Bruising characteristics discriminating physical child abuse from accidental trauma.

    abstract:OBJECTIVE:Our objective was to conduct a pilot study to identify discriminating bruising characteristics and to model those findings into a decision tool for screening children at high risk for abuse. METHODS:A case-control study of children 0 to 48 months of age who were admitted to a PICU because of trauma was perfo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-3632

    authors: Pierce MC,Kaczor K,Aldridge S,O'Flynn J,Lorenz DJ

    更新日期:2010-01-01 00:00:00

  • Transmission of hepatitis B virus infection by asymptomatic chronic HBsAg carrier mothers.

    abstract::The courses of 18 children born to 13 chronic hepatitis B surface antigen (HBsAg) carrier mothers were followed prospectively for serological and biochemical evidence of type B hepatitis. Three children developed transient HBsAg positivity accompanied by the appearance of antibody to the hepatitis B core antigen. Two ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Papaevangelou G,Hoofnagle JH

    更新日期:1979-04-01 00:00:00

  • Recurrent abdominal pain in children: lactose and sucrose intolerance, a prospective study.

    abstract::Thirty-eight consecutive children with recurrent abdominal pain underwent lactose tolerance tests; 28 of these were also given sucrose tolerance tests. Abdominal pain and abnormal lactose tolerance tests were noted in 11 of 38, while none of the 28 had an abnormal sucrose tolerance test; however, 1 had abdominal pain....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Liebman WM

    更新日期:1979-07-01 00:00:00

  • Ammonia encephalopathy secondary to urinary tract infection with Proteus mirabilis.

    abstract::Hyperammonemia with coma, tachypnea, and respiratory alkalosis developed in a 3-year-old boy with prune"-belly syndrome during a urinary tract infection with Proteus mirabilis. Hyperammonemia is thought to have resulted from the production within the massively dilated urinary tract of excessive amounts of ammonia due ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Samtoy B,DeBeukelaer MM

    更新日期:1980-02-01 00:00:00

  • Improving care through collaboration.

    abstract::The opportunity to improve health care using existing scientific knowledge is immense. Much is known that is not being used in routine care, leading to a large gap between knowledge and practice. Collaborative improvement models bring health care professionals together to focus on this gap and to accelerate the pace o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kilo CM

    更新日期:1999-01-01 00:00:00

  • Prevalence of retinal hemorrhages and child abuse in children who present with an apparent life-threatening event.

    abstract:OBJECTIVE:Child abuse (CA) can present with a spectrum of signs and symptoms. Apparent life-threatening events (ALTEs) may be a subtle presentation of CA. Retinal hemorrhages (RHs) are a well-described finding in some patients with CA. We hypothesized that screening children who present with a chief complaint of an ALT...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.3.557

    authors: Pitetti RD,Maffei F,Chang K,Hickey R,Berger R,Pierce MC

    更新日期:2002-09-01 00:00:00