Abstract:
:A fatal myocardial infarction in a 22-year-old man with hemophilia A and a factor VIII inhibitor is described. The catastrophic event occurred while the patient was receiving high doses of unactivated prothrombin complex concentrates. Autopsy examination revealed myocardial hemorrhage with no evidence of coronary artery disease or thrombosis. There also was postmortem evidence of previous myocardial infarctions. This is the fourth documented case of myocardial infarction occurring in a young hemophiliac patient using unactivated prothrombin complex concentrates. It is concluded that utilization of prothrombin complex concentrates in hemophiliac patients must be limited and closely monitored. Therapeutic guidelines are recommended.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Sullivan DW,Purdy LJ,Billingham M,Glader BEsubject
Has Abstractpub_date
1984-08-01 00:00:00pages
279-81issue
2eissn
0031-4005issn
1098-4275journal_volume
74pub_type
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