Food additives and hyperkinesis: a controlled double-blind experiment.

Abstract:

:A double-blind crossover trial involving a control diet and a diet eliminating artificial flavors, colors, and natural salicylates as recommended by Feingold was conducted on 15 hyperkinetic children. Teachers and parents observed the children for one month prior to treatment, using standardized rating scales. Both parents and teachers reported fewer hyperkinetic symptoms on the K-P diet as compared to the pretreatment baseline. The teachers noted a highly significant reduction of symptoms on the K-P diet as compared to the control diet but the parents did not. The control diet ratings did not differ from the baseline period ratings for either parents or teachers. It is concluded that the K-P diet may reduce hyperkinetic symptoms, though this result is put forth with caution in view of several features inherent in the present study which need further evaluation, including objective measures of change, manipulation of the independent variable, and reducing the independent variable to more specific components.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Conners CK,Goyette CH,Southwick DA,Lees JM,Andrulonis PA

subject

Has Abstract

pub_date

1976-08-01 00:00:00

pages

154-66

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

58

pub_type

临床试验,杂志文章
  • Identifying Child Abuse Fatalities During Infancy.

    abstract::When a healthy infant dies suddenly and unexpectedly, it is critical to correctly determine if the death was caused by child abuse or neglect. Sudden unexpected infant deaths should be comprehensively investigated, ancillary tests and forensic procedures should be used to more-accurately identify the cause of death, a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-2076

    authors: Palusci VJ,Council on Child Abuse and Neglect.,Kay AJ,Batra E,Section on Child Death Review and Prevention.,Moon RY,Task Force on Sudden Infant Death Syndrome.,NATIONAL ASSOCIATION OF MEDICAL EXAMINERS.,Corey TS,Andrew T,Graham M

    更新日期:2019-09-01 00:00:00

  • Association of intrapartum antibiotic exposure and late-onset serious bacterial infections in infants.

    abstract:OBJECTIVE:Recommendations to prevent vertical transmission of group B Streptococcus (GBS) infections have resulted in many women's receiving antibiotics during labor with an associated reduction in early-onset GBS infections in their newborn infants. However, a potential relationship of intrapartum antibiotics (IPA) to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2421

    authors: Glasgow TS,Young PC,Wallin J,Kwok C,Stoddard G,Firth S,Samore M,Byington CL

    更新日期:2005-09-01 00:00:00

  • Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort.

    abstract:OBJECTIVE:Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS:Forty-eight-hour personal air and/or spot urine samples were collected during the third tri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0325

    authors: Whyatt RM,Adibi JJ,Calafat AM,Camann DE,Rauh V,Bhat HK,Perera FP,Andrews H,Just AC,Hoepner L,Tang D,Hauser R

    更新日期:2009-12-01 00:00:00

  • Developmental Outcomes in Duarte Galactosemia.

    abstract::: media-1vid110.1542/5849572227001PEDS-VA_2018-2516Video Abstract OBJECTIVES: For decades, infants with Duarte galactosemia (DG) have been identified by newborn screening (NBS), but whether they should be treated with dietary restrictions of galactose has remained unknown. To clarify, we conducted a study of dietary a...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-2516

    authors: Carlock G,Fischer ST,Lynch ME,Potter NL,Coles CD,Epstein MP,Mulle JG,Kable JA,Barrett CE,Edwards SM,Wilson E,Fridovich-Keil JL

    更新日期:2019-01-01 00:00:00

  • A missense cystic fibrosis transmembrane conductance regulator mutation with variable phenotype.

    abstract:OBJECTIVE:Cystic fibrosis (CF) has variable clinical presentation. Disease severity is partially associated with the type of mutation. The aim of this study was to report genotype-phenotype analysis of the G85E mutation. PATIENTS:The phenotype of 12 patients (8 were from the same extended family, and 5 of them were si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.3.e5

    authors: Kerem E,Nissim-Rafinia M,Argaman Z,Augarten A,Bentur L,Klar A,Yahav Y,Szeinberg A,Hiba O,Branski D,Corey M,Kerem B

    更新日期:1997-09-01 00:00:00

  • Caustic ingestions mimicking anaphylaxis: case studies and literature review.

    abstract::Anaphylaxis presents in children with rapid involvement of typically 2 or more organ systems including cutaneous, gastrointestinal, and respiratory. Caustic ingestions (CI) may also present with acute involvement of cutaneous, gastrointestinal, and respiratory systems. We present 2 cases of "missed diagnosis" that ill...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-2394

    authors: Sherenian MG,Clee M,Schondelmeyer AC,de Alarcón A,Li J,Assa'ad A,Risma K

    更新日期:2015-02-01 00:00:00

  • Maternal glucocorticoid therapy and reduced risk of bronchopulmonary dysplasia.

    abstract::Because of substantial clinical and laboratory evidence of the efficacy of glucocorticoids in the treatment of acute pulmonary surfactant deficiency in preterm newborns, we explored the hypothesis that maternal antenatal glucocorticoid receipt is followed by reduced risk of bronchopulmonary dysplasia (BPD). A sample o...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:

    authors: Van Marter LJ,Leviton A,Kuban KC,Pagano M,Allred EN

    更新日期:1990-09-01 00:00:00

  • Cost-effective treatment of phimosis.

    abstract:OBJECTIVE:To determine the most cost-effective treatment for phimosis. DESIGN:The costs of three treatment strategies for treating phimosis were evaluated using a decision-tree analysis. Three therapeutic approaches were considered: circumcision, preputial plasty (the use of plastic surgical techniques to enlarge the ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.102.4.e43

    authors: Van Howe RS

    更新日期:1998-10-01 00:00:00

  • Management of children with sickle cell disease: a comprehensive review of the literature.

    abstract:OBJECTIVE:Sickle cell disease (SCD) affects 70 000 to 100 000 people in the United States, and 2000 infants are born with the disease each year. The purpose of this study was to review the quality of the literature for preventive interventions and treatment of complications for children with SCD to facilitate the use o...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2010-3686

    authors: Kavanagh PL,Sprinz PG,Vinci SR,Bauchner H,Wang CJ

    更新日期:2011-12-01 00:00:00

  • Clinical comparison of localized intestinal perforation and necrotizing enterocolitis in neonates.

    abstract:OBJECTIVE:To better define the prognosis of neonates with gastrointestinal perforation and improve their management. METHODS:We reviewed the results of physical examinations, laboratory results, and radiographic tests of 42 patients in whom gastrointestinal perforation was diagnosed in our neonatal intensive care unit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Buchheit JQ,Stewart DL

    更新日期:1994-01-01 00:00:00

  • Pilot interferon-beta trial in children with chronic hepatitis B who had previously not responded to interferon-alpha therapy.

    abstract:BACKGROUND:Recombinant interferon alpha (IFN-alpha) treatment is useful in 40% of children with chronic hepatitis B. However, nonresponder children continue to have viral replication and a progressive disease. OBJECTIVE:To administer natural IFN-beta to hepatitis B virus chronic carrier children who had not responded ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.2.222

    authors: Ruíz-Moreno M,Fernández P,Leal A,Bartolomé J,Castillo I,Oliva H,Carreño V

    更新日期:1997-02-01 00:00:00

  • Delay in caffeine elimination in breast-fed infants.

    abstract::Because of a persistently elevated caffeine half-life observed in a breast-fed infant during caffeine maintenance therapy, we conducted this prospective longitudinal study in two groups of infants (five exclusively breast-fed and 12 formula-fed). After 46 weeks' postconceptional age, all five breast-fed infants had a ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Le Guennec JC,Billon B

    更新日期:1987-02-01 00:00:00

  • Long-term reduction in adverse drug events: an evidence-based improvement model.

    abstract:OBJECTIVES:To develop and test an evidence-based model for reducing medication errors and harm in hospitalized children. METHODS:Prospective interrupted time series study evaluating the effectiveness of a multifaceted, staged intervention over 4 years in a major urban pediatric referral hospital. Guidelines for safe p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1902

    authors: Gazarian M,Graudins LV

    更新日期:2012-05-01 00:00:00

  • Congenital heart surgery outcomes in Down syndrome: analysis of a national clinical database.

    abstract:OBJECTIVE:We describe patient characteristics and postoperative morbidity and mortality rates for patients with Down syndrome undergoing congenital heart disease surgery. METHODS:This retrospective cohort study used the Society of Thoracic Surgeons Congenital Heart Surgery Database to compare patient characteristics a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3245

    authors: Fudge JC Jr,Li S,Jaggers J,O'Brien SM,Peterson ED,Jacobs JP,Welke KF,Jacobs ML,Li JS,Pasquali SK

    更新日期:2010-08-01 00:00:00

  • Diabetes in Pregnancy and Childhood Cognitive Development: A Systematic Review.

    abstract:CONTEXT:The effect of diabetes during pregnancy on the cognitive development of offspring is unclear because of inconsistent findings from limited studies. OBJECTIVE:This review was aimed to provide the best available scientific evidence on the associations between maternal pregnancy diabetes and the cognitive develop...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-4234

    authors: Adane AA,Mishra GD,Tooth LR

    更新日期:2016-05-01 00:00:00

  • Trends in Access to Health Care Services for US Children: 2000-2014.

    abstract:BACKGROUND AND OBJECTIVE:Recent years have witnessed substantial gains in health insurance coverage for children, but few studies have examined trends across a diverse set of access indicators. We examine US children's access to health services and whether trends vary by race/ethnicity and income. METHODS:Analysis of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-2176

    authors: Larson K,Cull WL,Racine AD,Olson LM

    更新日期:2016-12-01 00:00:00

  • Survival and Impairment of Extremely Premature Infants: A Meta-analysis.

    abstract:CONTEXT:Survival of infants born at the limit of viability varies between high-income countries. OBJECTIVE:To summarize the prognosis of survival and risk of impairment for infants born at 22 + 0/7 weeks' to 27 + 6/7 weeks' gestational age (GA) in high-income countries. DATA SOURCES:We searched 9 databases for cohort...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2018-0933

    authors: Myrhaug HT,Brurberg KG,Hov L,Markestad T

    更新日期:2019-02-01 00:00:00

  • Health supervision for children with fragile X syndrome.

    abstract::Fragile X syndrome (an FMR1-related disorder) is the most commonly inherited form of mental retardation. Early physical recognition is difficult, so boys with developmental delay should be strongly considered for molecular testing. The characteristic adult phenotype usually does not develop until the second decade of ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2010-3500

    authors: Hersh JH,Saul RA,Committee on Genetics.

    更新日期:2011-05-01 00:00:00

  • Practices of unregulated tanning facilities in Missouri: implications for statewide legislation.

    abstract:BACKGROUND:The incidence of skin cancer has increased in the United States, concomitant with increased UV radiation (UVR) exposure among young adults. We examined whether tanning facilities in Missouri, a state without indoor-tanning regulations, acted in accordance with the Food and Drug Administration's recommendatio...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2012-1781

    authors: Balaraman B,Biesbroeck LK,Lickerman SH,Cornelius LA,Jeffe DB

    更新日期:2013-03-01 00:00:00

  • Reevaluation of outpatients with Streptococcus pneumoniae bacteremia.

    abstract:BACKGROUND:The reevaluation process for outpatients recalled for Streptococcus pneumoniae bacteremia has not been standardized. Children who return ill or with new serious focal infections require admission and parenteral antibiotic therapy. Limited data exist to guide the follow-up management of those patients identif...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.3.502

    authors: Bachur R,Harper MB

    更新日期:2000-03-01 00:00:00

  • Azithromycin is as effective as and better tolerated than erythromycin estolate for the treatment of pertussis.

    abstract:OBJECTIVE:Although universal immunization against Bordetella pertussis (whooping cough) infection has resulted in dramatic reductions in the incidence of pertussis, outbreaks continue to occur in countries with excellent vaccine coverage. Treatment of infection may ameliorate symptom severity during the catarrhal phase...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.114.1.e96

    authors: Langley JM,Halperin SA,Boucher FD,Smith B,Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC).

    更新日期:2004-07-01 00:00:00

  • The vulnerability of the medical student: posthumous presentation of L.L. Stephens' ideas.

    abstract::L.L. Stephens described several critical issues in medical professionalization. The encounter with morbidity and mortality heightens the student's feelings of vulnerability. If he over-identifies with patients, he may suffer more and be unable to provide rational medical care. If he protects himself by dehumanizing pa...

    journal_title:Pediatrics

    pub_type: 传,历史文章,杂志文章

    doi:

    authors: Werner ER,Korsch BM

    更新日期:1976-03-01 00:00:00

  • Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study.

    abstract:OBJECTIVE:Despite the promising preliminary results observed in extremely low birth weight (ELBW) populations, the use of fluconazole to prevent fungal colonization and infection in preterm neonates in the NICU is still an open question and not yet recommended as a standard of care. We have reviewed our 6-year series t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2227

    authors: Manzoni P,Arisio R,Mostert M,Leonessa M,Farina D,Latino MA,Gomirato G

    更新日期:2006-01-01 00:00:00

  • Unmasking of childhood hypothyroidism by disseminated xanthomas.

    abstract::Secondary hyperlipidemia is a common laboratory finding in children with nephrotic syndrome, diabetes mellitus, and hypothyroidism. However, clinical signs of hyperlipidemia are extremely rare in childhood. We report on an 11-year-old girl who presented with a disseminated yellow papulomatous rash on the lower limbs a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.5.e96

    authors: Dötsch J,Zepf K,Schellmoser S,Rascher W,Dörr HG

    更新日期:2001-11-01 00:00:00

  • Association between bullying and psychosomatic problems: a meta-analysis.

    abstract:CONTEXT:In the last few years, there has been an increasing amount of research showing the concurrent and long-term consequences of bullying and being bullied by peers. OBJECTIVE. We performed a meta-analysis to quantify the association between involvement in bullying and psychosomatic complaints in the school-aged pop...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2008-1215

    authors: Gini G,Pozzoli T

    更新日期:2009-03-01 00:00:00

  • Multicenter trial of cryotherapy for retinopathy of prematurity: preliminary results. Cryotherapy for Retinopathy of Prematurity Cooperative Group.

    abstract::We report the preliminary 3-month outcome of a multicenter randomized trial of cryotherapy for treatment of retinopathy of prematurity (ROP). Transscleral cryotherapy to the avascular retina was applied to one randomly selected eye when there was threshold disease (defined as five or more contiguous or eight cumulativ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors:

    更新日期:1988-05-01 00:00:00

  • Cost-effectiveness analysis of bicycle helmet subsidies in a defined population.

    abstract:OBJECTIVE:To examine the potential effects of bicycle safety helmet cost subsidy on bicycle head injury rates and costs. DESIGN:Using empiric data on the incidence and costs of bicycle injuries to children, we examined the hypothetical effects of various bicycle helmet subsidies in a cost-effectiveness analysis. A hyp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Thompson RS,Thompson DC,Rivara FP,Salazar AA

    更新日期:1993-05-01 00:00:00

  • Severe varicella associated with steroid use.

    abstract:OBJECTIVE:To evaluate whether corticosteroid use is associated with severe varicella. DESIGN:The odds of corticosteroid exposure were compared among 35 children with severe varicella and 10,000 control subjects. RESULTS:Five (26.3%) of 19 case patients without known immunosuppression had received steroids within 30 d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dowell SF,Bresee JS

    更新日期:1993-08-01 00:00:00

  • Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy.

    abstract:OBJECTIVE:Knowing risk factors at birth for the development of childhood obesity could help to identify children who are in need of early obesity prevention efforts. The objective of this study was to determine whether children whose mothers were obese in early pregnancy were more likely to be obese at 2 to 4 years of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.1.e29

    authors: Whitaker RC

    更新日期:2004-07-01 00:00:00

  • Fluoroquinolone safety in pediatric patients: a prospective, multicenter, comparative cohort study in France.

    abstract:OBJECTIVE:To evaluate the safety of fluoroquinolones (FQ) in comparison with other antibiotics in pediatric patients. METHODS:A multicenter, observational, comparative cohort study was conducted between 1998 and 2000 in French pediatric departments. Patients who were receiving systemic FQ were included and matched to ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1542/peds.111.6.e714

    authors: Chalumeau M,Tonnelier S,D'Athis P,Tréluyer JM,Gendrel D,Bréart G,Pons G,Pediatric Fluoroquinolone Safety Study Investigators.

    更新日期:2003-06-01 00:00:00