Maternal glucocorticoid therapy and reduced risk of bronchopulmonary dysplasia.

Abstract:

:Because of substantial clinical and laboratory evidence of the efficacy of glucocorticoids in the treatment of acute pulmonary surfactant deficiency in preterm newborns, we explored the hypothesis that maternal antenatal glucocorticoid receipt is followed by reduced risk of bronchopulmonary dysplasia (BPD). A sample of 223 intubated infants weighing less than 1751 g birth weight provided 76 infants with BPD (defined by both oxygen requirement and compatible chest radiograph) and 147 who had neither BPD characteristic by day 28 of life. When compared to babies who received a complete and timely course of antenatal glucocorticoids, those whose mothers received no glucocorticoids were at prominently increased risk of BPD (odds ratio = 3.0; 95% confidence interval = 1.1, 8.2). Babies whose mothers received a partial course of glucocorticoids were not at increased risk of BPD (odds ratio = 1.3; 95% confidence interval = 0.4, 4.3). Stratification by gender and birth weight at 1 kg showed a benefit of therapy in all strata except that of extremely low birth weight male infants. These data support the hypothesis that maternal antenatal glucocorticoid therapy offers very low birth weight infants protection against BPD.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Van Marter LJ,Leviton A,Kuban KC,Pagano M,Allred EN

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

331-6

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

86

pub_type

临床试验,杂志文章,多中心研究,随机对照试验
  • Spontaneous Closure of Patent Ductus Arteriosus in Infants ≤1500 g.

    abstract:OBJECTIVES:Patent ductus arteriosus (PDA) remains a challenging issue in very low birth weight (VLBW) infants, and its management varies widely. Our aim in this study was to document the natural course of ductus arteriosus in a cohort of VLBW infants who underwent conservative PDA management with no medical or surgical...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-4258

    authors: Semberova J,Sirc J,Miletin J,Kucera J,Berka I,Sebkova S,O'Sullivan S,Franklin O,Stranak Z

    更新日期:2017-08-01 00:00:00

  • Cultivating Research Skills During Clinical Training to Promote Pediatric-Scientist Development.

    abstract::Physician-scientists represent a critical component of the biomedical and health research workforce. However, the proportion of physicians who spend a significant amount of effort on scientific research has declined over the past 40 years. This trend has been particularly noticeable in pediatrics despite recent scient...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0745

    authors: Hurst JH,Barrett KJ,Kelly MS,Staples BB,McGann KA,Cunningham CK,Reed AM,Gbadegesin RA,Permar SR

    更新日期:2019-08-01 00:00:00

  • A Centralized Approach for Practicing Genomic Medicine.

    abstract::Next-generation sequencing has revolutionized the diagnostic process, making broadscale testing affordable and applicable to almost all specialties; however, there remain several challenges in its widespread implementation. Barriers such as lack of infrastructure or expertise within local health systems and complex re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0855

    authors: Biswas S,Medne L,Devkota B,Bedoukian E,Berrodin D,Izumi K,Deardorff MA,Tarpinian J,Leonard J,Pyle L,Gray C,Montgomery J,Williams T,Fortunato S,Weatherly J,McEldrew D,Kaur M,Raible SE,Wilkens A,Spinner NB,Skraban C

    更新日期:2020-03-01 00:00:00

  • The International Liaison Committee on Resuscitation (ILCOR) consensus on science with treatment recommendations for pediatric and neonatal patients: pediatric basic and advanced life support.

    abstract::This publication contains the pediatric and neonatal sections of the 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (COSTR). The consensus process that produced this document was sponsored by the International Liaison Committee on ...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2006-0206

    authors: International Liaison Committee on Resuscitation.

    更新日期:2006-05-01 00:00:00

  • Effect of caffeine on oxygen consumption and metabolic rate in very low birth weight infants with idiopathic apnea.

    abstract:OBJECTIVE:Methylxanthines are among the most commonly prescribed drugs in neonatal intensive care. This study evaluates the effect of caffeine on oxygen consumption and metabolic rate in premature infants with idiopathic apnea. METHODS:Eighteen preterm infants at gestational ages from 28 to 33 weeks and birth weights ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.4.660

    authors: Bauer J,Maier K,Linderkamp O,Hentschel R

    更新日期:2001-04-01 00:00:00

  • Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography.

    abstract:OBJECTIVE:To define normal and abnormal patterns, test interobserver variability, and the prognostic accuracy of amplitude-integrated electroencephalography (aEEG) soon after the onset of neonatal encephalopathy. METHODS:Consecutive cases of neonatal encephalopathy (n = 56; gestation median, 40; range, 35-42 weeks) an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.1263

    authors: al Naqeeb N,Edwards AD,Cowan FM,Azzopardi D

    更新日期:1999-06-01 00:00:00

  • Effect of dose formulation on isoniazid absorption in two young children.

    abstract::In an 8-month-old infant with tuberculous meningitis treatment with isoniazid was unsuccessful and was associated with lower than expected plasma concentrations of isoniazid (measured concentration 0.1 microgram/mL). The infant had received isoniazid as a crushed tablet admixed with apple sauce. Oral administration of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Notterman DA,Nardi M,Saslow JG

    更新日期:1986-06-01 00:00:00

  • Parenting and early development among children of drug-abusing women: effects of home intervention.

    abstract:OBJECTIVE:To evaluate the efficacy of home intervention with drug-abusing women on parenting behavior and attitudes, and on children's development. DESIGN:A randomized, clinical trial of 60 drug-abusing women recruited prenatally and randomized into an intervention (n = 31) or comparison (n = 29) group. There were no ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Black MM,Nair P,Kight C,Wachtel R,Roby P,Schuler M

    更新日期:1994-10-01 00:00:00

  • One-Year Language Outcomes in Toddlers With Language Delays: An RCT Follow-up.

    abstract:OBJECTIVES:The current study is a 1-year follow-up analysis of data from a randomized controlled trial of Enhanced Milieu Teaching (EMT) for toddlers with language delays. Outcomes and predictors of child language and parent intervention implementation were examined 6 and 12 months after the end of the intervention. M...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2016-3646

    authors: Hampton LH,Kaiser AP,Roberts MY

    更新日期:2017-11-01 00:00:00

  • Elective high-frequency oscillatory ventilation versus conventional ventilation in preterm infants with pulmonary dysfunction: systematic review and meta-analyses.

    abstract:OBJECTIVES:To systematically review the evidence to determine whether the routine use of high-frequency oscillatory ventilation (HFOV) as compared with conventional ventilation (CV) is beneficial or harmful in preterm infants requiring mechanical ventilation for pulmonary failure principally due to respiratory distress...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.100.5.e6

    authors: Bhuta T,Henderson-Smart DJ

    更新日期:1997-11-01 00:00:00

  • Sleep environment and the risk of sudden infant death syndrome in an urban population: the Chicago Infant Mortality Study.

    abstract:OBJECTIVE:To examine risk factors for sudden infant death syndrome (SIDS) with the goal of reducing SIDS mortality among blacks, which continues to affect this group at twice the rate of whites. METHODS:We analyzed data from a population-based case-control study of 260 SIDS deaths that occurred in Chicago between 1993...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hauck FR,Herman SM,Donovan M,Iyasu S,Merrick Moore C,Donoghue E,Kirschner RH,Willinger M

    更新日期:2003-05-01 00:00:00

  • Cutaneous involvement in children with acute lymphoblastic leukemia or lymphoblastic lymphoma. The Children's Leukemia Cooperative Group of the European Organization of Research and Treatment of Cancer (EORTC).

    abstract:OBJECTIVE:Skin involvement in children with acute monocytic leukemia or CD30-positive anaplastic large-cell lymphoma is well-known. In contrast, very little is known about the malignant cutaneous infiltrates in children with acute lymphoblatic leukemia (ALL) or lymphoblastic lymphoma (LBL). This study was designed to d...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.100.1.60

    authors: Millot F,Robert A,Bertrand Y,Mechinaud F,Laureys G,Ferster A,Brock P,Rohrlich P,Mazingue F,Plantaz D,Plouvier E,Pacquement H,Behar C,Rialland X,Chantraine JM,Guilhot F,Otten J

    更新日期:1997-07-01 00:00:00

  • Can an alternative umbilical arterial catheter solution and flush regimen decrease iatrogenic hemolysis while enhancing nutrition? A double-blind, randomized, clinical trial comparing an isotonic amino acid with a hypotonic salt infusion.

    abstract:OBJECTIVE:In the process of sampling blood through an umbilical arterial catheter (UAC), infant blood comes into stagnant contact with infusion solution in the "waste syringe" before being reinfused. We have previously demonstrated in vitro that this process is associated with less hemolysis of red blood cells (RBCs) w...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.114.2.377

    authors: Jackson JK,Biondo DJ,Jones JM,Moor PJ,Simon SD,Hall RT,Kilbride HW

    更新日期:2004-08-01 00:00:00

  • STEPP IN: Working Together to Keep Infants Warm in the Perioperative Period.

    abstract:OBJECTIVES:Reduce postoperative hypothermia by up to 50% over a 12-month period in children's hospital NICUs and identify specific clinical practices that impact success. METHODS:Literature review, expert opinion, and benchmarking were used to develop clinical practice recommendations for maintaining perioperative eut...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1542/peds.2019-1121

    authors: Brozanski BS,Piazza AJ,Chuo J,Natarajan G,Grover TR,Smith JR,Mingrone T,McClead RE,Rakesh R,Rintoul N,Guidash J,Bellflower B,Holston M,Richardson T,Pallotto EK

    更新日期:2020-04-01 00:00:00

  • Pepsin, a marker of gastric contents, is increased in tracheal aspirates from preterm infants who develop bronchopulmonary dysplasia.

    abstract:OBJECTIVE:The objective of this study was to study the association between pepsin in tracheal aspirate samples and the development of bronchopulmonary dysplasia in preterm infants. METHODS:Serial tracheal aspirate samples were collected during the first 28 days from mechanically ventilated preterm neonates. Bronchopul...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0056

    authors: Farhath S,He Z,Nakhla T,Saslow J,Soundar S,Camacho J,Stahl G,Shaffer S,Mehta DI,Aghai ZH

    更新日期:2008-02-01 00:00:00

  • Relationship of human milk pH during course of lactation to concentrations of citrate and fatty acids.

    abstract::Human milk pH was measured in 309 samples obtained from 52 women who had delivered at term and lactated for as long as 10 months thereafter. The mean pH decreased from 7.45 for colostrum to a nadir of 7.04 during the second week of lactation. Thereafter, the pH of milk remained between 7.0 and 7.1 until 3 months postp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Morriss FH Jr,Brewer ED,Spedale SB,Riddle L,Temple DM,Caprioli RM,West MS

    更新日期:1986-09-01 00:00:00

  • Noninitiation or withdrawal of intensive care for high-risk newborns.

    abstract::Advances in medical technology have led to dilemmas in initiation and withdrawal of intensive care of newborn infants with a very poor prognosis. Physicians and parents together must make difficult decisions guided by their understanding of the child's best interest. The foundation for these decisions consists of seve...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3180

    authors: American Academy of Pediatrics Committee on Fetus and Newborn.,Bell EF

    更新日期:2007-02-01 00:00:00

  • The clinical, biochemical, and familial presentation of type V hyperlipoproteinemia in childhood.

    abstract::Primary type V hyperlipoproteinemia was identified in two preadolescent children. The propositus (kindred N) was a 10-year-old girl with severely creamy plasma, lipemia retinalis, hypertriglyceridemia (triglyceridelevel, 6,800 mg/100 ml), and ypercholesterolemia (cholesterol level, 490 mg/100 ml). Her parents and an 8...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kwiterovich PO Jr,Farah JR,Brown WV,Bachorik PS,Baylin SB,Neill CA

    更新日期:1977-04-01 00:00:00

  • Advanced Ultrasound Techniques for Pediatric Imaging.

    abstract::Ultrasound has become a useful tool in the workup of pediatric patients because of the highly convenient, cost-effective, and safe nature of the examination. With rapid advancements in anatomic and functional ultrasound techniques over the recent years, the diagnostic and interventional utility of ultrasound has risen...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2018-2609

    authors: Hwang M,Piskunowicz M,Darge K

    更新日期:2019-03-01 00:00:00

  • Failure of hydrocortisone to affect outcome in dengue shock syndrome.

    abstract::Despite the absence of a clear-cut rationale for their use, corticosteroids are widely employed in the treatment of dengue shock syndrome. Previous comparative therapeutic trials have yielded contradictory results. Resolution of this therapeutic controversy has been attempted with a double-blind evaluation of the clin...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Sumarmo,Talogo W,Asrin A,Isnuhandojo B,Sahudi A

    更新日期:1982-01-01 00:00:00

  • Blood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks' gestation.

    abstract::A total of 22 infants of less than 31 weeks' gestation who were mechanically ventilated for a minimum of 12 hours for respiratory distress syndrome were studied. The coefficient of variation of direct systolic pressure was measured each minute from six to 36 hours of age and averaged per hour after birth with a microc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Miall-Allen VM,de Vries LS,Dubowitz LM,Whitelaw AG

    更新日期:1989-05-01 00:00:00

  • Effectiveness of nebulized beclomethasone in preventing viral wheezing: an RCT.

    abstract:OBJECTIVE:The goal of this study was to evaluate the effectiveness of nebulized beclomethasone in preventing the recurrence of viral wheezing. METHODS:The study was designed as a randomized, double-blind, placebo-controlled trial. Outpatient children aged 1 to 5 years with at least 1 episode of viral wheezing in the l...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2013-2404

    authors: Clavenna A,Sequi M,Cartabia M,Fortinguerra F,Borghi M,Bonati M,ENBe Study Group.

    更新日期:2014-03-01 00:00:00

  • Alcohol Use by Youth.

    abstract::Alcohol use continues to be problematic for youth and young adults in the United States. Understanding of neurobiology and neuroplasticity continues to highlight the potential adverse impact of underage drinking on the developing brain. This policy statement provides the position of the American Academy of Pediatrics ...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2019-1356

    authors: Quigley J,COMMITTEE ON SUBSTANCE USE AND PREVENTION.

    更新日期:2019-07-01 00:00:00

  • Prevalence and characteristics of fetal alcohol spectrum disorders.

    abstract:OBJECTIVES:To determine the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) among first grade students (6- to 7-year-olds) in a representative Midwestern US community. METHODS:From a consented sample of 70.5% of all first graders enrolled in public and private schools, an oversample of small ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2013-3319

    authors: May PA,Baete A,Russo J,Elliott AJ,Blankenship J,Kalberg WO,Buckley D,Brooks M,Hasken J,Abdul-Rahman O,Adam MP,Robinson LK,Manning M,Hoyme HE

    更新日期:2014-11-01 00:00:00

  • Erythromelalgia.

    abstract::Erythromelalgia is an extraordinary disease which remains elusive in its pathophysiology and management. Victims suffer intense burning and redness of the hands and feet. In what appears to be the antithesis of Raynaud's disease, the pain is relieved by emersion in cold. A child with erythromelalgia is described whose...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mandell F,Folkman J,Matsumoto S

    更新日期:1977-01-01 00:00:00

  • Helping Children and Families Deal With Divorce and Separation.

    abstract::For the past several years in the United States, there have been more than 800 000 divorces and parent separations annually, with over 1 million children affected. Children and their parents can experience emotional trauma before, during, and after a separation or divorce. Pediatricians can be aware of their patients'...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-3020

    authors: Cohen GJ,Weitzman CC,COMMITTEE ON PSYCHOSOCIAL ASPECTS OF CHILD AND FAMILY HEALTH.,SECTION ON DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS.

    更新日期:2016-12-01 00:00:00

  • The Family Perspective on Hospital to Home Transitions: A Qualitative Study.

    abstract:BACKGROUND AND OBJECTIVE:Transitions from the hospital to home can be difficult for patients and families. Family-informed characterization of this vulnerable period may facilitate the identification of interventions to improve transitions home. Our objective was to develop a comprehensive understanding of hospital-to-...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2098

    authors: Solan LG,Beck AF,Brunswick SA,Sauers HS,Wade-Murphy S,Simmons JM,Shah SS,Sherman SN,H2O Study Group.

    更新日期:2015-12-01 00:00:00

  • Early-Life Predictors of Fetal Alcohol Spectrum Disorders.

    abstract:BACKGROUND AND OBJECTIVES:Fetal alcohol spectrum disorders (FASD) comprise the continuum of disabilities associated with prenatal alcohol exposure. Although infancy remains the most effective time for initiation of intervention services, current diagnostic schemes demonstrate the greatest confidence, accuracy, and reli...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2141

    authors: Kalberg WO,May PA,Buckley D,Hasken JM,Marais AS,De Vries MM,Bezuidenhout H,Manning MA,Robinson LK,Adam MP,Hoyme DB,Parry CDH,Seedat S,Elliott AJ,Hoyme HE

    更新日期:2019-12-01 00:00:00

  • Assessment of children's health-related quality of life in the United States with a multidimensional index.

    abstract:OBJECTIVE:Using nationally representative data, we examined biological, medical system, and sociodemographic factors that are associated with health-related quality of life as measured by a multidimensional index that accounts for a wide range of child health domains. METHODS:Children aged > or = 6 years (N = 69,031) ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0480

    authors: Simon AE,Chan KS,Forrest CB

    更新日期:2008-01-01 00:00:00

  • Prenatal Paternal Selective Serotonin Reuptake Inhibitors Use and Risk of ADHD in Offspring.

    abstract:OBJECTIVES:It has been shown that maternal prenatal exposure to selective serotonin reuptake inhibitors (SSRIs) may be a risk factor for attention-deficit/hyperactivity disorder (ADHD) in offspring. Our goal was to examine whether paternal SSRI use before conception increases the risk of ADHD in offspring. METHODS:On ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-1081

    authors: Yang F,Liang H,Chen J,Miao M,Yuan W,Nørgaard M,Li J

    更新日期:2018-01-01 00:00:00