Effectiveness of nebulized beclomethasone in preventing viral wheezing: an RCT.

Abstract:

OBJECTIVE:The goal of this study was to evaluate the effectiveness of nebulized beclomethasone in preventing the recurrence of viral wheezing. METHODS:The study was designed as a randomized, double-blind, placebo-controlled trial. Outpatient children aged 1 to 5 years with at least 1 episode of viral wheezing in the last 12 months, presenting to any of 40 Italian pediatricians for an upper respiratory tract infection, were randomly allocated to receive beclomethasone 400 μg or placebo twice daily for 10 days. Medications were administered through a nebulizer. A clinical evaluation was performed by the pediatrician at the start and end of the treatment period. A subjective evaluation of symptoms and efficacy of treatment was performed by the parents. The primary endpoint was the incidence of viral wheezing diagnosed by the pediatricians during the 10-day treatment period. RESULTS:A total of 525 children were enrolled in the study, 521 of whom were visited at the end of the treatment period. Wheezing was diagnosed by the pediatricians in 47 children (9.0% [95% confidence interval: 6.7 to 11.3]), with no statistically significant differences between treatment groups (beclomethasone versus placebo relative risk: 0.61 [95% confidence interval: 0.35 to 1.08]).The treatment was considered helpful by 63% of parents (64% in the beclomethasone group vs 61% in the placebo group). In all, 46% of children still had infection symptoms at the end of the treatment period, with no differences between groups. CONCLUSIONS:The findings from this study confirm that inhaled steroids are not effective in preventing recurrence of viral wheezing. Moreover, no benefits were found in reducing symptoms of respiratory tract infections.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Clavenna A,Sequi M,Cartabia M,Fortinguerra F,Borghi M,Bonati M,ENBe Study Group.

doi

10.1542/peds.2013-2404

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

e505-12

issue

3

eissn

0031-4005

issn

1098-4275

pii

peds.2013-2404

journal_volume

133

pub_type

杂志文章,多中心研究,随机对照试验
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    abstract:OBJECTIVE:Lifelong functional, adaptive, and economic outcomes of moderate to severe infantile malnutrition are not well known. We assessed social status and income at midlife in a cohort of Barbadian adults, hospitalized for protein-energy malnutrition (PEM) during the first year of life, with good nutrition and healt...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0073

    authors: Galler JR,Bryce C,Waber DP,Zichlin ML,Fitzmaurice GM,Eaglesfield D

    更新日期:2012-07-01 00:00:00

  • Childhood urolithiasis: experiences and advances.

    abstract::Between June 1979 and June 1989, 54 children with urolithiasis were evaluated and treated at the Johns Hopkins Children's Center. The most common symptoms were flank or abdominal pain (58%) and gross hematuria (28%). In 46 children (86%), stones were secondary to a preexisting condition and in only 8 (14%) no apparent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gearhart JP,Herzberg GZ,Jeffs RD

    更新日期:1991-04-01 00:00:00

  • Ethics Rounds: Death After Pediatric Dental Anesthesia: An Avoidable Tragedy?

    abstract::Early childhood caries (ECC) is the single most common chronic childhood disease. In the treatment of ECC, children are often given moderate sedation or general anesthesia. An estimated 100 000 to 250 000 pediatric dental sedations are performed annually in the United States. The most common medications are benzodiaze...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2370

    authors: Lee H,Milgrom P,Huebner CE,Weinstein P,Burke W,Blacksher E,Lantos JD

    更新日期:2017-12-01 00:00:00

  • Prescription opioid epidemic and infant outcomes.

    abstract:BACKGROUND AND OBJECTIVES:Although opioid pain relievers are commonly prescribed in pregnancy, their association with neonatal outcomes is poorly described. Our objectives were to identify neonatal complications associated with antenatal opioid pain reliever exposure and to establish predictors of neonatal abstinence s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-3299

    authors: Patrick SW,Dudley J,Martin PR,Harrell FE,Warren MD,Hartmann KE,Ely EW,Grijalva CG,Cooper WO

    更新日期:2015-05-01 00:00:00

  • Marijuana and Tobacco Coexposure in Hospitalized Children.

    abstract:BACKGROUND:The impact of secondhand marijuana smoke exposure on children is unknown. New methods allow for the detection of marijuana smoke exposure in children. METHODS:We studied children who were hospitalized in Colorado and had a parent participating in a smoking cessation study; all children had urine samples rem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0820

    authors: Wilson KM,Torok MR,Wei B,Wang L,Lowary M,Blount BC

    更新日期:2018-12-01 00:00:00

  • Home visitors and child health: analysis of selected programs.

    abstract::The relationships between selected child health outcomes and programmatic interventions using home visitors are analyzed. The following features of seven programs are systematically reported: program characteristics; description of the home visitors; program objectives, sample size, and research design; outcome measur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chapman J,Siegel E,Cross A

    更新日期:1990-06-01 00:00:00

  • Safety of the 9-Valent Human Papillomavirus Vaccine.

    abstract:BACKGROUND:The 9-valent human papillomavirus vaccine (9vHPV) was approved for females and males aged 9 to 26 years in 2014. We analyzed postlicensure surveillance reports to the Vaccine Adverse Event Reporting System (VAERS). METHODS:We searched VAERS data for US reports of adverse events (AEs) after 9vHPV from Decemb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-1791

    authors: Shimabukuro TT,Su JR,Marquez PL,Mba-Jonas A,Arana JE,Cano MV

    更新日期:2019-12-01 00:00:00

  • Noninitiation or withdrawal of intensive care for high-risk newborns.

    abstract::Advances in medical technology have led to dilemmas in initiation and withdrawal of intensive care of newborn infants with a very poor prognosis. Physicians and parents together must make difficult decisions guided by their understanding of the child's best interest. The foundation for these decisions consists of seve...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3180

    authors: American Academy of Pediatrics Committee on Fetus and Newborn.,Bell EF

    更新日期:2007-02-01 00:00:00

  • Who are the primary caretakers of children born to HIV-infected mothers? Results from a multistate surveillance project.

    abstract:OBJECTIVE:To determine the primary caretakers of children born to women with human immunodeficiency virus (HIV) infection. METHODS:We interviewed women at least 18 years of age who have been reported with HIV infection or acquired immunodeficiency syndrome to local health departments in 10 cities and states regarding ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Schable B,Diaz T,Chu SY,Caldwell MB,Conti L,Alston OM,Sorvillo F,Checko PJ,Hermann P,Davidson AJ

    更新日期:1995-04-01 00:00:00

  • Increased behavior problems associated with delayed school entry and delayed school progress.

    abstract:OBJECTIVE:To investigate whether students who are old-for-grade have higher rates of reported behavior problems and to investigate whether this association is independent of having been retained a grade in school. METHODS:Cross-sectional analyses of parental reports from the nationally representative sample of 9079 ch...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.4.654

    authors: Byrd RS,Weitzman M,Auinger P

    更新日期:1997-10-01 00:00:00

  • The Use of Pyridostigmine in a Child With Chronic Intestinal Pseudo-Obstruction.

    abstract::Chronic intestinal pseudo-obstruction is a rare disorder that affects the motility of the gastrointestinal tract. It results in acute or subacute intestinal obstruction symptoms in the absence of mechanical lesion. It can lead to intestinal failure in children with significant strain on nutrition, growth, and developm...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0007

    authors: Choudhury A,Rahyead A,Kammermeier J,Mutalib M

    更新日期:2018-04-01 00:00:00

  • Food additives and hyperkinesis: a controlled double-blind experiment.

    abstract::A double-blind crossover trial involving a control diet and a diet eliminating artificial flavors, colors, and natural salicylates as recommended by Feingold was conducted on 15 hyperkinetic children. Teachers and parents observed the children for one month prior to treatment, using standardized rating scales. Both pa...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Conners CK,Goyette CH,Southwick DA,Lees JM,Andrulonis PA

    更新日期:1976-08-01 00:00:00

  • Thrombopoietin in the thrombocytopenic term and preterm newborn.

    abstract:OBJECTIVES:Neonatal thrombocytopenia occurs commonly in neonatal intensive care units. The role of the thrombopoietin (Tpo) system in normal neonatal platelet regulation and neonatal thrombocytopenia is not well understood. The purpose of our study was to: 1) determine the normal Tpo level at birth in healthy nonthromb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.6.1286

    authors: Albert TS,Meng YG,Simms P,Cohen RL,Phibbs RH

    更新日期:2000-06-01 00:00:00

  • Newborn Screening for Cystic Fibrosis in California.

    abstract:OBJECTIVES:This article describes the methods used and the program performance results for the first 5 years of newborn screening for cystic fibrosis (CF) in California. METHODS:From July 16, 2007, to June 30, 2012, a total of 2,573,293 newborns were screened for CF by using a 3-step model: (1) measuring immunoreactiv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0811

    authors: Kharrazi M,Yang J,Bishop T,Lessing S,Young S,Graham S,Pearl M,Chow H,Ho T,Currier R,Gaffney L,Feuchtbaum L,California Cystic Fibrosis Newborn Screening Consortium.

    更新日期:2015-12-01 00:00:00

  • Use of bacterial antigen detection in the diagnosis of pediatric lower respiratory tract infections.

    abstract::Two immunochemical methods were used to identify Haemophilus influenzae and Streptococcus pneumoniae capsular antigens in the urine and serum of 162 children with acute lower respiratory tract infection. These methods were compared with standard bacterial blood culture. Viral and mycoplasma cultures of respiratory sec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ramsey BW,Marcuse EK,Foy HM,Cooney MK,Allan I,Brewer D,Smith AL

    更新日期:1986-07-01 00:00:00

  • Maternal avoidance of eggs, cow's milk, and fish during lactation: effect on allergic manifestations, skin-prick tests, and specific IgE antibodies in children at age 4 years.

    abstract::Two matched groups of children with a family history of atopy/allergy were observed from birth. In one group (n = 65) the mothers had a diet free from eggs, cow's milk, and fish during the first 3 months of lactation, whereas the mothers in the other group (n = 50) had a normal diet. Atopic/allergic manifestations, sk...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Sigurs N,Hattevig G,Kjellman B

    更新日期:1992-04-01 00:00:00

  • Breastfeeding and risk of infections at 6 years.

    abstract:BACKGROUND:Previous studies have shown that breastfeeding is associated with reductions in the risk of common infections among infants; however, whether breastfeeding confers longer term protection is inconclusive. METHODS:We linked data from the 2005-2007 IFPS II (Infant Feeding Practices Study II) and follow-up data...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0646D

    authors: Li R,Dee D,Li CM,Hoffman HJ,Grummer-Strawn LM

    更新日期:2014-09-01 00:00:00

  • Superiority of oral agar and phototherapy combination in the treatment of neonatal hyperbilirubinemia.

    abstract:OBJECTIVE:To determine the value of oral agar in the treatment of neonatal hyperbilirubinemia and to compare it with two other treatment modalities: phototherapy alone and phototherapy plus oral agar. METHODS:Two hundred eight jaundiced full-term newborns were divided into four groups. They were given either photother...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Caglayan S,Candemir H,Aksit S,Kansoy S,Asik S,Yaprak I

    更新日期:1993-07-01 00:00:00

  • Adoption as a risk factor for attempted suicide during adolescence.

    abstract:OBJECTIVE:Depression, impulsivity, and aggression during adolescence have been associated with both adoption and suicidal behavior. Studies of adopted adults suggest that impulsivity, even more than depression, may be an inherited factor that mediates suicidal behavior. However, the association between adoption and ado...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.2.e30

    authors: Slap G,Goodman E,Huang B

    更新日期:2001-08-01 00:00:00

  • The mononuclear phagocyte system: role in expression of immunocompetence in neonatal and adult life.

    abstract::The cells of the mononuclear phagocyte system are critical elements in host defense. They are essential to many specific immune processes in addition to their well-recognized role in nonspecific resistance. In this report we describe studies of the influence of the maturation of this system of cells on the capacity of...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Blaese RM,Poplack DG,Muchmore AV

    更新日期:1979-11-01 00:00:00

  • Day-by-day postnatal survival in very low birth weight infants.

    abstract:OBJECTIVES:Postnatal survival rates of very low birth weight (VLBW) infants are well established for each birth weight or gestational age category. These figures do not differentiate viable infants who survive the first few days of life from extremely immature ones who die shortly after birth. This study aimed to devel...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2810

    authors: Mohamed MA,Nada A,Aly H

    更新日期:2010-08-01 00:00:00

  • Human granulocytic ehrlichiosis presenting as abdominal pain.

    abstract::Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease that primarily affects adults. Typical clinical features include fever, headache, and myalgias. This case represents the youngest reported patient with HGE. Her clinical presentation was unusual in that she presented with severe abdominal pain. In...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.602

    authors: Gershel JC

    更新日期:2000-09-01 00:00:00

  • Occult spinal dysraphism: a series of 73 cases.

    abstract::The subject of occult spinal dysraphism or myelodysplasia is reviewed from standpoints of embryology, clinical manifestations, and treatment, and the management of 73 cases summarized. In general, these concealed lesions arise from developmental variants in the most distal part of the neural tube, a situation which ma...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Anderson FM

    更新日期:1975-06-01 00:00:00

  • Carbohydrate absorption from fruit juice in young children.

    abstract:OBJECTIVE:To compare carbohydrate absorption following ingestion of apple juice and white grape juice in 28 healthy children. DESIGN:Randomized, double-blind crossover study. SETTING:Outpatient pediatric clinic at Maimonides Medical Center. PARTICIPANTS:A total of 18 healthy infants (mean age 6.3 months) and 10 todd...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Smith MM,Davis M,Chasalow FI,Lifshitz F

    更新日期:1995-03-01 00:00:00

  • Medication errors in pediatric inpatients: prevalence and results of a prevention program.

    abstract:OBJECTIVE:The objective of this study was to assess the prevalence and characteristics of medication errors in pediatric and neonatal inpatients and to measure the impact of interventions to reduce medication errors. METHODS:A preintervention and postintervention cross-sectional study was conducted of a sample of pres...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2008-0014

    authors: Otero P,Leyton A,Mariani G,Ceriani Cernadas JM,Patient Safety Committee.

    更新日期:2008-09-01 00:00:00

  • Renal outcome of neonatal renal venous thrombosis: review of 28 patients and effectiveness of fibrinolytics and heparin in 10 patients.

    abstract:OBJECTIVES:Neonatal renal venous thrombosis is a rare disorder that can result in severe renal damage. To evaluate the experience over 10 years and review the effectiveness of fibrinolytic and/or heparin therapy, chart reviews were performed for newborns with renal venous thrombosis. PATIENTS, INTERVENTIONS, AND OUTCOM...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1461

    authors: Messinger Y,Sheaffer JW,Mrozek J,Smith CM,Sinaiko AR

    更新日期:2006-11-01 00:00:00

  • Collaborative office rounds: continuing education in the psychosocial/developmental aspects of child health.

    abstract:OBJECTIVES:In recent years there has been increasing emphasis on the mental health aspects of primary health care for children and adolescents. The Health Resources and Services Administration's Maternal and Child Health Bureau has contributed to efforts aimed at strengthening primary care not only in early identificat...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.4.e5

    authors: Fishman ME,Kessel W,Heppel DE,Brannon ME,Papai JJ,Bryn SD,Nora AH,Hutchins VL

    更新日期:1997-04-01 00:00:00

  • An environmental intervention to reduce dietary fat in school lunches.

    abstract:OBJECTIVE:To determine whether making a low-fat entree available as one of two choices in an elementary school lunch program would reduce the fat content of meals selected by children. DESIGN:In this before-after trial, students had a daily choice between two entrees, one of which was sometimes low-fat. For 93% of sch...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Whitaker RC,Wright JA,Finch AJ,Psaty BM

    更新日期:1993-06-01 00:00:00

  • Collagen scaffolding during development and its deformation with chronic lung disease.

    abstract:OBJECTIVE:Infants with chronic lung disease (CLD) have an arrest of primary and secondary septation. We hypothesized that this may be related to damage or abnormal development of lung collagen secondary to positive pressure ventilation. Our aims were to identify the sites and quantity of collagen in control infants 22 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.4.766

    authors: Thibeault DW,Mabry SM,Ekekezie II,Zhang X,Truog WE

    更新日期:2003-04-01 00:00:00

  • Body Composition in Adolescents During Treatment With Selective Serotonin Reuptake Inhibitors.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3943

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    更新日期:2017-07-01 00:00:00