Thrombopoietin in the thrombocytopenic term and preterm newborn.

Abstract:

OBJECTIVES:Neonatal thrombocytopenia occurs commonly in neonatal intensive care units. The role of the thrombopoietin (Tpo) system in normal neonatal platelet regulation and neonatal thrombocytopenia is not well understood. The purpose of our study was to: 1) determine the normal Tpo level at birth in healthy nonthrombocytopenic term (NTT) and nonthrombocytopenic preterm (NTP) infants and in infants born to women with preeclampsia; and 2) measure Tpo levels in infants during and after the resolution of thrombocytopenia. Characterizing Tpo levels in the healthy and thrombocytopenic newborn is an important step in furthering our understanding of the pathophysiology of neonatal thrombocytopenia. METHODS:This study is comprised of 2 parts. For the first part, cord blood was obtained at birth from both term (gestational age [GA]: 38-42 weeks) and preterm (GA: 25-36 weeks) infants. If birth platelet levels were >/=140 x 10(3)/microL and the infant fit criteria for being normal, or if the infant was born to a women with preeclampsia, Tpo levels were measured. For the second part, serial Tpo levels and concomitant platelet counts (Plts) were measured in both preterm and term infants during a period of marked thromboctyopenia (Plt < 100 x 10(3)/microL) until its resolution (Plt >/= 140 x 10(3)/microL). RESULTS:Median cord blood Tpo levels from NTP infants (n = 35) were higher than those of NTT infants (n = 32; 95 pg/mL vs 48 pg/mL, respectively). In addition, preterm infants born to women with preeclampsia (n = 11) had lower Tpo levels than NTP infants with a similar GA (<41 pg/mL vs 95 pg/mL). For infants with marked thrombocytopenia, median Tpo levels during thrombocytopenia were similar between term (n = 12) and preterm (n = 14) groups (223 pg/mL and 179 pg/mL, respectively), with the majority of individuals showing a decrease in Tpo with resolution of thrombocytopenia. Within each group, there was large variability in the Tpo response to thrombocytopenia. IMPRESSION:These data show that the Tpo system is intact in NTP and NTT neonates. Preeclampsia may be an example of a disorder that perturbs this system. The great variability in Tpo levels seen in infants during thrombocytopenia may be related to the mechanism of thrombocytopenia. The finding that, in general, Tpo levels decreased with resolution of thrombocytopenia is consistent with what has been described in adults and children.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Albert TS,Meng YG,Simms P,Cohen RL,Phibbs RH

doi

10.1542/peds.105.6.1286

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

1286-91

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

105

pub_type

杂志文章
  • Child abuse or osteogenesis imperfecta: how can we tell?

    abstract::Osteogenesis imperfecta may be difficult to differentiate from nonaccidental trauma. Social history may prejudice the physician in favor of or against considering the diagnosis of child abuse. Three cases of osteogenesis imperfecta that were initially diagnosed as nonaccidental trauma are presented. The availability o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gahagan S,Rimsza ME

    更新日期:1991-11-01 00:00:00

  • Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions.

    abstract:OBJECTIVE:Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability. The aim of this study was to assess patients' and parents' perceptions of health-related quality of life (QoL) for children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0114

    authors: Youssef NN,Murphy TG,Langseder AL,Rosh JR

    更新日期:2006-01-01 00:00:00

  • Parental Smoking Cessation: Impacting Children's Tobacco Smoke Exposure in the Home.

    abstract:OBJECTIVES:There is no safe or risk-free level of tobacco use or tobacco smoke exposure. In this randomized controlled trial, we tested a tobacco control intervention in families and specifically evaluated a tailored cessation intervention for the parents and/or caregivers (Ps/Cs) who were smokers while their children ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2017-1026M

    authors: Caldwell AL,Tingen MS,Nguyen JT,Andrews JO,Heath J,Waller JL,Treiber FA

    更新日期:2018-01-01 00:00:00

  • Hyperphenylalaninemia due to dihydropteridine reductase deficiency: diagnosis by measurement of oxidized and reduced pterins in urine.

    abstract::Hyperphenylalaninemia due to dihydropteridine reductase deficiency results from the inability to maintain the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in its reduced or active form. Diagnosis of the disease is usually made by direct enzymatic assay on liver biopsies or in cultured skin fibroblast...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Milstien S,Kaufman S,Summer GK

    更新日期:1980-04-01 00:00:00

  • Nutrient and mineral retention and vitamin D absorption in low-birth-weight infants: effect of medium-chain triglycerides.

    abstract::A randomized prospective study of the effect of medium-chain triglycerides (MCT) upon the absorption and retention of major minerals and nutrients, as well as upon 25-hydroxy vitamin D levels, was performed in low-birth-weight infants. Ten infants received a high-calcium and vitamin D-containing formula, which contain...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Huston RK,Reynolds JW,Jensen C,Buist NR

    更新日期:1983-07-01 00:00:00

  • Variability in head circumference growth rate during the first 2 years of life.

    abstract::The head circumference (HC) curves were plotted for a group of 415 healthy full-term babies over the first 2 years of life. Two hundred ten (51%) of the cohort demonstrated HC variability, defined as an HC acceleration or deceleration of at least 1 centile curve for at least 2 months. Of these, the deceleration patter...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jaffe M,Tal Y,Hadad B,Tirosh E,Tamir A

    更新日期:1992-08-01 00:00:00

  • Unilateral hearing loss is associated with worse speech-language scores in children.

    abstract:OBJECTIVE:To determine whether children with unilateral hearing loss (UHL) demonstrate worse language skills than their siblings with normal hearing, and whether children with UHL are more likely to receive extra assistance at school. PATIENTS AND METHODS:We conducted a case-control study of 6- to 12-year-old children...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2448

    authors: Lieu JE,Tye-Murray N,Karzon RK,Piccirillo JF

    更新日期:2010-06-01 00:00:00

  • Urinary tract infection in febrile infants younger than eight weeks of Age.

    abstract:OBJECTIVE:To assess the usefulness of laboratory parameters, including peripheral white blood cell (WBC) count, C-reactive protein (CRP) concentration, erythrocyte sedimentation rate (ESR), and microscopic urinalysis (UA), for identifying febrile infants younger than 8 weeks of age at risk for urinary tract infection (...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.2.e20

    authors: Lin DS,Huang SH,Lin CC,Tung YC,Huang TT,Chiu NC,Koa HA,Hung HY,Hsu CH,Hsieh WS,Yang DI,Huang FY

    更新日期:2000-02-01 00:00:00

  • Calcium and vitamin d requirements of enterally fed preterm infants.

    abstract::Bone health is a critical concern in managing preterm infants. Key nutrients of importance are calcium, vitamin D, and phosphorus. Although human milk is critical for the health of preterm infants, it is low in these nutrients relative to the needs of the infants during growth. Strategies should be in place to fortify...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-0420

    authors: Abrams SA,Committee on Nutrition.

    更新日期:2013-05-01 00:00:00

  • Patent Ductus Arteriosus of the Preterm Infant.

    abstract::Postnatal ductal closure is stimulated by rising oxygen tension and withdrawal of vasodilatory mediators (prostaglandins, nitric oxide, adenosine) and by vasoconstrictors (endothelin-1, catecholamines, contractile prostanoids), ion channels, calcium flux, platelets, morphologic maturity, and a favorable genetic predis...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2020-1209

    authors: Hamrick SEG,Sallmon H,Rose AT,Porras D,Shelton EL,Reese J,Hansmann G

    更新日期:2020-11-01 00:00:00

  • Randomized trial of a hearing conservation intervention for rural students: long-term outcomes.

    abstract:OBJECTIVES:We had the rare opportunity to conduct a cluster-randomized controlled trial to observe the long-term (16-year) effects of a well-designed hearing conservation intervention for rural high school students. This trial assessed whether the intervention resulted in (1) reduced prevalence of noise-induced hearing...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-0770

    authors: Marlenga B,Linneman JG,Pickett W,Wood DJ,Kirkhorn SR,Broste SK,Knobloch MJ,Berg RL

    更新日期:2011-11-01 00:00:00

  • An Extravagant Gift From a Grateful Patient.

    abstract::media-1vid110.1542/5787668327001PEDS-VA_2017-2837Video AbstractGift giving is psychologically and culturally complex. In any context, a gift can have multiple meanings. In the context of the doctor-patient relationship, the giving of gifts and decisions about whether to accept gifts raise complex ethical issues. In th...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2837

    authors: Sharma A,Johnson LM,Caruso Brown A,Unguru Y,Lantos JD

    更新日期:2018-06-01 00:00:00

  • Consequences of the delayed diagnosis of ataxia-telangiectasia.

    abstract:OBJECTIVES:Ataxia-telangiectasia (AT) is a rare, autosomal recessive neurodegenerative disorder in which the diagnosis is obvious when ataxia and telangiectasia are both present. However, the diagnosis can be made upon the onset of ataxia and before the appearance of telangiectasia if confirmed by laboratory tests. Ear...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.1.98

    authors: Cabana MD,Crawford TO,Winkelstein JA,Christensen JR,Lederman HM

    更新日期:1998-07-01 00:00:00

  • Invasive Bacterial Infections in Afebrile Infants Diagnosed With Acute Otitis Media.

    abstract:OBJECTIVES:To determine the prevalence of invasive bacterial infections (IBIs) and adverse events in afebrile infants with acute otitis media (AOM). METHODS:We conducted a 33-site cross-sectional study of afebrile infants ≤90 days of age with AOM seen in emergency departments from 2007 to 2017. Eligible infants were i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-1571

    authors: McLaren SH,Cruz AT,Yen K,Lipshaw MJ,Bergmann KR,Mistry RD,Gutman CK,Ahmad FA,Pruitt CM,Thompson GC,Steimle MD,Zhao X,Schuh AM,Thompson AD,Hanson HR,Ulrich SL,Meltzer JA,Dunnick J,Schmidt SM,Nigrovic LE,Waseem M,

    更新日期:2021-01-01 00:00:00

  • Tone and reflex development before term.

    abstract::The evolution of tone and reflexes from 25 weeks postmenstrual age (gestational age plus chronologic age) to term in a population of 42 surviving infants is described. The infants were born in 1983 at the Johns Hopkins Hospital, had birth weights less than 1300 g, were examined weekly until neonatal intensive care uni...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Allen MC,Capute AJ

    更新日期:1990-03-01 00:00:00

  • Airway clearance in Duchenne muscular dystrophy.

    abstract::This is a summary of the presentation on airway clearance in neuromuscular disorders presented as part of the program on airway clearance in Duchenne muscular dystrophy at the 30th annual Carrell-Krusen Neuromuscular Symposium on February 20, 2008. ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-2952G

    authors: Kravitz RM

    更新日期:2009-05-01 00:00:00

  • Fatal malignant hyperthermia-like syndrome with rhabdomyolysis complicating the presentation of diabetes mellitus in adolescent males.

    abstract:OBJECTIVE:This report describes a new fatal syndrome observed in adolescent males at the initial presentation of diabetes mellitus. The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability. DESIGN:Case se...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1542/peds.111.6.1447

    authors: Hollander AS,Olney RC,Blackett PR,Marshall BA

    更新日期:2003-06-01 00:00:00

  • Do pediatricians recognize mothers with depressive symptoms?

    abstract:OBJECTIVE:To determine whether pediatric health care providers recognize maternal depressive symptoms and to explore whether maternal, provider, and visit characteristics affect pediatric providers' ability to recognize inner-city mothers with depressive symptoms. DESIGN:A cross-sectional study was conducted at a hosp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.1367

    authors: Heneghan AM,Silver EJ,Bauman LJ,Stein RE

    更新日期:2000-12-01 00:00:00

  • Use of antimicrobial drugs in general hospitals: IV. Infants and children.

    abstract::The use of antimicrobial drugs was studied among 933 randomly selected infants and children who were hospitalized in 20 short-stay general hospitals in Pennsylvania. Twenty-two percent of pediatric patients received antimicrobial drugs: 5% of neonates and 57% of patients aged 12 to 18 months. Sixty-eight percent of th...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Townsend TR,Shapiro M,Rosner B,Kass EH

    更新日期:1979-11-01 00:00:00

  • Family history predicts stress fracture in active female adolescents.

    abstract:OBJECTIVE:Increased physical activity and menstrual irregularity have been associated with increased risk for stress fracture among adult women active in athletics. The purposes of this study were to determine whether menstrual irregularity is also a risk factor for stress fracture in active female adolescents and to e...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2145

    authors: Loud KJ,Micheli LJ,Bristol S,Austin SB,Gordon CM

    更新日期:2007-08-01 00:00:00

  • Tachypnea of infancy as the first sign of Sanfilippo syndrome.

    abstract::This report describes the first known case of Mucopolysaccharidosis type IIIA presenting with respiratory symptoms and characteristic lung pathology. This case highlights under-recognized areas of systemic involvement and earlier modes of presentation in lysosomal storage disorders as well as the importance of investi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-2765

    authors: Chiang J,Raiman J,Cutz E,Solomon M,Dell S

    更新日期:2014-09-01 00:00:00

  • Mental health screening in pediatric practice: factors related to positive screens and the contribution of parental/personal concern.

    abstract:OBJECTIVES:The goals were to examine factors related to positive Pediatric Symptom Checklist scores in an urban practice and to examine the relative contribution of parental/personal concern about emotional and behavioral problems to mental health problem identification. METHODS:Annual screening using the Pediatric Sy...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0026

    authors: Hacker KA,Myagmarjav E,Harris V,Suglia SF,Weidner D,Link D

    更新日期:2006-11-01 00:00:00

  • Trends in multiple births conceived using assisted reproductive technology, United States, 1997-2000.

    abstract:OBJECTIVE:To examine trends in multiple births conceived using assisted reproductive technology (ART) in the United States between 1997 and 2000 and to estimate the proportion of all US multiple births attributable to ART use. METHODS:We analyzed population-based data of 109 519 live-born infants who were conceived in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Reynolds MA,Schieve LA,Martin JA,Jeng G,Macaluso M

    更新日期:2003-05-01 00:00:00

  • Pneumococcal mastoiditis in children.

    abstract:OBJECTIVE:To determine the impact of antibiotic resistance on the frequency, clinical features, and management/outcome of mastoiditis attributable to Streptococcus pneumoniae. DESIGN:Retrospective review of the medical records of children with mastoiditis caused by S pneumoniae from September 1993 through December 199...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.106.4.695

    authors: Kaplan SL,Mason EO Jr,Wald ER,Kim KS,Givner LB,Bradley JS,Barson WJ,Tan TQ,Schutze GE,Yogev R

    更新日期:2000-10-01 00:00:00

  • The changing role and responsibilities of chairmen in clinical academic departments: the transition from autocracy.

    abstract::There is considerable literature dealing with the responsibilities of clinical department chairmen, which primarily emphasizes the importance of developing a sound and facilitating administration. This is dependent on the hiring of appropriate support personnel, developing a representative committee structure, being a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Brent RL

    更新日期:1992-07-01 00:00:00

  • Phenothiazine-induced sleep apneas in normal infants.

    abstract::A relationship between sudden infant death syndrome and the use of phenothiazine-containing medications is suspected. In order to investigate the influence of phenothiazines upon cardiorespiratory and sleep characteristics, four normal infants (mean age 15.8 weeks) had polygraphic recordings made for one night. The re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kahn A,Hasaerts D,Blum D

    更新日期:1985-05-01 00:00:00

  • Neonatal apnea: diagnosis by nurse versus computer.

    abstract::In an effort to characterize significant neonatal apnea and evaluate the nursing diagnosis of apnea, apnea type and frequency were determined in 27 infants by continuous computer recording of heart rate, respiratory impedance, end-tidal CO2, and either or both transcutaneous oxygen and pulse oximetry. Of the 1,266 rec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Muttitt SC,Finer NN,Tierney AJ,Rossmann J

    更新日期:1988-11-01 00:00:00

  • Levels of interleukin-2, interferon-gamma, and interleukin-4 in bronchoalveolar lavage fluid from patients with Mycoplasma pneumonia: implication of tendency toward increased immunoglobulin E production.

    abstract:OBJECTIVE:In connection with the possible relationship between Mycoplasma infection and the onset of asthma, several studies have shown not only a high level of serum total immunoglobulin E (IgE) but also the production of IgE specific to Mycoplasma or common allergens during the course of Mycoplasma infection. It has ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.3.e39

    authors: Koh YY,Park Y,Lee HJ,Kim CK

    更新日期:2001-03-01 00:00:00

  • Increasing breast milk production for premature infants with a relaxation/imagery audiotape.

    abstract::Many women whose premature infants are hospitalized in a newborn intensive care unit choose to express breast milk for their babies. Yet anxiety, fatigue, and emotional stress are powerful inhibitors of lactation. To facilitate the breast-feeding experience, intervention mothers were given a 20-minute audio cassette t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Feher SD,Berger LR,Johnson JD,Wilde JB

    更新日期:1989-01-01 00:00:00

  • Epidemiologic aspects of Kawasaki disease in a Manhattan hospital.

    abstract::Epidemiologic and clinical features of Kawasaki disease in 106 patients seen between 1980 and 1986 at The New York Hospital in midtown Manhattan were compared with those in large series from the United States, Canada, and Japan. Dissimilarities in our Kawasaki disease experience included ethnic heterogeneity of our pa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ichida F,Fatica NS,O'Loughlin JE,Klein AA,Snyder MS,Levin AR,Ehlers KH,Lesser ML,Engle MA

    更新日期:1989-08-01 00:00:00