Family history predicts stress fracture in active female adolescents.

Abstract:

OBJECTIVE:Increased physical activity and menstrual irregularity have been associated with increased risk for stress fracture among adult women active in athletics. The purposes of this study were to determine whether menstrual irregularity is also a risk factor for stress fracture in active female adolescents and to estimate the quantity of exercise associated with an increased risk for this injury. PATIENTS AND METHODS:A case-control study was conducted of 13- to 22-year-old females diagnosed with their first stress fracture, each matched prospectively on age and self-reported ethnicity with 2 controls. Patients with chronic illnesses or use of medications known to affect bone mineral density were excluded, including use of hormonal preparations that could alter menstrual cycles. The primary outcome, stress fracture in any extremity or the spine, was confirmed radiographically. Girls with stress fracture had bone mineral density measured at the lumbar spine by dual-energy x-ray absorptiometry. RESULTS:The mean +/- SD age of the 168 participants was 15.9 +/- 2.1 years; 91.7% were postmenarchal, with a mean age at menarche of 13.1 +/- 1.1 years. The prevalence of menstrual irregularity was similar among cases and controls. There was no significant difference in the mean hours per week of total physical activity between girls in this sample with stress fracture (8.2 hours/week) and those without (7.4 hours/week). In multivariate models, case subjects had nearly 3 times the odds of having a family member with osteoporosis or osteopenia. In secondary analyses, participants with stress fracture had a low mean spinal bone mineral density for their age. CONCLUSIONS:Among highly active female adolescents, only family history was independently associated with stress fracture. The magnitude of this association suggests that further investigations of inheritable skeletal factors are warranted in this population, along with evaluation of bone mineral density in girls with stress fracture.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Loud KJ,Micheli LJ,Bristol S,Austin SB,Gordon CM

doi

10.1542/peds.2006-2145

subject

Has Abstract

pub_date

2007-08-01 00:00:00

pages

e364-72

issue

2

eissn

0031-4005

issn

1098-4275

pii

peds.2006-2145

journal_volume

120

pub_type

杂志文章
  • Rapid, needle-free delivery of lidocaine for reducing the pain of venipuncture among pediatric subjects.

    abstract:OBJECTIVES:The purpose of this study was to determine the optimal configuration of an investigational, single-use, needle-free, drug system (ALGRX 3268) that delivers powdered lidocaine into the epidermis for the rapid production of local anesthesia among pediatric subjects undergoing venipuncture. METHODS:Children 3 ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0656

    authors: Migdal M,Chudzynska-Pomianowska E,Vause E,Henry E,Lazar J

    更新日期:2005-04-01 00:00:00

  • Obesity risk for female victims of childhood sexual abuse: a prospective study.

    abstract:OBJECTIVE:Efforts are under way to articulate environmental, psychosocial, and biological conditions that may predispose the development and maintenance of obesity. There is increasing evidence that adverse childhood experiences such as childhood abuse may be implicated in the development of obesity. Given the dearth o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3058

    authors: Noll JG,Zeller MH,Trickett PK,Putnam FW

    更新日期:2007-07-01 00:00:00

  • Postnatal serum insulin-like growth factor I deficiency is associated with retinopathy of prematurity and other complications of premature birth.

    abstract:OBJECTIVE:Insulin-like growth factor I (IGF-I) is necessary for normal development of retinal blood vessels in mice and humans. Because retinopathy of prematurity (ROP) is initiated by abnormal postnatal retinal development, we hypothesized that prolonged low IGF-I in premature infants might be a risk factor for ROP. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.5.1016

    authors: Hellström A,Engström E,Hård AL,Albertsson-Wikland K,Carlsson B,Niklasson A,Löfqvist C,Svensson E,Holm S,Ewald U,Holmström G,Smith LE

    更新日期:2003-11-01 00:00:00

  • The National Children's Study: Recruitment Outcomes Using the Provider-Based Recruitment Approach.

    abstract:OBJECTIVE:In 2009, the National Children's Study (NCS) Vanguard Study tested the feasibility of household-based recruitment and participant enrollment using a birth-rate probability sample. In 2010, the NCS Program Office launched 3 additional recruitment approaches. We tested whether provider-based recruitment could i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-4410E

    authors: Hale DE,Wyatt SB,Buka S,Cherry D,Cislo KK,Dudley DJ,McElfish PA,Norman GS,Reynolds SA,Siega-Riz AM,Wadlinger S,Walker CK,Robbins JM

    更新日期:2016-06-01 00:00:00

  • Psychological problems in children with daytime wetting.

    abstract:OBJECTIVE:This population-based study investigated the psychological problems associated with daytime wetting in children. METHODS:A sample of 8213 children (age range: 7 years 6 months to 9 years 3 months) who were enrolled in the population-based Avon Longitudinal Study of Parents and Children participated in this s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0894

    authors: Joinson C,Heron J,von Gontard A

    更新日期:2006-11-01 00:00:00

  • Media literacy education for elementary school substance use prevention: study of media detective.

    abstract:OBJECTIVES:Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this stud...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2010-0068

    authors: Kupersmidt JB,Scull TM,Austin EW

    更新日期:2010-09-01 00:00:00

  • Human metapneumovirus infection in the United States: clinical manifestations associated with a newly emerging respiratory infection in children.

    abstract:OBJECTIVE:Respiratory tract infections are a leading cause of morbidity and mortality worldwide. Recently, a newly identified human respiratory virus, human metapneumovirus (hMPV), was reported by investigators in the Netherlands. We sought to determine whether hMPV was circulating in our community and to determine the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.6.1407

    authors: Esper F,Boucher D,Weibel C,Martinello RA,Kahn JS

    更新日期:2003-06-01 00:00:00

  • Policy statement--Expert witness participation in civil and criminal proceedings.

    abstract::The interests of the public and both the medical and legal professions are best served when scientifically sound and unbiased expert witness testimony is readily available in civil and criminal proceedings. As members of the medical community, patient advocates, and private citizens, pediatricians have ethical and pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1132

    authors: Committee on Medical Liability and Risk Management.

    更新日期:2009-07-01 00:00:00

  • Acute profound dystonia in infants with glutaric acidemia.

    abstract::Acute profound dystonia developed in three previously well infants who were found to have glutaryl-CoA dehydrogenase deficiency in cultured skin fibroblasts. Two patients had excessive urinary excretion of glutaric acid, but one did not. Neuroradiologic studies performed in all three patients at the onset of their ill...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Bergman I,Finegold D,Gartner JC Jr,Zitelli BJ,Claassen D,Scarano J,Roe CR,Stanley C,Goodman SI

    更新日期:1989-02-01 00:00:00

  • Deception and the death of Ilyusha: truth and the best interest of a dying child in The Brothers Karamazov.

    abstract::For centuries, many physicians and parents assumed that it was ethically justifiable to lie to a dying child. The reasoning was clear. Because the lie would likely eliminate or prevent a concrete harm (the child's fear), and the lie is about a harm that is unavoidable anyway, a lie appeared to be the morally desirable...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-1394D

    authors: Martin C

    更新日期:2014-10-01 00:00:00

  • Serial assessment of mortality in the neonatal intensive care unit by algorithm and intuition: certainty, uncertainty, and informed consent.

    abstract:OBJECTIVES:Does predictive power for outcomes of neonatal intensive care unit (NICU) patients get better with time? Or does it get worse? We determined the predictive power of Score for Neonatal Acute Physiology (SNAP) scores and clinical intuitions as a function of day of life (DOL) for newborn infants admitted to our...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.5.878

    authors: Meadow W,Frain L,Ren Y,Lee G,Soneji S,Lantos J

    更新日期:2002-05-01 00:00:00

  • Epigenetics and primary care.

    abstract::Epigenetics, the study of functionally relevant chemical modifications to DNA that do not involve a change in the DNA nucleotide sequence, is at the interface between research and clinical medicine. Research on epigenetic marks, which regulate gene expression independently of the underlying genetic code, has dramatica...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-1032F

    authors: Wright R,Saul RA

    更新日期:2013-12-01 00:00:00

  • Should Neonatologists Give Opinions Withdrawing Life-sustaining Treatment?

    abstract::An infant has a massive intracranial hemorrhage. She is neurologically devastated and ventilator-dependent. The prognosis for pulmonary or neurologic recovery is bleak. The physicians and parents face a choice: withdraw the ventilator and allow her to die or perform a tracheotomy? The parents cling to hope for recover...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-2585

    authors: Blumenthal-Barby JS,Loftis L,Cummings CL,Meadow W,Lemmon M,Ubel PA,McCullough L,Rao E,Lantos JD

    更新日期:2016-12-01 00:00:00

  • Treatment of chronic childhood asthma with beclomethasone dipropionate aerosols: II. Effect on pituitary-adrenal function after substitution for oral corticosteroids.

    abstract::The effects of beclomethasone, dipropionate aerosol (DBA) (400 microgram/day) on clinical course, pulmonary function, and pituitary-adrenal function was studied in 34 steroid-dependent asthmatic children. Asthma severity was assessed by daily symptom and medication scores, peak flow measured three times a day, and wee...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Kershnar H,Klein R,Waldman D,Berger W,Rachelefsky G,Katz R,Siegel S

    更新日期:1978-08-01 00:00:00

  • Hepatitis C Testing Among Perinatally Exposed Infants.

    abstract:BACKGROUND:Hepatitis C virus (HCV) prevalence doubled among pregnant women from 2009 to 2014, reaching 3.4 per 1000 births nationwide. Infants exposed to HCV may acquire HCV by vertical transmission. National guidelines recommend that infants exposed to HCV be tested; however, it is unclear if these recommendations are...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-2482

    authors: Lopata SM,McNeer E,Dudley JA,Wester C,Cooper WO,Carlucci JG,Espinosa CM,Dupont W,Patrick SW

    更新日期:2020-03-01 00:00:00

  • Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy.

    abstract:OBJECTIVE:Knowing risk factors at birth for the development of childhood obesity could help to identify children who are in need of early obesity prevention efforts. The objective of this study was to determine whether children whose mothers were obese in early pregnancy were more likely to be obese at 2 to 4 years of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.1.e29

    authors: Whitaker RC

    更新日期:2004-07-01 00:00:00

  • Exemplar pediatric collaborative improvement networks: achieving results.

    abstract::A number of pediatric collaborative improvement networks have demonstrated improved care and outcomes for children. Regionally, Cincinnati Children's Hospital Medical Center Physician Hospital Organization has sustained key asthma processes, substantially increased the percentage of their asthma population receiving "...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3786F

    authors: Billett AL,Colletti RB,Mandel KE,Miller M,Muething SE,Sharek PJ,Lannon CM

    更新日期:2013-06-01 00:00:00

  • Epidemiology of Acute Lower Respiratory Tract Infection in HIV-Exposed Uninfected Infants.

    abstract:BACKGROUND:Increased morbidity and mortality from lower respiratory tract infection (LRTI) has been suggested in HIV-exposed uninfected (HEU) children; however, the contribution of respiratory viruses is unclear. We studied the epidemiology of LRTI hospitalization in HIV-unexposed uninfected (HUU) and HEU infants aged ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3272

    authors: Cohen C,Moyes J,Tempia S,Groome M,Walaza S,Pretorius M,Naby F,Mekgoe O,Kahn K,von Gottberg A,Wolter N,Cohen AL,von Mollendorf C,Venter M,Madhi SA

    更新日期:2016-04-01 00:00:00

  • Twenty-year follow-up of antenatal corticosteroid treatment.

    abstract:OBJECTIVE:To study late side effects of antenatal corticosteroid treatment on health and sexual development in subjects 20 to 22 years old. METHODS:A follow-up study among young adults whose mothers had, because of a threatening delivery, participated in a randomized, double-blind, placebo- controlled trial of betamet...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.105.6.e77

    authors: Dessens AB,Haas HS,Koppe JG

    更新日期:2000-06-01 00:00:00

  • Complete DiGeorge anomaly in the absence of neonatal hypocalcemia and velofacial and cardiac defects.

    abstract::We report an atypical case of complete DiGeorge (DG) anomaly that presented initially exclusively as severe combined immunodeficiency (SCID). The child had severe infections at diagnosis, in keeping with the SCID phenotype; however, normal lymphocyte counts and immunoglobulin levels were noted at admission, which dela...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0371

    authors: Al-Tamemi S,Mazer B,Mitchell D,Albuquerque P,Duncan AM,McCusker C,Jabado N

    更新日期:2005-09-01 00:00:00

  • Maternal employment and the quality of young children's diets: empirical evidence based on the 1987-1988 Nationwide Food Consumption Survey.

    abstract::Data from 442 children, aged 2 to 5, who were participants in the 1987-1988 Nationwide Food Consumption Survey, were examined to determine the effect of maternal employment on the quality of their diets. Diet quality was assessed by examining nutrient adequacy and nutrient overconsumption using the 3-day average of on...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Johnson RK,Smiciklas-Wright H,Crouter AC,Willits FK

    更新日期:1992-08-01 00:00:00

  • Athletic participation by children and adolescents who have systemic hypertension. American Academy of Pediatrics Committee on Sports Medicine and Fitness.

    abstract::Children and adolescents who have systemic hypertension may be at risk for complications when exercise causes their blood pressures to rise even higher. The purpose of this statement is to make recommendations concerning the athletic participation of individuals with hypertension using the 26th Bethesda Conference on ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.99.4.637

    authors:

    更新日期:1997-04-01 00:00:00

  • Mother-to-child transmission of human immunodeficiency virus type 1: risk of infection and correlates of transmission.

    abstract::One thousand eight hundred eighty-seven children born to human immunodeficiency virus type 1 (HIV-1) seropositive mothers, including 1045 infants prospectively followed up from birth, were studied. Intravenous drug use was the most frequent maternal risk factor, although the percentage of women infected by sexual cont...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Gabiano C,Tovo PA,de Martino M,Galli L,Giaquinto C,Loy A,Schoeller MC,Giovannini M,Ferranti G,Rancilio L

    更新日期:1992-09-01 00:00:00

  • Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography.

    abstract:OBJECTIVE:To define normal and abnormal patterns, test interobserver variability, and the prognostic accuracy of amplitude-integrated electroencephalography (aEEG) soon after the onset of neonatal encephalopathy. METHODS:Consecutive cases of neonatal encephalopathy (n = 56; gestation median, 40; range, 35-42 weeks) an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.1263

    authors: al Naqeeb N,Edwards AD,Cowan FM,Azzopardi D

    更新日期:1999-06-01 00:00:00

  • Lay Field-worker-Led School Health Program for Primary Schools in Low- and Middle-Income Countries.

    abstract:BACKGROUND AND OBJECTIVES:School health programs are frequently attempted in low- and/or middle-income countries; however, programmatic scope and reach is limited by human resource constraints. We sought to determine if trained community members could implement a school health program that improved outcomes in rural pr...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-0975

    authors: Matergia M,Ferrarone P,Khan Y,Matergia DW,Giri P,Thapa S,Simões EAF

    更新日期:2019-04-01 00:00:00

  • Clinical disease caused by Klebsiella in 2 unrelated patients with interleukin 12 receptor beta1 deficiency.

    abstract::Patients with interleukin 12 (IL-12)p40 or IL-12 receptor β1 (IL12Rβ1) deficiencies are prone to develop infections caused by mycobacteria and salmonella; other infections have only been rarely observed. In this report we describe 2 unrelated patients with complete autosomal recessive IL12Rβ1 deficiency who suffered f...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2504

    authors: Pedraza S,Lezana JL,Samarina A,Aldana R,Herrera MT,Boisson-Dupuis S,Bustamante J,Pages P,Casanova JL,Picard C

    更新日期:2010-10-01 00:00:00

  • The prevalence, severity, and distribution of childhood food allergy in the United States.

    abstract:OBJECTIVE:The goal of this study was to better estimate the prevalence and severity of childhood food allergy in the United States. METHODS:A randomized, cross-sectional survey was administered electronically to a representative sample of US households with children from June 2009 to February 2010. Eligible participan...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0204

    authors: Gupta RS,Springston EE,Warrier MR,Smith B,Kumar R,Pongracic J,Holl JL

    更新日期:2011-07-01 00:00:00

  • A controlled trial of high-intensity double-surface phototherapy on a fluid bed versus conventional phototherapy in neonatal jaundice.

    abstract:OBJECTIVE:To evaluate a simple, relatively inexpensive method using the fluid bed to provide high-intensity double-surface (HIDS) phototherapy and to confirm that the method described is more effective than conventional phototherapy (CPT) in the treatment of neonatal hyperbilirubinemia. DESIGN:Prospective controlled s...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Garg AK,Prasad RS,Hifzi IA

    更新日期:1995-06-01 00:00:00

  • Insulin receptors in cystic fibrosis: increased receptor number and altered affinity.

    abstract::Patients with cystic fibrosis are known to have pancreatic disorganization with associated pancreatic exocrine insufficiency. Endocrine hormonal secretion is also affected but diminution in insulin secretion is rarely accompanied by overt diabetes. We studied seven patients with cystic fibrosis to determine their carb...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lippe BM,Kaplan SA,Neufeld ND,Smith A,Scott M

    更新日期:1980-05-01 00:00:00

  • Growth and development in a child with resistance to thyroid hormone and ectopic thyroid gland.

    abstract::Resistance to thyroid hormone is an uncommon problem, which has rarely been associated with thyroid dysgenesis. We report a case with both thyroid gland ectopy and resistance to thyroid hormone and, thus, a reduced capacity to produce and respond to thyroid hormone. The patient presented at 2 years of age with develop...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0634

    authors: Heather N,Hall K,Neas K,Potter H,Wiltshire E

    更新日期:2012-03-01 00:00:00