Prevalence and characteristics of fetal alcohol spectrum disorders.

Abstract:

OBJECTIVES:To determine the prevalence and characteristics of fetal alcohol spectrum disorders (FASD) among first grade students (6- to 7-year-olds) in a representative Midwestern US community. METHODS:From a consented sample of 70.5% of all first graders enrolled in public and private schools, an oversample of small children (≤ 25th percentile on height, weight, and head circumference) and randomly selected control candidates were examined for physical growth, development, dysmorphology, cognition, and behavior. The children's mothers were interviewed for maternal risk. RESULTS:Total dysmorphology scores differentiate significantly fetal alcohol syndrome (FAS) and partial FAS (PFAS) from one another and from unexposed controls. Alcohol-related neurodevelopmental disorder (ARND) is not as clearly differentiated from controls. Children who had FASD performed, on average, significantly worse on 7 cognitive and behavioral tests and measures. The most predictive maternal risk variables in this community are late recognition of pregnancy, quantity of alcoholic drinks consumed 3 months before pregnancy, and quantity of drinking reported for the index child's father. From the final multidisciplinary case findings, 3 techniques were used to estimate prevalence. FAS in this community likely ranges from 6 to 9 per 1000 children (midpoint, 7.5), PFAS from 11 to 17 per 1000 children (midpoint, 14), and the total rate of FASD is estimated at 24 to 48 per 1000 children, or 2.4% to 4.8% (midpoint, 3.6%). CONCLUSIONS:Children who have FASD are more prevalent among first graders in this Midwestern city than predicted by previous, popular estimates.

journal_name

Pediatrics

journal_title

Pediatrics

authors

May PA,Baete A,Russo J,Elliott AJ,Blankenship J,Kalberg WO,Buckley D,Brooks M,Hasken J,Abdul-Rahman O,Adam MP,Robinson LK,Manning M,Hoyme HE

doi

10.1542/peds.2013-3319

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

855-66

issue

5

eissn

0031-4005

issn

1098-4275

pii

peds.2013-3319

journal_volume

134

pub_type

杂志文章,随机对照试验
  • Using registries to identify adverse events in rheumatic diseases.

    abstract::The proven effectiveness of biologics and other immunomodulatory products in inflammatory rheumatic diseases has resulted in their widespread use as well as reports of potential short- and long-term complications such as infection and malignancy. These complications are especially worrisome in children who often have ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-0755

    authors: Lionetti G,Kimura Y,Schanberg LE,Beukelman T,Wallace CA,Ilowite NT,Winsor J,Fox K,Natter M,Sundy JS,Brodsky E,Curtis JR,Del Gaizo V,Iyasu S,Jahreis A,Meeker-O'Connell A,Mittleman BB,Murphy BM,Peterson ED,Raymond SC

    更新日期:2013-11-01 00:00:00

  • Treatment of atypical mycobacterial cervical adenitis with rifampin.

    abstract::The clinical response of atypical mycobacterial cervical adenitis to standard antituberculous therapy has been disappointing. Surgical procedures in the anterior cervical triangle are difficult and often complete excision is impossible. In each of four children with atypical mycobacterial cervical adenitis in this stu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mandell F,Wright PF

    更新日期:1975-01-01 00:00:00

  • Foreign aid, international organizations, and the world's children.

    abstract::Recent improvement in child mortality has taken place in all regions of the world. In developing countries, major remaining causes are neonatal problems, diarrheal diseases, vaccine-preventable diseases, and respiratory diseases. Foreign aid has come in many forms, among them individual persons, nongovernmental organi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.3.646

    authors: Wegman ME

    更新日期:1999-03-01 00:00:00

  • Sleep duration and adolescent obesity.

    abstract:OBJECTIVES:Short sleep has been associated with adolescent obesity. Most studies used a cross-sectional design and modeled BMI categories. We sought to determine if sleep duration was associated with BMI distribution changes from age 14 to 18. METHODS:Adolescents were recruited from suburban high schools in Philadelph...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2368

    authors: Mitchell JA,Rodriguez D,Schmitz KH,Audrain-McGovern J

    更新日期:2013-05-01 00:00:00

  • Prospective randomized double-blind study comparing L-epinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup).

    abstract::Aerosolized racemic epinephrine, but not L-epinephrine, is commonly used in treating croup. The efficacy and adverse effects of nebulized racemic and L-epinephrine in the treatment of laryngotracheitis were compared. Children 6 months to 6 years of age with a croup score of 6 or above were assigned in a randomized dou...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Waisman Y,Klein BL,Boenning DA,Young GM,Chamberlain JM,O'Donnell R,Ochsenschlager DW

    更新日期:1992-02-01 00:00:00

  • Effect of duration and frequency of breast-feeding on postpartum amenorrhea.

    abstract::The relationship among duration and frequency of breast-feeding, age, level of education, and parity on postpartum amenorrhea were investigated retrospectively in selected married Nigerian women attending the two local maternity centers in Ile-Ife, Nigeria, between January and May 1980. The mean values for duration an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ojofeitimi EO

    更新日期:1982-02-01 00:00:00

  • Day-by-day postnatal survival in very low birth weight infants.

    abstract:OBJECTIVES:Postnatal survival rates of very low birth weight (VLBW) infants are well established for each birth weight or gestational age category. These figures do not differentiate viable infants who survive the first few days of life from extremely immature ones who die shortly after birth. This study aimed to devel...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2810

    authors: Mohamed MA,Nada A,Aly H

    更新日期:2010-08-01 00:00:00

  • Determination of genetic predisposition to patent ductus arteriosus in preterm infants.

    abstract:OBJECTIVE:Patent ductus arteriosus is a common morbidity associated with preterm birth. The incidence of patent ductus arteriosus increases with decreasing gestational age to approximately 70% in infants born at 25 weeks' gestation. Our major goal was to determine if genetic risk factors play a role in patent ductus ar...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0313

    authors: Dagle JM,Lepp NT,Cooper ME,Schaa KL,Kelsey KJ,Orr KL,Caprau D,Zimmerman CR,Steffen KM,Johnson KJ,Marazita ML,Murray JC

    更新日期:2009-04-01 00:00:00

  • Efficacy of psychosocial group intervention for children with chronic illness and their parents.

    abstract:OBJECTIVE:To investigate the efficacy of a cognitive-behavioral group intervention for children with chronic illnesses and to test the effect of an added parent component. METHODS:Children (n = 194) and their parents participated in a multicenter randomized clinical trial comparing a child-only intervention and a pare...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2012-2222

    authors: Scholten L,Willemen AM,Last BF,Maurice-Stam H,van Dijk EM,Ensink E,Zandbelt N,van der Hoop-Mooij A,Schuengel C,Grootenhuis MA

    更新日期:2013-04-01 00:00:00

  • Emotional, developmental, and behavioral health of American children and their families: a report from the 2003 National Survey of Children's Health.

    abstract:BACKGROUND:Recent children's health surveys have documented a high prevalence of emotional, developmental, and behavioral problems among children. Data from the 2003 National Survey of Children's Health provide new insights into these problems and their association with family function and community participation. Thes...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2606

    authors: Blanchard LT,Gurka MJ,Blackman JA

    更新日期:2006-06-01 00:00:00

  • Dietary fiber in weaning foods of young children.

    abstract:OBJECTIVE:An evaluation of the opportunity to introduce fiber in the diet of weaning infants. METHODS:A descriptive review of the literature to assess the role of fiber in the following dietary interventions: (1) definition of the nutrient amounts that meet the weaning infant's physiologic needs; (2) modulation of dig...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Agostoni C,Riva E,Giovannini M

    更新日期:1995-11-01 00:00:00

  • Athletic participation by children and adolescents who have systemic hypertension. American Academy of Pediatrics Committee on Sports Medicine and Fitness.

    abstract::Children and adolescents who have systemic hypertension may be at risk for complications when exercise causes their blood pressures to rise even higher. The purpose of this statement is to make recommendations concerning the athletic participation of individuals with hypertension using the 26th Bethesda Conference on ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.99.4.637

    authors:

    更新日期:1997-04-01 00:00:00

  • Herpes simplex virus central nervous system relapse during treatment of infantile spasms with corticotropin.

    abstract::Here we report an infant who had herpes simplex virus (HSV) encephalitis and sustained severe bilateral damage to the posterior frontal lobes, postcentral gyri, and the thalami despite intravenous acyclovir treatment. At 7 months of age, the patient developed infantile spasms and was treated with corticotropin injecti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1867

    authors: Bonkowsky JL,Filloux FM,Byington CL

    更新日期:2006-05-01 00:00:00

  • Trends in the prevalence of autism on the basis of special education data.

    abstract:OBJECTIVE:The goal was to determine whether the increasing prevalence of autism, on the basis of educational data, in Wisconsin between 2002 and 2008 was uniform in all school districts or was greatest in districts with lower baseline (2002) prevalence. METHODS:Special education counts were obtained for all Wisconsin ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1023

    authors: Maenner MJ,Durkin MS

    更新日期:2010-11-01 00:00:00

  • Tight glycemic control with insulin in hyperglycemic preterm babies: a randomized controlled trial.

    abstract:OBJECTIVE:The optimal treatment of neonatal hyperglycemia is unclear. The aim of this trial was to determine whether tight glycemic control with insulin improves growth in hyperglycemic preterm infants, without increasing the incidence of hypoglycemia. METHODS:Randomized, controlled, nonblinded trial of 88 infants bor...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-2470

    authors: Alsweiler JM,Harding JE,Bloomfield FH

    更新日期:2012-04-01 00:00:00

  • Clinical Considerations Related to the Behavioral Manifestations of Child Maltreatment.

    abstract::Children who have suffered early abuse or neglect may later present with significant health and behavior problems that may persist long after the abusive or neglectful environment has been remediated. Neurobiological research suggests that early maltreatment may result in an altered psychological and physiologic respo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0100

    authors: Sege RD,Amaya-Jackson L,AMERICAN ACADEMY OF PEDIATRICS Committee on Child Abuse and Neglect, Council on Foster Care, Adoption, and Kinship Care; AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY Committee on Child Maltreatment and Violence; NATION

    更新日期:2017-04-01 00:00:00

  • Medicaid policy statement.

    abstract::Medicaid is a vital safety net for children that must be maintained. It is the largest single insurer of children, yet millions of children who are eligible remain unenrolled. Every effort should be made to implement expanded eligibility and streamlined enrollment procedures. Early and Periodic Screening, Diagnosis, a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0891

    authors: American Academy of Pediatrics Committee on Child Health Financing.

    更新日期:2005-07-01 00:00:00

  • Interfacility transfers of noncritically ill children to academic pediatric emergency departments.

    abstract:OBJECTIVES:We aimed to characterize the demographics, diagnoses, and management of transferred patients who were directly discharged from the emergency department (ED) or admitted less than 24 hours. METHODS:We conducted a retrospective, cross-sectional study of patients classified as interfacility ED transfers over a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1819

    authors: Li J,Monuteaux MC,Bachur RG

    更新日期:2012-07-01 00:00:00

  • Prescribing assistive-technology systems: focus on children with impaired communication.

    abstract::This clinical report defines common terms of use and provides information on current practice, research, and limitations of assistive technology that can be used in systems for communication. The assessment process to determine the best devices for use with a particular child (ie, the best fit of a device) is also rev...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2008-0695

    authors: Desch LW,Gaebler-Spira D,Council on Children With Disabilities.

    更新日期:2008-06-01 00:00:00

  • Patterns of Comorbidity Among Girls With ADHD: A Meta-analysis.

    abstract:CONTEXT:Although children with attention-deficit/hyperactivity disorder (ADHD) are at elevated risk for comorbid psychopathology, the clinical correlates of ADHD in girls are far less understood relative to boys, despite ADHD being one of the most common childhood disorders in girls. OBJECTIVE:To meta-analytically sum...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1542/peds.2016-0430

    authors: Tung I,Li JJ,Meza JI,Jezior KL,Kianmahd JS,Hentschel PG,O'Neil PM,Lee SS

    更新日期:2016-10-01 00:00:00

  • Age and height at diagnosis in Turner syndrome: influence of parental height.

    abstract::Age and height at diagnosis was studied in 100 patients with Turner syndrome: 41 with the 45,X karyotype and 59 with various other karyotypes. In 15 patients diagnosis was made at birth. In the remaining patients median age at diagnosis was 12.9 years in those with 45,X karyotype and 11.6 years in the others. Mean +/-...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Massa GG,Vanderschueren-Lodeweyckx M

    更新日期:1991-12-01 00:00:00

  • The pivotal role of deep vein thrombophlebitis in the development of acute disseminated staphylococcal disease in children.

    abstract::Deep vein thrombophlebitis (DVT) and septic pulmonary emboli (PE) are rare in children. The association of DVT and acute disseminated staphylococcal disease (DSD) during childhood has not been previously reported. We report 3 children who developed a triad of DVT, septic PE, and acute osteomyelitis with Staphylococcus...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.e87

    authors: Gorenstein A,Gross E,Houri S,Gewirts G,Katz S

    更新日期:2000-12-01 00:00:00

  • Should fewer premature infants be screened for retinopathy of prematurity in the managed care era?

    abstract:OBJECTIVE:To determine appropriate upper limits for gestational age and birth weight when screening infants for retinopathy of prematurity (ROP). DESIGN:Retrospective survey. SETTING:Tertiary neonatal intensive care nursery. PATIENTS:Seven hundred seven infants born July 1, 1990 to June 30, 1996 and screened for ROP...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.1.31

    authors: Wright K,Anderson ME,Walker E,Lorch V

    更新日期:1998-07-01 00:00:00

  • Nafcillin-induced neutropenia in children.

    abstract::Neutropenia developed in three pediatric patients treated intravenously with nafcillin. This association has not been, to our knowledge, previously reported in children. One of the patients is the youngest reported who had neutropenia associated with any penicillin; another patient had a prolonged recovery. The litera...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Greene GR,Cohen E

    更新日期:1978-01-01 00:00:00

  • Effects of the accreditation council for graduate medical education duty hour limits on sleep, work hours, and safety.

    abstract:OBJECTIVE:To mitigate the risks of fatigue-related medical errors, the Accreditation Council for Graduate Medical Education introduced work hour limits for resident physicians in 2003. Our goal was to determine whether work hours, sleep, and safety changed after implementation of the Accreditation Council for Graduate ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2306

    authors: Landrigan CP,Fahrenkopf AM,Lewin D,Sharek PJ,Barger LK,Eisner M,Edwards S,Chiang VW,Wiedermann BL,Sectish TC

    更新日期:2008-08-01 00:00:00

  • Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities.

    abstract:BACKGROUND:Iron deficiency affects 2.4 million US children, and childhood iron-deficiency anemia is associated with behavioral and cognitive delays. Given the detrimental long-term effects and high prevalence of iron deficiency, its prevention in early childhood is an important public health issue. OBJECTIVES:The stud...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0572

    authors: Brotanek JM,Gosz J,Weitzman M,Flores G

    更新日期:2007-09-01 00:00:00

  • Screening and counseling associated with obesity diagnosis in a national survey of ambulatory pediatric visits.

    abstract:OBJECTIVE:To examine clinician-reported diagnosis of obesity and frequency of blood pressure assessment and diet and exercise counseling during ambulatory visits made by children and adolescents. METHODS:The National Ambulatory Medical Care Survey and National Hospital Ambulatory Medical Care Survey 1997 to 2000 were ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1517

    authors: Cook S,Weitzman M,Auinger P,Barlow SE

    更新日期:2005-07-01 00:00:00

  • Infant sleep position: pediatricians' advice to parents.

    abstract:OBJECTIVE:The American Academy of Pediatrics' (AAP) recommendation for side or supine sleep position in healthy babies has generated much controversy. We surveyed primary care physicians to determine the effect of the AAP statement on physician attitude toward infant sleep position and advice to parents. METHODS:We se...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hudak BB,O'Donnell J,Mazyrka N

    更新日期:1995-01-01 00:00:00

  • Potential cost savings attributable to influenza vaccination of school-aged children.

    abstract:OBJECTIVE:To analyze the costs and benefits of influenza vaccination of healthy school-aged children. DESIGN:The analysis was based on data from the literature. Total costs included direct medical costs for vaccination, physician visits, and treatment as well as indirect costs. Indirect costs were in the form of lost ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.e73

    authors: White T,Lavoie S,Nettleman MD

    更新日期:1999-06-01 00:00:00

  • Infantile lobar hyperinflation: expectant treatment.

    abstract::Arterial blood gases and regional lung function, measured with a 133xenon technique, were used to evalute the physiological defects and follow the natural history of 16 infants with lobar hyperinflation ("emphysema"). Hypoxemia was due to V/Q inequality at rest. Worsening of hypoxemia (mean Pao2 delta--26 mm Hg) with ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Shannon DC,Todres ID,Moylan FM

    更新日期:1977-06-01 00:00:00