Abstract:
BACKGROUND AND OBJECTIVES:Fetal alcohol spectrum disorders (FASD) comprise the continuum of disabilities associated with prenatal alcohol exposure. Although infancy remains the most effective time for initiation of intervention services, current diagnostic schemes demonstrate the greatest confidence, accuracy, and reliability in school-aged children. Our aims for the current study were to identify growth, dysmorphology, and neurodevelopmental features in infants that were most predictive of FASD at age 5, thereby improving the timeliness of diagnoses. METHODS:A cohort of pregnant South African women attending primary health care clinics or giving birth in provincial hospitals was enrolled in the project. Children were followed longitudinally from birth to 60 months to determine their physical and developmental trajectories (N = 155). Standardized protocols were used to assess growth, dysmorphology, and development at 6 weeks and at 9, 18, 42, and 60 months. A structured maternal interview, including estimation of prenatal alcohol intake, was administered at 42 or 60 months. RESULTS:Growth restriction and total dysmorphology scores differentiated among children with and without FASD as early as 9 months (area under the receiver operating characteristic curve = 0.777; P < .001; 95% confidence interval: 0.705-0.849), although children who were severely affected could be identified earlier. Assessment of developmental milestones revealed significant developmental differences emerging among children with and without FASD between 18 and 42 months. Mothers of children with FASD were significantly smaller, with lower BMIs and higher alcohol intake during pregnancy, than mothers of children without FASD. CONCLUSIONS:Assessment of a combination of growth, dysmorphology, and neurobehavioral characteristics allows for accurate identification of most children with FASD as early as 9 to 18 months.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Kalberg WO,May PA,Buckley D,Hasken JM,Marais AS,De Vries MM,Bezuidenhout H,Manning MA,Robinson LK,Adam MP,Hoyme DB,Parry CDH,Seedat S,Elliott AJ,Hoyme HEdoi
10.1542/peds.2018-2141subject
Has Abstractpub_date
2019-12-01 00:00:00issue
6eissn
0031-4005issn
1098-4275pii
peds.2018-2141journal_volume
144pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:BACKGROUND:In 2000, the American Diabetes Association issued recommendations for type 2 diabetes mellitus screening among children. They recommended testing children > or =10 years of age who have a body mass index (BMI) of >85th percentile for age and at least 2 other risk factors (family history of type 2 diabetes, h...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.114.1.141
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this work was to describe levels of maternal anxiety, depressive symptoms, and perceptions of infant vulnerability associated with newborn genetic screening for susceptibility to type 1 diabetes. PATIENTS AND METHODS:Mothers of infants tested at birth for genetic susceptibility to type 1 diabe...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2006-1381
更新日期:2007-08-01 00:00:00
abstract::We are reporting a previously well 5-year-old child with varicella-zoster meningitis who had a history of a previous immunization against varicella. This child also developed a transient sensorineural hearing loss. The child was treated with acyclovir and made a full recovery. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.114.2.e273
更新日期:2004-08-01 00:00:00
abstract:OBJECTIVE:Newborn infants are vitamin K deficient. Vitamin K status in full-term infants after intramuscular vitamin K supplementation at birth has been described. Similar information in growing premature infants has not been reported. The objective of this study was to assess vitamin K status in premature infants by m...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.5.1117
更新日期:2001-11-01 00:00:00
abstract:OBJECTIVE:The purpose of this controlled study was to provide a description of children's postoperative pain, including pain intensity and analgesic consumption. METHODS:Participants included 261 children, 2 to 12 years of age, undergoing routine tonsillectomy and adenoidectomy surgery. Baseline and demographic data w...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-3529
更新日期:2009-10-01 00:00:00
abstract:OBJECTIVE:This study examined the factors that affect children's receipt of recommended well-child and dental visits using nationally representative data. METHODS:We analyzed the Child Public Use File of the 1999 National Survey of America's Families, including 35 938 children who were younger than 18 years. Bivariate...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.110.6.e73
更新日期:2002-12-01 00:00:00
abstract:OBJECTIVES:Pain in children with cerebral palsy (CP) is underrecognized, undertreated, and negatively affects quality of life. Communication challenges and multiple pain etiologies complicate diagnosis and treatment. The primary objectives of this study were to determine the impact of pain on activities and to identify...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0224
更新日期:2013-08-01 00:00:00
abstract:OBJECTIVE:To examine the effect of experimental changes in children's sleep duration on self-reported food intake, food reinforcement, appetite-regulating hormones, and measured weight. METHODS:Using a within-subjects, counterbalanced, crossover design, 37 children, 8 to 11 years of age (27% overweight/obese) complete...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2013-1274
更新日期:2013-12-01 00:00:00
abstract::Cases of ophthalmia neonatorum diagnosed at Grady Memorial Hospital 1967-1973 were reviewed. Of 302 cases 43 could be diagnosed as gonococcal, 86 chlamydial, 3 gonococcal and chlamydial, 31 staphylococcal, and 5 chemical. Silver nitrate prophylaxis was routinely employed. Gonococcal cases peaked during the third quart...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-06-01 00:00:00
abstract:OBJECTIVE:To improve the frequency of electronic prescribing (e-prescribing) of discharge prescriptions at a children's hospital via a bundle of quality improvement interventions. METHODS:Surveys and focus groups were conducted with patient families and pediatric residents to identify barriers and propose solutions to...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0760
更新日期:2016-11-01 00:00:00
abstract:OBJECTIVE:We compared the development of adverse neurodevelopmental outcomes at corrected ages of 18 to 22 months for extremely low birth weight infants exposed prenatally to dexamethasone, betamethasone, or no steroid. METHODS:Study infants were extremely low birth weight (401-1000 g) infants who were in the care of ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1103
更新日期:2008-02-01 00:00:00
abstract:CONTEXT:Child and adolescent bicycling is beneficial, but injuries occur and can be severe and costly. OBJECTIVE:To systematically review the individual and environmental factors associated with bicycling injury risk in children and adolescents. DATA SOURCES:Fourteen electronic databases were searched. STUDY SELECTI...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-0282
更新日期:2016-11-01 00:00:00
abstract:CONTEXT:The optimal oxygen saturation target for extremely preterm infants remains unclear. OBJECTIVE:To systematically review evidence evaluating the effect of lower (85%-89%) versus higher (91%-95%) pulse oxygen saturation (Spo2) target on mortality and neurodevelopmental impairment (NDI) at 18 to 24 months. DATA S...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-1609
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:To estimate the prevalence of elevated blood lead levels in children receiving well-care checkups; and to evaluate the effectiveness of certain key risk factors in detecting children at higher risk for elevated blood lead levels. DESIGN:Cross-sectional study. SETTING:Two facilities of the Kaiser Permanente...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:
更新日期:1996-01-01 00:00:00
abstract:OBJECTIVE:This study examines the development of television (TV) behaviors across the first 18 months of life and identifies maternal and infant predictors of infant TV exposure. METHODS:We used longitudinal TV exposure, maternal sociodemographic, and infant temperament data from 217 African-American mother-infant pai...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1224
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:To determine appropriate upper limits for gestational age and birth weight when screening infants for retinopathy of prematurity (ROP). DESIGN:Retrospective survey. SETTING:Tertiary neonatal intensive care nursery. PATIENTS:Seven hundred seven infants born July 1, 1990 to June 30, 1996 and screened for ROP...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.1.31
更新日期:1998-07-01 00:00:00
abstract::Several recommendations in the American Academy of Pediatrics policy statement "The Pediatrician's Role in Community Pediatrics" underscore the essential role of research as an agent of change to promote the health and well-being of children. This article provides (1) a framework for thinking about research in communi...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2825T
更新日期:2005-04-01 00:00:00
abstract::Two different tetravalent polysaccharide vaccines against group A, C, Y, and W135 meningococci were given to 118 infants aged 6 to 23 months; the same vaccines were administered in a second dose 12 months later to those infants aged 6 to 11 months at first vaccination. Forty of the infants received vaccine containing ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1985-07-01 00:00:00
abstract::Children's well-being has become the focal consideration in legal and public policy debates regarding same-sex marriage. In this article, we critically examine and rebut the central moral argument made by opponents of same-sex marriage: that the state should not license any domestic arrangement other than "traditional...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2012-2665
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:Bronchiolitis is a major cause of infant morbidity and contributes to millions of dollars in health care costs. Care guidelines may cut costs by reducing unnecessary resource utilization. Through the implementation of a guideline, we sought to reduce unnecessary resource utilization and improve the value of c...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-1991
更新日期:2014-01-01 00:00:00
abstract::Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history." They argued that "not all SIDS victims were normal," and referred to their hypothesis that SIDS results from...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.110.5.e64
更新日期:2002-11-01 00:00:00
abstract::There is general agreement that case management should be provided to children with chronic illnesses, yet it is not clear who should provide this service. A survey of physicians and parents of children with chronic illnesses was conducted to evaluate the practice and views of pediatricians and compare their assessmen...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-09-01 00:00:00
abstract:OBJECTIVE:Methylxanthines are among the most commonly prescribed drugs in neonatal intensive care. This study evaluates the effect of caffeine on oxygen consumption and metabolic rate in premature infants with idiopathic apnea. METHODS:Eighteen preterm infants at gestational ages from 28 to 33 weeks and birth weights ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.4.660
更新日期:2001-04-01 00:00:00
abstract::The Accreditation Council for Graduate Medical Education (ACGME) established guidelines in 1989 requiring pediatric residents to attend a continuity clinic (CC) one half-day per week. OBJECTIVE. To assess pediatric residents' CCs, with an emphasis on those factors potentially affecting house staff education and patien...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-10-01 00:00:00
abstract::Sixty-one patients with chronic sinusitis who were referred for an allergy evaluation were evaluated for immunologic competence including assessment of quantitative serum immunoglobulin levels, IgG subclass levels, and response to pneumococcal and Haemophilus influenzae vaccines. In addition to chronic sinus disease, ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-03-01 00:00:00
abstract:OBJECTIVE:Adolescence is an important period of risk for the development of lifelong smoking behaviors. Compelling, although inconsistent, evidence suggests a relationship between parental smoking and the risk of smoking initiation during adolescence. This study investigates unresolved issues concerning the strength an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2251
更新日期:2009-02-01 00:00:00
abstract::A recent population-based study in the Canadian province of British Columbia showed that, since the mid-1960s, there has been a significant increase in the incidence of retinopathy of prematurity-induced blindness in infants weighing 750 to 999 g at birth. To determine the impact of changing birth weight-specific surv...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1990-09-01 00:00:00
abstract:OBJECTIVE:Data from acute studies of atomoxetine in patients with attention-deficit/hyperactivity disorder suggest that a dose of approximately 1.2 mg/kg per day is required to attain a maximal symptom response. However, lower doses could be effective during maintenance treatment, which would reduce drug exposure and p...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2005-2999
更新日期:2006-12-01 00:00:00
abstract::Developmental dysplasia of the hip (DDH) encompasses a wide spectrum of clinical severity, from mild developmental abnormalities to frank dislocation. Clinical hip instability occurs in 1% to 2% of full-term infants, and up to 15% have hip instability or hip immaturity detectable by imaging studies. Hip dysplasia is t...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-3107
更新日期:2016-12-01 00:00:00
abstract:BACKGROUND:Little is known about duration of protection after the infant primary series of hepatitis B (HB) vaccine in settings of low HB endemicity. This study sought to determine the proportion of adolescents immunized as infants who had protective titers of antibody to hepatitis B surface antigen (anti-HBs) before a...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2013-2940
更新日期:2014-06-01 00:00:00