Immunologic defects in patients with refractory sinusitis.

Abstract:

:Sixty-one patients with chronic sinusitis who were referred for an allergy evaluation were evaluated for immunologic competence including assessment of quantitative serum immunoglobulin levels, IgG subclass levels, and response to pneumococcal and Haemophilus influenzae vaccines. In addition to chronic sinus disease, recurrent otitis media and asthma exacerbation were common problems in this group. Five patients had an elevated age-adjusted IgE level and 22 patients had positive prick tests to one or more environmental inhalants; these findings suggest an allergic component in this subgroup. Twelve additional patients had highly reactive intradermal tests to common environmental allergens, which also may be clinically significant for underlying atopy. Eleven patients had low immunoglobulin levels, 6 had low immunoglobulin levels and vaccine hyporesponsiveness, and 17 had poor vaccine response only. Thus, 34 of 61 patients with refractory sinusitis had abnormal results on immune studies, with depressed IgG3 levels and poor response to pneumococcal antigen 7 being most common. In addition to allergy, immunologic incompetence may be an important etiologic factor in patients with chronic, refractory sinusitis.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Shapiro GG,Virant FS,Furukawa CT,Pierson WE,Bierman CW

subject

Has Abstract

pub_date

1991-03-01 00:00:00

pages

311-6

issue

3

eissn

0031-4005

issn

1098-4275

journal_volume

87

pub_type

杂志文章
  • Clinical aspects of gastrointestinal food allergy in childhood.

    abstract::Gastrointestinal food allergies are a spectrum of disorders that result from adverse immune responses to dietary antigens. The named disorders include immediate gastrointestinal hypersensitivity (anaphylaxis), oral allergy syndrome, allergic eosinophilic esophagitis, gastritis, and gastroenterocolitis; dietary protein...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Sicherer SH

    更新日期:2003-06-01 00:00:00

  • Serum transaminase levels in boys with Duchenne and Becker muscular dystrophy.

    abstract:OBJECTIVE:Serum alanine transaminase (ALT) and aspartate transaminase (AST) levels are commonly used as biochemical indicators of hepatocellular injury but can also detect occult muscle disease. High concomitant serum creatine phosphokinase (CPK) levels can point to muscle as the source of high transaminase levels. Nev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0929

    authors: McMillan HJ,Gregas M,Darras BT,Kang PB

    更新日期:2011-01-01 00:00:00

  • Ethical Implications for Providers Regarding Cannabis Use in Children With Autism Spectrum Disorders.

    abstract::Children with autism spectrum disorder (ASD) are at risk for self-injurious behaviors that can be difficult to treat in the context of co-occurring low IQ and adaptive skills. Increased prevalence and decriminalization of cannabis in some states have led to more frequent questions for pediatricians about the use of ca...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-0558

    authors: Duvall SW,Lindly O,Zuckerman K,Msall ME,Weddle M

    更新日期:2019-02-01 00:00:00

  • Skin lesions in association with beta-hemolytic Streptococcus group B.

    abstract::A full-term male infant delivered by caesarean section following a prolonged rupture of the amniotic membranes of 30 hours' duration manifested peculiar skin lesions at the time of birth consistent with the healing phase of bullous impetigo. He was colonized with beta-hemolytic Streptococcus group B that was also cult...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lopez JB,Gross P,Boggs TR

    更新日期:1976-12-01 00:00:00

  • Chronic Pain Assessment Tools for Cerebral Palsy: A Systematic Review.

    abstract:BACKGROUND AND OBJECTIVE:Chronic pain in children with cerebral palsy (CP) is underrecognized, leading to detriments in their physical, social, and mental well-being. Our objective was to identify, describe, and critique pediatric chronic pain assessment tools and make recommendations for clinical use for children with...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-0273

    authors: Kingsnorth S,Orava T,Provvidenza C,Adler E,Ami N,Gresley-Jones T,Mankad D,Slonim N,Fay L,Joachimides N,Hoffman A,Hung R,Fehlings D

    更新日期:2015-10-01 00:00:00

  • Impact of prenatal chlorpyrifos exposure on neurodevelopment in the first 3 years of life among inner-city children.

    abstract:OBJECTIVE:The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children. METHODS:As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal expo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0338

    authors: Rauh VA,Garfinkel R,Perera FP,Andrews HF,Hoepner L,Barr DB,Whitehead R,Tang D,Whyatt RW

    更新日期:2006-12-01 00:00:00

  • Quality-of-life concerns differ among patients, parents, and medical providers in children and adolescents with congenital and acquired heart disease.

    abstract:OBJECTIVES:Mortality rates in pediatric patients with heart disease have decreased dramatically in recent decades, resulting in an increasing number of survivors with morbidities that impact quality of life. The purpose of this study was to assess and compare how heart disease affects the quality of life of the pediatr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2572

    authors: Marino BS,Tomlinson RS,Drotar D,Claybon ES,Aguirre A,Ittenbach R,Welkom JS,Helfaer MA,Wernovsky G,Shea JA

    更新日期:2009-04-01 00:00:00

  • Rape prevention through empowerment of adolescent girls.

    abstract:BACKGROUND AND OBJECTIVE:Sexual assault is a major cause of injury, unplanned pregnancy, HIV infection, and mental health problems worldwide. In parts of sub-Saharan Africa, sexual assault has reached epidemic proportions. This study evaluated the efficacy of an empowerment and self-defense intervention for adolescent ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2013-3414

    authors: Sarnquist C,Omondi B,Sinclair J,Gitau C,Paiva L,Mulinge M,Cornfield DN,Maldonado Y

    更新日期:2014-05-01 00:00:00

  • FDA's pediatric device consortia: national program fosters pediatric medical device development.

    abstract:OBJECTIVES:This article reports on the progress made in addressing pediatric medical device needs through the establishment of the Pediatric Device Consortia Grant Program. Pediatric practitioners should be aware of both the imperative for well-studied devices for children and the existence of recently created resource...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1534

    authors: Ulrich LC,Joseph FD,Lewis DY,Koenig RL

    更新日期:2013-05-01 00:00:00

  • In situ hybridization detection of human herpesvirus 6 in brain tissue from fatal encephalitis.

    abstract::A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.2.431

    authors: Ahtiluoto S,Mannonen L,Paetau A,Vaheri A,Koskiniemi M,Rautiainen P,Muttilainen M

    更新日期:2000-02-01 00:00:00

  • Toxic hydroperoxides in intravenous lipid emulsions used in preterm infants.

    abstract::The unsaturated fatty acids that make up a large component of the lipid emulsion Intralipid are highly susceptible to peroxidation, and the products of this reaction could explain the toxicity that has been associated with the administration of some emulsions. Lipid peroxidation produces hydroperoxides, which can alte...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Helbock HJ,Motchnik PA,Ames BN

    更新日期:1993-01-01 00:00:00

  • Previsit Screening for Parental Vaccine Hesitancy: A Cluster Randomized Trial.

    abstract:OBJECTIVE:To evaluate the effect of vaccine hesitancy screening on childhood vaccine uptake. METHODS:We conducted a cluster randomized controlled trial in pediatric primary care clinics in Washington state. Vaccine-hesitant parents (VHPs) with a healthy newborn receiving health supervision at participating clinics wer...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2019-0802

    authors: Opel DJ,Henrikson N,Lepere K,Hawkes R,Zhou C,Dunn J,Taylor JA

    更新日期:2019-11-01 00:00:00

  • Q-oTc interval and blood calcium levels in newborn infants.

    abstract::The interval from the beginning of the Q wave to the origin of the T wave (Q-oTc interval) and total and ionized serum calcium levels were measured in 27 full-term and 77 premature infants. The correlation between Q-oTc and total and ionized calcium levels was significant in both full-term and normal premature infants...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Giacoia GP,Wagner HR

    更新日期:1978-06-01 00:00:00

  • Clinical report--guidelines for the ethical conduct of studies to evaluate drugs in pediatric populations.

    abstract::The proper ethical conduct of studies to evaluate drugs in children is of paramount importance to all those involved in these types of studies. This report is an updated revision to the previously published guidelines from the American Academy of Pediatrics in 1995. Since the previous publication, there have been grea...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0082

    authors: Shaddy RE,Denne SC,Committee on Drugs and Committee on Pediatric Research.

    更新日期:2010-04-01 00:00:00

  • Technology Use for Adolescent Health and Wellness.

    abstract::As avid users of technology, adolescents are a key demographic to engage when designing and developing technology applications for health. There are multiple opportunities for improving adolescent health, from promoting preventive behaviors to providing guidance for adolescents with chronic illness in supporting treat...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2019-2056G

    authors: Radovic A,Badawy SM

    更新日期:2020-05-01 00:00:00

  • The associations of suicide attempts in adolescents.

    abstract:OBJECTIVE:Suicide completion has increased in the United States among 15- to 24-year-olds from 4.5 per 100 000 (1950) to 13.2 per 100 000 (1990). Suicide attempts have been found to be associated with depression, substance use, overall number of life stressors, gender, and impulsive behaviors. We hypothesized that suic...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.6.791

    authors: Woods ER,Lin YG,Middleman A,Beckford P,Chase L,DuRant RH

    更新日期:1997-06-01 00:00:00

  • Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children.

    abstract:OBJECTIVES:Development of asthma in children is influenced by interactions between genetic and environmental factors. It is unclear whether paternal or maternal histories of disease confer different risks. Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3742

    authors: Bjerg A,Hedman L,Perzanowski MS,Platts-Mills T,Lundbäck B,Rönmark E

    更新日期:2007-10-01 00:00:00

  • Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns.

    abstract:BACKGROUND AND OBJECTIVES:Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0796

    authors: Terrin G,Passariello A,De Curtis M,Manguso F,Salvia G,Lega L,Messina F,Paludetto R,Canani RB

    更新日期:2012-01-01 00:00:00

  • Eosinophilic cystitis in a 4-year-old boy: successful long-term treatment with cyclosporin A.

    abstract::A 4-year-old Jewish boy presented with dysuria, urinary dribbling, increased urinary frequency, and new onset of diurnal enuresis. An infiltrating solid mass involving the entire bladder wall was found. Biopsy revealed "tumor-forming" eosinophilic cystitis, a rare bladder lesion of unclear cause. Antitoxocariasis trea...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.6.e113

    authors: Pomeranz A,Eliakim A,Uziel Y,Gottesman G,Rathaus V,Zehavi T,Wolach B

    更新日期:2001-12-01 00:00:00

  • Randomized trial of a hearing conservation intervention for rural students: long-term outcomes.

    abstract:OBJECTIVES:We had the rare opportunity to conduct a cluster-randomized controlled trial to observe the long-term (16-year) effects of a well-designed hearing conservation intervention for rural high school students. This trial assessed whether the intervention resulted in (1) reduced prevalence of noise-induced hearing...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-0770

    authors: Marlenga B,Linneman JG,Pickett W,Wood DJ,Kirkhorn SR,Broste SK,Knobloch MJ,Berg RL

    更新日期:2011-11-01 00:00:00

  • Association between diabetes control and visits to a multidisciplinary pediatric diabetes clinic.

    abstract:OBJECTIVE:To determine if there is a relationship between diabetes outcome as measured by HbA1C and the number of multidisciplinary clinic visits per year in children and youth with diabetes. RESEARCH DESIGN AND METHODS:The number of clinic visits per year, the mean HbA1C (by DCA 2000, Miles, Tarrytown, NY), type of i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.5.948

    authors: Kaufman FR,Halvorson M,Carpenter S

    更新日期:1999-05-01 00:00:00

  • Coarctation of the abdominal aorta and renal artery stenosis related to an umbilical artery catheter placement in a neonate.

    abstract::Umbilical artery catheters have been associated with thrombotic complications, such as partial or complete occlusion in the aorta, the renal arteries, and other blood vessels. There have been few reports of the long-term consequences of either symptomatic or asymptomatic thrombi. We report a patient, now 22 years of a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.e36

    authors: Adelman RD,Morrell RE

    更新日期:2000-09-01 00:00:00

  • US National Longitudinal Lesbian Family Study: psychological adjustment of 17-year-old adolescents.

    abstract:OBJECTIVES:The objective of this study was to document the psychological adjustment of adolescents who were conceived through donor insemination by lesbian mothers who enrolled before these offspring were born in the largest, longest running, prospective, longitudinal study of same-sex-parented families. METHODS:Betwe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3153

    authors: Gartrell N,Bos H

    更新日期:2010-07-01 00:00:00

  • Identifying the Misshapen Head: Craniosynostosis and Related Disorders.

    abstract::Pediatric care providers, pediatricians, pediatric subspecialty physicians, and other health care providers should be able to recognize children with abnormal head shapes that occur as a result of both synostotic and deformational processes. The purpose of this clinical report is to review the characteristic head shap...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-015511

    authors: Dias MS,Samson T,Rizk EB,Governale LS,Richtsmeier JT,SECTION ON NEUROLOGIC SURGERY, SECTION ON PLASTIC AND RECONSTRUCTIVE SURGERY.

    更新日期:2020-09-01 00:00:00

  • Timing of adiposity rebound and adiposity in adolescence.

    abstract:OBJECTIVES:To investigate associations between timing of adiposity rebound (AR; the period in childhood where BMI begins to increase from its nadir) and adiposity (BMI, fat mass) at age 15 years in the Avon Longitudinal Study of Parents and Children (ALSPAC). METHODS:The sample consisted of 546 children with AR derive...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2014-1908

    authors: Hughes AR,Sherriff A,Ness AR,Reilly JJ

    更新日期:2014-11-01 00:00:00

  • Telemedicine for evaluation of retinopathy of prematurity.

    abstract::Retinopathy of prematurity (ROP) remains a significant threat to vision for extremely premature infants despite the availability of therapeutic modalities capable, in most cases, of managing this disorder. It has been shown in many controlled trials that application of therapies at the appropriate time is essential to...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-0978

    authors: Fierson WM,Capone A Jr,American Academy of Pediatrics Section on Ophthalmology.,American Academy of Ophthalmology, American Association of Certified Orthoptists.

    更新日期:2015-01-01 00:00:00

  • Violaceous discoloration in pneumococcal cellulitis.

    abstract::Two patients with periobital cellulitis, one of whom also had buccal cellulitis, had violaceous discoloration of the skin. Blood cultures from both patients yielded Streptococcus pneumoniae. Therefore, pneumococci should be considered, in addition to Haemophilus influenzae, as possible causes of cellulitis with violac...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Thirumoorthi MC,Asmar BI,Dajani AS

    更新日期:1978-10-01 00:00:00

  • Socioeconomic outcomes in adults malnourished in the first year of life: a 40-year study.

    abstract:OBJECTIVE:Lifelong functional, adaptive, and economic outcomes of moderate to severe infantile malnutrition are not well known. We assessed social status and income at midlife in a cohort of Barbadian adults, hospitalized for protein-energy malnutrition (PEM) during the first year of life, with good nutrition and healt...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0073

    authors: Galler JR,Bryce C,Waber DP,Zichlin ML,Fitzmaurice GM,Eaglesfield D

    更新日期:2012-07-01 00:00:00

  • Stable prevalence but changing risk factors for sudden infant death syndrome in child care settings in 2001.

    abstract:OBJECTIVE:A total of 20% of sudden infant death syndrome (SIDS) cases in the 1990s occurred in child care settings. This is much higher than the 8% expected from Census Bureau data. Factors that were associated with child care SIDS included older age; white race; older, more educated mothers; and unaccustomed prone pos...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0924

    authors: Moon RY,Sprague BM,Patel KM

    更新日期:2005-10-01 00:00:00

  • Quality of life for children with functional abdominal pain: a comparison study of patients' and parents' perceptions.

    abstract:OBJECTIVE:Children with chronic abdominal pain of nonorganic origin, termed functional abdominal pain (FAP), experience school absences and social withdrawal and report impaired physical ability. The aim of this study was to assess patients' and parents' perceptions of health-related quality of life (QoL) for children ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0114

    authors: Youssef NN,Murphy TG,Langseder AL,Rosh JR

    更新日期:2006-01-01 00:00:00