Abstract:
:A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Ahtiluoto S,Mannonen L,Paetau A,Vaheri A,Koskiniemi M,Rautiainen P,Muttilainen Mdoi
10.1542/peds.105.2.431subject
Has Abstractpub_date
2000-02-01 00:00:00pages
431-3issue
2eissn
0031-4005issn
1098-4275journal_volume
105pub_type
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