In situ hybridization detection of human herpesvirus 6 in brain tissue from fatal encephalitis.

Abstract:

:A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase chain reaction for HHV-6 of serum and paraffin-embedded pontine tissue was positive, and serology indicated an acute primary infection. This is the first case showing HHV-6 DNA in the brain cells of an immunocompetent patient with acute encephalitis.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Ahtiluoto S,Mannonen L,Paetau A,Vaheri A,Koskiniemi M,Rautiainen P,Muttilainen M

doi

10.1542/peds.105.2.431

subject

Has Abstract

pub_date

2000-02-01 00:00:00

pages

431-3

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

105

pub_type

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