Abstract:
OBJECTIVE:Propranolol hydrochloride is a safe and effective medication for treating infantile hemangiomas (IHs), with decreases in IH volume, color, and elevation. METHODS:Forty children between the ages of 9 weeks and 5 years with facial IHs or IHs in sites with the potential for disfigurement were randomly assigned to receive propranolol or placebo oral solution 2 mg/kg per day divided 3 times daily for 6 months. Baseline electrocardiogram, echocardiogram, and laboratory evaluations were performed. Monitoring of heart rate, blood pressure, and blood glucose was performed at each visit. Children younger than 6 months were admitted to the hospital for monitoring after their first dose at weeks 1 and 2. Efficacy was assessed by performing blinded volume measurements at weeks 0, 4, 8, 12, 16, 20, and 24 and blinded investigator scoring of photographs at weeks 0, 12, and 24. RESULTS:IH growth stopped by week 4 in the propranolol group. Significant differences in the percent change in volume were seen between groups, with the largest difference at week 12. Significant decrease in IH redness and elevation occurred in the propranolol group at weeks 12 and 24 (P = .01 and .001, respectively). No significant hypoglycemia, hypotension, or bradycardia occurred. One child discontinued the study because of an upper respiratory tract infection. Other adverse events included bronchiolitis, gastroenteritis, streptococcal infection, cool extremities, dental caries, and sleep disturbance. CONCLUSION:Propranolol hydrochloride administered orally at 2 mg/kg per day reduced the volume, color, and elevation of focal and segmental IH in infants younger than 6 months and children up to 5 years of age.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Hogeling M,Adams S,Wargon Odoi
10.1542/peds.2010-0029subject
Has Abstractpub_date
2011-08-01 00:00:00pages
e259-66issue
2eissn
0031-4005issn
1098-4275pii
peds.2010-0029journal_volume
128pub_type
杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract::The return of information from genomic sequencing in children, especially in early life, brings up complex issues around parental autonomy, the child's future autonomy, the best interest standard, and the best interests of the family. These issues are particularly important in considering the return of genomic results...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-1099H
更新日期:2019-01-01 00:00:00
abstract::Human breast milk samples were collected from lactating mothers, and aliquots were maintained at room temperature, frozen, and pasteurized. Samples were inoculated with 10 to 50 colony-forming units per milliliter (cfu/ml) of Escherichia coli or group B streptococcus, and incubated at 37 C. Quantitative growth was mea...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-04-01 00:00:00
abstract:OBJECTIVE:To ascertain the prevalence of and risk factors for obstructive sleep apnea syndrome (OSAS) in children with sickle cell anemia (SCA). METHODS:Cross-sectional baseline data were analyzed from the Sleep and Asthma Cohort Study, a multicenter prospective study designed to evaluate the contribution of sleep and...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-4223
更新日期:2014-08-01 00:00:00
abstract:OBJECTIVE:To standardize the use of phototherapy consistent with the American Academy of Pediatrics clinical practice guideline for the management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation. METHODS:Relevant literature was reviewed. Phototherapy devices currently marketed in the United S...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2011-1494
更新日期:2011-10-01 00:00:00
abstract:OBJECTIVE:The first rotavirus vaccine that was licensed in the United States, RotaShield, could have prevented the enormous burden of rotavirus diarrhea in American children but left instead the unfortunate legacy that live oral rotavirus vaccines may be associated with a serious but rare adverse event: intussusception...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-2874
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:Despite the magnitude of the problem of catheter-associated bloodstream infections (CA-BSIs) in children, relatively little research has been performed to identify effective strategies to reduce these complications. In this study, we aimed to develop and evaluate effective catheter-care practices to reduce pe...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2009-1382
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:To assess the physiologic response to salt depletion in subjects with cystic fibrosis (CF) and control male adolescents for sodium balance, sodium space, and stimulation of the renin-angiotensin-aldosterone axis. DESIGN:Seven subjects with CF and six controls received a salt-replete (150 or 290 mmol NaCl per...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.101.1.48
更新日期:1998-01-01 00:00:00
abstract:OBJECTIVE:Infants with chronic lung disease (CLD) have an arrest of primary and secondary septation. We hypothesized that this may be related to damage or abnormal development of lung collagen secondary to positive pressure ventilation. Our aims were to identify the sites and quantity of collagen in control infants 22 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.4.766
更新日期:2003-04-01 00:00:00
abstract:OBJECTIVE:There have been few studies concerning serum titers of anti-Helicobacter pylori immunoglobulin G (IgG) antibody >12 months after eradication of the original infection. Moreover, clinical usefulness of immunoglobulin A (IgA) antibody levels remains to be established. The purpose of this study was to investigat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.104.2.e22
更新日期:1999-08-01 00:00:00
abstract:OBJECTIVE:Dental caries is a common, chronic disease of childhood. The impact of contemporary changes in beverage patterns, specifically decreased milk intakes and increased 100% juice and soda pop intakes, on dental caries in young children is unknown. We describe associations among caries experience and intakes of da...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.3.e184
更新日期:2003-09-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to evaluate the effects on breastfeeding rates of a private-sector early discharge program and a subsequent government mandate guaranteeing 48 hours of hospital coverage. METHODS:Interrupted time-series analyses were conducted on retrospective data from the automated medical rec...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.3.519
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVE:With male gender as a strong predictor of cardiovascular instability, we hypothesized that gender-specific differences in circulating carbon monoxide levels contributed to dysregulated microvascular function in preterm male infants. METHODS:Infants born at 24 to 34 weeks of gestation (N = 84) were studied in...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0877
更新日期:2009-07-01 00:00:00
abstract::Venipuncture and intravenous cannulation are among the most common and widespread medical procedures performed on children today. Therefore, effective treatment of venous access pain can benefit from an integrated systems approach that enlists multiple players in the health care system. By using case studies that anal...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2008-1055i
更新日期:2008-11-01 00:00:00
abstract::Parental requests for gastrostomies, tracheostomies, or assisted ventilation in children with profound disabilities raise ethical concerns about children's interests, parental decision-making, and health care costs. The underlying concern for many relates to the perceived value of these children. Clinicians should mak...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-3608H
更新日期:2014-02-01 00:00:00
abstract::Developmental dysplasia of the hip (DDH) encompasses a wide spectrum of clinical severity, from mild developmental abnormalities to frank dislocation. Clinical hip instability occurs in 1% to 2% of full-term infants, and up to 15% have hip instability or hip immaturity detectable by imaging studies. Hip dysplasia is t...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2016-3107
更新日期:2016-12-01 00:00:00
abstract::Three Laotian refugee children with chronic pulmonary complaints and findings were found to have pulmonary paragonimiasis during a one-year period in Chicago. These patients ranged from 8 to 11 years of age and the diagnosis was delayed five to six months in two children because of the unfamiliarity of American physic...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1982-08-01 00:00:00
abstract::During and after respiratory tract infections in 29 hospitalized infants, 12 cardiorespiratory measurements were performed on 24-hour recordings of ECG and respiratory activity. These measurements were compared with similar data obtained from 110 age-matched control infants without infection. Respiratory and heart rat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1986-07-01 00:00:00
abstract:BACKGROUND:Provision of high-quality care to acutely ill and injured children is a challenge to US hospitals because many have low pediatric volume. Delineating national trends in definitive pediatric acute care would inform improvements in care. METHODS:We analyzed emergency department (ED) visits by children between...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2203
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:Implementation of an asthma clinical practice guideline did not achieve desired chest radiograph (CXR) usage goals. We attempt to use quality improvement methodology to decrease the percentage of CXRs obtained for pediatric patients with acute asthma exacerbations from 29.3% to <20% and to evaluate whether d...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-4003
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVE:Numerous nutrition policy statements recommend the consumption of 800 to 1500 mg of calcium largely from dairy products for osteoporosis prevention; however, the findings of epidemiologic and prospective studies have raised questions about the efficacy of the use of dairy products for the promotion of bone he...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2004-0548
更新日期:2005-03-01 00:00:00
abstract:OBJECTIVE:The frequency of children who are hospitalized with pneumococcal pneumonia complicated by necrosis, empyema/complicated parapneumonic effusion, and lung abscess seems to be increasing. The factors that contribute to this increase are unclear; therefore, the objective of this study was to describe and compare ...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.110.1.1
更新日期:2002-07-01 00:00:00
abstract::The scope of pediatric autonomic disorders is not well recognized. The goal of this review is to increase awareness of the expanding spectrum of pediatric autonomic disorders by providing an overview of the autonomic nervous system, including the roles of its various components and its pervasive influence, as well as ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2005-3032
更新日期:2006-07-01 00:00:00
abstract:OBJECTIVE:Patent ductus arteriosus is a common morbidity associated with preterm birth. The incidence of patent ductus arteriosus increases with decreasing gestational age to approximately 70% in infants born at 25 weeks' gestation. Our major goal was to determine if genetic risk factors play a role in patent ductus ar...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-0313
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVE:Although invasive pneumococcal disease is infrequent in cystic fibrosis (CF), it is recommended that all patients with CF receive pneumococcal immunization. As part of a comprehensive program to immunize our clinic population, we obtained preimmunization anti-pneumococcal antibody levels. We hypothesized that...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.4.e62
更新日期:2001-10-01 00:00:00
abstract:OBJECTIVE:Although adverse health outcomes are increased among children with BMI above the 85th (overweight) and 95th (obese) percentiles, previous studies have not clearly defined the BMI percentile at which adverse health outcomes begin to increase. We examined whether the existing BMI percentile cutoffs are optimal ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0179
更新日期:2009-11-01 00:00:00
abstract::Mechanical vibration encountered in land transports was assessed objectively through measurement of vertical acceleration experienced by neonates in transit. Vibration was most predominant in the hazardous low frequency range of 3 to 18 Hz. The peak acceleration amplitudes (intermittent thrusts) ranged from 5 to 13 m/...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-07-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the risk for separation (ending cohabitation) of the parents of a child with a diagnosis of cancer. METHODS:In a nationwide cohort, we compared the risk for ending cohabitation of the parents of 2450 children (aged 0-20 years) given a diagnosis of cancer with the ri...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-2657
更新日期:2012-05-01 00:00:00
abstract::The relationship among duration and frequency of breast-feeding, age, level of education, and parity on postpartum amenorrhea were investigated retrospectively in selected married Nigerian women attending the two local maternity centers in Ile-Ife, Nigeria, between January and May 1980. The mean values for duration an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1982-02-01 00:00:00
abstract::It is unclear why children of adolescent mothers experience more developmental problems than children of adult mothers. There has been minimal systematic investigation of whether there is a relationship between the young age of the mother and her mothering behaviors. Our data fail to demonstrate any relationship betwe...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-03-01 00:00:00
abstract::On October 25, 2011, the Advisory Committee on Immunization Practices of the Centers for Disease Control and Prevention recommended that the quadrivalent human papillomavirus vaccine (Gardasil; Merck & Co, Inc, Whitehouse Station, NJ) be used routinely in males. The American Academy of Pediatrics has reviewed updated ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-3865
更新日期:2012-03-01 00:00:00