Family history of asthma and atopy: in-depth analyses of the impact on asthma and wheeze in 7- to 8-year-old children.

Abstract:

OBJECTIVES:Development of asthma in children is influenced by interactions between genetic and environmental factors. It is unclear whether paternal or maternal histories of disease confer different risks. Previous population-based studies have not stratified analyses by child gender and sensitization status. Our aim was to study in detail the hereditary component of childhood asthma. METHODS:A population-based cohort of 3430 (97% of invited) 7- to 8-year-old school children participated in an expanded International Study of Asthma and Allergy in Childhood survey, and two thirds were skin-prick tested. Heredity was defined as a family history of (1) asthma and (2) atopy (allergic rhinitis or eczema). Multivariate analyses corrected for known risk factors for asthma. RESULTS:At ages 7 to 8, prevalence of asthma was 5.3% among the children and 9.0% among the parents. In children without parental asthma or parental atopy, the prevalence of asthma was 2.8%. Corrected for parental asthma, parental atopy was a weak but significant risk factor. There were minor differences in the impact of parental disease between sensitized and nonsensitized children and between boys and girls. CONCLUSIONS:As risk factors for childhood asthma, there were major differences between parental asthma and parental atopy. Sibling asthma was only a marker of parental disease. Interactions between parental disease and the child's allergic sensitization or gender were not statistically significant. Asthma in both parents conferred a multiplicative risk, whereas the effect of parental atopy was additive, however limited. Asthma and atopy, despite their causal relationship, are separate entities and could be inherited differently. This large, population-based, and well-characterized cohort study does not confirm parent-of-origin effects found in previous studies.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Bjerg A,Hedman L,Perzanowski MS,Platts-Mills T,Lundbäck B,Rönmark E

doi

10.1542/peds.2006-3742

subject

Has Abstract

pub_date

2007-10-01 00:00:00

pages

741-8

issue

4

eissn

0031-4005

issn

1098-4275

pii

120/4/741

journal_volume

120

pub_type

杂志文章
  • SunSafe in the Middle School Years: a community-wide intervention to change early-adolescent sun protection.

    abstract:OBJECTIVE:Rising rates of skin cancer associated with early-life sun exposure make it important to improve adolescent sun-protection practices. Our study objective was to determine if a multicomponent community-wide intervention could alter the decline in sun protection that begins in early adolescence. METHODS:A rand...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2006-1579

    authors: Olson AL,Gaffney C,Starr P,Gibson JJ,Cole BF,Dietrich AJ

    更新日期:2007-01-01 00:00:00

  • Research ethics in the MySpace era.

    abstract::Social networking web sites are popular among adolescents and may represent a new venue for conducting adolescent health research. Conducting research by using social networking web sites raises several concerns, including the social value of this research, fair subject selection, confidentiality, privacy, and informe...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2007-3015

    authors: Moreno MA,Fost NC,Christakis DA

    更新日期:2008-01-01 00:00:00

  • The Diagnosis of Polycystic Ovary Syndrome in Adolescents.

    abstract::Consensus has recently been reached by international pediatric subspecialty societies that otherwise unexplained persistent hyperandrogenic anovulation using age- and stage-appropriate standards are appropriate diagnostic criteria for polycystic ovary syndrome (PCOS) in adolescents. The purpose of this review is to su...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-1430

    authors: Rosenfield RL

    更新日期:2015-12-01 00:00:00

  • Surfactant replacement therapy for respiratory distress syndrome. American Academy of Pediatrics. Committee on Fetus and Newborn.

    abstract::Respiratory failure secondary to surfactant deficiency is a major cause of morbidity and mortality in low birth weight immature infants. Surfactant therapy substantially reduces mortality and respiratory morbidity for this population. The statement summarizes the indications for surfactant replacement therapy. Because...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:

    authors:

    更新日期:1999-03-01 00:00:00

  • Age Limit of Pediatrics.

    abstract::Pediatrics is a multifaceted specialty that encompasses children's physical, psychosocial, developmental, and mental health. Pediatric care may begin periconceptionally and continues through gestation, infancy, childhood, adolescence, and young adulthood. Although adolescence and young adulthood are recognizable phase...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2151

    authors: Hardin AP,Hackell JM,COMMITTEE ON PRACTICE AND AMBULATORY MEDICINE.

    更新日期:2017-09-01 00:00:00

  • Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol.

    abstract::In summary: (1) Colestipol therapy plus diet reduced total cholesterol 19 +/- 3% in 11 hypercholesterolemic children after two months and 13 +/- 5% after two years in five children. (2) Diet therapy did not significantly reduce serum concentration of any of the fat-soluble vitamins or folate. (3) During 24 months of c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Schwarz KB,Goldstein PD,Witztum JL,Schonfeld G

    更新日期:1980-02-01 00:00:00

  • Birth weight and hearing impairment in norwegians born from 1967 to 1993.

    abstract:OBJECTIVES:To estimate the association between birth weight and hearing impairment among Norwegians born between 1967 and 1993, taking other pregnancy-related conditions into consideration. METHODS:A cohort study was conducted of all Norwegian live births from 1967 to 1993 (n = 1 548 429) linking information of the Me...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.3.e30

    authors: Nafstad P,Samuelsen SO,Irgens LM,Bjerkedal T

    更新日期:2002-09-01 00:00:00

  • Clinical profile of 30 infants with acute pulmonary hemorrhage in Cleveland.

    abstract::Between 1993 and 2000, 30 infants were hospitalized with acute pulmonary hemorrhage at Rainbow Babies and Children's Hospital in Cleveland. Most infants presented with severe pulmonary symptoms requiring intensive support, but a few infants had less severe hemorrhage. Three quarters of the patients required ventilator...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.3.627

    authors: Dearborn DG,Smith PG,Dahms BB,Allan TM,Sorenson WG,Montana E,Etzel RA

    更新日期:2002-09-01 00:00:00

  • Exclusive breastfeeding protects against bacterial colonization and day care exposure to otitis media.

    abstract:OBJECTIVE:We followed a cohort (N = 306) of infants at well-baby visits in two suburban pediatric practices to assess the relation of exclusive breastfeeding, and other environmental exposures, to episodes of acute otitis media (AOM) and otitis media with effusion (OME). METHODS:Detailed prospective information about ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.4.e7

    authors: Duffy LC,Faden H,Wasielewski R,Wolf J,Krystofik D

    更新日期:1997-10-01 00:00:00

  • Death of a child in the emergency department.

    abstract::The death of a child in the emergency department (ED) is one of the most challenging problems facing ED clinicians. This revised technical report and accompanying policy statement reaffirm principles of patient- and family-centered care. Recent literature is examined regarding family presence, termination of resuscita...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.2014-1246

    authors: O'Malley P,Barata I,Snow S,American Academy of Pediatrics Committee on Pediatric Emergency Medicine.,American College of Emergency Physicians Pediatric Emergency Medicine Committee.,Emergency Nurses Association Pediatric Committee.

    更新日期:2014-07-01 00:00:00

  • Physician Communication Training and Parental Vaccine Hesitancy: A Randomized Trial.

    abstract:BACKGROUND AND OBJECTIVES:Physicians have a major influence on parental vaccine decisions. We tested a physician-targeted communication intervention designed to (1) reduce vaccine hesitancy in mothers of infants seen by trained physicians and (2) increase physician confidence in communicating about vaccines. METHODS:W...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2014-3199

    authors: Henrikson NB,Opel DJ,Grothaus L,Nelson J,Scrol A,Dunn J,Faubion T,Roberts M,Marcuse EK,Grossman DC

    更新日期:2015-07-01 00:00:00

  • Does sensitization to contact allergens begin in infancy?

    abstract:OBJECTIVE:Because previous studies have found allergic contact sensitization common in children by 5 years of age, our aim was to determine the prevalence of positive epicutaneous test results in children <5 years of age and to determine whether sensitization to contact allergens was as common in infancy. METHODS:We r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.1.e3

    authors: Bruckner AL,Weston WL,Morelli JG

    更新日期:2000-01-01 00:00:00

  • Missed insulin meal boluses and elevated hemoglobin A1c levels in children receiving insulin pump therapy.

    abstract:OBJECTIVE:To identify possible causes of suboptimal glycemic control (ascertained by hemoglobin A1c [HbA1c] level) in youths using insulin pump therapy. METHODS:Forty-eight youths who were receiving insulin pump therapy for > or =6 months, and who were using insulin pumps and blood glucose meters with data that could ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.3.e221

    authors: Burdick J,Chase HP,Slover RH,Knievel K,Scrimgeour L,Maniatis AK,Klingensmith GJ

    更新日期:2004-03-01 00:00:00

  • Randomized, controlled trial on tracheal colonization of ventilated infants: can gravity prevent ventilator-associated pneumonia?

    abstract:OBJECTIVE:The goal was to test the hypothesis that intubated infants positioned on their sides would be less likely to contract bacterial colonization in their tracheae, compared with those positioned supine. METHODS:We conducted a prospective, randomized, controlled trial with 60 intubated infants; 30 infants were po...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2007-1826

    authors: Aly H,Badawy M,El-Kholy A,Nabil R,Mohamed A

    更新日期:2008-10-01 00:00:00

  • The triple risk hypotheses in sudden infant death syndrome.

    abstract::Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history." They argued that "not all SIDS victims were normal," and referred to their hypothesis that SIDS results from...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.110.5.e64

    authors: Guntheroth WG,Spiers PS

    更新日期:2002-11-01 00:00:00

  • Girls with attention deficit disorder: a silent minority? A report on behavioral and cognitive characteristics.

    abstract::A sample of girls and boys with attention deficit disorder (ADD) were examined for within-group sex differences and compared with control boys and girls on historical, behavioral, and cognitive characteristics. Profiles of essential and secondary features of ADD support the Diagnostic and Statistical Manual of Mental ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Berry CA,Shaywitz SE,Shaywitz BA

    更新日期:1985-11-01 00:00:00

  • Prepubertal female genitalia: examination for evidence of sexual abuse.

    abstract::Experience with more than 375 cases of possible sexual abuse has taught us that much work still needs to be done in understanding normal prepubertal female anatomy and interpreting findings in sexual abuse cases. Because pediatric clinicians are often called upon to assess possible sexual abuse victims, knowledge of w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Herman-Giddens ME,Frothingham TE

    更新日期:1987-08-01 00:00:00

  • Pretransport and posttransport characteristics and outcomes of neonates who were admitted to a cardiac intensive care unit.

    abstract:OBJECTIVE:The objective for this study was to characterize the impact and the safety of transporting neonates with known or suspected cardiac abnormalities. METHODS:We reviewed retrospectively the charts and computerized records of 192 admissions to a cardiac ICU in 2002. Patients were included when they were < 28 day...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0719

    authors: Yeager SB,Horbar JD,Greco KM,Duff J,Thiagarajan RR,Laussen PC

    更新日期:2006-09-01 00:00:00

  • Administration of epinephrine for life-threatening allergic reactions in school settings.

    abstract:OBJECTIVE:Although the potential for life-threatening allergic reactions in children is a significant health concern for schools, there is little information about the circumstances surrounding anaphylactic events that occur in schools. The objectives of this study were to determine the incidence of anaphylaxis in scho...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1475

    authors: McIntyre CL,Sheetz AH,Carroll CR,Young MC

    更新日期:2005-11-01 00:00:00

  • Identification of Extremely Premature Infants at Low Risk for Early-Onset Sepsis.

    abstract:BACKGROUND:Premature infants are at high risk of early-onset sepsis (EOS) relative to term infants, and most are administered empirical antibiotics after birth. We aimed to determine if factors evident at birth could be used to identify premature infants at lower risk of EOS. METHODS:Study infants were born at 22 to 2...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2017-0925

    authors: Puopolo KM,Mukhopadhyay S,Hansen NI,Cotten CM,Stoll BJ,Sanchez PJ,Bell EF,Das A,Hensman AM,Van Meurs KP,Wyckoff MH,NICHD Neonatal Research Network.

    更新日期:2017-11-01 00:00:00

  • Dating violence and associated sexual risk and pregnancy among adolescent girls in the United States.

    abstract:OBJECTIVES:To assess the annual prevalence of physical violence from dating partners among a representative sample of sexually experienced adolescent girls attending US public and private high schools, as well as sexual risk behaviors and pregnancy among this population. DESIGN, SETTING, PARTICIPANTS, AND MEASURES:Fem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.2.e220

    authors: Silverman JG,Raj A,Clements K

    更新日期:2004-08-01 00:00:00

  • Prevalence of retinal hemorrhages and child abuse in children who present with an apparent life-threatening event.

    abstract:OBJECTIVE:Child abuse (CA) can present with a spectrum of signs and symptoms. Apparent life-threatening events (ALTEs) may be a subtle presentation of CA. Retinal hemorrhages (RHs) are a well-described finding in some patients with CA. We hypothesized that screening children who present with a chief complaint of an ALT...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.3.557

    authors: Pitetti RD,Maffei F,Chang K,Hickey R,Berger R,Pierce MC

    更新日期:2002-09-01 00:00:00

  • Early-Onset Sepsis Risk Calculator Integration Into an Electronic Health Record in the Nursery.

    abstract:BACKGROUND AND OBJECTIVES:An early-onset sepsis (EOS) risk calculator tool to guide evaluation and treatment of infants at risk for sepsis has reduced antibiotic use without increased adverse outcomes. We performed an electronic health record (EHR)-driven quality improvement intervention to increase calculator use for ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-3464

    authors: Stipelman CH,Smith ER,Diaz-Ochu M,Spackman J,Stoddard G,Kawamoto K,Shakib JH

    更新日期:2019-08-01 00:00:00

  • Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

    abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0196

    authors: Dalziel SR,Liang A,Parag V,Rodgers A,Harding JE

    更新日期:2004-09-01 00:00:00

  • Evaluation and treatment of jaundice in the term newborn: a kinder, gentler approach.

    abstract::Standard recommendations for evaluating and treating jaundice in term babies include following all babies closely for jaundice, obtaining several laboratory tests in those with early jaundice or bilirubin levels more than 12 to 13 mg/dL (205 to 222 mumol/L), using phototherapy to try to keep bilirubin levels below 20 ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Newman TB,Maisels MJ

    更新日期:1992-05-01 00:00:00

  • Hospitalizations of newborns with folate-sensitive birth defects before and after fortification of foods with folic acid.

    abstract:CONTEXT:The prevalence of neural tube defects is reduced in populations of women who receive folic acid supplementation. Since 1998, grain products in the United States have been fortified with folic acid. Fortification may have additional benefits by reducing the national prevalence of newborn hospitalizations for oth...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2784

    authors: Robbins JM,Tilford JM,Bird TM,Cleves MA,Reading JA,Hobbs CA

    更新日期:2006-09-01 00:00:00

  • Observations on a recent increase in plagiocephaly without synostosis.

    abstract:OBJECTIVE:To verify and determine the cause of an increase in the referral of infants with plagiocephaly without synostosis (PWS) to a single tertiary craniofacial center. DESIGN:A chart review was performed for 269 infants with a diagnosis of PWS who presented to a single tertiary craniofacial center between 1979 and...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kane AA,Mitchell LE,Craven KP,Marsh JL

    更新日期:1996-06-01 00:00:00

  • Prospective randomized double-blind study comparing L-epinephrine and racemic epinephrine aerosols in the treatment of laryngotracheitis (croup).

    abstract::Aerosolized racemic epinephrine, but not L-epinephrine, is commonly used in treating croup. The efficacy and adverse effects of nebulized racemic and L-epinephrine in the treatment of laryngotracheitis were compared. Children 6 months to 6 years of age with a croup score of 6 or above were assigned in a randomized dou...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Waisman Y,Klein BL,Boenning DA,Young GM,Chamberlain JM,O'Donnell R,Ochsenschlager DW

    更新日期:1992-02-01 00:00:00

  • Dietary Fats and Atherosclerosis From Childhood to Adulthood.

    abstract:BACKGROUND:The association of dietary fat distribution with markers of subclinical atherosclerosis during early life is unknown. We examined whether success in achieving the main target of an infancy-onset dietary intervention based on the distribution of dietary fat was associated with aortic and carotid intima-media ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2019-2786

    authors: Laitinen TT,Nuotio J,Rovio SP,Niinikoski H,Juonala M,Magnussen CG,Jokinen E,Lagström H,Jula A,Viikari JSA,Rönnemaa T,Simell O,Raitakari OT,Pahkala K

    更新日期:2020-04-01 00:00:00

  • Treatment of congenital generalized lymphangiectasia with propranolol in a preterm infant.

    abstract::Generalized lymphangiectasia is a rare congenital disorder characterized by dilated lymphatic vessels with a fatal prognosis, especially in cases with thoracic involvement. We describe the use of propranolol in the therapy of generalized lymphangiectasia in a preterm infant with hydrops fetalis. Propranolol was well t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2087

    authors: Poralla C,Specht S,Born M,Müller A,Bartmann P,Müller A

    更新日期:2014-02-01 00:00:00