Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol.

Abstract:

:In summary: (1) Colestipol therapy plus diet reduced total cholesterol 19 +/- 3% in 11 hypercholesterolemic children after two months and 13 +/- 5% after two years in five children. (2) Diet therapy did not significantly reduce serum concentration of any of the fat-soluble vitamins or folate. (3) During 24 months of colestipol therapy plus diet serum vitamin A and E concentrations did decrease in the five patients with good drug adherence (vitamin A, 68 +/- 11 vs 35 +/- 4 microgram/100 ml, P less than .005) (vitamin E, 14 +/- 1 vs 11 +/- 1 microgram/ml, P less than .05). However, those concentrations remained within normal limits. (4) Colestipol therapy plus diet had no effect on prothrombin time, serum 25-hydroxycholecalciferol, folate, or calcium metabolism (as studied by sequential determination of serum total and ionized calcium phosphorus, alkaline phosphatase, and parathyroid hormone).

journal_name

Pediatrics

journal_title

Pediatrics

authors

Schwarz KB,Goldstein PD,Witztum JL,Schonfeld G

subject

Has Abstract

pub_date

1980-02-01 00:00:00

pages

243-50

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

65

pub_type

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