Erratic absorption of a slow-release theophylline sprinkle product.

Abstract:

:The bioavailability and absorption pattern of theophylline from a slow-release theophylline sprinkle preparation were investigated in 12 asthmatic children both in fasting conditions and after a standardized meal. Theophylline given intravenously was used as a reference. Theophylline from the slow-release theophylline product was well absorbed under fasting conditions, but both absorption pattern and bioavailability were severely affected by concomitant food intake: a delay in absorption was found and the bioavailability was reduced from 91% (fasting) to 44% (P less than .001). The erratic absorption of theophylline after food intake complicates safe therapy with the preparation and calls attention to the fact that it is not sufficient to investigate the absorption characteristics of slow-release theophylline preparations under fasting conditions only.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Pedersen S,Møller-Petersen J

subject

Has Abstract

pub_date

1984-10-01 00:00:00

pages

534-8

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

74

pub_type

临床试验,杂志文章,随机对照试验
  • Delayed recognition of human immunodeficiency virus infection in preadolescent children.

    abstract::Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Persaud D,Chandwani S,Rigaud M,Leibovitz E,Kaul A,Lawrence R,Pollack H,DiJohn D,Krasinski K,Borkowsky W

    更新日期:1992-11-01 00:00:00

  • Prescribing practices and knowledge of tricyclic antidepressants among physicians caring for children.

    abstract::We did not find any significant difference between pediatricians and family practitioners with regard to their knowledge of the potentially serious toxicities of the tricyclic antidepressants. One of this group, imipramine, is in widespread use for the treatment of enuresis. A large proportion of the pediatricians (40...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Rauber A,Maroncelli R

    更新日期:1984-01-01 00:00:00

  • Respiratory failure and hypercoagulability in a toddler with Lemierre's syndrome.

    abstract::A 3.5-year-old healthy boy with 4 days of fever was referred to the emergency department for respiratory distress. The physical examination was remarkable for stupor, tachycardia, tachypnea, and dyspnea. Initial blood tests showed pancytopenia. He rapidly developed torticollis. Computerized tomography of the neck reve...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2505

    authors: Schmid T,Miskin H,Schlesinger Y,Argaman Z,Kleid D

    更新日期:2005-05-01 00:00:00

  • Selective intrapartum prophylaxis for group B streptococcus colonization: management and outcome of newborns.

    abstract:OBJECTIVE:Intrapartum antibiotic prophylaxis (IAP) in mothers with group B streptococcus (GBS) colonization presents difficult neonatal management decisions. IAP was instituted in response to an increased incidence of early-onset GBS sepsis (EOGBSS), and a study was conducted to evaluate the outcome of these newborns. ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Pylipow M,Gaddis M,Kinney JS

    更新日期:1994-04-01 00:00:00

  • Screening for congenital adrenal hyperplasia: the Delfia Screening Test overestimates serum 17-hydroxyprogesterone in preterm infants.

    abstract:OBJECTIVE:To compare 17-hydroxyprogesterone (17-OHP) levels measured by quantitative serum radioimmunoassay (RIA), including an extraction step, and by screening fluoroimmunoassay (FIA) on blood spots in preterm infants. METHODS:Subjects were 39 healthy infants born at less than 31 weeks' gestational age. Each infant ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: al Saedi S,Dean H,Dent W,Stockl E,Cronin C

    更新日期:1996-01-01 00:00:00

  • Bone scintigraphy in the evaluation of children with obscure skeletal pain.

    abstract::A retrospective analysis of bone scans of 381 children with unexplained skeletal pain was made. Of these, findings are reported on 358 for whom there were sufficient clinical data. The bone scan results suggested trauma as the cause of pain in 43 patients, inflammatory disease in 73 patients, and neoplasia in ten pati...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: ter Meulen DC,Majd M

    更新日期:1987-04-01 00:00:00

  • Parent-Adolescent Agreement About Adolescents' Suicidal Thoughts.

    abstract::: media-1vid110.1542/5972300121001PEDS-VA_2018-1771Video Abstract OBJECTIVES: To examine agreement between parent and adolescent reports of adolescents' suicidal thoughts and explore demographic and clinical factors associated with agreement in a large community sample. METHODS:Participants included 5137 adolescents ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-1771

    authors: Jones JD,Boyd RC,Calkins ME,Ahmed A,Moore TM,Barzilay R,Benton TD,Gur RE

    更新日期:2019-02-01 00:00:00

  • A comparative review of developmental screening tests.

    abstract::Public Law 99-457 amends the Education of the Handicapped Act to include services for children from birth through 3 years. Inasmuch as detection and referral of children with developmental delays continues to reside largely with pediatricians and other health care professionals, developmental screening, using standard...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Glascoe FP,Martin ED,Humphrey S

    更新日期:1990-10-01 00:00:00

  • Severe renal osteodystrophy without elevated serum immunoreactive parathyroid hormone concentrations in hypomagnesemia due to renal magnesium wasting.

    abstract::An 8 1/2-year-old girl presented with a long history of seizures, growth retardation, muscle weakness, gait disturbance, and hearing loss. Her evaluation revealed chronic moderate renal failure (serum creatinine 2.2 mg/dL), severe hypocalcemia (5 mg/dL), hyperphosphatemia (8.1 mg/dL), hypomagnesemia (1.5 mg/dL), incre...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Zelikovic I,Dabbagh S,Friedman AL,Goelzer ML,Chesney RW

    更新日期:1987-03-01 00:00:00

  • The triple risk hypotheses in sudden infant death syndrome.

    abstract::Sudden infant death syndrome (SIDS) victims were regarded as normal as a matter of definition (Beckwith 1970) until 1952 when Kinney and colleagues argued for elimination of the clause, "unexpected by history." They argued that "not all SIDS victims were normal," and referred to their hypothesis that SIDS results from...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.110.5.e64

    authors: Guntheroth WG,Spiers PS

    更新日期:2002-11-01 00:00:00

  • Out-of-school suspension and expulsion. American Academy of Pediatrics Committee on School Health.

    abstract::Suspension and expulsion from school are used to punish students, alert parents, and protect other students and school staff. Unintended consequences of these practices require more attention from health care professionals. Suspension and expulsion may exacerbate academic deterioration, and when students are provided ...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.112.5.1206

    authors: American Academy of Pediatrics Committee on School Health.

    更新日期:2003-11-01 00:00:00

  • Sodium space and intravascular volume: dietary sodium effects in cystic fibrosis and healthy adolescent subjects.

    abstract:OBJECTIVE:To assess the physiologic response to salt depletion in subjects with cystic fibrosis (CF) and control male adolescents for sodium balance, sodium space, and stimulation of the renin-angiotensin-aldosterone axis. DESIGN:Seven subjects with CF and six controls received a salt-replete (150 or 290 mmol NaCl per...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.1.48

    authors: Legris GJ,Dearborn D,Stern RC,Geiss CL,Hopfer U,Douglas JG,Doershuk CF

    更新日期:1998-01-01 00:00:00

  • Ostensible versus actual reasons for seeking pediatric attention: another look at the parental ticket of admission.

    abstract::The presentation of parental anxiety that appears excessive in view of the nature of the child's "chief complaint" is a frequent occurrence in pediatric practice. This study reviews 370 sick-patient visits in one pediatric office during a three-month period. Additional questioning in the area of parental anxieties con...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bass LW,Cohen RL

    更新日期:1982-12-01 00:00:00

  • Delivery Room Management of Meconium-Stained Newborns and Respiratory Support.

    abstract::: media-1vid110.1542/5839992674001PEDS-VA_2018-1485Video Abstract BACKGROUND AND OBJECTIVES: Recently, the Neonatal Resuscitation Program (NRP) recommended against routine endotracheal suctioning of meconium-stained nonvigorous newborns but suggested resuscitation with positive pressure ventilation. Our purpose is to ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2018-1485

    authors: Chiruvolu A,Miklis KK,Chen E,Petrey B,Desai S

    更新日期:2018-12-01 00:00:00

  • Cost-effective treatment of phimosis.

    abstract:OBJECTIVE:To determine the most cost-effective treatment for phimosis. DESIGN:The costs of three treatment strategies for treating phimosis were evaluated using a decision-tree analysis. Three therapeutic approaches were considered: circumcision, preputial plasty (the use of plastic surgical techniques to enlarge the ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.102.4.e43

    authors: Van Howe RS

    更新日期:1998-10-01 00:00:00

  • Recurrent pneumonia in children and its relationship to bronchial hyperreactivity.

    abstract::To determine what conditions are most likely to cause persistent or recurrent pneumonia (PRP) in children, the records of 81 children referred to James Whitcomb Riley Hospital for Children for evaluation of PRP were reviewed. Twenty patients had an apparent underlying cause that predisposed them to PRP. Of the 61 rema...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Eigen H,Laughlin JJ,Homrighausen J

    更新日期:1982-11-01 00:00:00

  • Household routines and obesity in US preschool-aged children.

    abstract:OBJECTIVE:To determine the association between the prevalence of obesity in preschool-aged children and exposure to 3 household routines: regularly eating the evening meal as a family, obtaining adequate sleep, and limiting screen-viewing time. METHODS:We conducted a cross-sectional analysis of a nationally representa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0417

    authors: Anderson SE,Whitaker RC

    更新日期:2010-03-01 00:00:00

  • Successive multisite peripheral nerve catheters for treatment of complex regional pain syndrome type I.

    abstract::Complex regional pain syndrome (CRPS) type I is a painful and disabling syndrome that is accompanied by physical changes in the affected extremity. It generally occurs after trauma, manifesting as pain that is out of proportion to the inciting event. Treatment of the disorder is difficult, with many patients being ref...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-3779

    authors: Martin DP,Bhalla T,Rehman S,Tobias JD

    更新日期:2013-01-01 00:00:00

  • Nosocomial rotavirus infections: a meta-analysis.

    abstract:BACKGROUND AND OBJECTIVES:Nosocomial rotavirus (nRV) infections represent an important part of rotavirus (RV)-associated morbidity. The incidence of nRV influences the estimated total RV disease burden, an important determinant of cost-effectiveness of RV vaccination programs. Our aim is to summarize the existing evide...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1542/peds.2011-2779

    authors: Bruijning-Verhagen P,Quach C,Bonten M

    更新日期:2012-04-01 00:00:00

  • Reflex sympathetic dystrophy in children.

    abstract::Two pediatric patients had reflex sympathetic dystrophy, which has been well described in adults but is rarely recognized in children. The syndrome consists of continuous pain, hyperesthesia, and autonomic symptoms occurring in an extremity, usually following trauma. The various types of presentation, differential dia...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fermaglich DR

    更新日期:1977-12-01 00:00:00

  • Weight teasing and disordered eating behaviors in adolescents: longitudinal findings from Project EAT (Eating Among Teens).

    abstract:OBJECTIVE:To assess whether weight-related teasing predicts the development of binge eating, unhealthy weight control behaviors, and frequent dieting among male and female adolescents. METHODS:A prospective study was conducted with an ethnically and socioeconomically diverse sample of 2516 adolescents who completed su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1242

    authors: Haines J,Neumark-Sztainer D,Eisenberg ME,Hannan PJ

    更新日期:2006-02-01 00:00:00

  • Prenatal detection of neuroblastoma: a ten-year experience from the Dana-Farber Cancer Institute and Children's Hospital.

    abstract:OBJECTIVES:To assess the relative frequency of, the clinical and pathological correlates in, and the prognosis of the subset of infants with neuroblastoma who were identified initially by prenatal ultrasonography. DESIGN:Retrospective review of all patients with neuroblastoma evaluated between 1982 and 1992. SETTING:...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ho PT,Estroff JA,Kozakewich H,Shamberger RC,Lillehei CW,Grier HE,Diller L

    更新日期:1993-09-01 00:00:00

  • Multiple organ failure after ingestion of pennyroyal oil from herbal tea in two infants.

    abstract:BACKGROUND:Hepatic and neurologic injury developed in two infants after ingestion of mint tea. Examination of the mint plants, from which the teas were brewed, indicated that they contained the toxic agent pennyroyal oil. METHODS:Sera from each infant were analyzed for the toxic constituents of pennyroyal oil, includi...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bakerink JA,Gospe SM Jr,Dimand RJ,Eldridge MW

    更新日期:1996-11-01 00:00:00

  • The Questionnaire for Identifying Children with Chronic Conditions: a measure based on a noncategorical approach.

    abstract:OBJECTIVE:To report on the development of the Questionnaire for Identifying Children with Chronic Conditions (QuICCC). This new instrument identifies children and adolescents who have chronic health conditions based on the noncategorical conceptual framework outlined in our earlier work. It uses the consequences of con...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.4.513

    authors: Stein RE,Westbrook LE,Bauman LJ

    更新日期:1997-04-01 00:00:00

  • Infantile colic: child and family three years later.

    abstract:OBJECTIVE:To assess differences in family functioning or child-rearing attitudes within families with previously colicky infants and to assess whether the children differed in their behavior, development, or frequency of allergies. STUDY DESIGN:A controlled, prospective study with infants (3 months to 3 years of age) ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Rautava P,Lehtonen L,Helenius H,Sillanpää M

    更新日期:1995-07-01 00:00:00

  • Children riding in the back of pickup trucks: a neglected safety issue.

    abstract::Motor vehicle-related trauma is the leading cause of death in children in the United States. All states have pediatric restraint requirements for passenger vehicles to help prevent these deaths and injuries. Only a few states, however, possess safety laws or restrictions for passengers who ride in the back of pickup t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Woodward GA,Bolte RG

    更新日期:1990-11-01 00:00:00

  • Tracheostomies and assisted ventilation in children with profound disabilities: navigating family and professional values.

    abstract::Parental requests for gastrostomies, tracheostomies, or assisted ventilation in children with profound disabilities raise ethical concerns about children's interests, parental decision-making, and health care costs. The underlying concern for many relates to the perceived value of these children. Clinicians should mak...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3608H

    authors: Wilfond BS

    更新日期:2014-02-01 00:00:00

  • Dietary fiber in weaning foods of young children.

    abstract:OBJECTIVE:An evaluation of the opportunity to introduce fiber in the diet of weaning infants. METHODS:A descriptive review of the literature to assess the role of fiber in the following dietary interventions: (1) definition of the nutrient amounts that meet the weaning infant's physiologic needs; (2) modulation of dig...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Agostoni C,Riva E,Giovannini M

    更新日期:1995-11-01 00:00:00

  • Rotavirus vaccination and intussusception: can we decrease temporally associated background cases of intussusception by restricting the vaccination schedule?

    abstract:OBJECTIVE:The first rotavirus vaccine that was licensed in the United States, RotaShield, could have prevented the enormous burden of rotavirus diarrhea in American children but left instead the unfortunate legacy that live oral rotavirus vaccines may be associated with a serious but rare adverse event: intussusception...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2874

    authors: Tai JH,Curns AT,Parashar UD,Bresee JS,Glass RI

    更新日期:2006-08-01 00:00:00

  • Recognizing and treating toilet-seat contact dermatitis in children.

    abstract::Toilet-seat contact dermatitis is a common condition around the world and is reemerging in the United States. It can be easily recognized and treated. However, few practitioners consider this diagnosis, which results in a delay in treatment and often exacerbation of the skin eruption. In the past, exposure to wooden t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2430

    authors: Litvinov IV,Sugathan P,Cohen BA

    更新日期:2010-02-01 00:00:00