Abstract:
OBJECTIVE:The first rotavirus vaccine that was licensed in the United States, RotaShield, could have prevented the enormous burden of rotavirus diarrhea in American children but left instead the unfortunate legacy that live oral rotavirus vaccines may be associated with a serious but rare adverse event: intussusception. Although large trials indicate that the next generation of rotavirus vaccines is not associated with this complication, many children likely will develop intussusception by chance alone in the 2-week window after immunization, raising concerns about whether these cases might be "caused" by the vaccine. Our objective for this study was to model and compare the number of temporally associated intussusception events that are expected by chance alone under 2 rotavirus vaccination strategies. METHODS:We used national vaccine coverage rates and age-specific incidence of intussusception by months to model the number of temporally associated cases of intussusception that are expected by chance alone for 2 potential vaccination strategies: a strict schedule, limiting immunization to children within 1 month of the designated age for each dose (ie, 60-89, 120-149, and 180-209 days for doses 1, 2, and 3, respectively) versus a free schedule whereby infants are immunized whenever they appear for their routine vaccines up to 1 year of age. RESULTS:The number of intussusception events during the 2-week postvaccination window was 24% lower for the strict versus the free schedule (138 vs 182, respectively). This reduction was attributable largely to the smaller number of infants who were immunized fully under the strict schedule (vaccine coverage for 3 doses, 67% vs 89%). The cumulative risk for intussusception's occurring by chance in the 2-week postvaccination window essentially was the same between schedules (4.59 vs 4.76 per 100000 doses). Most cases occurred after the second or third dose. CONCLUSIONS:Although an age-restricted vaccination schedule substantially reduced the number of intussusception events that were observed in the 2-week postvaccination window when compared with a schedule with fewer restrictions, this decrease was attributable to a lower rate of vaccine coverage rather than a safer schedule of vaccination. The risk for intussusception did not differ significantly between vaccination strategies. Public health policy and education messages for physicians and parents should be developed to anticipate intussusception events that will occur by chance alone but are temporally related to rotavirus vaccination.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Tai JH,Curns AT,Parashar UD,Bresee JS,Glass RIdoi
10.1542/peds.2005-2874subject
Has Abstractpub_date
2006-08-01 00:00:00pages
e258-64issue
2eissn
0031-4005issn
1098-4275pii
118/2/e258journal_volume
118pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVES:Bedside delivery of discharge medications improves caregiver understanding and experience. Less is known about its impact on medication adherence. We aimed to improve antimicrobial adherence by increasing on-time first home doses for patients discharged from the pediatric hospital medicine service from 33% t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-2413
更新日期:2021-01-01 00:00:00
abstract:OBJECTIVE:The goal was to examine the association between the New York State (NYS) upgraded child restraint law (UCRL) implemented in 2005 and the traffic injury rate among 4- to 6-year-old children in New York State. METHODS:A before/after comparison study of population-based, traffic injury rates for 4- to 6-year-ol...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-0249
更新日期:2010-09-01 00:00:00
abstract:INTRODUCTION:Identifying trends in smoking behaviors among youth cigarette smokers could inform youth policy and interventions. METHODS:Using 2011-2018 National Youth Tobacco Survey data, logistic/linear regressions were used to analyze trends in smoking frequency, intensity, age of first cigarette use, and electronic...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-3047
更新日期:2020-03-01 00:00:00
abstract::This clinical report serves to update the statement titled "Guidelines for the Evaluation of Sexual Abuse of Children," which was first published in 1991 and revised in 1999. The medical assessment of suspected sexual abuse is outlined with respect to obtaining a history, physical examination, and appropriate laborato...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2005-1336
更新日期:2005-08-01 00:00:00
abstract:OBJECTIVES:To describe infant sleep patterns and investigate relationships between infant sleep problems and maternal well-being in the community setting. DESIGN:Cross-sectional community survey. Setting. Maternal and Child Health Centers in 3 middle-class local government areas in Melbourne, Australia. PARTICIPANTS:...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.6.1317
更新日期:2001-06-01 00:00:00
abstract:BACKGROUND:Severe acute respiratory syndrome was relatively mild in children, and the incidence was significantly lower when compared with adults. Although previous seroepidemiological studies demonstrated that asymptomatic infection was uncommon among health care workers and adult contacts of patients with severe acut...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1476
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Motivational interviewing (MI) has been shown to be an effective strategy for targeting obesity in adolescents, and parental involvement is associated with increased effectiveness. The aim of this study was to evaluate and compare the role of parental involvement in MI interventions for obese a...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2014-1987
更新日期:2015-03-01 00:00:00
abstract::Ifosfamide is widely used in the treatment of pediatric solid tumors. Its main adverse effects are various forms of renal tubular and glomerular damage. Many risk factors have been proposed to play a role in the development and severity of nephrotoxicity in children receiving ifosfamide, among which are 1) patient's a...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.101.6.e8
更新日期:1998-06-01 00:00:00
abstract:BACKGROUND:Identity formation and exploration of interpersonal relationships are important tasks that occur during adolescence. Transgender, gender diverse, and gender-nonconforming (TGNC) individuals must face these developmental milestones in the context of their transgender identity. Our aim with this article is to ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-007906
更新日期:2021-02-01 00:00:00
abstract:BACKGROUND:Increased morbidity and mortality from lower respiratory tract infection (LRTI) has been suggested in HIV-exposed uninfected (HEU) children; however, the contribution of respiratory viruses is unclear. We studied the epidemiology of LRTI hospitalization in HIV-unexposed uninfected (HUU) and HEU infants aged ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2015-3272
更新日期:2016-04-01 00:00:00
abstract:OBJECTIVE:Health-e-Access, a telemedicine service providing care for acute illnesses in children, has delivered >6500 telemedicine visits from 10 primary care practices in Rochester, New York, by using telemedicine access at 22 child care and school sites. The goal was to assess the hypotheses that children served by H...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2698
更新日期:2009-06-01 00:00:00
abstract:OBJECTIVE:The goal was to describe variable costs to providers of delivering childhood immunizations. METHODS:We documented variable costs (costs that vary with the amount of services rendered), including time spent by pediatric staff members and physicians on immunization-related activities, as well as supply costs a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-1542H
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Immunization rates have improved in the United States, but are still far from the national 90% goal for the year 2000. There is scant evidence about the effectiveness and costs of automated telephone messages to improve immunization rates among privately insured children. OBJECTIVE:To evaluate the effective...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1542/peds.101.4.e3
更新日期:1998-04-01 00:00:00
abstract::Deep vein thrombophlebitis (DVT) and septic pulmonary emboli (PE) are rare in children. The association of DVT and acute disseminated staphylococcal disease (DSD) during childhood has not been previously reported. We report 3 children who developed a triad of DVT, septic PE, and acute osteomyelitis with Staphylococcus...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.6.e87
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:Low socioeconomic status (SES) has emerged as an important risk factor for higher short-term mortality and neurodevelopmental outcomes in children with hypoplastic left heart syndrome and related anomalies; yet little is known about how SES affects these outcomes over the long-term. METHODS:We linked data f...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2020-1240
更新日期:2020-10-01 00:00:00
abstract::The effect of taurine supplementation on the absorption of a fat meal was evaluated in patients with cystic fibrosis. In a cross-over design study, five patients with cystic fibrosis (12.1 +/- 2.6 years of age) and three control subjects received either placebo or taurine (30 mg/kg/d) for two 1-week periods, a month a...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1987-10-01 00:00:00
abstract:BACKGROUND:Acute sinusitis is frequently diagnosed in young children, yet little is known regarding pediatrician practices surrounding its diagnosis and management. OBJECTIVES:The purpose of this work was to describe how pediatricians diagnose and manage nonsevere acute sinusitis in otherwise healthy children < or =6 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2479
更新日期:2009-02-01 00:00:00
abstract:OBJECTIVES:Clinical evidence indicates newborn critical congenital heart disease (CCHD) screening through pulse oximetry is lifesaving. In 2011, CCHD was added to the US Recommended Uniform Screening Panel for newborns. Several states have implemented or are considering screening mandates. This study aimed to estimate ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0332
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To describe the prevalence and secular trends of high weight-for-length among infants (ages, 3-23 months) in the biennial US Department of Agriculture Women, Infants, and Children Program and Participants Characteristic (WIC-PC) Survey from 2000 through 2014 (n = 16 927 120). METHODS:Weight-for-length was c...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-2034
更新日期:2017-01-01 00:00:00
abstract:OBJECTIVES:Media Detective is a 10-lesson elementary school substance use prevention program developed on the basis of the message interpretation processing model designed to increase children's critical thinking skills about media messages and reduce intent to use tobacco and alcohol products. The purpose of this stud...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1542/peds.2010-0068
更新日期:2010-09-01 00:00:00
abstract:BACKGROUND:In previous studies, the oral calcium loading and deprivation test has been used to distinguish between children with renal (fasting) hypercalciuria (RH) and absorptive hypercalciuria (AH). OBJECTIVE:We evaluated the long-term clinical course of 30 children with idiopathic hypercalciuria and investigated th...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-02-01 00:00:00
abstract::Investigations in which statistically significant differences between treatment groups have not been observed are less likely than others to be reported in scientific journals. In clinical research, this selective suppression of "negative" results may lead to the adoption of ineffective or hazardous treatments. In an ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1989-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Medication use may be a target for quality improvement, cost containment, and research. We aimed to identify medication classes associated with the highest expenditures among pediatric Medicaid enrollees and to characterize the demographic, clinical, and health service use of children prescrib...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-1095
更新日期:2017-09-01 00:00:00
abstract::The free running test has been successfully carried out in patients from 5 to 21 years old. It has the following advantages: (1) it simulates normal exercise pattern; (2) it is readily performed in any health care setting; (3) it is simple to perform and noninvasive in nature; and (4) it reveals a maximum decrease in ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-11-01 00:00:00
abstract:BACKGROUND:Parental smoking has been associated with increased rates of sudden infant death syndrome, low birth weight, otitis media, asthma, and decreased lung growth. No prior parent surveys have assessed national rates of screening and counseling for parental tobacco use in the context of their child's visit to prim...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.5.1146
更新日期:2003-11-01 00:00:00
abstract::Thirty-two (18%) of 181 children cared for at our institution who were infected with the human immunodeficiency virus type 1 (HIV-1) were first seen, and HIV was diagnosed, when they were 4 years of age and older. Initial complaints or diagnoses for these children included the following: hematologic disorders (5) (3 i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1992-11-01 00:00:00
abstract:CONTEXT:Evidence is emerging that preterm infants are at risk for autism spectrum disorder (ASD). OBJECTIVES:To conduct a systematic review and meta-analysis to estimate the prevalence of ASD in preterm infants. DATA SOURCES:Medline (via PubMed and Ovid), Embase, PsycINFO, and relevant conference proceedings were sea...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2018-0134
更新日期:2018-09-01 00:00:00
abstract::A 23-month-old girl died after 2 days' illness with rash, fever, and convulsions. Neuropathologic findings were consistent with viral hemorrhagic encephalitis in pontine tegmentum and medial thalamic areas. Human herpesvirus 6 (HHV-6) DNA was detected in pontine nuclei by in situ hybridization. In addition, polymerase...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.2.431
更新日期:2000-02-01 00:00:00
abstract::Nucleotide (NT) nitrogen, a component of nonprotein nitrogen, accounts for approximately 0.1% to 0.15% of the total nitrogen content of human milk. The results of studies in animals indicate that dietary NTs may be required for maintenance of normal immune function. Thirty-seven healthy term infants were either breast...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-08-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to investigate the impact of prenatal exposure to chlorpyrifos on 3-year neurodevelopment and behavior in a sample of inner-city minority children. METHODS:As part of an ongoing prospective cohort study in an inner-city minority population, neurotoxicant effects of prenatal expo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0338
更新日期:2006-12-01 00:00:00