Cost-effectiveness of routine screening for critical congenital heart disease in US newborns.


OBJECTIVES:Clinical evidence indicates newborn critical congenital heart disease (CCHD) screening through pulse oximetry is lifesaving. In 2011, CCHD was added to the US Recommended Uniform Screening Panel for newborns. Several states have implemented or are considering screening mandates. This study aimed to estimate the cost-effectiveness of routine screening among US newborns unsuspected of having CCHD. METHODS:We developed a cohort model with a time horizon of infancy to estimate the inpatient medical costs and health benefits of CCHD screening. Model inputs were derived from new estimates of hospital screening costs and inpatient care for infants with late-detected CCHD, defined as no diagnosis at the birth hospital. We estimated the number of newborns with CCHD detected at birth hospitals and life-years saved with routine screening compared with no screening. RESULTS:Screening was estimated to incur an additional cost of $6.28 per newborn, with incremental costs of $20 862 per newborn with CCHD detected at birth hospitals and $40 385 per life-year gained (2011 US dollars). We estimated 1189 more newborns with CCHD would be identified at birth hospitals and 20 infant deaths averted annually with screening. Another 1975 false-positive results not associated with CCHD were estimated to occur, although these results had a minimal impact on total estimated costs. CONCLUSIONS:This study provides the first US cost-effectiveness analysis of CCHD screening in the United States could be reasonably cost-effective. We anticipate data from states that have recently approved or initiated CCHD screening will become available over the next few years to refine these projections.






Peterson C,Grosse SD,Oster ME,Olney RS,Cassell CH




Has Abstract


2013-09-01 00:00:00














  • Environmental Enteric Dysfunction and Growth Failure/Stunting in Global Child Health.

    abstract::Approximately 25% of the world's children aged <5 years have stunted growth, which is associated with increased mortality, cognitive dysfunction, and loss of productivity. Reducing by 40% the number of stunted children is a global target for 2030. The pathogenesis of stunting is poorly understood. Prenatal and postnat...


    pub_type: 杂志文章,评审


    authors: Owino V,Ahmed T,Freemark M,Kelly P,Loy A,Manary M,Loechl C

    更新日期:2016-12-01 00:00:00

  • Body image and dieting behavior in cystic fibrosis.

    abstract:OBJECTIVE:To examine the relationship between pulmonary function, nutritional status, body image, and eating attitudes in children with cystic fibrosis (CF) compared with healthy controls. METHOD:Seventy-six children with CF (39 girls) and 153 healthy control children (82 girls) were recruited. All children were betwe...


    pub_type: 杂志文章


    authors: Truby H,Paxton AS

    更新日期:2001-06-01 00:00:00

  • Measurement of interleukin 8 in combination with C-reactive protein reduced unnecessary antibiotic therapy in newborn infants: a multicenter, randomized, controlled trial.

    abstract:OBJECTIVE:Neonatal bacterial infections carry a high mortality when diagnosed late. Early diagnosis is difficult because initial clinical signs are nonspecific. Consequently, physicians frequently prescribe antibiotic treatment to newborn infants for fear of missing a life-threatening infection. This study was designed...


    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验


    authors: Franz AR,Bauer K,Schalk A,Garland SM,Bowman ED,Rex K,Nyholm C,Norman M,Bougatef A,Kron M,Mihatsch WA,Pohlandt F,International IL-8 Study Group.

    更新日期:2004-07-01 00:00:00

  • Pediatric Readiness in Emergency Medical Services Systems.

    abstract::This is a joint policy statement from the American Academy of Pediatrics, American College of Emergency Physicians, Emergency Nurses Association, National Association of Emergency Medical Services Physicians, and National Association of Emergency Medical Technicians on pediatric readiness in emergency medical services...


    pub_type: 指南,杂志文章


    authors: Moore B,Shah MI,Owusu-Ansah S,Gross T,Brown K,Gausche-Hill M,Remick K,Adelgais K,Lyng J,Rappaport L,Snow S,Wright-Johnson C,Leonard JC,AMERICAN ACADEMY OF PEDIATRICS COMMITTEE ON PEDIATRIC EMERGENCY MEDICINE AND SECTION ON EMER

    更新日期:2020-01-01 00:00:00

  • Injury patterns in obese versus nonobese children presenting to a pediatric emergency department.

    abstract:BACKGROUND:Two of the most prevalent problems facing youth in the United States are injury and obesity. Obesity increases the risk of injury, prolongs recovery time, and increases morbidity among injured children. OBJECTIVE:The purpose of this study was to compare characteristics of injuries between obese and nonobese...


    pub_type: 杂志文章


    authors: Pomerantz WJ,Timm NL,Gittelman MA

    更新日期:2010-04-01 00:00:00

  • Egg Freezing in Childhood and Young Adult Cancer Survivors.

    abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...


    pub_type: 杂志文章


    authors: Filippi F,Meazza C,Paffoni A,Raspagliesi F,Terenziani M,Somigliana E

    更新日期:2016-10-01 00:00:00

  • The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children.

    abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...


    pub_type: 杂志文章


    authors: Trepka MJ,Belongia EA,Chyou PH,Davis JP,Schwartz B

    更新日期:2001-01-01 00:00:00

  • When Bad News Isn't Necessarily Bad: Recognizing Provider Bias When Sharing Unexpected News.

    abstract::: media-1vid110.1542/5771272502001PEDS-VA_2018-0503Video Abstract. ...


    pub_type: 杂志文章


    authors: Carroll C,Carroll C,Goloff N,Pitt MB

    更新日期:2018-07-01 00:00:00

  • Sacral Myeloradiculitis: An Uncommon Complication of Genital Herpes Infection.

    abstract::Herpes simplex virus 1 and 2 infections affect up to 50 million people in the United States, with a natural history of recurrent viral shedding with or without recurrence of symptoms. Although many patients remain asymptomatic or with mild symptoms, a spectrum of rare but significant nervous system complications have ...


    pub_type: 杂志文章


    authors: Whalen AM,Mateo CM,Growdon AS,Miller AF

    更新日期:2019-07-01 00:00:00

  • Congenital Trismus From Brainstem Dysgenesis: Case Report and Review of Literature.

    abstract::Trismus refers to any condition inducing limited mouth opening and may present as a result of acquired or congenital pathology. We present the case of a newborn who presented with severe, congenital trismus due to brainstem dysgenesis. We describe the course of his investigations, and a multidisciplinary approach to t...


    pub_type: 杂志文章,评审


    authors: Hong CJ,Caulley L,Kohlert S,Graham GE,McMillan HJ,Michaud J,Vaccani JP

    更新日期:2016-07-01 00:00:00

  • Considering complementary and alternative medicine alternatives in cases of life-threatening illness: applying the best-interests test.

    abstract::In this article we explore decision-making about treatment when a child faces a life-threatening illness but conventional treatment presents substantial risk and uncertain benefit. When is it acceptable for parents to decide to use complementary and alternative medicine as an alternative, rather than a complement, to ...


    pub_type: 杂志文章


    authors: Gilmour J,Harrison C,Asadi L,Cohen MH,Aung S,Vohra S

    更新日期:2011-11-01 00:00:00

  • Correlates of lactation in mothers of very low birth weight infants.

    abstract:OBJECTIVE:We sought to determine the correlates of intent to breastfeed and of successful lactation and nursing at the breast in mothers of very low birth weight (VLBW; <1.5 kg) infants. METHODS:We conducted a prospective observational study of 119 mothers of singleton VLBW infants (mean birth weight: 1056 g; mean ges...


    pub_type: 杂志文章


    authors: Furman L,Minich N,Hack M

    更新日期:2002-04-01 00:00:00

  • Exemptions From Mandatory Immunization After Legally Mandated Parental Counseling.

    abstract:BACKGROUND:The success of health care provider counseling-based interventions to address vaccine hesitancy is not clear. In 2011, Washington State implemented Senate Bill 5005 (SB5005), requiring counseling and a signed form from a licensed health care provider to obtain an exemption. Evaluating the impact of a counsel...


    pub_type: 杂志文章


    authors: Omer SB,Allen K,Chang DH,Guterman LB,Bednarczyk RA,Jordan A,Buttenheim A,Jones M,Hannan C,deHart MP,Salmon DA

    更新日期:2018-01-01 00:00:00

  • The changing role and responsibilities of chairmen in clinical academic departments: the transition from autocracy.

    abstract::There is considerable literature dealing with the responsibilities of clinical department chairmen, which primarily emphasizes the importance of developing a sound and facilitating administration. This is dependent on the hiring of appropriate support personnel, developing a representative committee structure, being a...


    pub_type: 杂志文章


    authors: Brent RL

    更新日期:1992-07-01 00:00:00

  • Predicting preschooler obesity at birth: the role of maternal obesity in early pregnancy.

    abstract:OBJECTIVE:Knowing risk factors at birth for the development of childhood obesity could help to identify children who are in need of early obesity prevention efforts. The objective of this study was to determine whether children whose mothers were obese in early pregnancy were more likely to be obese at 2 to 4 years of ...


    pub_type: 杂志文章


    authors: Whitaker RC

    更新日期:2004-07-01 00:00:00

  • Socioeconomic, family, and pediatric practice factors that affect level of asthma control.

    abstract:BACKGROUND:Multiple issues play a role in the effective control of childhood asthma. OBJECTIVE:To identify factors related to the level of asthma control in children receiving asthma care from community pediatricians. PATIENTS AND METHODS:Data for 362 children participating in an intervention study to reduce asthma m...


    pub_type: 杂志文章


    authors: Bloomberg GR,Banister C,Sterkel R,Epstein J,Bruns J,Swerczek L,Wells S,Yan Y,Garbutt JM

    更新日期:2009-03-01 00:00:00

  • Growth of children on classical and medium-chain triglyceride ketogenic diets.

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    pub_type: 杂志文章


    authors: Neal EG,Chaffe HM,Edwards N,Lawson MS,Schwartz RH,Cross JH

    更新日期:2008-08-01 00:00:00

  • Effect of age and sedative agent on the accuracy of bispectral index in detecting depth of sedation in children.

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    pub_type: 杂志文章,meta分析


    authors: Malviya S,Voepel-Lewis T,Tait AR,Watcha MF,Sadhasivam S,Friesen RH

    更新日期:2007-09-01 00:00:00

  • The impact of record scattering on the measurement of immunization coverage.

    abstract:BACKGROUND:Lack of a consolidated immunization record may lead to problems with determining individual immunization needs at office visits as well as measuring vaccination coverage levels of a clinician's practice or a community's population. OBJECTIVES:For children with multiple immunization providers, evaluate the d...


    pub_type: 杂志文章


    authors: Stokley S,Rodewald LE,Maes EF

    更新日期:2001-01-01 00:00:00

  • Disaster Preparedness in Neonatal Intensive Care Units.

    abstract::Disasters disproportionally affect vulnerable, technology-dependent people, including preterm and critically ill newborn infants. It is important for health care providers to be aware of and prepared for the potential consequences of disasters for the NICU. Neonatal intensive care personnel can provide specialized exp...


    pub_type: 杂志文章



    更新日期:2017-05-01 00:00:00

  • Pediatrician Perspectives on Feasibility and Acceptability of the MOCA-Peds 2017 Pilot.

    abstract:BACKGROUND AND OBJECTIVES:The American Board of Pediatrics (ABP) certifies that general and subspecialty pediatricians meet standards of excellence established by their peers, immediately after training and over the course of their careers (ie, Maintenance of Certification [MOC]). In 2015-2016, the ABP developed the Ma...


    pub_type: 杂志文章


    authors: Leslie LK,Turner AL,Smith AC,Dounoucos V,Olmsted MG,Althouse L

    更新日期:2019-12-01 00:00:00

  • Mental health screening in pediatric practice: factors related to positive screens and the contribution of parental/personal concern.

    abstract:OBJECTIVES:The goals were to examine factors related to positive Pediatric Symptom Checklist scores in an urban practice and to examine the relative contribution of parental/personal concern about emotional and behavioral problems to mental health problem identification. METHODS:Annual screening using the Pediatric Sy...


    pub_type: 杂志文章


    authors: Hacker KA,Myagmarjav E,Harris V,Suglia SF,Weidner D,Link D

    更新日期:2006-11-01 00:00:00

  • Treatment of congenital generalized lymphangiectasia with propranolol in a preterm infant.

    abstract::Generalized lymphangiectasia is a rare congenital disorder characterized by dilated lymphatic vessels with a fatal prognosis, especially in cases with thoracic involvement. We describe the use of propranolol in the therapy of generalized lymphangiectasia in a preterm infant with hydrops fetalis. Propranolol was well t...


    pub_type: 杂志文章


    authors: Poralla C,Specht S,Born M,Müller A,Bartmann P,Müller A

    更新日期:2014-02-01 00:00:00

  • Successful resection of localized intestinal lymphangiectasia post-Fontan: role of (99m)technetium-dextran scintigraphy.

    abstract::Intestinal lymphangiectasia is a well-recognized complication of the Fontan procedure, occurring in up to 24% of patients. Because of the loss of chylous fluid into the gut lumen, protein-losing enteropathy results as well as lymphopenia and hypogammaglobulinaemia. In some cases, dilated lymphatics in the intestinal s...


    pub_type: 杂志文章


    authors: Connor FL,Angelides S,Gibson M,Larden DW,Roman MR,Jones O,Currie BG,Day AS,Bohane TD

    更新日期:2003-09-01 00:00:00

  • Croup hospitalizations in Ontario: a 14-year time-series analysis.

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    pub_type: 杂志文章


    authors: Segal AO,Crighton EJ,Moineddin R,Mamdani M,Upshur RE

    更新日期:2005-07-01 00:00:00

  • Thyroid "vise" in an infant with neonatal Graves' disease.

    abstract::On the rare occasion when neonatal goiter is the cause of airway compromise, it typically presents with a palpable neck mass. In the setting of maternal Graves' disease (GD), fetal and neonatal goiters are most commonly caused by maternal treatment with antithyroid medication, and the goiter resolves within days of in...


    pub_type: 杂志文章


    authors: Regelmann MO,Sullivan CK,Rapaport R

    更新日期:2013-10-01 00:00:00

  • Unilateral hearing impairment in children.

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    pub_type: 杂志文章


    authors: Bess FH,Tharpe AM

    更新日期:1984-08-01 00:00:00

  • Retrospective and prospective identification of unpublished controlled trials: lessons from a survey of obstetricians and pediatricians.

    abstract::Investigations in which statistically significant differences between treatment groups have not been observed are less likely than others to be reported in scientific journals. In clinical research, this selective suppression of "negative" results may lead to the adoption of ineffective or hazardous treatments. In an ...


    pub_type: 杂志文章


    authors: Hetherington J,Dickersin K,Chalmers I,Meinert CL

    更新日期:1989-08-01 00:00:00

  • IL-10RA Mutation as a Risk Factor of Severe Influenza-Associated Encephalopathy: A Case Report.

    abstract::Influenza-associated encephalitis and encephalopathy (IAE) is a severe complication of influenza infection with high morbidity and mortality. We present the case of a patient with IL-10RA mutation who developed encephalopathy after influenza infection. A 10-day-old boy developed recurrent fever and anal fistula. Growt...


    pub_type: 杂志文章


    authors: Ishige T,Igarashi Y,Hatori R,Tatsuki M,Sasahara Y,Takizawa T,Arakawa H

    更新日期:2018-06-01 00:00:00

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    pub_type: 杂志文章


    authors: Dearborn DG,Smith PG,Dahms BB,Allan TM,Sorenson WG,Montana E,Etzel RA

    更新日期:2002-09-01 00:00:00