Taurine improves the absorption of a fat meal in patients with cystic fibrosis.

Abstract:

:The effect of taurine supplementation on the absorption of a fat meal was evaluated in patients with cystic fibrosis. In a cross-over design study, five patients with cystic fibrosis (12.1 +/- 2.6 years of age) and three control subjects received either placebo or taurine (30 mg/kg/d) for two 1-week periods, a month apart, followed by a fat meal test. Blood samples were drawn 0, 1, 2, 3, 5, 8 hours after the meal. Four patients with cystic fibrosis and severe steatorrhea despite appropriate enzyme therapy showed a significant (P less than .05) improvement in the absorption of triglycerides, total fatty acids, and linoleic acid while receiving taurine supplements. Three control subjects and one child with cystic fibrosis and mild steatorrhea receiving enzyme therapy did not experience such an effect. The difference in triglyceride absorption, when calculated as the area under the curve, receiving and not receiving taurine was significantly (P less than .05) correlated with the degree of steatorrhea. Furthermore, in contrast to control subjects, the fatty acid composition of chylomicrons in these four study patients showed important discrepancies with that of the fat meal and was corrected, in part, by taurine supplementation. These results suggest that taurine supplementation could be a useful adjunct in the management of patients with cystic fibrosis with ongoing fat malabsorption and essential fatty acid deficiency.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Belli DC,Levy E,Darling P,Leroy C,Lepage G,Giguère R,Roy CC

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

517-23

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

80

pub_type

临床试验,杂志文章,随机对照试验
  • Risk-stratified seroprevalence of severe acute respiratory syndrome coronavirus among children in Hong Kong.

    abstract:BACKGROUND:Severe acute respiratory syndrome was relatively mild in children, and the incidence was significantly lower when compared with adults. Although previous seroepidemiological studies demonstrated that asymptomatic infection was uncommon among health care workers and adult contacts of patients with severe acut...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-1476

    authors: Lee PP,Wong WH,Leung GM,Chiu SS,Chan KH,Peiris JS,Lam TH,Lau YL

    更新日期:2006-06-01 00:00:00

  • Antibiotic Prophylaxis for Children With Sickle Cell Anemia.

    abstract:BACKGROUND:Children with sickle cell anemia (SCA) are at increased risk for invasive pneumococcal disease; antibiotic prophylaxis significantly reduces this risk. We calculated the proportion of children with SCA who received ≥300 days of antibiotic prophylaxis and identified predictors of such receipt. METHODS:Childr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-2182

    authors: Reeves SL,Tribble AC,Madden B,Freed GL,Dombkowski KJ

    更新日期:2018-03-01 00:00:00

  • Functional gastrointestinal disorders in children: an Italian prospective survey.

    abstract:OBJECTIVES:To assess the prevalence and natural history of functional gastrointestinal disorders (FGIDs) in children using the Rome Criteria. METHODS:Thirteen primary care pediatricians were randomly selected from the Campania region of the Italian National Health Service. Each pediatrician completed a detailed FGID q...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.1.73

    authors: Miele E,Simeone D,Marino A,Greco L,Auricchio R,Novek SJ,Staiano A

    更新日期:2004-07-01 00:00:00

  • US National Longitudinal Lesbian Family Study: psychological adjustment of 17-year-old adolescents.

    abstract:OBJECTIVES:The objective of this study was to document the psychological adjustment of adolescents who were conceived through donor insemination by lesbian mothers who enrolled before these offspring were born in the largest, longest running, prospective, longitudinal study of same-sex-parented families. METHODS:Betwe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3153

    authors: Gartrell N,Bos H

    更新日期:2010-07-01 00:00:00

  • Nonmedical vaccine exemptions and pertussis in California, 2010.

    abstract:BACKGROUND:In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity of the acellular vaccine, the role of vaccine refusal has not been explored in the published literature. Many factors likely contributed to the o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0878

    authors: Atwell JE,Van Otterloo J,Zipprich J,Winter K,Harriman K,Salmon DA,Halsey NA,Omer SB

    更新日期:2013-10-01 00:00:00

  • Effects of polychlorinated biphenyl/dioxin exposure and feeding type on infants' mental and psychomotor development.

    abstract:OBJECTIVE:To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. DESIGN:Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Koopman-Esseboom C,Weisglas-Kuperus N,de Ridder MA,Van der Paauw CG,Tuinstra LG,Sauer PJ

    更新日期:1996-05-01 00:00:00

  • Effectiveness of pandemic H1N1 vaccine against influenza-related hospitalization in children.

    abstract:OBJECTIVE:Young children are generally considered immunologically naive with respect to influenza exposure opportunities; thus, a 2-dose schedule is recommended when a child is first immunized with conventional influenza vaccine lacking adjuvant. We estimated the effectiveness of a single pediatric dose of AS03-adjuvan...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3492

    authors: Gilca R,Deceuninck G,De Serres G,Boulianne N,Sauvageau C,Quach C,Boucher FD,Skowronski DM

    更新日期:2011-11-01 00:00:00

  • Effectiveness of pulse oximetry screening for congenital heart disease in asymptomatic newborns.

    abstract:OBJECTIVE:To determine the sensitivity, specificity, predictive value, and accuracy of a program of pulse oximetry screening of asymptomatic newborns for critical congenital cardiovascular malformation (CCVM). METHODS:Pulse oximetry was performed on asymptomatic newborns in the well-infant nurseries of 2 hospitals. Ca...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.111.3.451

    authors: Koppel RI,Druschel CM,Carter T,Goldberg BE,Mehta PN,Talwar R,Bierman FZ

    更新日期:2003-03-01 00:00:00

  • Reduced endothelial progenitor cells in children with hemodialysis but not predialysis chronic kidney disease.

    abstract::In adults with chronic kidney disease (CKD), reduced levels of vasculoprotective endothelial progenitor cells (EPCs) may contribute to their increased risk of cardiovascular disease. Children with CKD also show signs of cardiovascular disease. However, to our knowledge, there have been no studies on circulating EPC le...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3346

    authors: Jie KE,Lilien MR,Goossens MH,Westerweel PE,Klein MK,Verhaar MC

    更新日期:2010-10-01 00:00:00

  • Breastfeeding and risk of infections at 6 years.

    abstract:BACKGROUND:Previous studies have shown that breastfeeding is associated with reductions in the risk of common infections among infants; however, whether breastfeeding confers longer term protection is inconclusive. METHODS:We linked data from the 2005-2007 IFPS II (Infant Feeding Practices Study II) and follow-up data...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-0646D

    authors: Li R,Dee D,Li CM,Hoffman HJ,Grummer-Strawn LM

    更新日期:2014-09-01 00:00:00

  • A 2017 US Reference for Singleton Birth Weight Percentiles Using Obstetric Estimates of Gestation.

    abstract:OBJECTIVE:To provide an updated birth weight-for-gestational age (BW-for-GA) reference in the United States by using the most recent, nationally representative birth data with obstetric estimates of gestational age (GA). METHODS:We abstracted 3 285 552 singleton births between 22 and 42 weeks' gestation with nonmissin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2019-0076

    authors: Aris IM,Kleinman KP,Belfort MB,Kaimal A,Oken E

    更新日期:2019-07-01 00:00:00

  • Hyperinsulinism in infancy: diagnosis by demonstration of abnormal response to fasting hypoglycemia.

    abstract::The metabolic adaptation to fasting in infants with hyperinsulinism was examined to see whether a characteristic abnormality could be found that would aid in the diagnosis of this disorder. Seven infants under 1 year of age with hyperinsulinism were studied; 7 control infants of similar age and 12 children with ketoti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stanley CA,Baker L

    更新日期:1976-05-01 00:00:00

  • Yersinia enterocolitica arthritis.

    abstract::Human infections with Yersinia were first recognized and reported in upper New York State almost 40 years ago. Recently, there have been increasing numbers of reports from Scandinavia of episodes of polyarthritis associated with Yersinia infections. A 6-month-old girl from upstate New York had a fever of 40 C for two ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Jacobs JC

    更新日期:1975-02-01 00:00:00

  • Interventions to improve cortisol regulation in children: a systematic review.

    abstract::Childhood adversity is associated with physiologic dysregulation across multiple biological systems; however, relatively little is known about whether these changes are reversible with intervention. The objective of this review was to examine evidence for the effectiveness of interventions to promote healthy cortisol ...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-1632

    authors: Slopen N,McLaughlin KA,Shonkoff JP

    更新日期:2014-02-01 00:00:00

  • Should Pediatric Practices Have Policies to Not Care for Children With Vaccine-Hesitant Parents?

    abstract::One of the most divisive issues in pediatrics today concerns the proper response by pediatricians to parents who refuse routine childhood immunizations for their children. Many pediatricians refuse to care for such families. Others continue to provide care and continue to try to convince parents that the benefits of i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-1597

    authors: Alexander K,Lacy TA,Myers AL,Lantos JD

    更新日期:2016-10-01 00:00:00

  • Prenatal di(2-ethylhexyl)phthalate exposure and length of gestation among an inner-city cohort.

    abstract:OBJECTIVE:Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS:Forty-eight-hour personal air and/or spot urine samples were collected during the third tri...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0325

    authors: Whyatt RM,Adibi JJ,Calafat AM,Camann DE,Rauh V,Bhat HK,Perera FP,Andrews H,Just AC,Hoepner L,Tang D,Hauser R

    更新日期:2009-12-01 00:00:00

  • Dimensions of the local health care environment and use of care by uninsured children in rural and urban areas.

    abstract:OBJECTIVE:Despite concerted policy efforts, a sizeable percentage of children lack health insurance coverage. This article examines the impact of the health care safety net and health care market structure on the use of health care by uninsured children. METHODS:We used the Medical Expenditure Panel Survey linked with...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0733

    authors: Gresenz CR,Rogowski J,Escarce JJ

    更新日期:2006-03-01 00:00:00

  • When is lack of supervision neglect?

    abstract::Occasionally, pediatricians become aware of children who are inadequately supervised. More frequently, pediatricians treat children for traumatic injuries or ingestions that they suspect could have been prevented with better supervision. This clinical report contains guidance for pediatricians considering a referral t...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2006-1780

    authors: Hymel KP,Committee on Child Abuse and Neglect.

    更新日期:2006-09-01 00:00:00

  • Routine quantitative blood cultures in children with Haemophilus influenzae or Streptococcus pneumoniae bacteremia.

    abstract::The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with g...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bell LM,Alpert G,Campos JM,Plotkin SA

    更新日期:1985-12-01 00:00:00

  • Down Syndrome and the Risk of Severe RSV Infection: A Meta-analysis.

    abstract:CONTEXT:Down syndrome (DS) is the most common chromosomal condition in live-born infants worldwide, and lower respiratory infection caused by respiratory syncytial virus (RSV) is a leading cause of hospital admissions. OBJECTIVE:To evaluate RSV-associated morbidity among children with DS compared with a population wit...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2018-0225

    authors: Beckhaus AA,Castro-Rodriguez JA

    更新日期:2018-09-01 00:00:00

  • Recommendations for influenza immunization of children.

    abstract::Epidemiologic studies indicate that children of all ages with certain chronic conditions and otherwise healthy children younger than 24 months of age are hospitalized for influenza infection and its complications at high rates similar to those experienced by the elderly. Annual influenza immunization is recommended fo...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章,实务指引

    doi:10.1542/peds.113.5.1441

    authors: American Academy of Pediatrics Committee on Infectious Diseases.

    更新日期:2004-05-01 00:00:00

  • Increased rates of morbidity, mortality, and charges for hospitalized children with public or no health insurance as compared with children with private insurance in Colorado and the United States.

    abstract:BACKGROUND:There has been a gradual decrease in the proportion of children covered by private health insurance in Colorado and the United States with a commensurate increase in those with public insurance or having no insurance which may impact access to care and outcomes. OBJECTIVE:The purpose of this work was to det...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0162

    authors: Todd J,Armon C,Griggs A,Poole S,Berman S

    更新日期:2006-08-01 00:00:00

  • Trends in the prevalence of autism on the basis of special education data.

    abstract:OBJECTIVE:The goal was to determine whether the increasing prevalence of autism, on the basis of educational data, in Wisconsin between 2002 and 2008 was uniform in all school districts or was greatest in districts with lower baseline (2002) prevalence. METHODS:Special education counts were obtained for all Wisconsin ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1023

    authors: Maenner MJ,Durkin MS

    更新日期:2010-11-01 00:00:00

  • Effects of nephrotic syndrome on the family: a controlled study.

    abstract::The hypothesis that the parents and siblings of children with nephrotic syndrome are more likely to develop psychosocial problems than those of healthy children was tested. Seventy-nine siblings from 36 such families were compared with 79 healthy children from closely matched families using interviews, parent rating s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Vance JC,Fazan LE,Satterwhite B,Pless IB

    更新日期:1980-05-01 00:00:00

  • Obesity rather than severity of sleep-disordered breathing as the major determinant of insulin resistance and altered lipidemia in snoring children.

    abstract:OBJECTIVE:Sleep-disordered breathing (SDB) is associated with insulin resistance and dyslipidemia in adults and in obese children. However, the prevalence of such metabolic abnormalities among snoring children is unknown. This study was done to prospectively assess the relative contribution of SDB and obesity to metabo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2527

    authors: Tauman R,O'Brien LM,Ivanenko A,Gozal D

    更新日期:2005-07-01 00:00:00

  • Definition and classification of negative motor signs in childhood.

    abstract::In this report we describe the outcome of a consensus meeting that occurred at the National Institutes of Health in Bethesda, Maryland, March 12 through 14, 2005. The meeting brought together 39 specialists from multiple clinical and research disciplines including developmental pediatrics, neurology, neurosurgery, ort...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-3016

    authors: Sanger TD,Chen D,Delgado MR,Gaebler-Spira D,Hallett M,Mink JW,Taskforce on Childhood Motor Disorders.

    更新日期:2006-11-01 00:00:00

  • Fluoride ingestion in children: a review of 87 cases.

    abstract::All cases of fluoride ingestion in children younger than 12 years old reported to the Rocky Mountain Poison Center between January 1 and December 31, 1986, were retrospectively reviewed. Eighty-seven cases were identified. Eighty-four cases involved accidental ingestion of dental fluoride products in the home (tablets...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Augenstein WL,Spoerke DG,Kulig KW,Hall AH,Hall PK,Riggs BS,el Saadi M,Rumack BH

    更新日期:1991-11-01 00:00:00

  • Helping Babies Survive Programs as an Impetus for Quality Improvement.

    abstract::Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-016915J

    authors: Ehret DEY,Patterson JK,Kc A,Worku B,Kamath-Rayne BD,Bose CL

    更新日期:2020-10-01 00:00:00

  • Educational principles of community-based education.

    abstract::Much of medical education remains teacher centered, as exemplified by the continued emphasis on lectures. Increasingly, however, the importance of the learner is being recognized and acknowledged in medical school curricula. The distinction between teaching and learning is also an issue for graduate medical education;...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roberts KB

    更新日期:1996-12-01 00:00:00

  • Language problems in children with ADHD: a community-based study.

    abstract:OBJECTIVES:To examine the prevalence of language problems in children with attention-deficit/hyperactivity disorder (ADHD) versus non-ADHD controls, and the impact of language problems on the social and academic functioning of children with ADHD. METHODS:Children (6 to 8 years) with ADHD (n = 179) and controls (n = 21...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-3355

    authors: Sciberras E,Mueller KL,Efron D,Bisset M,Anderson V,Schilpzand EJ,Jongeling B,Nicholson JM

    更新日期:2014-05-01 00:00:00