Abstract:
:The effect of taurine supplementation on the absorption of a fat meal was evaluated in patients with cystic fibrosis. In a cross-over design study, five patients with cystic fibrosis (12.1 +/- 2.6 years of age) and three control subjects received either placebo or taurine (30 mg/kg/d) for two 1-week periods, a month apart, followed by a fat meal test. Blood samples were drawn 0, 1, 2, 3, 5, 8 hours after the meal. Four patients with cystic fibrosis and severe steatorrhea despite appropriate enzyme therapy showed a significant (P less than .05) improvement in the absorption of triglycerides, total fatty acids, and linoleic acid while receiving taurine supplements. Three control subjects and one child with cystic fibrosis and mild steatorrhea receiving enzyme therapy did not experience such an effect. The difference in triglyceride absorption, when calculated as the area under the curve, receiving and not receiving taurine was significantly (P less than .05) correlated with the degree of steatorrhea. Furthermore, in contrast to control subjects, the fatty acid composition of chylomicrons in these four study patients showed important discrepancies with that of the fat meal and was corrected, in part, by taurine supplementation. These results suggest that taurine supplementation could be a useful adjunct in the management of patients with cystic fibrosis with ongoing fat malabsorption and essential fatty acid deficiency.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Belli DC,Levy E,Darling P,Leroy C,Lepage G,Giguère R,Roy CCsubject
Has Abstractpub_date
1987-10-01 00:00:00pages
517-23issue
4eissn
0031-4005issn
1098-4275journal_volume
80pub_type
临床试验,杂志文章,随机对照试验相关文献
PEDIATRICS文献大全abstract:BACKGROUND:Severe acute respiratory syndrome was relatively mild in children, and the incidence was significantly lower when compared with adults. Although previous seroepidemiological studies demonstrated that asymptomatic infection was uncommon among health care workers and adult contacts of patients with severe acut...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-1476
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Children with sickle cell anemia (SCA) are at increased risk for invasive pneumococcal disease; antibiotic prophylaxis significantly reduces this risk. We calculated the proportion of children with SCA who received ≥300 days of antibiotic prophylaxis and identified predictors of such receipt. METHODS:Childr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2182
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To assess the prevalence and natural history of functional gastrointestinal disorders (FGIDs) in children using the Rome Criteria. METHODS:Thirteen primary care pediatricians were randomly selected from the Campania region of the Italian National Health Service. Each pediatrician completed a detailed FGID q...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.114.1.73
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVES:The objective of this study was to document the psychological adjustment of adolescents who were conceived through donor insemination by lesbian mothers who enrolled before these offspring were born in the largest, longest running, prospective, longitudinal study of same-sex-parented families. METHODS:Betwe...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3153
更新日期:2010-07-01 00:00:00
abstract:BACKGROUND:In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity of the acellular vaccine, the role of vaccine refusal has not been explored in the published literature. Many factors likely contributed to the o...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-0878
更新日期:2013-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the effects of in utero and lactational exposure to polychlorinated biphenyls (PCBs) and dioxins on the mental and psychomotor development of infants. DESIGN:Prenatal PCB exposure was estimated from the levels in maternal plasma during the last month of pregnancy. Postnatal PCB and dioxin exposur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-05-01 00:00:00
abstract:OBJECTIVE:Young children are generally considered immunologically naive with respect to influenza exposure opportunities; thus, a 2-dose schedule is recommended when a child is first immunized with conventional influenza vaccine lacking adjuvant. We estimated the effectiveness of a single pediatric dose of AS03-adjuvan...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-3492
更新日期:2011-11-01 00:00:00
abstract:OBJECTIVE:To determine the sensitivity, specificity, predictive value, and accuracy of a program of pulse oximetry screening of asymptomatic newborns for critical congenital cardiovascular malformation (CCVM). METHODS:Pulse oximetry was performed on asymptomatic newborns in the well-infant nurseries of 2 hospitals. Ca...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.111.3.451
更新日期:2003-03-01 00:00:00
abstract::In adults with chronic kidney disease (CKD), reduced levels of vasculoprotective endothelial progenitor cells (EPCs) may contribute to their increased risk of cardiovascular disease. Children with CKD also show signs of cardiovascular disease. However, to our knowledge, there have been no studies on circulating EPC le...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-3346
更新日期:2010-10-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that breastfeeding is associated with reductions in the risk of common infections among infants; however, whether breastfeeding confers longer term protection is inconclusive. METHODS:We linked data from the 2005-2007 IFPS II (Infant Feeding Practices Study II) and follow-up data...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-0646D
更新日期:2014-09-01 00:00:00
abstract:OBJECTIVE:To provide an updated birth weight-for-gestational age (BW-for-GA) reference in the United States by using the most recent, nationally representative birth data with obstetric estimates of gestational age (GA). METHODS:We abstracted 3 285 552 singleton births between 22 and 42 weeks' gestation with nonmissin...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2019-0076
更新日期:2019-07-01 00:00:00
abstract::The metabolic adaptation to fasting in infants with hyperinsulinism was examined to see whether a characteristic abnormality could be found that would aid in the diagnosis of this disorder. Seven infants under 1 year of age with hyperinsulinism were studied; 7 control infants of similar age and 12 children with ketoti...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1976-05-01 00:00:00
abstract::Human infections with Yersinia were first recognized and reported in upper New York State almost 40 years ago. Recently, there have been increasing numbers of reports from Scandinavia of episodes of polyarthritis associated with Yersinia infections. A 6-month-old girl from upstate New York had a fever of 40 C for two ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1975-02-01 00:00:00
abstract::Childhood adversity is associated with physiologic dysregulation across multiple biological systems; however, relatively little is known about whether these changes are reversible with intervention. The objective of this review was to examine evidence for the effectiveness of interventions to promote healthy cortisol ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2013-1632
更新日期:2014-02-01 00:00:00
abstract::One of the most divisive issues in pediatrics today concerns the proper response by pediatricians to parents who refuse routine childhood immunizations for their children. Many pediatricians refuse to care for such families. Others continue to provide care and continue to try to convince parents that the benefits of i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-1597
更新日期:2016-10-01 00:00:00
abstract:OBJECTIVE:Our objective was to assess the relationship between di(2-ethylhexyl)phthalate (DEHP) exposure during pregnancy and gestational age at delivery among 311 African American or Dominican women from New York City. METHODS:Forty-eight-hour personal air and/or spot urine samples were collected during the third tri...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0325
更新日期:2009-12-01 00:00:00
abstract:OBJECTIVE:Despite concerted policy efforts, a sizeable percentage of children lack health insurance coverage. This article examines the impact of the health care safety net and health care market structure on the use of health care by uninsured children. METHODS:We used the Medical Expenditure Panel Survey linked with...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-0733
更新日期:2006-03-01 00:00:00
abstract::Occasionally, pediatricians become aware of children who are inadequately supervised. More frequently, pediatricians treat children for traumatic injuries or ingestions that they suspect could have been prevented with better supervision. This clinical report contains guidance for pediatricians considering a referral t...
journal_title:Pediatrics
pub_type: 指南,杂志文章
doi:10.1542/peds.2006-1780
更新日期:2006-09-01 00:00:00
abstract::The potential clinical value of quantitative blood cultures determined by a commercially available lysis-direct plating method was studied in 50 children with either Haemophilus influenzae or Streptococcus pneumoniae bacteremia. The magnitude of bacteremia correlated with the severity of the infection; patients with g...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1985-12-01 00:00:00
abstract:CONTEXT:Down syndrome (DS) is the most common chromosomal condition in live-born infants worldwide, and lower respiratory infection caused by respiratory syncytial virus (RSV) is a leading cause of hospital admissions. OBJECTIVE:To evaluate RSV-associated morbidity among children with DS compared with a population wit...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2018-0225
更新日期:2018-09-01 00:00:00
abstract::Epidemiologic studies indicate that children of all ages with certain chronic conditions and otherwise healthy children younger than 24 months of age are hospitalized for influenza infection and its complications at high rates similar to those experienced by the elderly. Annual influenza immunization is recommended fo...
journal_title:Pediatrics
pub_type: 指南,杂志文章,实务指引
doi:10.1542/peds.113.5.1441
更新日期:2004-05-01 00:00:00
abstract:BACKGROUND:There has been a gradual decrease in the proportion of children covered by private health insurance in Colorado and the United States with a commensurate increase in those with public insurance or having no insurance which may impact access to care and outcomes. OBJECTIVE:The purpose of this work was to det...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-0162
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:The goal was to determine whether the increasing prevalence of autism, on the basis of educational data, in Wisconsin between 2002 and 2008 was uniform in all school districts or was greatest in districts with lower baseline (2002) prevalence. METHODS:Special education counts were obtained for all Wisconsin ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1023
更新日期:2010-11-01 00:00:00
abstract::The hypothesis that the parents and siblings of children with nephrotic syndrome are more likely to develop psychosocial problems than those of healthy children was tested. Seventy-nine siblings from 36 such families were compared with 79 healthy children from closely matched families using interviews, parent rating s...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1980-05-01 00:00:00
abstract:OBJECTIVE:Sleep-disordered breathing (SDB) is associated with insulin resistance and dyslipidemia in adults and in obese children. However, the prevalence of such metabolic abnormalities among snoring children is unknown. This study was done to prospectively assess the relative contribution of SDB and obesity to metabo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2527
更新日期:2005-07-01 00:00:00
abstract::In this report we describe the outcome of a consensus meeting that occurred at the National Institutes of Health in Bethesda, Maryland, March 12 through 14, 2005. The meeting brought together 39 specialists from multiple clinical and research disciplines including developmental pediatrics, neurology, neurosurgery, ort...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-3016
更新日期:2006-11-01 00:00:00
abstract::All cases of fluoride ingestion in children younger than 12 years old reported to the Rocky Mountain Poison Center between January 1 and December 31, 1986, were retrospectively reviewed. Eighty-seven cases were identified. Eighty-four cases involved accidental ingestion of dental fluoride products in the home (tablets...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1991-11-01 00:00:00
abstract::Achieving the ambitious reduction in global neonatal mortality targeted in the Sustainable Development Goals and Every Newborn Action Plan will require reducing geographic disparities in newborn deaths through targeted implementation of evidence-based practices. Helping Babies Survive, a suite of educational programs ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-016915J
更新日期:2020-10-01 00:00:00
abstract::Much of medical education remains teacher centered, as exemplified by the continued emphasis on lectures. Increasingly, however, the importance of the learner is being recognized and acknowledged in medical school curricula. The distinction between teaching and learning is also an issue for graduate medical education;...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-12-01 00:00:00
abstract:OBJECTIVES:To examine the prevalence of language problems in children with attention-deficit/hyperactivity disorder (ADHD) versus non-ADHD controls, and the impact of language problems on the social and academic functioning of children with ADHD. METHODS:Children (6 to 8 years) with ADHD (n = 179) and controls (n = 21...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2013-3355
更新日期:2014-05-01 00:00:00