Reduced endothelial progenitor cells in children with hemodialysis but not predialysis chronic kidney disease.

Abstract:

:In adults with chronic kidney disease (CKD), reduced levels of vasculoprotective endothelial progenitor cells (EPCs) may contribute to their increased risk of cardiovascular disease. Children with CKD also show signs of cardiovascular disease. However, to our knowledge, there have been no studies on circulating EPC levels in pediatric patients with CKD. We investigated CD34+KDR+ EPC numbers by using flow cytometry in 15 children with predialysis CKD, 13 children on hemodialysis, and 18 age-matched healthy controls. Children on hemodialysis showed 47% reduced EPC levels compared with controls, whereas no significant difference was found for patients with predialysis CKD. Lower EPC levels were found in patients with higher levels of inflammatory marker high-sensitivity C-reactive protein. Our data show, for the first time, that children on hemodialysis have reduced CD34+KDR+ EPC levels, which potentially contributes to their increased cardiovascular risk. In children with predialysis CKD, a decline in renal function was not associated with reduced EPC levels, which may reflect a capacity for preservation of the endogenous repair system during relatively moderate disturbances of the systemic environment.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Jie KE,Lilien MR,Goossens MH,Westerweel PE,Klein MK,Verhaar MC

doi

10.1542/peds.2009-3346

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

e990-3

issue

4

eissn

0031-4005

issn

1098-4275

pii

peds.2009-3346

journal_volume

126

pub_type

杂志文章
  • 15-year follow-up of recurrent "hypoglycemia" in preterm infants.

    abstract:BACKGROUND:Observational study of 543 infants who weighed <1850 g, published in 1988 reported seriously impaired motor and cognitive development at 18 months in those with recurrent, asymptomatic hypoglycemia (plasma glucose level ≤2.5 mmol/L on ≥3 days). No study has yet replicated this observation. AIM:To quantify d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-0776

    authors: Tin W,Brunskill G,Kelly T,Fritz S

    更新日期:2012-12-01 00:00:00

  • Serum luteinizing hormone rises within minutes after depot leuprolide injection: implications for monitoring therapy.

    abstract:OBJECTIVE:To find the time of the serum gonadotropin peak after depot leuprolide injection in children and to show that depot leuprolide therapy can be monitored by measuring serum luteinizing hormone (LH) immediately after injections. STUDY DESIGN:We measured concentrations of leuprolide, LH, and follicle-stimulating...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.2.e30

    authors: Bhatia S,Neely EK,Wilson DM

    更新日期:2002-02-01 00:00:00

  • Psychopathology in children and adolescents with migraine in clinical studies: a systematic review.

    abstract:BACKGROUND:In past decades, numerous population- and hospital-based studies have revealed a relationship between migraine or headache and psychopathology in children. OBJECTIVE:To describe and assess all clinical studies on the prevalence and manifestations of psychological functioning and psychiatric comorbidity in c...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2009-3293

    authors: Bruijn J,Locher H,Passchier J,Dijkstra N,Arts WF

    更新日期:2010-08-01 00:00:00

  • Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study.

    abstract:OBJECTIVE:Despite the promising preliminary results observed in extremely low birth weight (ELBW) populations, the use of fluconazole to prevent fungal colonization and infection in preterm neonates in the NICU is still an open question and not yet recommended as a standard of care. We have reviewed our 6-year series t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2227

    authors: Manzoni P,Arisio R,Mostert M,Leonessa M,Farina D,Latino MA,Gomirato G

    更新日期:2006-01-01 00:00:00

  • Microbiology of the vagina in children: normal and potentially pathogenic organisms.

    abstract::Vaginal cultures from 100 healthy girls, 2 months to 15 years of age, were examined for the presence of normal and potentially pathogenic microorganisms. Corynebacterium vaginale, yeast species, and genital mycoplasmas were isolated from vaginal cultures from 13.5 %, 28%, and 28% of the girls examined, respectively. C...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Hammerschlag MR,Alpert S,Rosner I,Thurston P,Semine D,McComb D,McCormack WM

    更新日期:1978-07-01 00:00:00

  • Restless legs syndrome: prevalence and impact in children and adolescents--the Peds REST study.

    abstract:OBJECTIVES:Restless legs syndrome, a common neurologic sleep disorder, occurs in 5% to 10% of adults in the United States and Western Europe. Although approximately 25% of adults with restless legs syndrome report onset of symptoms between the ages of 10 and 20 years, there is very little literature looking directly at...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-2767

    authors: Picchietti D,Allen RP,Walters AS,Davidson JE,Myers A,Ferini-Strambi L

    更新日期:2007-08-01 00:00:00

  • Severe varicella associated with steroid use.

    abstract:OBJECTIVE:To evaluate whether corticosteroid use is associated with severe varicella. DESIGN:The odds of corticosteroid exposure were compared among 35 children with severe varicella and 10,000 control subjects. RESULTS:Five (26.3%) of 19 case patients without known immunosuppression had received steroids within 30 d...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dowell SF,Bresee JS

    更新日期:1993-08-01 00:00:00

  • General pediatric attending physicians' and residents' knowledge of inpatient hospital finances.

    abstract:BACKGROUND AND OBJECTIVE:There is evidence suggesting that physicians have a limited foundation of knowledge on health care finances and limited awareness of hospital costs and charges. The objective was to analyze general pediatric attending physicians' and residents' knowledge of costs, charges, and reimbursements fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1753

    authors: Rock TA,Xiao R,Fieldston E

    更新日期:2013-06-01 00:00:00

  • The efficacy of motivational interviewing versus brief advice for adolescent smoking behavior change.

    abstract:OBJECTIVE:In this study we sought to evaluate the efficacy of motivational interviewing (MI) compared with structured brief advice (SBA) for adolescent smoking behavior change. METHODS:Participants (N=355) were randomly assigned to 5 sessions of either MI or SBA. The primary outcomes were attempts to reduce and to qui...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2010-2174

    authors: Audrain-McGovern J,Stevens S,Murray PJ,Kinsman S,Zuckoff A,Pletcher J,Moss D,Baumritter A,Kalkhuis-Beam S,Carlson E,Rodriguez D,Wileyto EP

    更新日期:2011-07-01 00:00:00

  • Detection of Mycobacterium tuberculosis in clinical specimens from children using a polymerase chain reaction.

    abstract:OBJECTIVE:We evaluated the usefulness of the polymerase chain reaction (PCR) using the insertion sequence IS6110 as the target for DNA to detect Mycobacterium tuberculosis in clinical specimens from children. STUDY DESIGN:This was a prospective, controlled, blinded study comparing PCR on clinical specimens, mycobacter...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究

    doi:

    authors: Smith KC,Starke JR,Eisenach K,Ong LT,Denby M

    更新日期:1996-02-01 00:00:00

  • Effects of the accreditation council for graduate medical education duty hour limits on sleep, work hours, and safety.

    abstract:OBJECTIVE:To mitigate the risks of fatigue-related medical errors, the Accreditation Council for Graduate Medical Education introduced work hour limits for resident physicians in 2003. Our goal was to determine whether work hours, sleep, and safety changed after implementation of the Accreditation Council for Graduate ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2306

    authors: Landrigan CP,Fahrenkopf AM,Lewin D,Sharek PJ,Barger LK,Eisner M,Edwards S,Chiang VW,Wiedermann BL,Sectish TC

    更新日期:2008-08-01 00:00:00

  • The delivery of immunizations and other preventive services in private practices.

    abstract:OBJECTIVES:To measure the proportion of children cared for in private practices who are fully immunized and have been screened for anemia, tuberculosis (TB), and lead poisoning by 2 years of age. DESIGN:Cross-sectional chart review. SETTING:Fifteen private pediatric practices in central North Carolina (11 chosen rand...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bordley WC,Margolis PA,Lannon CM

    更新日期:1996-04-01 00:00:00

  • Carbohydrate absorption from fruit juice in young children.

    abstract:OBJECTIVE:To compare carbohydrate absorption following ingestion of apple juice and white grape juice in 28 healthy children. DESIGN:Randomized, double-blind crossover study. SETTING:Outpatient pediatric clinic at Maimonides Medical Center. PARTICIPANTS:A total of 18 healthy infants (mean age 6.3 months) and 10 todd...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Smith MM,Davis M,Chasalow FI,Lifshitz F

    更新日期:1995-03-01 00:00:00

  • Methadone-induced rigid-chest syndrome after substantial overdose.

    abstract::We report here the case of an infant who developed life-threatening rigid-chest syndrome after receiving an accidental overdose of methadone. The child responded to narcotic reversal. Pediatric physicians should be aware of this possible complication. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3243

    authors: Lynch RE,Hack RA

    更新日期:2010-07-01 00:00:00

  • Health outcomes of a community-based therapy program for children with cancer--a shared-management approach.

    abstract::Critical to providing cancer therapy to children in rural areas is finding dependable sources of therapy near the patients' homes. In this study, comparison was made of 668 visits by 24 patients to nearby private practitioners, who carried out 70% of the therapy, with 712 visits by 22 other patients for whom all care ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kisker CT,Strayer F,Wong K,Clarke W,Strauss R,Tannous R,Janco R,Spevak J

    更新日期:1980-12-01 00:00:00

  • Long-term study of a quadrivalent human papillomavirus vaccine.

    abstract:BACKGROUND:We present a long-term safety, immunogenicity, and effectiveness study of a quadrivalent human papillomavirus (HPV4) vaccine. METHODS:Sexually naive boys and girls aged 9 to 15 years (N = 1781) were assigned (2:1) to receive HPV4 vaccine or saline placebo at day 1 and months 2 and 6. At month 30, the placeb...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2013-4144

    authors: Ferris D,Samakoses R,Block SL,Lazcano-Ponce E,Restrepo JA,Reisinger KS,Mehlsen J,Chatterjee A,Iversen OE,Sings HL,Shou Q,Sausser TA,Saah A

    更新日期:2014-09-01 00:00:00

  • Clinical characteristics of peanut-allergic children: recent changes.

    abstract:OBJECTIVE:The goal was to determine whether patients seen in a referral clinic are experiencing initial allergic reactions to peanuts earlier, compared with a similar population profiled at a different medical center 10 years ago, and to investigate other changes in clinical characteristics of the patients between the ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0350

    authors: Green TD,LaBelle VS,Steele PH,Kim EH,Lee LA,Mankad VS,Williams LW,Anstrom KJ,Burks AW

    更新日期:2007-12-01 00:00:00

  • Newborn Screening for Cystic Fibrosis in California.

    abstract:OBJECTIVES:This article describes the methods used and the program performance results for the first 5 years of newborn screening for cystic fibrosis (CF) in California. METHODS:From July 16, 2007, to June 30, 2012, a total of 2,573,293 newborns were screened for CF by using a 3-step model: (1) measuring immunoreactiv...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0811

    authors: Kharrazi M,Yang J,Bishop T,Lessing S,Young S,Graham S,Pearl M,Chow H,Ho T,Currier R,Gaffney L,Feuchtbaum L,California Cystic Fibrosis Newborn Screening Consortium.

    更新日期:2015-12-01 00:00:00

  • Race, otitis media, and antibiotic selection.

    abstract:BACKGROUND AND OBJECTIVE:Previous research suggests that physicians may be less likely to diagnose otitis media (OM) and to prescribe broad-spectrum antibiotics for black versus nonblack children. Our objective was to determine whether race is associated with differences in OM diagnosis and antibiotic prescribing natio...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-1781

    authors: Fleming-Dutra KE,Shapiro DJ,Hicks LA,Gerber JS,Hersh AL

    更新日期:2014-12-01 00:00:00

  • Preparation for emergencies in the offices of pediatricians and pediatric primary care providers.

    abstract::High-quality pediatric emergency care can be provided only through the collaborative efforts of many health care professionals and child advocates working together throughout a continuum of care that extends from prevention and the medical home to prehospital care, to emergency department stabilization, to critical ca...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2007-1109

    authors: American Academy of Pediatrics Committee on Pediatric Emergency Medicine.,Frush K

    更新日期:2007-07-01 00:00:00

  • Verbal autopsy methods to ascertain birth asphyxia deaths in a community-based setting in southern Nepal.

    abstract:OBJECTIVES:The goals of this study were to (1) develop an approach to ascertain birth asphyxia deaths by using verbal autopsy data from a community-based setting in Nepal, and (2) explore variations in birth asphyxia mortality fractions by using different birth asphyxia case definitions and hierarchical classifications...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2644

    authors: Lee AC,Mullany LC,Tielsch JM,Katz J,Khatry SK,LeClerq SC,Adhikari RK,Shrestha SR,Darmstadt GL

    更新日期:2008-05-01 00:00:00

  • Legal, ethical, and financial dilemmas in electronic health record adoption and use.

    abstract::Electronic health records (EHRs) facilitate several innovations capable of reforming health care. Despite their promise, many currently unanswered legal, ethical, and financial questions threaten the widespread adoption and use of EHRs. Key legal dilemmas that must be addressed in the near-term pertain to the extent o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-2184

    authors: Sittig DF,Singh H

    更新日期:2011-04-01 00:00:00

  • Use of complementary and alternative medical therapies among children with special health care needs in southern Arizona.

    abstract:OBJECTIVE:The objective of this study was to assess the frequency and type of complementary and alternative medicine (CAM) therapies used by families of children with special health care needs in southern Arizona, as well as the correlates of their use. METHODS:Families of 376 children who were receiving services in a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.3.584

    authors: Sanders H,Davis MF,Duncan B,Meaney FJ,Haynes J,Barton LL

    更新日期:2003-03-01 00:00:00

  • Prevalence and impact of respiratory viral infections in young children with cystic fibrosis: prospective cohort study.

    abstract:OBJECTIVE:We aimed to investigate differences in upper and lower respiratory tract symptoms in relation to respiratory viral infections detected with polymerase chain reaction assays in young children with cystic fibrosis and healthy control subjects. METHODS:In a 6-month winter period, 20 young children with cystic f...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-3139

    authors: van Ewijk BE,van der Zalm MM,Wolfs TF,Fleer A,Kimpen JL,Wilbrink B,van der Ent CK

    更新日期:2008-12-01 00:00:00

  • Exclusive breastfeeding protects against bacterial colonization and day care exposure to otitis media.

    abstract:OBJECTIVE:We followed a cohort (N = 306) of infants at well-baby visits in two suburban pediatric practices to assess the relation of exclusive breastfeeding, and other environmental exposures, to episodes of acute otitis media (AOM) and otitis media with effusion (OME). METHODS:Detailed prospective information about ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.100.4.e7

    authors: Duffy LC,Faden H,Wasielewski R,Wolf J,Krystofik D

    更新日期:1997-10-01 00:00:00

  • Hepatitis B virus infection in Honolulu students.

    abstract:OBJECTIVES:To determine hepatitis B virus (HBV) carrier and infection rates and HBV epidemiology in Honolulu students. DESIGN:Cross-sectional survey. SETTING:Honolulu public elementary, intermediate, and high schools. PATIENTS:A volunteer sample of 4936 students from 43 Honolulu schools. MAIN OUTCOME MEASURES:HBV c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Pon EW,Ren H,Margolis H,Zhao Z,Schatz GC,Diwan A

    更新日期:1993-10-01 00:00:00

  • Securing central lines in rambunctious toddlers.

    abstract::Central line dislodgment in toddlers continues to be a problem. The deployment of a spandex/nylon bodysuit has resulted in eliminating this problem in two overactive toddlers. We highly recommend using this type of garment in appropriate clinical situations. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Janik JP,Wayne ER,Janik JS

    更新日期:1995-09-01 00:00:00

  • Obesity and Mortality Risk in Critically Ill Children.

    abstract:BACKGROUND AND OBJECTIVES:Childhood obesity is epidemic and may be associated with PICU mortality. Using a large multicenter PICU database, we investigated the association between obesity and PICU mortality, adjusting for initial severity of illness. We further investigated whether height- and weight-based classificati...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2015-2035

    authors: Ross PA,Newth CJ,Leung D,Wetzel RC,Khemani RG

    更新日期:2016-03-01 00:00:00

  • Hematopoietic stem cell transplantation corrects the immunologic abnormalities associated with immunodeficiency-centromeric instability-facial dysmorphism syndrome.

    abstract::Immunodeficiency-centromeric instability-facial dysmorphism syndrome, characterized by variable immunodeficiency, centromeric instability, and facial anomalies caused by epigenetic dysregulation resulting in hypomethylation, is caused in many patients by mutations in DNMT3B, a DNA methyltransferase gene; associated in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0640

    authors: Gennery AR,Slatter MA,Bredius RG,Hagleitner MM,Weemaes C,Cant AJ,Lankester AC

    更新日期:2007-11-01 00:00:00

  • Iron deficiency in early childhood in the United States: risk factors and racial/ethnic disparities.

    abstract:BACKGROUND:Iron deficiency affects 2.4 million US children, and childhood iron-deficiency anemia is associated with behavioral and cognitive delays. Given the detrimental long-term effects and high prevalence of iron deficiency, its prevention in early childhood is an important public health issue. OBJECTIVES:The stud...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0572

    authors: Brotanek JM,Gosz J,Weitzman M,Flores G

    更新日期:2007-09-01 00:00:00