Abstract:
:Investigations in which statistically significant differences between treatment groups have not been observed are less likely than others to be reported in scientific journals. In clinical research, this selective suppression of "negative" results may lead to the adoption of ineffective or hazardous treatments. In an attempt to obtain information about unpublished trials in perinatal medicine, letters were sent to 42,000 obstetricians and pediatricians in 18 countries. As a result, we were notified of 395 unpublished randomized trials. Only 18 of the trials had been completed more than 2 years before the survey, a period during which at least 2300 reports of perinatal trials had been published. Of the 395 unpublished trials, 125 had ceased recruitment within the 2 years prior to the survey, 193 were actively recruiting at the time of the survey, and 59 were about to begin recruitment. It was concluded that publication bias will not be addressed successfully by attempts to obtain information about unpublished trials retrospectively. However, since the response rate to our request for details about ongoing and planned trials was good, prospective registration of trials at inception appears to be a feasible approach to reducing publication bias and its adverse consequences. An additional merit of prospective registration of clinical trials is that it should reduce unnecessary duplication (as opposed to necessary replication) in research and promote more effective collaboration.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Hetherington J,Dickersin K,Chalmers I,Meinert CLsubject
Has Abstractpub_date
1989-08-01 00:00:00pages
374-80issue
2eissn
0031-4005issn
1098-4275journal_volume
84pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract::Withdrawal of steroid medications from patients who have been receiving them for management of chronic disease carries the risk of certain serious complications. An understanding of adrenal physiology, coupled with a rational plan for evaluating the individual patient, when necessary, and for protecting against certai...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1981-02-01 00:00:00
abstract:BACKGROUND:Light smoking, consuming a few cigarettes daily, and intermittent, or nondaily, smoking patterns are increasingly common but carry health risks comparable to heavier smoking patterns. Nearly all smokers begin smoking as adolescents, who are at risk for developing these smoking patterns. Previous research sug...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2014-2502
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To determine whether pediatric health care providers recognize maternal depressive symptoms and to explore whether maternal, provider, and visit characteristics affect pediatric providers' ability to recognize inner-city mothers with depressive symptoms. DESIGN:A cross-sectional study was conducted at a hosp...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.106.6.1367
更新日期:2000-12-01 00:00:00
abstract::In 2005, the Enhancing Developmentally Oriented Primary Care (EDOPC) project of the Illinois chapter of the American Academy of Pediatrics and the Illinois Department of Healthcare and Family Services began a project to improve the delivery and financing of preventive health and developmental services for children in ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-1466K
更新日期:2010-12-01 00:00:00
abstract:OBJECTIVES:Emergency department (ED) overcrowding has become a national problem. Children account for nearly 25% of overall ED visits. It has been reported that uninsured and publicly insured children are likely to visit the ED for urgent and nonurgent problems, yet it remains unclear to what extent health insurance st...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.2.314
更新日期:2003-08-01 00:00:00
abstract::A study was done to assess the necessity of hospital care for poisoning episodes in children less than 5 years old and to evaluate the impact of a regional poison center on the use of emergency rooms for pediatric poisonings. Of the pediatric patients seen in emergency rooms for acute poisonings, 63% did not require t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1983-08-01 00:00:00
abstract:OBJECTIVE:The aim of this study was to assess the prevalence of congenital defects observed in patients with Prader-Willi syndrome (PWS) and to compare this prevalence with that described in the general population. In addition, these findings were correlated with the different etiologic subtypes. METHODS:A total of 18...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1103
更新日期:2013-02-01 00:00:00
abstract:OBJECTIVE:Our aim was to define the relationship of PaO(2) and pulse oxygen saturation values during routine clinical practice and to evaluate whether pulse oxygen saturation values between 85% and 93% were associated with PaO(2) levels of <40 mmHg. METHODS:Prospective comparison of PaO(2) and pulse oxygen saturation ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-0117
更新日期:2008-05-01 00:00:00
abstract:OBJECTIVE:The goal was to estimate the level of delivered continuous positive airway pressure by measuring oral cavity pressure with the mouth closed in infants of various weights and ages treated with heated, humidified high-flow nasal cannula at flow rates of 1-5 L/minute. We hypothesized that clinically relevant lev...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-0957
更新日期:2008-01-01 00:00:00
abstract:OBJECTIVES:In a population-based case-control study, we investigated the association between congenital heart defects and maternal smoking. METHODS:The National Birth Defects Prevention Study enrolled 3067 infants with nonsyndromic congenital heart defects and their parents and 3947 infants without birth defects and t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-1519
更新日期:2008-04-01 00:00:00
abstract:OBJECTIVE:The anion exchanger gene (AE1) or band 3 encodes a chloride-bicarbonate (Cl(-)/HCO(3)(-)) exchanger expressed in the erythrocyte and in the renal alpha-intercalated cells involved in urine acidification. The purpose of the present study was to screen for mutations in the AE1 gene in 2 brothers (10 and 15 year...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.6.1361
更新日期:2003-12-01 00:00:00
abstract::Abdominal muscle deficiency, urinary tract abnormalities, and cryptorchidism are the three major features of the prune-belly syndrome, also referred to as triad syndrome or Eagle-Barrett syndrome. The etiology is unclear and the pathogenesis a subject of continuing debate. Clinical and pathologic experience with seven...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1984-04-01 00:00:00
abstract:OBJECTIVE:To determine parents' knowledge and attitudes of medicolegal issues affecting adolescent medical care. DESIGN:An anonymous, mailed survey with 16 questions concerning Minnesota consent and confidentiality laws that affect adolescents' medical care. SETTING:A community of >70 000 in rural, southeastern Minne...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.3.582
更新日期:1999-03-01 00:00:00
abstract:OBJECTIVE:To determine if there is a relationship between diabetes outcome as measured by HbA1C and the number of multidisciplinary clinic visits per year in children and youth with diabetes. RESEARCH DESIGN AND METHODS:The number of clinic visits per year, the mean HbA1C (by DCA 2000, Miles, Tarrytown, NY), type of i...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.5.948
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVE:As neonatal discharge before 24 hours of life becomes commonplace, the rejection of congenital hypothyroidism (CH) screening specimens obtained too early has created the need for numerous additional tests. We sought to determine whether the specimens obtained before 24 hours could be used safely. METHODS:Dur...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1996-07-01 00:00:00
abstract::Occasionally, pediatricians become aware of children who are inadequately supervised. More frequently, pediatricians treat children for traumatic injuries or ingestions that they suspect could have been prevented with better supervision. This clinical report contains guidance for pediatricians considering a referral t...
journal_title:Pediatrics
pub_type: 指南,杂志文章
doi:10.1542/peds.2006-1780
更新日期:2006-09-01 00:00:00
abstract::This article, written by a group of experienced parents of children with medical complexity (CMC), provides an overview of the demands of managing care from their unique perspective. The article articulates why attention to understanding the challenges that families of CMC face with a fragmented health care system, in...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2017-1284D
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND:The Reach Out and Read (ROR) program promotes early literacy as part of pediatric primary care through the distribution of children's books and anticipatory guidance during early childhood. OBJECTIVES:To improve the rates of age-appropriate book-giving during well-child care and the delivery of ROR-recommen...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2010-2290
更新日期:2011-04-01 00:00:00
abstract::Historically, fruit juice was recommended by pediatricians as a source of vitamin C and as an extra source of water for healthy infants and young children as their diets expanded to include solid foods with higher renal solute load. It was also sometimes recommended for children with constipation. Fruit juice is marke...
journal_title:Pediatrics
pub_type: 指南,杂志文章
doi:10.1542/peds.2017-0967
更新日期:2017-06-01 00:00:00
abstract:OBJECTIVES:To assess the annual prevalence of physical violence from dating partners among a representative sample of sexually experienced adolescent girls attending US public and private high schools, as well as sexual risk behaviors and pregnancy among this population. DESIGN, SETTING, PARTICIPANTS, AND MEASURES:Fem...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.114.2.e220
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Both the social environment and the physical environment are increasingly recognized as important to childhood diseases such as asthma. This study tested a novel hypothesis: that living in areas high in greenspace may help buffer the effects of difficult family relationships for children with ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-3056
更新日期:2017-04-01 00:00:00
abstract:OBJECTIVE:Circumstances surrounding parental availability and decision-making were examined in the setting of a research protocol involving newborn screening (NBS) for fragile X syndrome, in which the institutional review board (IRB) had determined that consent (permission) was required from both parents. METHODS:A su...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2012-1278
更新日期:2013-01-01 00:00:00
abstract::Streptococcus pneumoniae-associated hemolytic uremic syndrome (HUS) is an underrecognized condition that mainly occurs in young children. Early diagnosis is important because of the potential to improve morbidity and mortality rates. The purposes of this report are to review the clinical and laboratory features of 14 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2007-2017
更新日期:2010-01-01 00:00:00
abstract::Safe transportation of preterm and low birth weight infants requires special considerations. Both physiologic immaturity and low birth weight must be taken into account to properly position such infants. This clinical report provides guidelines for pediatricians and other caregivers who counsel parents of preterm and ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2009-0559
更新日期:2009-05-01 00:00:00
abstract::Intestinal lymphangiectasia is characterized by obstruction of lymph drainage from the small intestine and lacteal dilation that distorts the villus architecture. Lymphatic vessel obstruction and elevated intestinal lymphatic pressure in turn cause lymphatic leakage into the intestinal lumen, thus resulting in malabso...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.2.416
更新日期:2001-02-01 00:00:00
abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.107.1.e6
更新日期:2001-01-01 00:00:00
abstract:OBJECTIVE:To characterize neuroimaging, physical, neurobehavioral, and developmental findings in children with inflicted and noninflicted traumatic brain injury (TBI) and to identify characteristic features of inflicted TBI. METHODS AND PATIENTS:Forty children, 0 to 6 years of age, hospitalized for TBI who had no docu...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.102.2.300
更新日期:1998-08-01 00:00:00
abstract::This publication contains the pediatric and neonatal sections of the 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (COSTR). The consensus process that produced this document was sponsored by the International Liaison Committee on ...
journal_title:Pediatrics
pub_type: 杂志文章,实务指引
doi:10.1542/peds.2006-0206
更新日期:2006-05-01 00:00:00
abstract::The impact of a system of primary pediatric care on emergency room use in a municipal hospital was measured by comparing that use in two randomly selected populations. The population that was offered participation in a primary care program consistently used the emergency room less than did the control group. Analysis ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1979-03-01 00:00:00
abstract:BACKGROUND:Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for cardiovascular disease, including higher blood pressure and insulin resistance. OBJECTIVE:We studied, in young adults born at a VLBW, early signs of an accelerated atherosclerotic process and th...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2010-2199
更新日期:2011-02-01 00:00:00