Retrospective and prospective identification of unpublished controlled trials: lessons from a survey of obstetricians and pediatricians.

Abstract:

:Investigations in which statistically significant differences between treatment groups have not been observed are less likely than others to be reported in scientific journals. In clinical research, this selective suppression of "negative" results may lead to the adoption of ineffective or hazardous treatments. In an attempt to obtain information about unpublished trials in perinatal medicine, letters were sent to 42,000 obstetricians and pediatricians in 18 countries. As a result, we were notified of 395 unpublished randomized trials. Only 18 of the trials had been completed more than 2 years before the survey, a period during which at least 2300 reports of perinatal trials had been published. Of the 395 unpublished trials, 125 had ceased recruitment within the 2 years prior to the survey, 193 were actively recruiting at the time of the survey, and 59 were about to begin recruitment. It was concluded that publication bias will not be addressed successfully by attempts to obtain information about unpublished trials retrospectively. However, since the response rate to our request for details about ongoing and planned trials was good, prospective registration of trials at inception appears to be a feasible approach to reducing publication bias and its adverse consequences. An additional merit of prospective registration of clinical trials is that it should reduce unnecessary duplication (as opposed to necessary replication) in research and promote more effective collaboration.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Hetherington J,Dickersin K,Chalmers I,Meinert CL

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

374-80

issue

2

eissn

0031-4005

issn

1098-4275

journal_volume

84

pub_type

杂志文章
  • Management of pituitary-adrenal suppression secondary to corticosteroid therapy.

    abstract::Withdrawal of steroid medications from patients who have been receiving them for management of chronic disease carries the risk of certain serious complications. An understanding of adrenal physiology, coupled with a rational plan for evaluating the individual patient, when necessary, and for protecting against certai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chamberlin P,Meyer WJ 3rd

    更新日期:1981-02-01 00:00:00

  • Adolescents' perceptions of light and intermittent smoking in the United States.

    abstract:BACKGROUND:Light smoking, consuming a few cigarettes daily, and intermittent, or nondaily, smoking patterns are increasingly common but carry health risks comparable to heavier smoking patterns. Nearly all smokers begin smoking as adolescents, who are at risk for developing these smoking patterns. Previous research sug...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2502

    authors: Amrock SM,Weitzman M

    更新日期:2015-02-01 00:00:00

  • Do pediatricians recognize mothers with depressive symptoms?

    abstract:OBJECTIVE:To determine whether pediatric health care providers recognize maternal depressive symptoms and to explore whether maternal, provider, and visit characteristics affect pediatric providers' ability to recognize inner-city mothers with depressive symptoms. DESIGN:A cross-sectional study was conducted at a hosp...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.1367

    authors: Heneghan AM,Silver EJ,Bauman LJ,Stein RE

    更新日期:2000-12-01 00:00:00

  • Enhancing developmentally oriented primary care: an Illinois initiative to increase developmental screening in medical homes.

    abstract::In 2005, the Enhancing Developmentally Oriented Primary Care (EDOPC) project of the Illinois chapter of the American Academy of Pediatrics and the Illinois Department of Healthcare and Family Services began a project to improve the delivery and financing of preventive health and developmental services for children in ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-1466K

    authors: Allen SG,Berry AD,Brewster JA,Chalasani RK,Mack PK

    更新日期:2010-12-01 00:00:00

  • Children's health insurance status and emergency department utilization in the United States.

    abstract:OBJECTIVES:Emergency department (ED) overcrowding has become a national problem. Children account for nearly 25% of overall ED visits. It has been reported that uninsured and publicly insured children are likely to visit the ED for urgent and nonurgent problems, yet it remains unclear to what extent health insurance st...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.2.314

    authors: Luo X,Liu G,Frush K,Hey LA

    更新日期:2003-08-01 00:00:00

  • Effectiveness of a regional poison center in reducing excess emergency room visits for children's poisonings.

    abstract::A study was done to assess the necessity of hospital care for poisoning episodes in children less than 5 years old and to evaluate the impact of a regional poison center on the use of emergency rooms for pediatric poisonings. Of the pediatric patients seen in emergency rooms for acute poisonings, 63% did not require t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chafee-Bahamon C,Lovejoy FH Jr

    更新日期:1983-08-01 00:00:00

  • Change in prevalence of congenital defects in children with Prader-Willi syndrome.

    abstract:OBJECTIVE:The aim of this study was to assess the prevalence of congenital defects observed in patients with Prader-Willi syndrome (PWS) and to compare this prevalence with that described in the general population. In addition, these findings were correlated with the different etiologic subtypes. METHODS:A total of 18...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1103

    authors: Torrado M,Foncuberta ME,Perez MF,Gravina LP,Araoz HV,Baialardo E,Chertkoff LP

    更新日期:2013-02-01 00:00:00

  • Pulse oxygen saturation levels and arterial oxygen tension values in newborns receiving oxygen therapy in the neonatal intensive care unit: is 85% to 93% an acceptable range?

    abstract:OBJECTIVE:Our aim was to define the relationship of PaO(2) and pulse oxygen saturation values during routine clinical practice and to evaluate whether pulse oxygen saturation values between 85% and 93% were associated with PaO(2) levels of <40 mmHg. METHODS:Prospective comparison of PaO(2) and pulse oxygen saturation ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0117

    authors: Castillo A,Sola A,Baquero H,Neira F,Alvis R,Deulofeut R,Critz A

    更新日期:2008-05-01 00:00:00

  • Heated, humidified high-flow nasal cannula therapy: yet another way to deliver continuous positive airway pressure?

    abstract:OBJECTIVE:The goal was to estimate the level of delivered continuous positive airway pressure by measuring oral cavity pressure with the mouth closed in infants of various weights and ages treated with heated, humidified high-flow nasal cannula at flow rates of 1-5 L/minute. We hypothesized that clinically relevant lev...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-0957

    authors: Kubicka ZJ,Limauro J,Darnall RA

    更新日期:2008-01-01 00:00:00

  • Maternal smoking and congenital heart defects.

    abstract:OBJECTIVES:In a population-based case-control study, we investigated the association between congenital heart defects and maternal smoking. METHODS:The National Birth Defects Prevention Study enrolled 3067 infants with nonsyndromic congenital heart defects and their parents and 3947 infants without birth defects and t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1519

    authors: Malik S,Cleves MA,Honein MA,Romitti PA,Botto LD,Yang S,Hobbs CA,National Birth Defects Prevention Study.

    更新日期:2008-04-01 00:00:00

  • A novel mutation in the anion exchanger 1 gene is associated with familial distal renal tubular acidosis and nephrocalcinosis.

    abstract:OBJECTIVE:The anion exchanger gene (AE1) or band 3 encodes a chloride-bicarbonate (Cl(-)/HCO(3)(-)) exchanger expressed in the erythrocyte and in the renal alpha-intercalated cells involved in urine acidification. The purpose of the present study was to screen for mutations in the AE1 gene in 2 brothers (10 and 15 year...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.6.1361

    authors: Cheidde L,Vieira TC,Lima PR,Saad ST,Heilberg IP

    更新日期:2003-12-01 00:00:00

  • Pathogenesis of the prune-belly syndrome: a functional urethral obstruction caused by prostatic hypoplasia.

    abstract::Abdominal muscle deficiency, urinary tract abnormalities, and cryptorchidism are the three major features of the prune-belly syndrome, also referred to as triad syndrome or Eagle-Barrett syndrome. The etiology is unclear and the pathogenesis a subject of continuing debate. Clinical and pathologic experience with seven...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Moerman P,Fryns JP,Goddeeris P,Lauweryns JM

    更新日期:1984-04-01 00:00:00

  • Parental knowledge and attitudes of Minnesota laws concerning adolescent medical care.

    abstract:OBJECTIVE:To determine parents' knowledge and attitudes of medicolegal issues affecting adolescent medical care. DESIGN:An anonymous, mailed survey with 16 questions concerning Minnesota consent and confidentiality laws that affect adolescents' medical care. SETTING:A community of >70 000 in rural, southeastern Minne...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.3.582

    authors: Cutler EM,Bateman MD,Wollan PC,Simmons PS

    更新日期:1999-03-01 00:00:00

  • Association between diabetes control and visits to a multidisciplinary pediatric diabetes clinic.

    abstract:OBJECTIVE:To determine if there is a relationship between diabetes outcome as measured by HbA1C and the number of multidisciplinary clinic visits per year in children and youth with diabetes. RESEARCH DESIGN AND METHODS:The number of clinic visits per year, the mean HbA1C (by DCA 2000, Miles, Tarrytown, NY), type of i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.5.948

    authors: Kaufman FR,Halvorson M,Carpenter S

    更新日期:1999-05-01 00:00:00

  • Thyroid screening for early discharged infants.

    abstract:OBJECTIVE:As neonatal discharge before 24 hours of life becomes commonplace, the rejection of congenital hypothyroidism (CH) screening specimens obtained too early has created the need for numerous additional tests. We sought to determine whether the specimens obtained before 24 hours could be used safely. METHODS:Dur...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Saslow JG,Post EM,Southard CA

    更新日期:1996-07-01 00:00:00

  • When is lack of supervision neglect?

    abstract::Occasionally, pediatricians become aware of children who are inadequately supervised. More frequently, pediatricians treat children for traumatic injuries or ingestions that they suspect could have been prevented with better supervision. This clinical report contains guidance for pediatricians considering a referral t...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2006-1780

    authors: Hymel KP,Committee on Child Abuse and Neglect.

    更新日期:2006-09-01 00:00:00

  • Families of Children With Medical Complexity: A View From the Front Lines.

    abstract::This article, written by a group of experienced parents of children with medical complexity (CMC), provides an overview of the demands of managing care from their unique perspective. The article articulates why attention to understanding the challenges that families of CMC face with a fragmented health care system, in...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2017-1284D

    authors: Allshouse C,Comeau M,Rodgers R,Wells N

    更新日期:2018-03-01 00:00:00

  • Improving early literacy promotion: a quality-improvement project for Reach Out and Read.

    abstract:BACKGROUND:The Reach Out and Read (ROR) program promotes early literacy as part of pediatric primary care through the distribution of children's books and anticipatory guidance during early childhood. OBJECTIVES:To improve the rates of age-appropriate book-giving during well-child care and the delivery of ROR-recommen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-2290

    authors: Khandekar AA,Augustyn M,Sanders L,Zuckerman B

    更新日期:2011-04-01 00:00:00

  • Fruit Juice in Infants, Children, and Adolescents: Current Recommendations.

    abstract::Historically, fruit juice was recommended by pediatricians as a source of vitamin C and as an extra source of water for healthy infants and young children as their diets expanded to include solid foods with higher renal solute load. It was also sometimes recommended for children with constipation. Fruit juice is marke...

    journal_title:Pediatrics

    pub_type: 指南,杂志文章

    doi:10.1542/peds.2017-0967

    authors: Heyman MB,Abrams SA,SECTION ON GASTROENTEROLOGY, HEPATOLOGY, AND NUTRITION.,COMMITTEE ON NUTRITION.

    更新日期:2017-06-01 00:00:00

  • Dating violence and associated sexual risk and pregnancy among adolescent girls in the United States.

    abstract:OBJECTIVES:To assess the annual prevalence of physical violence from dating partners among a representative sample of sexually experienced adolescent girls attending US public and private high schools, as well as sexual risk behaviors and pregnancy among this population. DESIGN, SETTING, PARTICIPANTS, AND MEASURES:Fem...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.2.e220

    authors: Silverman JG,Raj A,Clements K

    更新日期:2004-08-01 00:00:00

  • Difficult Family Relationships, Residential Greenspace, and Childhood Asthma.

    abstract:BACKGROUND AND OBJECTIVES:Both the social environment and the physical environment are increasingly recognized as important to childhood diseases such as asthma. This study tested a novel hypothesis: that living in areas high in greenspace may help buffer the effects of difficult family relationships for children with ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3056

    authors: Chen E,Miller GE,Shalowitz MU,Story RE,Levine CS,Hayen R,Sbihi H,Brauer M

    更新日期:2017-04-01 00:00:00

  • Obtaining consent from both parents for pediatric research: what does "reasonably available" mean?

    abstract:OBJECTIVE:Circumstances surrounding parental availability and decision-making were examined in the setting of a research protocol involving newborn screening (NBS) for fragile X syndrome, in which the institutional review board (IRB) had determined that consent (permission) was required from both parents. METHODS:A su...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1278

    authors: Nelson DK,Skinner D,Guarda S,Choudhury S,Sideris J,Barnum L,Ten Haagen K,Heyward Q,Bailey DB Jr

    更新日期:2013-01-01 00:00:00

  • Streptococcus pneumoniae--associated hemolytic uremic syndrome: classification and the emergence of serotype 19A.

    abstract::Streptococcus pneumoniae-associated hemolytic uremic syndrome (HUS) is an underrecognized condition that mainly occurs in young children. Early diagnosis is important because of the potential to improve morbidity and mortality rates. The purposes of this report are to review the clinical and laboratory features of 14 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2017

    authors: Copelovitch L,Kaplan BS

    更新日期:2010-01-01 00:00:00

  • Safe transportation of preterm and low birth weight infants at hospital discharge.

    abstract::Safe transportation of preterm and low birth weight infants requires special considerations. Both physiologic immaturity and low birth weight must be taken into account to properly position such infants. This clinical report provides guidelines for pediatricians and other caregivers who counsel parents of preterm and ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0559

    authors: Bull MJ,Engle WA,Committee on Injury, Violence, and Poison Prevention and Committee on Fetus and Newborn.,American Academy of Pediatrics.

    更新日期:2009-05-01 00:00:00

  • A case of protein-losing enteropathy caused by intestinal lymphangiectasia in a preterm infant.

    abstract::Intestinal lymphangiectasia is characterized by obstruction of lymph drainage from the small intestine and lacteal dilation that distorts the villus architecture. Lymphatic vessel obstruction and elevated intestinal lymphatic pressure in turn cause lymphatic leakage into the intestinal lumen, thus resulting in malabso...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.2.416

    authors: Salvia G,Cascioli CF,Ciccimarra F,Terrin G,Cucchiara S

    更新日期:2001-02-01 00:00:00

  • The effect of a community intervention trial on parental knowledge and awareness of antibiotic resistance and appropriate antibiotic use in children.

    abstract:BACKGROUND:Overuse of antibiotics for children's upper respiratory infections is widespread and contributes to the emergence of antibiotic-resistant bacteria. OBJECTIVE:To assess changes in knowledge and awareness regarding antibiotic resistance and appropriate antibiotic use after community-wide educational intervent...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.1.e6

    authors: Trepka MJ,Belongia EA,Chyou PH,Davis JP,Schwartz B

    更新日期:2001-01-01 00:00:00

  • Neuroimaging, physical, and developmental findings after inflicted and noninflicted traumatic brain injury in young children.

    abstract:OBJECTIVE:To characterize neuroimaging, physical, neurobehavioral, and developmental findings in children with inflicted and noninflicted traumatic brain injury (TBI) and to identify characteristic features of inflicted TBI. METHODS AND PATIENTS:Forty children, 0 to 6 years of age, hospitalized for TBI who had no docu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.2.300

    authors: Ewing-Cobbs L,Kramer L,Prasad M,Canales DN,Louis PT,Fletcher JM,Vollero H,Landry SH,Cheung K

    更新日期:1998-08-01 00:00:00

  • The International Liaison Committee on Resuscitation (ILCOR) consensus on science with treatment recommendations for pediatric and neonatal patients: pediatric basic and advanced life support.

    abstract::This publication contains the pediatric and neonatal sections of the 2005 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations (COSTR). The consensus process that produced this document was sponsored by the International Liaison Committee on ...

    journal_title:Pediatrics

    pub_type: 杂志文章,实务指引

    doi:10.1542/peds.2006-0206

    authors: International Liaison Committee on Resuscitation.

    更新日期:2006-05-01 00:00:00

  • Emergency room utilization in the first 15 months of life: a randomized study.

    abstract::The impact of a system of primary pediatric care on emergency room use in a municipal hospital was measured by comparing that use in two randomly selected populations. The population that was offered participation in a primary care program consistently used the emergency room less than did the control group. Analysis ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Paneth N,Bell D,Stein RE

    更新日期:1979-03-01 00:00:00

  • Intima-media thickness and flow-mediated dilatation in the Helsinki study of very low birth weight adults.

    abstract:BACKGROUND:Adults born at a very low birth weight (VLBW) (< 1500 g), compared with those born at term, bear risk factors for cardiovascular disease, including higher blood pressure and insulin resistance. OBJECTIVE:We studied, in young adults born at a VLBW, early signs of an accelerated atherosclerotic process and th...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2010-2199

    authors: Hovi P,Turanlahti M,Strang-Karlsson S,Wehkalampi K,Järvenpää AL,Eriksson JG,Kajantie E,Andersson S

    更新日期:2011-02-01 00:00:00