Streptococcus pneumoniae--associated hemolytic uremic syndrome: classification and the emergence of serotype 19A.

Abstract:

:Streptococcus pneumoniae-associated hemolytic uremic syndrome (HUS) is an underrecognized condition that mainly occurs in young children. Early diagnosis is important because of the potential to improve morbidity and mortality rates. The purposes of this report are to review the clinical and laboratory features of 14 patients with pneumococcal HUS and present a modified classification to capture cases that may not have been documented with a diagnosis of pneumococcal HUS. We thereby provide a rationale for including patients with concurrent disseminated intravascular coagulopathy and/or those whose culture results were negative, and we highlight the emergence of serotype 19A subsequent to the introduction of 7-valent pneumococcal protein conjugate vaccine (Prevnar). This is the largest series of such subjects (to our knowledge) from a single center. Sixty-four percent of the patients recovered without any long-term sequelae. Three patients developed chronic kidney disease, 1 developed end-stage renal failure, and 1 died in the acute phase. The greatest risk factor for the development of chronic kidney disease is the need for acute dialysis for >20 days, and death in the acute phase is rare unless meningitis is the primary infection.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Copelovitch L,Kaplan BS

doi

10.1542/peds.2007-2017

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

e174-82

issue

1

eissn

0031-4005

issn

1098-4275

pii

peds.2007-2017

journal_volume

125

pub_type

杂志文章
  • Aspirin and acetaminophen: a comparative view of their antipyretic and analgesic activity.

    abstract::Aspirin and acetaminophen have excellent and essentially similar antipyretic activity. For the child, lowering of temperature will be indicated for excessively high temperature and when there is a history of febrile seizures. Specific clinical contraindications will often dictate the selection of one drug over the oth...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Lovejoy FH Jr

    更新日期:1978-11-01 00:00:00

  • Attention deficit disorder with and without hyperactivity: clinical response to three dose levels of methylphenidate.

    abstract::The response of 23 children with attention deficit disorder (ADD) with hyperactivity (+H) and 17 children with ADD without hyperactivity (-H) to three doses of methylphenidate (5, 10, and 15 mg twice a day) was evaluated in a triple-blind, placebo-controlled cross-over design using parent and teacher ratings of behavi...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Barkley RA,DuPaul GJ,McMurray MB

    更新日期:1991-04-01 00:00:00

  • Acute profound dystonia in infants with glutaric acidemia.

    abstract::Acute profound dystonia developed in three previously well infants who were found to have glutaryl-CoA dehydrogenase deficiency in cultured skin fibroblasts. Two patients had excessive urinary excretion of glutaric acid, but one did not. Neuroradiologic studies performed in all three patients at the onset of their ill...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Bergman I,Finegold D,Gartner JC Jr,Zitelli BJ,Claassen D,Scarano J,Roe CR,Stanley C,Goodman SI

    更新日期:1989-02-01 00:00:00

  • Recurrent infections, hypotonia, and mental retardation caused by duplication of MECP2 and adjacent region in Xq28.

    abstract:OBJECTIVE:Our goal was to describe the neurologic and clinical features of affected males from families with X-linked patterns of severe mental retardation, hypotonia, recurrent respiratory infection, and microduplication of Xq28 that consistently includes the MECP2 (methyl-CpG binding protein 2) gene. STUDY DESIGN:To...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0395

    authors: Friez MJ,Jones JR,Clarkson K,Lubs H,Abuelo D,Bier JA,Pai S,Simensen R,Williams C,Giampietro PF,Schwartz CE,Stevenson RE

    更新日期:2006-12-01 00:00:00

  • Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study.

    abstract::Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT). In phase I, 4 of 10 babies...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: O'Rourke PP,Crone RK,Vacanti JP,Ware JH,Lillehei CW,Parad RB,Epstein MF

    更新日期:1989-12-01 00:00:00

  • Families of Children With Medical Complexity: A View From the Front Lines.

    abstract::This article, written by a group of experienced parents of children with medical complexity (CMC), provides an overview of the demands of managing care from their unique perspective. The article articulates why attention to understanding the challenges that families of CMC face with a fragmented health care system, in...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2017-1284D

    authors: Allshouse C,Comeau M,Rodgers R,Wells N

    更新日期:2018-03-01 00:00:00

  • The Revised WIC Food Package and Child Development: A Quasi-Experimental Study.

    abstract:BACKGROUND AND OBJECTIVES:The Special Supplemental Nutrition Program for Women, Infants, and Children (WIC), one of the largest US safety net programs, was revised in 2009 to be more congruent with dietary guidelines. We hypothesize that this revision led to improvements in child development. METHODS:Data were drawn f...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-1853

    authors: Guan A,Hamad R,Batra A,Bush NR,Tylavsky FA,LeWinn KZ

    更新日期:2021-02-01 00:00:00

  • Has prenatal screening influenced the prevalence of comorbidities associated with Down syndrome and subsequent survival rates?

    abstract:OBJECTIVES:With this study we aimed to compare survival rates for children with Down syndrome in 2 time periods, 1 before prenatal screening (1988-1990) and 1 contemporaneous with screening (1998-2000), and to examine the frequency of comorbidities and their influence on survival rates. METHODS:Record-linkage was perf...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2840

    authors: Halliday J,Collins V,Riley M,Youssef D,Muggli E

    更新日期:2009-01-01 00:00:00

  • Substantial reduction in severe diarrheal morbidity by daily zinc supplementation in young north Indian children.

    abstract:OBJECTIVE:To evaluate the impact of 4 months of daily zinc supplementation on the incidence of severe and recurrent diarrhea in children 6 to 30 months of age. METHODS:A double-blind, randomized, placebo-controlled trial was conducted on children who were identified by a door-to-door survey to be aged 6 to 30 months a...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.109.6.e86

    authors: Bhandari N,Bahl R,Taneja S,Strand T,Mølbak K,Ulvik RJ,Sommerfelt H,Bhan MK

    更新日期:2002-06-01 00:00:00

  • False-positive tricyclic antidepressant drug screen results leading to the diagnosis of carbamazepine intoxication.

    abstract::Ingestion of toxic substances is a common problem in pediatrics. When presented with the limited history of an unknown ingestion in a patient with altered mental status, a clinician depends on the physical examination and a toxic screen to determine the ingested substance(s). Some toxic screens yield false-positive or...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.5.e66

    authors: Matos ME,Burns MM,Shannon MW

    更新日期:2000-05-01 00:00:00

  • Serial immune markers do not correlate with clinical exacerbations in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections.

    abstract:OBJECTIVE:Pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections is hypothesized to be a poststreptococcal autoimmune disorder. If clinical exacerbations are triggered by a streptococcal infection that activates cross-reacting antibodies against neuronal tissue or alters the production...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-2658

    authors: Singer HS,Gause C,Morris C,Lopez P,Tourette Syndrome Study Group.

    更新日期:2008-06-01 00:00:00

  • Chloral hydrate and the carbon dioxide chemoreceptor response: a study of puppies and infants.

    abstract::CO2 chemoreceptor function was assessed during natural sleep and following the administration of 100 mg/kg of chloral hydrate to 26 puppies. With chloral hydrate-induced sleep, there were no significant changes in ventilation or in CO2 chemoreceptor response. The ventilation and CO2 chemoreceptor response of a group o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Lees MH,Olsen GD,McGilliard KL,Newcomb JD,Sunderland CO

    更新日期:1982-09-01 00:00:00

  • Blood pressure fluctuation and intraventricular hemorrhage in the preterm infant of less than 31 weeks' gestation.

    abstract::A total of 22 infants of less than 31 weeks' gestation who were mechanically ventilated for a minimum of 12 hours for respiratory distress syndrome were studied. The coefficient of variation of direct systolic pressure was measured each minute from six to 36 hours of age and averaged per hour after birth with a microc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Miall-Allen VM,de Vries LS,Dubowitz LM,Whitelaw AG

    更新日期:1989-05-01 00:00:00

  • Two-year follow-up of an adolescent behavioral weight control intervention.

    abstract:OBJECTIVE:This study examined the 24-month outcomes of a randomized controlled trial of a group-based behavioral weight control (BWC) program combined with either activity-based peer intervention or aerobic exercise. METHODS:At baseline, 118 obese adolescents (68% female; BMI = 31.41 ± 3.33) ages 13 to 16 years (mean ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2011-3283

    authors: Lloyd-Richardson EE,Jelalian E,Sato AF,Hart CN,Mehlenbeck R,Wing RR

    更新日期:2012-08-01 00:00:00

  • Outcomes of a universal shared reading intervention by 2 years of age: the Let's Read trial.

    abstract:BACKGROUND:Early shared reading and literacy promotion benefits have stimulated international interest in the development of early-years literacy-promotion programs despite limited evidence of effectiveness at a broader population level. OBJECTIVE:To determine whether a population-based primary care literacy promotion...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2009-3043

    authors: Goldfeld S,Napiza N,Quach J,Reilly S,Ukoumunne OC,Wake M

    更新日期:2011-03-01 00:00:00

  • Effects of nephrotic syndrome on the family: a controlled study.

    abstract::The hypothesis that the parents and siblings of children with nephrotic syndrome are more likely to develop psychosocial problems than those of healthy children was tested. Seventy-nine siblings from 36 such families were compared with 79 healthy children from closely matched families using interviews, parent rating s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Vance JC,Fazan LE,Satterwhite B,Pless IB

    更新日期:1980-05-01 00:00:00

  • Comorbidities and Complications of Spinal Fusion for Scoliosis.

    abstract:BACKGROUND AND OBJECTIVES:General pediatricians and hospitalists are increasingly summoned to optimize the comorbid conditions of children with medical complexity (CMC) undergoing major surgery. We assessed the relationship between specific chronic conditions of CMC and hospital resource use with spinal fusion for scol...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2016-2574

    authors: Berry JG,Glotzbecker M,Rodean J,Leahy I,Hall M,Ferrari L

    更新日期:2017-03-01 00:00:00

  • External Validation of the PediBIRN Clinical Prediction Rule for Abusive Head Trauma.

    abstract:BACKGROUND AND OBJECTIVES:A 4-variable abusive head trauma (AHT) clinical prediction rule (CPR) for use in the PICU was derived and validated for children <3 years of age by the Pediatric Brain Injury Research Network (PediBIRN). We aimed to externally validate PediBIRN as designed (PICU only) as well as using broader ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2017-3674

    authors: Pfeiffer H,Smith A,Kemp AM,Cowley LE,Cheek JA,Dalziel SR,Borland ML,O'Brien S,Bonisch M,Neutze J,Oakley E,Crowe L,Hearps SJC,Lyttle MD,Bressan S,Babl FE,Paediatric Research in Emergency Department International Collaborat

    更新日期:2018-05-01 00:00:00

  • Incidence of and risk factors for neonatal respiratory depression and encephalopathy in rural Sarlahi, Nepal.

    abstract:OBJECTIVES:To characterize the incidence of, risk factors for, and neonatal morbidity and mortality associated with respiratory depression at birth and neonatal encephalopathy (NE) among term infants in a developing country. METHODS:Data were collected prospectively in 2002-2006 during a community-based trial that enr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3590

    authors: Lee AC,Mullany LC,Tielsch JM,Katz J,Khatry SK,LeClerq SC,Adhikari RK,Darmstadt GL

    更新日期:2011-10-01 00:00:00

  • Pneumococcal meningitis in children: epidemiology, serotypes, and outcomes from 1997-2010 in Utah.

    abstract:BACKGROUND:After licensure of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, the incidence of pediatric pneumococcal meningitis decreased significantly. However, cases continue to occur. It is unknown whether meningitis due to PCV7 and non-PCV7 serotypes causes similar morbidity and mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0621

    authors: Stockmann C,Ampofo K,Byington CL,Filloux F,Hersh AL,Blaschke AJ,Cowan P,Korgenski K,Mason EO,Pavia AT

    更新日期:2013-09-01 00:00:00

  • The delivery of immunizations and other preventive services in private practices.

    abstract:OBJECTIVES:To measure the proportion of children cared for in private practices who are fully immunized and have been screened for anemia, tuberculosis (TB), and lead poisoning by 2 years of age. DESIGN:Cross-sectional chart review. SETTING:Fifteen private pediatric practices in central North Carolina (11 chosen rand...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Bordley WC,Margolis PA,Lannon CM

    更新日期:1996-04-01 00:00:00

  • Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

    abstract:OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand)...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.2004-0196

    authors: Dalziel SR,Liang A,Parag V,Rodgers A,Harding JE

    更新日期:2004-09-01 00:00:00

  • Reevaluation of outpatients with Streptococcus pneumoniae bacteremia.

    abstract:BACKGROUND:The reevaluation process for outpatients recalled for Streptococcus pneumoniae bacteremia has not been standardized. Children who return ill or with new serious focal infections require admission and parenteral antibiotic therapy. Limited data exist to guide the follow-up management of those patients identif...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.105.3.502

    authors: Bachur R,Harper MB

    更新日期:2000-03-01 00:00:00

  • Milk intolerance in children with persistent sleeplessness: a prospective double-blind crossover evaluation.

    abstract::From July 1986 to July 1988, 146 children less than 5 years of age were referred by their physicians to our university sleep clinic for continual waking and crying during sleep hours. For 85 children (58.2%), the sleeplessness was attributed to inappropriate sleep habits. For 17 children (11.6%), no explanation was fo...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kahn A,Mozin MJ,Rebuffat E,Sottiaux M,Muller MF

    更新日期:1989-10-01 00:00:00

  • Breastfeeding and infant eczema in the first year of life in the KOALA birth cohort study: a risk period-specific analysis.

    abstract:OBJECTIVE:We studied the association between breastfeeding and eczema, taking into account the possible influence of reverse causation, with risk period-specific analyses. METHODS:Information on breastfeeding, determinants, and outcomes at 1 year of age was collected with repeated questionnaires for 2405 mother-infant...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0772

    authors: Snijders BE,Thijs C,Kummeling I,Penders J,van den Brandt PA

    更新日期:2007-01-01 00:00:00

  • The effectiveness of baby books for providing pediatric anticipatory guidance to new mothers.

    abstract:OBJECTIVE:To assess whether embedding pediatric anticipatory guidance into books read to infants is an effective way to educate low-income, first-time mothers about injury-prevention and health-promotion practices. PATIENTS AND METHODS:Primiparous women (N = 168) were randomly assigned to 1 of 3 groups: an educational...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2009-2728

    authors: Reich SM,Bickman L,Saville BR,Alvarez J

    更新日期:2010-05-01 00:00:00

  • Evidence from proton magnetic resonance spectroscopy for a metabolic cascade of neuronal damage in shaken baby syndrome.

    abstract:OBJECTIVE:The purpose of this study was to use proton magnetic resonance spectroscopy (MRS) as a metabolic assay to describe biochemical changes during the evolution of neuronal injury in infants after shaken baby syndrome (SBS), that explain the disparity between apparent physical injury and the neurological deficit a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.99.1.4

    authors: Haseler LJ,Arcinue E,Danielsen ER,Bluml S,Ross BD

    更新日期:1997-01-01 00:00:00

  • Relationship of serum S100B levels and intracranial injury in children with closed head trauma.

    abstract:OBJECTIVE:To determine if serum levels of S100B are higher in children with CHT and ICI as detected by cranial CT and if long bone fractures affect the level of S100B in children with CHT and skeletal injury. METHODS:Children <18 years of age who presented to an urban pediatric emergency department or were transferred...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-1493

    authors: Bechtel K,Frasure S,Marshall C,Dziura J,Simpson C

    更新日期:2009-10-01 00:00:00

  • Pediatricians and general practitioners: a comparison of the management of children with febrile illness.

    abstract::To assess the relative competence of pediatricians and general practitioners in managing febrile illnesses in childhood, a prospective study was undertaken of 259 children less than 10 years of age seen consecutively at the emergency room of a children's hospital and a general hospital. Both groups of patients were si...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Leduc DG,Pless IB

    更新日期:1982-10-01 00:00:00

  • Comprehensive evaluation of the child with intellectual disability or global developmental delays.

    abstract::Global developmental delay and intellectual disability are relatively common pediatric conditions. This report describes the recommended clinical genetics diagnostic approach. The report is based on a review of published reports, most consisting of medium to large case series of diagnostic tests used, and the proporti...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2014-1839

    authors: Moeschler JB,Shevell M,Committee on Genetics.

    更新日期:2014-09-01 00:00:00