Blood pressure at 6 years of age after prenatal exposure to betamethasone: follow-up results of a randomized, controlled trial.

Abstract:

OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand). PARTICIPANTS:Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS. INTERVENTION:Mothers received 2 doses of betamethasone (12 mg) or placebo, administered through intramuscular injection, 24 hours apart. MAIN OUTCOME MEASURES:Systolic and diastolic blood pressure at 6 years of age. RESULTS:Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg). CONCLUSION:Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Dalziel SR,Liang A,Parag V,Rodgers A,Harding JE

doi

10.1542/peds.2004-0196

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

e373-7

issue

3

eissn

0031-4005

issn

1098-4275

pii

114/3/e373

journal_volume

114

pub_type

临床试验,杂志文章,随机对照试验
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