Abstract:
OBJECTIVE:To determine whether prenatal exposure to betamethasone for the prevention of neonatal respiratory distress syndrome (RDS) alters blood pressure in childhood. DESIGN:Prospective follow-up study of a randomized, double-blind, placebo-controlled trial. SETTING:National Women's Hospital (Auckland, New Zealand). PARTICIPANTS:Two hundred twenty-three 6-year-old children of mothers who presented with unplanned premature labor and took part in a randomized, controlled trial of prenatal betamethasone therapy for the prevention of neonatal RDS. INTERVENTION:Mothers received 2 doses of betamethasone (12 mg) or placebo, administered through intramuscular injection, 24 hours apart. MAIN OUTCOME MEASURES:Systolic and diastolic blood pressure at 6 years of age. RESULTS:Children exposed prenatally to betamethasone (n = 121) did not differ in systolic or diastolic blood pressure from children exposed to placebo (n = 102) (mean difference: systolic: -1.6 mm Hg; 95% confidence interval: -4.1 to 0.8 mm Hg; diastolic: -0.3 mm Hg; 95% confidence interval: -2.5 to 1.8 mm Hg). CONCLUSION:Prenatal exposure to betamethasone for prevention of neonatal RDS does not alter blood pressure at 6 years of age.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Dalziel SR,Liang A,Parag V,Rodgers A,Harding JEdoi
10.1542/peds.2004-0196subject
Has Abstractpub_date
2004-09-01 00:00:00pages
e373-7issue
3eissn
0031-4005issn
1098-4275pii
114/3/e373journal_volume
114pub_type
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