Trends in otitis media treatment failure and relapse.

Abstract:

OBJECTIVES:The goals were to describe trends in acute otitis media, treatment failure, and relapse and in high-dose amoxicillin use and to determine whether treatment of acute otitis media with high-dose amoxicillin was associated with treatment failure or relapse. METHODS:We conducted a retrospective study of acute otitis media visits made between 1996 and 2004 by children 2 months to 12 years of age in a large group practice, using computerized data. We defined acute otitis media as an otitis media visit with antibiotics dispensed (preceded by 30 days without otitis media visits), treatment failure as initiation of treatment with a second antibiotic before the first prescription was finished, and relapse as initiation of antibiotic treatment after the first prescription was finished but within 30 days after the index acute otitis media episode. The primary independent measure was high-dose amoxicillin (>70 mg/kg per day). We evaluated changes over time and determined whether high-dose amoxicillin use was associated with otitis media treatment failure or relapse. RESULTS:We identified 111,335 acute otitis media visits over a 9-year period. The incidence of acute otitis media decreased from 385.1 visits per 1000 enrollees in 1996 to 188.8 visits per 1000 enrollees in 2004. The proportion of acute otitis media visits treated with high-dose amoxicillin increased from 1.7% in 1996 to 41.9% in 2004. Both otitis media treatment failure and relapse rates decreased from 1996 to 2004 (from 3.9% to 2.6% and from 9.2% to 8.9%, respectively). The odds of treatment failure or relapse did not differ between acute otitis media episodes treated with high-dose and low-dose amoxicillin. CONCLUSIONS:During the past decade, acute otitis media, treatment failure, and relapse became less common and high-dose amoxicillin use increased. However, high-dose amoxicillin treatment did not reduce the risk of individual infections resulting in adverse outcomes.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Sox CM,Finkelstein JA,Yin R,Kleinman K,Lieu TA

doi

10.1542/peds.2007-1565

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

674-9

issue

4

eissn

0031-4005

issn

1098-4275

pii

121/4/674

journal_volume

121

pub_type

杂志文章
  • A multicenter, randomized, masked, comparison trial of lucinactant, colfosceril palmitate, and beractant for the prevention of respiratory distress syndrome among very preterm infants.

    abstract:BACKGROUND AND OBJECTIVE:Evidence suggests that synthetic surfactants consisting solely of phospholipids can be improved through the addition of peptides, such as sinapultide, that mimic the action of human surfactant protein-B (SP-B). A synthetic surfactant containing a mimic of SP-B may also reduce the potential risk...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2004-2183

    authors: Moya FR,Gadzinowski J,Bancalari E,Salinas V,Kopelman B,Bancalari A,Kornacka MK,Merritt TA,Segal R,Schaber CJ,Tsai H,Massaro J,d'Agostino R,International Surfaxin Collaborative Study Group.

    更新日期:2005-04-01 00:00:00

  • Diabetes in Pregnancy and Childhood Cognitive Development: A Systematic Review.

    abstract:CONTEXT:The effect of diabetes during pregnancy on the cognitive development of offspring is unclear because of inconsistent findings from limited studies. OBJECTIVE:This review was aimed to provide the best available scientific evidence on the associations between maternal pregnancy diabetes and the cognitive develop...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2015-4234

    authors: Adane AA,Mishra GD,Tooth LR

    更新日期:2016-05-01 00:00:00

  • Does television viewing increase obesity and reduce physical activity? Cross-sectional and longitudinal analyses among adolescent girls.

    abstract::To examine the relationships between hours of television viewing and adiposity and physical activity among female adolescents, a cohort study with follow-up assessments 7, 14, and 24 months after baseline was conducted. All sixth- and seventh-grade girls (N = 971) attending four northern California middle schools were...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Robinson TN,Hammer LD,Killen JD,Kraemer HC,Wilson DM,Hayward C,Taylor CB

    更新日期:1993-02-01 00:00:00

  • Frequency and significance of physical evidence in legally proven cases of child sexual abuse.

    abstract::Clinicians have long recognized and attorneys have disputed that physical evidence of injury, sexually transmitted diseases, and seminal fluid are often absent in cases of child sexual abuse. To determine the frequency and significance of physical evidence in legally "proven" felony cases with penetration, a retrospec...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: De Jong AR,Rose M

    更新日期:1989-12-01 00:00:00

  • Association of race and ethnicity with management of abdominal pain in the emergency department.

    abstract:OBJECTIVE:To determine if race/ethnicity-based differences exist in the management of pediatric abdominal pain in emergency departments (EDs). METHODS:Secondary analysis of data from the 2006-2009 National Hospital Ambulatory Medical Care Survey regarding 2298 visits by patients ≤ 21 years old who presented to EDs wit...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3127

    authors: Johnson TJ,Weaver MD,Borrero S,Davis EM,Myaskovsky L,Zuckerbraun NS,Kraemer KL

    更新日期:2013-10-01 00:00:00

  • Recurrent abdominal pain in children: lactose and sucrose intolerance, a prospective study.

    abstract::Thirty-eight consecutive children with recurrent abdominal pain underwent lactose tolerance tests; 28 of these were also given sucrose tolerance tests. Abdominal pain and abnormal lactose tolerance tests were noted in 11 of 38, while none of the 28 had an abnormal sucrose tolerance test; however, 1 had abdominal pain....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Liebman WM

    更新日期:1979-07-01 00:00:00

  • Acute myositis associated with influenza B infection.

    abstract::An epidemic of acute myositis affecting children occurred in association with influenza B infections. The myositis followed the initial influenza-like episode, and almost exclusively involved the gastrocnemius and soleus muscles. Patients improved without specific treatment and made a complete recovery in four to five...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Dietzman DE,Schaller JG,Ray CG,Reed ME

    更新日期:1976-02-01 00:00:00

  • Dimensions of the local health care environment and use of care by uninsured children in rural and urban areas.

    abstract:OBJECTIVE:Despite concerted policy efforts, a sizeable percentage of children lack health insurance coverage. This article examines the impact of the health care safety net and health care market structure on the use of health care by uninsured children. METHODS:We used the Medical Expenditure Panel Survey linked with...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0733

    authors: Gresenz CR,Rogowski J,Escarce JJ

    更新日期:2006-03-01 00:00:00

  • Neurodevelopment and in utero antiretroviral exposure of HIV-exposed uninfected infants.

    abstract:OBJECTIVE:Antiretroviral (ARV) drugs are routinely provided to HIV-infected pregnant women to prevent HIV mother-to-child transmission. Although ARV use has significantly reduced mother-to-child transmission to <2% in the United States, it remains crucial to monitor uninfected infants and children for adverse consequen...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-1112

    authors: Williams PL,Marino M,Malee K,Brogly S,Hughes MD,Mofenson LM,PACTG 219C Team.

    更新日期:2010-02-01 00:00:00

  • Principles of patient safety in pediatrics.

    abstract::The American Academy of Pediatrics and its members are committed to improving the health care system to provide the best and safest health care for infants, children, adolescents, and young adults. In response to a 1999 Institute of Medicine report on building a safer health system, a set of principles was established...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.107.6.1473

    authors: Lannon CM,Coven BJ,Lane France F,Hickson GB,Miles PV,Swanson JT,Takayama JI,Wood DL,Yamamoto L,National Initiative for Children's Health Care Quality Project Advisory Committee.

    更新日期:2001-06-01 00:00:00

  • IL-10RA Mutation as a Risk Factor of Severe Influenza-Associated Encephalopathy: A Case Report.

    abstract::Influenza-associated encephalitis and encephalopathy (IAE) is a severe complication of influenza infection with high morbidity and mortality. We present the case of a patient with IL-10RA mutation who developed encephalopathy after influenza infection. A 10-day-old boy developed recurrent fever and anal fistula. Growt...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-3548

    authors: Ishige T,Igarashi Y,Hatori R,Tatsuki M,Sasahara Y,Takizawa T,Arakawa H

    更新日期:2018-06-01 00:00:00

  • A Multifaceted Approach to Improving Outcomes in the NICU: The Pediatrix 100 000 Babies Campaign.

    abstract:BACKGROUND AND OBJECTIVE:Despite advances in neonatal medicine, infants requiring neonatal intensive care continue to experience substantial morbidity and mortality. The purpose of this initiative was to generate large-scale simultaneous improvements in multiple domains of care in a large neonatal network through a pro...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-0389

    authors: Ellsbury DL,Clark RH,Ursprung R,Handler DL,Dodd ED,Spitzer AR

    更新日期:2016-04-01 00:00:00

  • Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment.

    abstract:OBJECTIVES:The long-acting beta2-adrenergic agonist salmeterol prevents exercise-induced asthma, but tolerance may develop to its bronchoprotective effect. We wanted to ascertain if the development of tolerance could be prevented by using a low-dose treatment regimen of 50 microg once daily, instead of the usual dose o...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1542/peds.99.5.655

    authors: Simons FE,Gerstner TV,Cheang MS

    更新日期:1997-05-01 00:00:00

  • Childhood Assets and Cardiometabolic Health in Adolescence.

    abstract:BACKGROUND:Research shows that the development of cardiometabolic disease can begin early in life with risk factors accumulating over time, but less is known about protective pathways to positive health. In this study, we use prospective data to test whether childhood assets predict a greater likelihood of being in opt...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2018-2004

    authors: Qureshi F,Koenen KC,Tiemeier H,Williams MA,Misra S,Kubzansky LD

    更新日期:2019-03-01 00:00:00

  • Pediatric patient safety in hospitals: a national picture in 2000.

    abstract:OBJECTIVE:To describe potential patient safety events for hospitalized children, examine associated factors, and explore impacts of safety events. METHODS:The newly released Patient Safety Indicators (PSIs), developed by researchers at the Agency for Healthcare Research and Quality to identify potential in-hospital pa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.6.1741

    authors: Miller MR,Zhan C

    更新日期:2004-06-01 00:00:00

  • Development of a child safety seat Hassles Scale in a largely low-income Latino population.

    abstract:OBJECTIVE:High rates of use of child safety seats have been achieved. A remaining challenge in child passenger safety is to reach the Healthy People 2010 objective of child safety seat use to 100%. Several factors have been reported to influence child safety seat use. A child safety seat Hassles Scale was developed to ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2211

    authors: Agran PF,Anderson C,Winn DG

    更新日期:2006-07-01 00:00:00

  • Impact of the thimerosal controversy on hepatitis B vaccine coverage of infants born to women of unknown hepatitis B surface antigen status in Michigan.

    abstract:OBJECTIVE:Hepatitis B vaccine is recommended for all infants, and the series may be started during the delivery admission. For infants who are born either to women who are positive for hepatitis B surface antigen (HBsAg) or to women whose HBsAg status is unknown, vaccination should be started within 12 hours of birth t...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.111.6.e645

    authors: Biroscak BJ,Fiore AE,Fasano N,Fineis P,Collins MP,Stoltman G

    更新日期:2003-06-01 00:00:00

  • Involvement of Fathers in Pediatric Obesity Treatment and Prevention Trials: A Systematic Review.

    abstract:CONTEXT:Despite their important influence on child health, it is assumed that fathers are less likely than mothers to participate in pediatric obesity treatment and prevention research. OBJECTIVE:This review investigated the involvement of fathers in obesity treatment and prevention programs targeting children and ado...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-2635

    authors: Morgan PJ,Young MD,Lloyd AB,Wang ML,Eather N,Miller A,Murtagh EM,Barnes AT,Pagoto SL

    更新日期:2017-02-01 00:00:00

  • Initial Experience With Propranolol Treatment of Lymphatic Anomalies: A Case Series.

    abstract::Lymphatic malformations (LMs) are congenital lymphatic lesions that impose significant and costly morbidities on affected patients. Treatment options are limited due to incomplete understanding of LM pathobiology. Expression of an activated β2-adrenergic receptor has been described in LM tissue, suggesting that this p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-4545

    authors: Wu JK,Hooper ED,Laifer-Narin SL,Simpson LL,Kandel J,Shawber CJ,Lymphatics Work Group at CUMC.

    更新日期:2016-09-01 00:00:00

  • Pneumococcal meningitis in children: epidemiology, serotypes, and outcomes from 1997-2010 in Utah.

    abstract:BACKGROUND:After licensure of the 7-valent pneumococcal conjugate vaccine (PCV7) in the United States in 2000, the incidence of pediatric pneumococcal meningitis decreased significantly. However, cases continue to occur. It is unknown whether meningitis due to PCV7 and non-PCV7 serotypes causes similar morbidity and mo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0621

    authors: Stockmann C,Ampofo K,Byington CL,Filloux F,Hersh AL,Blaschke AJ,Cowan P,Korgenski K,Mason EO,Pavia AT

    更新日期:2013-09-01 00:00:00

  • Utilization of pediatric hospitals in New York State.

    abstract:BACKGROUND:Little published information is available regarding the proportion of hospitals that offer pediatric services at specified levels, or the actual utilization of such services. OBJECTIVE:To determine if an existing national accreditation process created for educational purposes identifies hospitals with a dis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.5.1068

    authors: Kanter RK,Egan M

    更新日期:2003-05-01 00:00:00

  • Feeding and urine cotinine values in babies whose mothers smoke.

    abstract::In Canada, 8% to 20% of infants are breast-fed by mothers who smoke. To determine whether breast-feeding increases infants' exposure to tobacco smoke products, urinary cotinine excretion was measured in 172 babies, 33 of whom were breast-fed. A milk sample was taken from the mothers who were breast-feeding, and cotini...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Labrecque M,Marcoux S,Weber JP,Fabia J,Ferron L

    更新日期:1989-01-01 00:00:00

  • Statistical uncertainty of mortality rates and rankings for children's hospitals.

    abstract:OBJECTIVES:Hospitals are being required to report publically their adjusted mortality rates, which are then being used to rank hospitals. Our objectives were to assess the statistical reliability of the determination of a hospital's adjusted mortality rate, of comparisons of that rate with the rates of other hospitals,...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-3074

    authors: Feudtner C,Berry JG,Parry G,Hain P,Morse RB,Slonim AD,Shah SS,Hall M

    更新日期:2011-10-01 00:00:00

  • Parenting and early development among children of drug-abusing women: effects of home intervention.

    abstract:OBJECTIVE:To evaluate the efficacy of home intervention with drug-abusing women on parenting behavior and attitudes, and on children's development. DESIGN:A randomized, clinical trial of 60 drug-abusing women recruited prenatally and randomized into an intervention (n = 31) or comparison (n = 29) group. There were no ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Black MM,Nair P,Kight C,Wachtel R,Roby P,Schuler M

    更新日期:1994-10-01 00:00:00

  • Daptomycin for Complicated Skin Infections: A Randomized Trial.

    abstract:BACKGROUND:Complicated skin and skin structure infections (cSSSI) are common in children. Due to safety and resistance issues with recommended agents, new treatment options would be advantageous. METHODS:Multicenter, evaluator-blinded clinical trial. Patients 1 to 17 years old with cSSSI caused by Gram-positive pathog...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2016-2477

    authors: Bradley J,Glasser C,Patino H,Arnold SR,Arrieta A,Congeni B,Daum RS,Kojaoghlanian T,Yoon M,Anastasiou D,Wolf DJ,Bokesch P

    更新日期:2017-03-01 00:00:00

  • The pediatric subspecialty workforce: public policy and forces for change.

    abstract::Policy has not adequately addressed the unique circumstances of pediatric subspecialties, many of which are facing workforce shortages. Pediatric subspecialties, which we define to include all medical and surgical subspecialties, are discrete disciplines that differ significantly from each other and from adult medicin...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2339

    authors: Jewett EA,Anderson MR,Gilchrist GS

    更新日期:2005-11-01 00:00:00

  • Nosocomial rotavirus infections: a meta-analysis.

    abstract:BACKGROUND AND OBJECTIVES:Nosocomial rotavirus (nRV) infections represent an important part of rotavirus (RV)-associated morbidity. The incidence of nRV influences the estimated total RV disease burden, an important determinant of cost-effectiveness of RV vaccination programs. Our aim is to summarize the existing evide...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析,评审

    doi:10.1542/peds.2011-2779

    authors: Bruijning-Verhagen P,Quach C,Bonten M

    更新日期:2012-04-01 00:00:00

  • Bladder retention of urine as a result of continuous intravenous infusion of fentanyl: 2 case reports.

    abstract::Sedation has been commonly used in the neonate to decrease the stress and pain from the noxious stimuli and invasive procedures in the neonatal intensive care unit, as well as to facilitate synchrony between ventilator and spontaneous breaths. Fentanyl, an opioid analgesic, is frequently used in the neonatal intensive...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.4.1012

    authors: Das UG,Sasidharan P

    更新日期:2001-10-01 00:00:00

  • A program to limit donor exposures to neonates undergoing extracorporeal membrane oxygenation.

    abstract:OBJECTIVE:Extracorporeal membrane oxygenation (ECMO) has dramatically improved the survival of neonates with life-threatening respiratory and cardiac failure. However, ECMO requires numerous transfusions with significant risks. This study evaluated the effects of changing transfusion practices and blood component manag...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Rosenberg EM,Chambers LA,Gunter JM,Good JA

    更新日期:1994-09-01 00:00:00

  • Safety and efficacy of a topical anesthetic for neonatal circumcision.

    abstract:OBJECTIVE:Circumcision is a common neonatal surgical procedure routinely performed without the use of anesthesia. The purpose of this study was to evaluate the safety and efficacy of topical lidocaine cream as an anesthetic for circumcision. METHODS:Thirty newborns were studied in a randomized, double-blind, placebo-c...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Weatherstone KB,Rasmussen LB,Erenberg A,Jackson EM,Claflin KS,Leff RD

    更新日期:1993-11-01 00:00:00