Tolerance to the bronchoprotective effect of salmeterol in adolescents with exercise-induced asthma using concurrent inhaled glucocorticoid treatment.

Abstract:

OBJECTIVES:The long-acting beta2-adrenergic agonist salmeterol prevents exercise-induced asthma, but tolerance may develop to its bronchoprotective effect. We wanted to ascertain if the development of tolerance could be prevented by using a low-dose treatment regimen of 50 microg once daily, instead of the usual dose of 50 microg twice daily, in adolescents receiving regular glucocorticoid inhalations. Methods. In a randomized, double-blind, 2x28-day crossover study, we administered salmeterol (50 microg) or placebo once daily via a metered-dose inhaler and Nebulizer Chronolog device to monitor compliance. Exercise challenge tests were performed 1 and 9 hours after salmeterol or placebo inhalation on the 1st and 28th day of each treatment period. The primary outcome variable was the maximum decrease in percent predicted FEV1 postexercise. RESULTS:Fourteen subjects with a mean age of 13.1 years completed the study. The first dose of salmeterol had an excellent bronchoprotective effect against exercise-induced asthma at 1 and 9 hours. After the 28th consecutive daily dose of salmeterol, the bronchoprotective effect was significantly greater than that of placebo at 1 hour, but not at 9 hours. CONCLUSIONS:We conclude that a single 50-microg dose of salmeterol has an excellent protective effect against exercise-induced asthma for at least 9 hours, but that this effect may wane during regular once-daily salmeterol treatment, despite the reduced frequency of dosing and despite concomitant use of inhaled glucocorticoids.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Simons FE,Gerstner TV,Cheang MS

doi

10.1542/peds.99.5.655

subject

Has Abstract

pub_date

1997-05-01 00:00:00

pages

655-9

issue

5

eissn

0031-4005

issn

1098-4275

journal_volume

99

pub_type

临床试验,杂志文章,随机对照试验
  • Physical growth in phenylketonuria: II. Growth of treated children in the PKU collaborative study from birth to 4 years of age.

    abstract::Height, weight, and head circumference data up to age 4 years are reported for 124 children with phenylketonuria (PKU) who had been started on diet management before 4 months (121 days) of age and who were participating in the Collaborative Study of Children Treated for Phenylketonuria. Growth measurements of both the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Holm VA,Kronmal RA,Williamson M,Roche AF

    更新日期:1979-05-01 00:00:00

  • Management of pituitary-adrenal suppression secondary to corticosteroid therapy.

    abstract::Withdrawal of steroid medications from patients who have been receiving them for management of chronic disease carries the risk of certain serious complications. An understanding of adrenal physiology, coupled with a rational plan for evaluating the individual patient, when necessary, and for protecting against certai...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Chamberlin P,Meyer WJ 3rd

    更新日期:1981-02-01 00:00:00

  • Rotavirus vaccination and intussusception: can we decrease temporally associated background cases of intussusception by restricting the vaccination schedule?

    abstract:OBJECTIVE:The first rotavirus vaccine that was licensed in the United States, RotaShield, could have prevented the enormous burden of rotavirus diarrhea in American children but left instead the unfortunate legacy that live oral rotavirus vaccines may be associated with a serious but rare adverse event: intussusception...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2874

    authors: Tai JH,Curns AT,Parashar UD,Bresee JS,Glass RI

    更新日期:2006-08-01 00:00:00

  • Summary proceedings from the cardiology group on cardiovascular instability in preterm infants.

    abstract::The appropriate determination of adequate tissue perfusion and the best approach to treatment of perceived abnormalities in blood pressure in the neonate remain controversial. There is no consensus regarding the actual definition of hypotension in the neonate or how best to raise perceived low blood pressure. In addit...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.2005-0620F

    authors: Short BL,Van Meurs K,Evans JR,Cardiology Group.

    更新日期:2006-03-01 00:00:00

  • Ifosfamide-induced nephrotoxicity in children: critical review of predictive risk factors.

    abstract::Ifosfamide is widely used in the treatment of pediatric solid tumors. Its main adverse effects are various forms of renal tubular and glomerular damage. Many risk factors have been proposed to play a role in the development and severity of nephrotoxicity in children receiving ifosfamide, among which are 1) patient's a...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.101.6.e8

    authors: Loebstein R,Koren G

    更新日期:1998-06-01 00:00:00

  • The value of brain imaging in children with headaches.

    abstract:OBJECTIVE:To determine the value of performing computed tomography (CT) on magnetic resonance imaging (MRI) studies in children with chronic headaches. BACKGROUND:Headache is a common complaint in children. With the proliferation of brain imaging centers and the increasing patient demand for CT or MRI studies, brain i...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Maytal J,Bienkowski RS,Patel M,Eviatar L

    更新日期:1995-09-01 00:00:00

  • A Core Outcome Set for Neonatal Opioid Withdrawal Syndrome.

    abstract:BACKGROUND:As rates of neonatal opioid withdrawal are increasing, the need for research to evaluate new treatments is growing. Large heterogeneity exists in health outcomes reported in current literature. Our objective is to develop an evidence-informed and consensus-based core outcome set in neonatal opioid withdrawal...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2020-0018

    authors: Kelly LE,Shan F,MacVicar S,Czaplinksi E,Moulsdale W,Simpson S,Allegaert K,Jansson LM,Offringa M

    更新日期:2020-07-01 00:00:00

  • Rhabdomyolysis and myoglobinemia in neonates.

    abstract::Serial myoglobin determinations were made in 20 neonates during the first week of life to determine whether birth asphyxia results in ischemic damage to muscle with the subsequent pathologic release of myoglobin. Serum myoglobin values were significantly elevated in asphyxiated infants compared with control infants. H...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kasik JW,Leuschen MP,Bolam DL,Nelson RM

    更新日期:1985-08-01 00:00:00

  • Self-referral and serious illness in children with fever.

    abstract:OBJECTIVE:The goal of this study was to evaluate parents' capability to assess their febrile child's severity of illness and decision to present to the emergency department. We compared children referred by a general practitioner (GP) with those self-referred on the basis of illness-severity markers. METHODS:This was ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1952

    authors: van Ierland Y,Seiger N,van Veen M,van Meurs AH,Ruige M,Oostenbrink R,Moll HA

    更新日期:2012-03-01 00:00:00

  • Physician advice to adolescents about drinking and other health behaviors.

    abstract:BACKGROUND:This report assessed the proportion of US 10th graders (average age, 16) who saw a physician in the past year and were asked and given advice about their drinking. We hypothesized that advice would vary by whether students were asked about drinking and their drinking, bingeing, and drunkenness frequency. ME...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1496

    authors: Hingson RW,Zha W,Iannotti RJ,Simons-Morton B

    更新日期:2013-02-01 00:00:00

  • Children's health insurance status and emergency department utilization in the United States.

    abstract:OBJECTIVES:Emergency department (ED) overcrowding has become a national problem. Children account for nearly 25% of overall ED visits. It has been reported that uninsured and publicly insured children are likely to visit the ED for urgent and nonurgent problems, yet it remains unclear to what extent health insurance st...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.2.314

    authors: Luo X,Liu G,Frush K,Hey LA

    更新日期:2003-08-01 00:00:00

  • Longitudinal study of exposure to entertainment media and alcohol use among german adolescents.

    abstract:BACKGROUND:Entertainment media exposure may predict teenager alcohol use, but few longitudinal studies have been reported. METHODS:A longitudinal study was conducted of 2708 German adolescents aged 10 to 16 years who had never drunk alcohol. Each adolescent was surveyed at school about daily television use, whether th...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-1465

    authors: Hanewinkel R,Sargent JD

    更新日期:2009-03-01 00:00:00

  • Pacifier use and morbidity in the first six months of life.

    abstract:OBJECTIVE:To assess the prevalence of pacifier use and whether this habit adversely affects the health of 6-month-old infants. DESIGN:Data collected via self-completion questionnaires from mothers forming part of the prospective, population-based Avon Longitudinal Study of Pregnancy and Childhood. METHODS:The mothers...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.3.e34

    authors: North K,Fleming P,Golding J

    更新日期:1999-03-01 00:00:00

  • Diagnosis and management of acute sinusitis by pediatricians.

    abstract:BACKGROUND:Acute sinusitis is frequently diagnosed in young children, yet little is known regarding pediatrician practices surrounding its diagnosis and management. OBJECTIVES:The purpose of this work was to describe how pediatricians diagnose and manage nonsevere acute sinusitis in otherwise healthy children < or =6 ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-2479

    authors: McQuillan L,Crane LA,Kempe A

    更新日期:2009-02-01 00:00:00

  • Fatal malignant hyperthermia-like syndrome with rhabdomyolysis complicating the presentation of diabetes mellitus in adolescent males.

    abstract:OBJECTIVE:This report describes a new fatal syndrome observed in adolescent males at the initial presentation of diabetes mellitus. The features include hyperglycemic hyperosmolar coma complicated by a malignant hyperthermia-like picture with fever, rhabdomyolysis, and severe cardiovascular instability. DESIGN:Case se...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,评审

    doi:10.1542/peds.111.6.1447

    authors: Hollander AS,Olney RC,Blackett PR,Marshall BA

    更新日期:2003-06-01 00:00:00

  • Incidence and short-term outcome of children with symptomatic presentation of organic acid and fatty acid oxidation disorders in Germany.

    abstract:OBJECTIVE:To determine the incidence of symptomatic children with inherited organic acid disorders (OADs) and fatty acid oxidation disorders (FAODs) in Germany. METHODS:An active surveillance of symptomatic children with inherited OADs and FAODs was conducted during a time period of 24 months (1999-2000) in Germany. M...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.6.1204

    authors: Klose DA,Kölker S,Heinrich B,Prietsch V,Mayatepek E,von Kries R,Hoffmann GF

    更新日期:2002-12-01 00:00:00

  • A Family-Centered Rounds Checklist, Family Engagement, and Patient Safety: A Randomized Trial.

    abstract:BACKGROUND AND OBJECTIVES:Family-centered rounds (FCRs) have become standard of care, despite the limited evaluation of FCRs' benefits or interventions to support high-quality FCR delivery. This work examines the impact of the FCR checklist intervention, a checklist and associated provider training, on performance of F...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2016-1688

    authors: Cox ED,Jacobsohn GC,Rajamanickam VP,Carayon P,Kelly MM,Wetterneck TB,Rathouz PJ,Brown RL

    更新日期:2017-05-01 00:00:00

  • Voiding after neonatal circumcision.

    abstract:OBJECTIVE:To determine whether it is necessary to delay discharge of newly circumcised male neonates to observe voiding. SUBJECTS AND METHODS:A prospective study was conducted in 1992 and 1993 of 51 healthy male, newly circumcised neonates between 0 and 10 days of age. The neonates were observed for the time of first ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Perlmutter DF,Lawrence JM,Krauss AN,Auld PA

    更新日期:1995-12-01 00:00:00

  • Partial liquid ventilation in critically ill infants receiving extracorporeal life support. Philadelphia Liquid Ventilation Consortium.

    abstract:OBJECTIVES:To demonstrate that a period of partial liquid ventilation (PLV) with perflubron improves pulmonary function, without adverse events, in a select group of critically ill infants receiving extracorporeal life support (ECLS) with a high likelihood of mortality. METHODS:This was an open-label, noncontrolled, p...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.99.1.e2

    authors: Greenspan JS,Fox WW,Rubenstein SD,Wolfson MR,Spinner SS,Shaffer TH

    更新日期:1997-01-01 00:00:00

  • Adult patient visits to children's hospital emergency departments.

    abstract:BACKGROUND:Adults frequently seek medical services in children's hospital emergency departments (CHEDs), and are required to be admitted to CHEDs under the provisions of the Emergency Medical Transfer and Active Labor Act (EMTALA), which requires medical evaluation and stabilization of every patient who presents to an ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.111.6.1268

    authors: Bourgeois FT,Shannon MW

    更新日期:2003-06-01 00:00:00

  • Who are the primary caretakers of children born to HIV-infected mothers? Results from a multistate surveillance project.

    abstract:OBJECTIVE:To determine the primary caretakers of children born to women with human immunodeficiency virus (HIV) infection. METHODS:We interviewed women at least 18 years of age who have been reported with HIV infection or acquired immunodeficiency syndrome to local health departments in 10 cities and states regarding ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:

    authors: Schable B,Diaz T,Chu SY,Caldwell MB,Conti L,Alston OM,Sorvillo F,Checko PJ,Hermann P,Davidson AJ

    更新日期:1995-04-01 00:00:00

  • Increased risk of precocious puberty in internationally adopted children in Denmark.

    abstract:BACKGROUND:Studies have indicated that internationally adopted children have an increased risk of developing precocious puberty, but no epidemiologic risk estimates have previously been calculated. We aimed to assess the risk of developing precocious puberty in intercountry adoptees, children immigrating with their fam...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-2939

    authors: Teilmann G,Pedersen CB,Skakkebaek NE,Jensen TK

    更新日期:2006-08-01 00:00:00

  • Parechovirus Encephalitis and Neurodevelopmental Outcomes.

    abstract:OBJECTIVE:We aimed to describe the clinical features and outcome of human parechovirus (HPeV) encephalitis cases identified by the Australian Childhood Encephalitis (ACE) study. METHODS:Infants with suspected encephalitis were prospectively identified in 5 hospitals through the (ACE) study. Cases of confirmed HPeV inf...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2015-2848

    authors: Britton PN,Dale RC,Nissen MD,Crawford N,Elliott E,Macartney K,Khandaker G,Booy R,Jones CA,PAEDS-ACE Investigators.

    更新日期:2016-02-01 00:00:00

  • Prevention of influenza: recommendations for influenza immunization of children, 2007-2008.

    abstract::The American Academy of Pediatrics recommends annual influenza immunization for all children with high-risk conditions who are 6 months of age and older, for all healthy children ages 6 through 59 months, for all household contacts and out-of-home caregivers of children with high-risk conditions and of healthy childre...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2008-0160

    authors: American Academy of Pediatrics Committee on Infectious Diseases.

    更新日期:2008-04-01 00:00:00

  • Should Neonatologists Give Opinions Withdrawing Life-sustaining Treatment?

    abstract::An infant has a massive intracranial hemorrhage. She is neurologically devastated and ventilator-dependent. The prognosis for pulmonary or neurologic recovery is bleak. The physicians and parents face a choice: withdraw the ventilator and allow her to die or perform a tracheotomy? The parents cling to hope for recover...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2016-2585

    authors: Blumenthal-Barby JS,Loftis L,Cummings CL,Meadow W,Lemmon M,Ubel PA,McCullough L,Rao E,Lantos JD

    更新日期:2016-12-01 00:00:00

  • Management of childhood onset nephrotic syndrome.

    abstract::The therapeutic approach to childhood nephrotic syndrome is based on a series of studies that began with an international collaborative effort sponsored by the International Study of Kidney Disease in Children in 1967. The characteristics of children presenting with nephrotic syndrome have changed over recent decades ...

    journal_title:Pediatrics

    pub_type: 共识发展会议,杂志文章

    doi:10.1542/peds.2008-1559

    authors: Gipson DS,Massengill SF,Yao L,Nagaraj S,Smoyer WE,Mahan JD,Wigfall D,Miles P,Powell L,Lin JJ,Trachtman H,Greenbaum LA

    更新日期:2009-08-01 00:00:00

  • Inhaled nitric oxide in preterm infants: an individual-patient data meta-analysis of randomized trials.

    abstract:BACKGROUND:Inhaled nitric oxide (iNO) is an effective therapy for pulmonary hypertension and hypoxic respiratory failure in term infants. Fourteen randomized controlled trials (n = 3430 infants) have been conducted on preterm infants at risk for chronic lung disease (CLD). The study results seem contradictory. DESIGN/...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2010-2725

    authors: Askie LM,Ballard RA,Cutter GR,Dani C,Elbourne D,Field D,Hascoet JM,Hibbs AM,Kinsella JP,Mercier JC,Rich W,Schreiber MD,Wongsiridej PS,Subhedar NV,Van Meurs KP,Voysey M,Barrington K,Ehrenkranz RA,Finer NN,Meta-analys

    更新日期:2011-10-01 00:00:00

  • Ranitidine is associated with infections, necrotizing enterocolitis, and fatal outcome in newborns.

    abstract:BACKGROUND AND OBJECTIVES:Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome....

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0796

    authors: Terrin G,Passariello A,De Curtis M,Manguso F,Salvia G,Lega L,Messina F,Paludetto R,Canani RB

    更新日期:2012-01-01 00:00:00

  • A prospective multicenter study of cervical spine injury in children.

    abstract:OBJECTIVE:Pediatric victims of blunt trauma have developmental and anatomic characteristics that can make it difficult to assess their risk of cervical spine injury (CSI). Previous reports, all retrospective in nature, have not identified any cases of CSI in either children or adults in the absence of neck pain, neurol...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.108.2.e20

    authors: Viccellio P,Simon H,Pressman BD,Shah MN,Mower WR,Hoffman JR,NEXUS Group.

    更新日期:2001-08-01 00:00:00

  • Phenothiazine-induced sleep apneas in normal infants.

    abstract::A relationship between sudden infant death syndrome and the use of phenothiazine-containing medications is suspected. In order to investigate the influence of phenothiazines upon cardiorespiratory and sleep characteristics, four normal infants (mean age 15.8 weeks) had polygraphic recordings made for one night. The re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Kahn A,Hasaerts D,Blum D

    更新日期:1985-05-01 00:00:00