Abstract:
BACKGROUND AND OBJECTIVES:Gastric acidity is a major nonimmune defense mechanism against infections. The objective of this study was to investigate whether ranitidine treatment in very low birth weight (VLBW) infants is associated with an increased risk of infections, necrotizing enterocolitis (NEC), and fatal outcome. METHODS:Newborns with birth weight between 401 and 1500 g or gestational age between 24 and 32 weeks, consecutively observed in neonatal intensive care units, were enrolled in a multicenter prospective observational study. The rates of infectious diseases, NEC, and death in enrolled subjects exposed or not to ranitidine were recorded. RESULTS:We evaluated 274 VLBW infants: 91 had taken ranitidine and 183 had not. The main clinical and demographic characteristics did not differ between the 2 groups. Thirty-four (37.4%) of the 91 children exposed to ranitidine and 18 (9.8%) of the 183 not exposed to ranitidine had contracted infections (odds ratio 5.5, 95% confidence interval 2.9-10.4, P < .001). The risk of NEC was 6.6-fold higher in ranitidine-treated VLBW infants (95% confidence interval 1.7-25.0, P = .003) than in control subjects. Mortality rate was significantly higher in newborns receiving ranitidine (9.9% vs 1.6%, P = .003). CONCLUSIONS:Ranitidine therapy is associated with an increased risk of infections, NEC, and fatal outcome in VLBW infants. Caution is advocated in the use of this drug in neonatal age.
journal_name
Pediatricsjournal_title
Pediatricsauthors
Terrin G,Passariello A,De Curtis M,Manguso F,Salvia G,Lega L,Messina F,Paludetto R,Canani RBdoi
10.1542/peds.2011-0796subject
Has Abstractpub_date
2012-01-01 00:00:00pages
e40-5issue
1eissn
0031-4005issn
1098-4275pii
peds.2011-0796journal_volume
129pub_type
杂志文章相关文献
PEDIATRICS文献大全abstract:OBJECTIVE:Osteonecrosis of the hip has been reported in human immunodeficiency virus (HIV)-infected adults; whether this is related to HIV infection or its treatment is unknown. There has been 1 report of osteonecrosis among HIV-infected children. Specifically, avascular necrosis of the hip consistent with Legg-Calvé-P...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.109.5.e74
更新日期:2002-05-01 00:00:00
abstract::Thirty-two 5- to 17-year-old children who had severe, acute asthma were randomly assigned to receive either high doses (0.15 mg/kg of body weight per dose) or low doses (0.05 mg/kg of body weight per dose) of nebulized albuterol every 20 minutes for six doses. Compared with the low-dose regimen, the high-dose regimen ...
journal_title:Pediatrics
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1989-04-01 00:00:00
abstract:OBJECTIVE:Most clinical descriptions of invasive staphylococcal disease (ISD) in neonates date from before the mid-1980s, when neonatal viability and intensive care differed substantially from current standards. We aimed to describe the contemporary incidence, clinical features, and outcome of infants with ISD in a neo...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-0043
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:To examine among adolescents (1) the prevalence of neck/shoulder, low back, and arm pain within different sociodemographic groups and (2) the association of neck/shoulder, low back, and arm pain with computer use, physical activity, depression, and stress. METHODS:A school-based questionnaire survey in 2002 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2004-2766
更新日期:2006-02-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:The effects of in utero methamphetamine exposure on behavioral problems in school-aged children are unclear. Our objective for this study was to evaluate behavior problems in children at aged 3, 5, and 7.5 years who were prenatally exposed to methamphetamine. METHODS:Subjects were enrolled in...
journal_title:Pediatrics
pub_type: 杂志文章,多中心研究
doi:10.1542/peds.2019-0270
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:Children with sickle cell anemia (SCA) are at increased risk for invasive pneumococcal disease; antibiotic prophylaxis significantly reduces this risk. We calculated the proportion of children with SCA who received ≥300 days of antibiotic prophylaxis and identified predictors of such receipt. METHODS:Childr...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-2182
更新日期:2018-03-01 00:00:00
abstract:BACKGROUND AND OBJECTIVES:Variability in primary medication nonadherence (PMN), or failure to fill a new prescription, influences disparities and widens equity gaps. This study sought to evaluate PMN across 1 metropolitan area and assess relationships with underlying zip code-level measures. METHODS:This was a retrosp...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-3402
更新日期:2018-04-01 00:00:00
abstract::Twelve infants with severe perinatal asphyxia were found to have elevated blood ammonia levels (302 to 960 microgram/100 ml). In the seven survivors, hyperammonemia was associated with CNS irritability, hyperthermia, hypertension, and wide neonatal heart rate oscillations. Follow-up examinations revealed severe neurol...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1979-09-01 00:00:00
abstract:OBJECTIVE:We investigated whether the duration and exclusivity of breastfeeding affects the likelihood of gross and fine motor delay in infants and examined the effect of factors that might explain any observed differences. METHODS:The study sample included all term singleton infants who weighed > 2500 g at birth and ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2005-3141
更新日期:2006-09-01 00:00:00
abstract:CONTEXT:The growing prevalence of pediatric mental and behavioral health disorders, coupled with scarce psychiatric resources, has resulted in a substantial increase in the number of youth waiting in emergency departments (EDs) and medical units for inpatient psychiatric care. OBJECTIVE:To characterize the prevalence ...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2020-1174
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:Despite voluntary restrictions prohibiting direct and indirect cigarette marketing to youth and paid product placement, tobacco use remains prevalent in movies. This article presents a systematic review of the evidence on the nature and effect of smoking in the movies on adolescents (and others). METHODOLOGY...
journal_title:Pediatrics
pub_type: 杂志文章,评审
doi:10.1542/peds.2005-0141
更新日期:2005-12-01 00:00:00
abstract:OBJECTIVE:To determine the prevalence of domestic violence against mothers in a pediatric emergency department and the relationship of their children to the abusers. DESIGN:Cross-sectional survey of a convenience sample of mothers seeking treatment for their children. SETTING:An urban pediatric emergency department. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.103.5.1007
更新日期:1999-05-01 00:00:00
abstract:OBJECTIVES:Children with generalized hypermobility of the joints and musculoskeletal complaints frequently visit pediatric clinics, but many show no currently known collagen or other possibly related diseases. Whether the symptoms are confined to the musculoskeletal system is unknown. We assessed whether such children ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.3.e248
更新日期:2003-03-01 00:00:00
abstract:OBJECTIVES:To estimate the effects of maternal and birth characteristics on the decision to breastfeed and to relate breastfeeding practices to racial differences in infant mortality. METHODS:Using a sample of women with young children from the National Survey of Family Growth (NSFG), Cycle V, 1995, the likelihood of ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.108.2.291
更新日期:2001-08-01 00:00:00
abstract::Congenital cataracts and other ocular media opacities are a leading cause of preventable childhood blindness. Because of the importance of early recognition and treatment of congenital media opacities in newborn infants, we designed a study to determine the ability of relatively inexperienced examiners to detect such ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1987-05-01 00:00:00
abstract:OBJECTIVES:To determine neurodevelopmental outcomes at 3 years of age in children born with a birth weight (BW) of ≤500 g. METHODS:Infants who were born with a BW of ≤500 g from 2003 to 2012 in the Neonatal Research Network of Japan and survived to discharge from the NICU were eligible in this study. The study populat...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-4286
更新日期:2018-12-01 00:00:00
abstract:OBJECTIVE:To identify clinical factors in term neonates with severe respiratory failure that predict which neonates are unlikely to respond to high-frequency oscillatory ventilation (HFOV). DESIGN:This was a retrospective review of patient charts and medical records. PATIENTS:We studied 190 newborns treated with HFOV...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1995-03-01 00:00:00
abstract:OBJECTIVES:Autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD) frequently co-occur. Understanding the endophenotype of children with both ASD and ADHD may impact clinical management. In this study, we compare the comorbidity of anxiety and mood disorders in children with ASD, with and wit...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2017-1377
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVE:The purpose of this study was to determine the risk for separation (ending cohabitation) of the parents of a child with a diagnosis of cancer. METHODS:In a nationwide cohort, we compared the risk for ending cohabitation of the parents of 2450 children (aged 0-20 years) given a diagnosis of cancer with the ri...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2011-2657
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:Because previous studies have found allergic contact sensitization common in children by 5 years of age, our aim was to determine the prevalence of positive epicutaneous test results in children <5 years of age and to determine whether sensitization to contact allergens was as common in infancy. METHODS:We r...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.105.1.e3
更新日期:2000-01-01 00:00:00
abstract:OBJECTIVE:A human papillomavirus vaccine was licensed in June 2006. The vaccine is quadrivalent, protecting against 2 human papillomavirus strains that cause cervical cancer and 2 that cause genital warts. The objective of this study was to determine physician characteristics, knowledge, and attitudes associated with a...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2006-1946
更新日期:2006-12-01 00:00:00
abstract:OBJECTIVE:Infants with chronic lung disease (CLD) have an arrest of primary and secondary septation. We hypothesized that this may be related to damage or abnormal development of lung collagen secondary to positive pressure ventilation. Our aims were to identify the sites and quantity of collagen in control infants 22 ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.111.4.766
更新日期:2003-04-01 00:00:00
abstract:CONTEXT:The usefulness of S100B has been noted as a biomarker in the management of mild traumatic brain injury (mTBI) in adults. However, S100B efficacy as a biomarker in children has previously been relatively unclear. OBJECTIVE:A meta-analysis is conducted to assess the prognostic value of S100B in predicting intrac...
journal_title:Pediatrics
pub_type: 杂志文章,meta分析
doi:10.1542/peds.2018-0037
更新日期:2018-06-01 00:00:00
abstract:OBJECTIVES:Adolescents often display heterogenous trajectories of alcohol use. Initiation and escalation of drinking may be important predictors of later harms, including alcohol use disorder (AUD). Previous conceptualizations of these trajectories lacked adjustment for known confounders of adolescent drinking, which w...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2020-0440
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVE:To compare the effect of 800 vs 400 IU of daily oral vitamin D3 on the prevalence of vitamin D deficiency (VDD) at 40 weeks' postmenstrual age (PMA) in preterm infants of 28 to 34 weeks' gestation. METHODS:In this randomized double-blind trial, we allocated eligible infants to receive either 800 or 400 IU of...
journal_title:Pediatrics
pub_type: 杂志文章,随机对照试验
doi:10.1542/peds.2012-3395
更新日期:2014-03-01 00:00:00
abstract:OBJECTIVE:Computed tomography is commonly used in the diagnosis of pediatric lung disease. Although the radiation is not negligible, the yield has never been studied. METHODS:Clinical and imaging data were collected for all children who underwent chest computed tomography, as part of the diagnostic process. Cases were...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2008-2694
更新日期:2009-08-01 00:00:00
abstract:OBJECTIVE:To assess compliance with the Centers for Disease Control and Prevention (CDC) evidence-based guidelines for the judicious use of antimicrobials in children with acute otitis media (AOM). METHODS:Compliance with CDC's recommended diagnostic criteria and antimicrobial treatments for management of AOM was asse...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.112.1.143
更新日期:2003-07-01 00:00:00
abstract::Children and parents who attend pediatric oncology clinics often develop close relationships with other patients and may question clinic staff about another child's disease, therapy, or status. To assess parental attitudes concerning the dissemination of information by the clinic staff, questionnaires were mailed to t...
journal_title:Pediatrics
pub_type: 杂志文章
doi:
更新日期:1988-02-01 00:00:00
abstract::Fertility preservation in prepubertal and young adolescent girls scheduled for chemotherapy is a demanding situation. Despite the recent impressive improvements of ovarian cortex cryopreservation, significant limitations persist. The technique remains experimental, it exposes the girl to the risks of surgery and to an...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2016-0291
更新日期:2016-10-01 00:00:00
abstract::: media-1vid110.1542/5771272502001PEDS-VA_2018-0503Video Abstract. ...
journal_title:Pediatrics
pub_type: 杂志文章
doi:10.1542/peds.2018-0503
更新日期:2018-07-01 00:00:00