Milk intolerance in children with persistent sleeplessness: a prospective double-blind crossover evaluation.

Abstract:

:From July 1986 to July 1988, 146 children less than 5 years of age were referred by their physicians to our university sleep clinic for continual waking and crying during sleep hours. For 85 children (58.2%), the sleeplessness was attributed to inappropriate sleep habits. For 17 children (11.6%), no explanation was found for the sleep difficulties in spite of an extensive workup. Their median age at referral was 13.5 months (range 2.5 to 29 months). Their persistent sleeplessness was tentatively attributed to an undiagnosed intolerance to cow's milk. Cow's milk was excluded from their diet. In 15 children sleep normalized after 5 weeks (range 4 to 6 weeks). As seen from the parents' logs, the median time needed by the children to fall asleep decreased from 15 minutes (range 15 to 60 minutes) to 10 minutes (range 10 to 15 minutes, P = .001). The number of complete arousals decreased from 5 (range 1 to 12) to less than 1 per night (range 0 to 2) (P = .001). Total sleep time per 24 hours increased from 5.5 hours (range 3 to 8.5 hours) to 13.0 hours (range 10 to 14.5 hours, P = .001). Sleep normalized in one child who continued to receive no cow's milk only after the hydrolyzed hypoallergenic diet was discontinued. In every child, a double-blind crossover challenge was conducted involving a control diet containing no cow's milk and a diet containing cow's milk. The challenge induced the reappearance of insomnia and agitated behavior in all except one child. The child's initial sleep difficulties were retrospectively attributed to inappropriate sleep habits.(ABSTRACT TRUNCATED AT 250 WORDS)

journal_name

Pediatrics

journal_title

Pediatrics

authors

Kahn A,Mozin MJ,Rebuffat E,Sottiaux M,Muller MF

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

595-603

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

84

pub_type

临床试验,杂志文章,随机对照试验
  • Disparities for LGBTQ and Gender Nonconforming Adolescents.

    abstract:OBJECTIVES:To identify patterns of childhood adversity in a sample of adolescents and assess disparities in these experiences for lesbian, gay, bisexual, transgender, and questioning adolescents and by level of gender nonconformity. METHOD:By using the cross-sectional, statewide, anonymous 2016 Minnesota Student Surve...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-3004

    authors: Baams L

    更新日期:2018-05-01 00:00:00

  • Self-referral and serious illness in children with fever.

    abstract:OBJECTIVE:The goal of this study was to evaluate parents' capability to assess their febrile child's severity of illness and decision to present to the emergency department. We compared children referred by a general practitioner (GP) with those self-referred on the basis of illness-severity markers. METHODS:This was ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1952

    authors: van Ierland Y,Seiger N,van Veen M,van Meurs AH,Ruige M,Oostenbrink R,Moll HA

    更新日期:2012-03-01 00:00:00

  • Quality of primary care and subsequent pediatric emergency department utilization.

    abstract:OBJECTIVE:Our objective was to determine whether parent-reported, high-quality primary care was associated with decreased nonurgent pediatric emergency department utilization. METHODS:A retrospective analysis of prospectively collected data for a cohort of children from the 2000-2001 and 2001-2002 Medical Expenditure ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-3518

    authors: Brousseau DC,Hoffmann RG,Nattinger AB,Flores G,Zhang Y,Gorelick M

    更新日期:2007-06-01 00:00:00

  • Adolescent Alcohol Use Trajectories: Risk Factors and Adult Outcomes.

    abstract:OBJECTIVES:Adolescents often display heterogenous trajectories of alcohol use. Initiation and escalation of drinking may be important predictors of later harms, including alcohol use disorder (AUD). Previous conceptualizations of these trajectories lacked adjustment for known confounders of adolescent drinking, which w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-0440

    authors: Yuen WS,Chan G,Bruno R,Clare P,Mattick R,Aiken A,Boland V,McBride N,McCambridge J,Slade T,Kypri K,Horwood J,Hutchinson D,Najman J,De Torres C,Peacock A

    更新日期:2020-10-01 00:00:00

  • Primary hyperparathyroidism mimicking vaso-occlusive crises in sickle cell disease.

    abstract::We report a case of bone pain associated with primary hyperparathyroidism in a patient with sickle cell disease. A 17-year-old girl with sickle cell disease (SS phenotype) was seen for bilateral knee and back pain. She had had recurrent severe vaso-occlusive crises and acute chest syndrome in the course of her disease...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0337

    authors: Krishnamoorthy P,Alyaarubi S,Abish S,Gale M,Albuquerque P,Jabado N

    更新日期:2006-08-01 00:00:00

  • Nebulized hypertonic saline without adjunctive bronchodilators for children with bronchiolitis.

    abstract:OBJECTIVE:The goal was to determine an adverse event rate for nebulized hypertonic saline solution administered without adjunctive bronchodilators for infants with bronchiolitis. METHODS:This was a retrospective cohort study of the use of nebulized 3% saline for children<2 years of age who were hospitalized with the p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-3105

    authors: Ralston S,Hill V,Martinez M

    更新日期:2010-09-01 00:00:00

  • Gaucher's disease and fatal hepatic fibrosis despite prolonged enzyme replacement therapy.

    abstract::We report on the case of a girl with type 1 Gaucher's disease, treated from age 9 to 15 with high-dose enzyme replacement therapy. This treatment did not avert the development of an extensive mutilating hepatic fibrosis warranting a liver transplantation, which was followed by death. In some cases of Gaucher's disease...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.109.6.1170

    authors: Perel Y,Bioulac-Sage P,Chateil JF,Trillaud H,Carles J,Lamireau T,Guillard JM

    更新日期:2002-06-01 00:00:00

  • Assessment of neonatal encephalopathy by amplitude-integrated electroencephalography.

    abstract:OBJECTIVE:To define normal and abnormal patterns, test interobserver variability, and the prognostic accuracy of amplitude-integrated electroencephalography (aEEG) soon after the onset of neonatal encephalopathy. METHODS:Consecutive cases of neonatal encephalopathy (n = 56; gestation median, 40; range, 35-42 weeks) an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.103.6.1263

    authors: al Naqeeb N,Edwards AD,Cowan FM,Azzopardi D

    更新日期:1999-06-01 00:00:00

  • Renal function in obstructive nephropathy: long-term effect of reconstructive surgery.

    abstract::Renal function was studied in 24 children with chronic hydronephrosis and renal insufficiency. The follow-up period after reconstructive surgery was 1 to 12 years. Glomerular filtration rate (GFR) was assessed by the clearance of endogenous creatinine or inulin. Effective renal plasma flow was assessed by the clearanc...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Mayor G,Genton N,Torrado A,Guignard JP

    更新日期:1975-11-01 00:00:00

  • Impact of very preterm birth on health care costs at five years of age.

    abstract:OBJECTIVE:We assessed the effects of very preterm birth (gestational age <32 weeks or birth weight <1501 g) and prematurity-related morbidities on health care costs during the fifth year of life. METHODS:The study population consisted of 588 very preterm children and 176 term control subjects born in 2001-2002. Costs ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-2882

    authors: Korvenranta E,Lehtonen L,Rautava L,Häkkinen U,Andersson S,Gissler M,Hallman M,Leipälä J,Peltola M,Tammela O,Linna M,PERFECT Preterm Infant Study Group.

    更新日期:2010-05-01 00:00:00

  • Work of breathing and different levels of volume-targeted ventilation.

    abstract:OBJECTIVES:The objectives of this study were to determine the impact of different volume-targeted levels on the work of breathing and to investigate whether a level that reduced the work of breathing below that experienced during ventilatory support without volume targeting could be determined. METHODS:The transdiaphr...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2008-2635

    authors: Patel DS,Sharma A,Prendergast M,Rafferty GF,Greenough A

    更新日期:2009-04-01 00:00:00

  • Increasing breast milk production for premature infants with a relaxation/imagery audiotape.

    abstract::Many women whose premature infants are hospitalized in a newborn intensive care unit choose to express breast milk for their babies. Yet anxiety, fatigue, and emotional stress are powerful inhibitors of lactation. To facilitate the breast-feeding experience, intervention mothers were given a 20-minute audio cassette t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Feher SD,Berger LR,Johnson JD,Wilde JB

    更新日期:1989-01-01 00:00:00

  • A randomized comparison of nitrous oxide plus hematoma block versus ketamine plus midazolam for emergency department forearm fracture reduction in children.

    abstract:OBJECTIVES:Ketamine provides effective and relatively safe sedation analgesia for reduction of fractures in children in the emergency department. However, prolonged recovery and adverse effects suggest the opportunity to develop alternative strategies. We compared the efficacy and adverse effects of ketamine/midazolam ...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-1694

    authors: Luhmann JD,Schootman M,Luhmann SJ,Kennedy RM

    更新日期:2006-10-01 00:00:00

  • Down Syndrome and the Risk of Severe RSV Infection: A Meta-analysis.

    abstract:CONTEXT:Down syndrome (DS) is the most common chromosomal condition in live-born infants worldwide, and lower respiratory infection caused by respiratory syncytial virus (RSV) is a leading cause of hospital admissions. OBJECTIVE:To evaluate RSV-associated morbidity among children with DS compared with a population wit...

    journal_title:Pediatrics

    pub_type: 杂志文章,meta分析

    doi:10.1542/peds.2018-0225

    authors: Beckhaus AA,Castro-Rodriguez JA

    更新日期:2018-09-01 00:00:00

  • Specialized assessments for children in foster care.

    abstract:OBJECTIVE:To investigate the differences in health problems identified and health services received by children newly entering foster care who participated in a comprehensive multidisciplinary program, compared with children newly entering foster care who received customary community-based services. METHODS:Using a 2-...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.1.59

    authors: Horwitz SM,Owens P,Simms MD

    更新日期:2000-07-01 00:00:00

  • Improved access and quality of care after enrollment in the New York State Children's Health Insurance Program (SCHIP).

    abstract:BACKGROUND:Although many studies have noted that uninsured children have poorer access and quality of health care than do insured children, few studies have been able to demonstrate the direct benefits of providing health insurance to previously uninsured children. The State Children's Health Insurance Program (SCHIP),...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.5.e395

    authors: Szilagyi PG,Dick AW,Klein JD,Shone LP,Zwanziger J,McInerny T

    更新日期:2004-05-01 00:00:00

  • Promoting the well-being of children whose parents are gay or lesbian.

    abstract::Extensive data available from more than 30 years of research reveal that children raised by gay and lesbian parents have demonstrated resilience with regard to social, psychological, and sexual health despite economic and legal disparities and social stigma. Many studies have demonstrated that children's well-being is...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:10.1542/peds.2013-0377

    authors: Perrin EC,Siegel BS,Committee on Psychosocial Aspects of Child and Family Health of the American Academy of Pediatrics.

    更新日期:2013-04-01 00:00:00

  • Developmental changes in energy expenditure and physical activity in children: evidence for a decline in physical activity in girls before puberty.

    abstract:OBJECTIVE:To examine individual changes in energy expenditure and physical activity during prepubertal growth in boys and girls. METHODS:Total energy expenditure (TEE), resting energy expenditure, physical activity-related energy expenditure, reported physical activity, and fat and fat-free mass were measured three ti...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.5.887

    authors: Goran MI,Gower BA,Nagy TR,Johnson RK

    更新日期:1998-05-01 00:00:00

  • Disseminated fungal infections in very low-birth-weight infants: therapeutic toxicity.

    abstract::The improved survival of very low-birth-weight infants, who require prolonged hospitalization and many invasive procedures, increases the risks for nosocomial illnesses, such as disseminated fungal infections. In a 2-year period, systemic fungal infections were clinically diagnosed in ten infants. This necessitated th...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Baley JE,Kliegman RM,Fanaroff AA

    更新日期:1984-02-01 00:00:00

  • Vesicoureteral reflux in the primate. IV. Infection as cause of prolonged high-grade reflux.

    abstract::High-grade reflux commonly lasts longer than moderate reflux, which disappears with maturation of the ureterovesical junction. It is known that ureteral function is affected by urinary tract infection from studies in experimental animals, as well as through clinical findings in patients with upper tract infection. Whe...

    journal_title:Pediatrics

    pub_type: 杂志文章,评审

    doi:

    authors: Roberts JA,Kaack MB,Morvant AB

    更新日期:1988-07-01 00:00:00

  • Informing schools about children's chronic illnesses: parents' opinions.

    abstract::Parents of 217 chronically ill children and adolescents were surveyed concerning their opinions about disclosing medical information to schools. The sample consisted of parents of more than one third of the children and adolescents meeting inclusion criteria who were seen at a university-based pediatric clinic during ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Andrews SG

    更新日期:1991-08-01 00:00:00

  • Effect of allopurinol on postasphyxial free radical formation, cerebral hemodynamics, and electrical brain activity.

    abstract:OBJECTIVE:Free radical-induced postasphyxial reperfusion injury has been recognized as an important cause of brain tissue damage. We investigated the effect of high-dose allopurinol (ALLO; 40 mg/kg), a xanthine-oxidase inhibitor and free radical scavenger, on free radical status in severely asphyxiated newborns and on ...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.101.2.185

    authors: Van Bel F,Shadid M,Moison RM,Dorrepaal CA,Fontijn J,Monteiro L,Van De Bor M,Berger HM

    更新日期:1998-02-01 00:00:00

  • Motivational interviewing with parents for obesity: an RCT.

    abstract:BACKGROUND AND OBJECTIVE:Motivational interviewing (MI) has been shown to be an effective strategy for targeting obesity in adolescents, and parental involvement is associated with increased effectiveness. The aim of this study was to evaluate and compare the role of parental involvement in MI interventions for obese a...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2014-1987

    authors: Pakpour AH,Gellert P,Dombrowski SU,Fridlund B

    更新日期:2015-03-01 00:00:00

  • Predictors of phrase and fluent speech in children with autism and severe language delay.

    abstract:OBJECTIVE:To examine the prevalence and predictors of language attainment in children with autism spectrum disorder (ASD) and severe language delay. We hypothesized greater autism symptomatology and lower intelligence among children who do not attain phrase/fluent speech, with nonverbal intelligence and social engageme...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-2221

    authors: Wodka EL,Mathy P,Kalb L

    更新日期:2013-04-01 00:00:00

  • Morbidity among human immunodeficiency virus-1-infected and -uninfected African children.

    abstract:OBJECTIVE:To assess patterns of morbidity and associated factors in late infancy and early childhood among human immunodeficiency virus (HIV)-infected and -uninfected African children. DESIGN:Prospective study. SETTING:The Queen Elizabeth Central Hospital, Blantyre, Malawi. PARTICIPANTS:Children with known HIV statu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.6.e77

    authors: Taha TE,Graham SM,Kumwenda NI,Broadhead RL,Hoover DR,Markakis D,van Der Hoeven L,Liomba GN,Chiphangwi JD,Miotti PG

    更新日期:2000-12-01 00:00:00

  • Clinical Prediction Rule for Distinguishing Bacterial From Aseptic Meningitis.

    abstract:BACKGROUND:New biomarkers like procalcitonin and C-reactive protein may help design an accurate decision support tool used to identify children with pleocytosis at low or high risk of bacterial meningitis. Our objective was to develop and validate a score (that we call the meningitis score for emergencies [MSE]) to dis...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-1126

    authors: Mintegi S,García S,Martín MJ,Durán I,Arana-Arri E,Fernandez CL,Benito J,Hernández-Bou S,Meningitis Group of the Spanish Society of Pediatric Emergencies.

    更新日期:2020-09-01 00:00:00

  • Nonmedical vaccine exemptions and pertussis in California, 2010.

    abstract:BACKGROUND:In 2010, 9120 cases of pertussis were reported in California, more than any year since 1947. Although this resurgence has been widely attributed to waning immunity of the acellular vaccine, the role of vaccine refusal has not been explored in the published literature. Many factors likely contributed to the o...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-0878

    authors: Atwell JE,Van Otterloo J,Zipprich J,Winter K,Harriman K,Salmon DA,Halsey NA,Omer SB

    更新日期:2013-10-01 00:00:00

  • Pulse Oximetry and Auscultation for Congenital Heart Disease Detection.

    abstract:OBJECTIVES:Pulse oximetry (POX) has been confirmed as a specific screening modality for critical congenital heart disease (CCHD), with moderate sensitivity. However, POX is not able to detect most serious and critical cardiac lesions (major congenital heart disease [CHD]) without hypoxemia. In this study, we investigat...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2017-1154

    authors: Hu XJ,Ma XJ,Zhao QM,Yan WL,Ge XL,Jia B,Liu F,Wu L,Ye M,Liang XC,Zhang J,Gao Y,Zhai XW,Huang GY

    更新日期:2017-10-01 00:00:00

  • Toxicity of over-the-counter cough and cold medications.

    abstract::Over-the-counter (OTC) cough and cold medications are marketed widely for relief of common cold symptoms, and yet studies have failed to demonstrate a benefit of these medications for young children. In addition, OTC medications can be associated with significant morbidity and even mortality in both acute overdoses an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.3.e52

    authors: Gunn VL,Taha SH,Liebelt EL,Serwint JR

    更新日期:2001-09-01 00:00:00

  • Successful direct extubation of very low birth weight infants from low intermittent mandatory ventilation rate.

    abstract::It is common practice to use endotracheal continuous positive airway pressure for various time periods up to 24 hours before attempting extubation in infants who are mechanically ventilated. A few studies in newborns have indicated that airway resistance is increased through small endotracheal tubes. This increases th...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Kim EH,Boutwell WC

    更新日期:1987-09-01 00:00:00