Abstract:
:Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT). In phase I, 4 of 10 babies in the CMT group died and 9 of 9 babies in the ECMO group survived. Randomization was halted after the fourth CMT death, as planned before initiating the study, and the next 20 babies were treated with ECMO (phase II). Of the 20, 19 survived. All three treatment groups (CMT and ECMO in phase I and ECMO, phase II) were comparable in severity of illness and mechanical ventilator support. The overall survival of ECMO-treated infants was 97% (28 of 29) compared with 60% (6 of 10) in the CMT group (P less than .05).
journal_name
Pediatricsjournal_title
Pediatricsauthors
O'Rourke PP,Crone RK,Vacanti JP,Ware JH,Lillehei CW,Parad RB,Epstein MFsubject
Has Abstractpub_date
1989-12-01 00:00:00pages
957-63issue
6eissn
0031-4005issn
1098-4275journal_volume
84pub_type
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