Extracorporeal membrane oxygenation and conventional medical therapy in neonates with persistent pulmonary hypertension of the newborn: a prospective randomized study.

Abstract:

:Thirty-nine newborn infants with severe persistent pulmonary hypertension and respiratory failure who met criteria for 85% likelihood of dying were enrolled in a randomized trial in which extracorporeal membrane oxygenation (ECMO) therapy was compared with conventional medical therapy (CMT). In phase I, 4 of 10 babies in the CMT group died and 9 of 9 babies in the ECMO group survived. Randomization was halted after the fourth CMT death, as planned before initiating the study, and the next 20 babies were treated with ECMO (phase II). Of the 20, 19 survived. All three treatment groups (CMT and ECMO in phase I and ECMO, phase II) were comparable in severity of illness and mechanical ventilator support. The overall survival of ECMO-treated infants was 97% (28 of 29) compared with 60% (6 of 10) in the CMT group (P less than .05).

journal_name

Pediatrics

journal_title

Pediatrics

authors

O'Rourke PP,Crone RK,Vacanti JP,Ware JH,Lillehei CW,Parad RB,Epstein MF

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

957-63

issue

6

eissn

0031-4005

issn

1098-4275

journal_volume

84

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:OBJECTIVES:Television viewing and physical inactivity increase the risk of obesity in youth. Thus, identifying new interventions that increase physical activity and reduce television viewing would be helpful in the prevention and treatment of pediatric obesity. This study evaluated the effects of open-loop feedback plu...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2005-3052

    authors: Goldfield GS,Mallory R,Parker T,Cunningham T,Legg C,Lumb A,Parker K,Prud'homme D,Gaboury I,Adamo KB

    更新日期:2006-07-01 00:00:00

  • Acceptability of Family-Centered Advanced Care Planning for Adolescents With HIV.

    abstract:BACKGROUND AND OBJECTIVE:Small pilot studies support the appropriateness of engaging adolescents with chronic or life-limiting illnesses in pediatric advance care planning (pACP). We do not yet know if pACP is acceptable, feasible, and worthwhile, even if emotionally intense, in a fully powered randomized controlled tr...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2016-1854

    authors: Dallas RH,Kimmel A,Wilkins ML,Rana S,Garcia A,Cheng YI,Wang J,Lyon ME,Adolescent Palliative Care Consortium.

    更新日期:2016-12-01 00:00:00

  • Unmasking of childhood hypothyroidism by disseminated xanthomas.

    abstract::Secondary hyperlipidemia is a common laboratory finding in children with nephrotic syndrome, diabetes mellitus, and hypothyroidism. However, clinical signs of hyperlipidemia are extremely rare in childhood. We report on an 11-year-old girl who presented with a disseminated yellow papulomatous rash on the lower limbs a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.108.5.e96

    authors: Dötsch J,Zepf K,Schellmoser S,Rascher W,Dörr HG

    更新日期:2001-11-01 00:00:00

  • An outbreak of measles in an undervaccinated community.

    abstract::Measles is readily spread to susceptible individuals, but is no longer endemic in the United States. In March 2011, measles was confirmed in a Minnesota child without travel abroad. This was the first identified case-patient of an outbreak. An investigation was initiated to determine the source, prevent transmission, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2013-4260

    authors: Gahr P,DeVries AS,Wallace G,Miller C,Kenyon C,Sweet K,Martin K,White K,Bagstad E,Hooker C,Krawczynski G,Boxrud D,Liu G,Stinchfield P,LeBlanc J,Hickman C,Bahta L,Barskey A,Lynfield R

    更新日期:2014-07-01 00:00:00

  • School-age outcomes in children who were extremely low birth weight from four international population-based cohorts.

    abstract:OBJECTIVE:The aim of this study was to determine whether learning and school problems in extremely low birth weight (ELBW) and reference children differ between cohorts in different countries. METHODS:Participants were 4 international population-based cohorts of ELBW survivors who were 500 to 1000 g birth weight from ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.112.4.943

    authors: Saigal S,den Ouden L,Wolke D,Hoult L,Paneth N,Streiner DL,Whitaker A,Pinto-Martin J

    更新日期:2003-10-01 00:00:00

  • Patient education for immunizations.

    abstract::Many physicians and parents consider immunizations routine; as a result, they fail to discuss this important aspect of health care. Parents should be educated about each vaccine and the role it plays in the well-being of their child. To ensure that parents will be able to give informed consent to have their child immu...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Fulginiti VA

    更新日期:1984-11-01 00:00:00

  • Validation of the Rapid Estimate for Adolescent Literacy in Medicine Short Form (REALM-TeenS).

    abstract:BACKGROUND:This study was designed to develop and validate a brief adolescent health literacy assessment tool (Rapid Estimate of Adolescent Literacy in Medicine Short Form [REALM-TeenS]). METHODS:We combined datasets from 2 existing research studies that used the REALM-Teen (n = 665) and conducted an item response the...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2016-3286

    authors: Manganello JA,Colvin KF,Chisolm DJ,Arnold C,Hancock J,Davis T

    更新日期:2017-05-01 00:00:00

  • Prophylactic fluconazole is effective in preventing fungal colonization and fungal systemic infections in preterm neonates: a single-center, 6-year, retrospective cohort study.

    abstract:OBJECTIVE:Despite the promising preliminary results observed in extremely low birth weight (ELBW) populations, the use of fluconazole to prevent fungal colonization and infection in preterm neonates in the NICU is still an open question and not yet recommended as a standard of care. We have reviewed our 6-year series t...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-2227

    authors: Manzoni P,Arisio R,Mostert M,Leonessa M,Farina D,Latino MA,Gomirato G

    更新日期:2006-01-01 00:00:00

  • Nonresponse bias in a follow-up study of 19-year-old adolescents born as preterm infants.

    abstract:OBJECTIVE:To assess the effect of demographic and neonatal risk factors and outcome at the last available assessment on the probability of full responders, postal responders (those who only responded to the mailed questionnaire), or nonresponders in a follow-up study of 19-year-old adolescents who were born as preterm ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2005-0682

    authors: Hille ET,Elbertse L,Gravenhorst JB,Brand R,Verloove-Vanhorick SP,Dutch POPS-19 Collaborative Study Group.

    更新日期:2005-11-01 00:00:00

  • Computer-based documentation: effects on parent-provider communication during pediatric health maintenance encounters.

    abstract:OBJECTIVE:The goal was to investigate the impact of a computer-based documentation tool on parent-health care provider communication during a pediatric health maintenance encounter. METHODS:We used a quasiexperimental study design to compare communication dynamics between clinicians and parents/children in health main...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-3005

    authors: Johnson KB,Serwint JR,Fagan LA,Thompson RE,Wilson ME,Roter D

    更新日期:2008-09-01 00:00:00

  • Thyroid "vise" in an infant with neonatal Graves' disease.

    abstract::On the rare occasion when neonatal goiter is the cause of airway compromise, it typically presents with a palpable neck mass. In the setting of maternal Graves' disease (GD), fetal and neonatal goiters are most commonly caused by maternal treatment with antithyroid medication, and the goiter resolves within days of in...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-3000

    authors: Regelmann MO,Sullivan CK,Rapaport R

    更新日期:2013-10-01 00:00:00

  • Effect of ampicillin and chloramphenicol against Haemophilus influenzae.

    abstract::Synergy, determined by isobolograms constructed from the minimal inhibitory concentrations of combinations of ampicillin and chloramphenicol, was observed against six of 13 ampicillin-susceptible Haemophilus influenzae type b isolates and against five of eight ampicillin-resistant strains by using a small inoculum of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.406

    authors: Feldman WE

    更新日期:1978-03-01 00:00:00

  • Iatrogenic Cushing's Syndrome Due to Intranasal Usage of Ophthalmic Dexamethasone: A Case Report.

    abstract::Iatrogenic Cushing's syndrome (ICS) is caused by exogenous corticosteroid administration with suppression of the hypothalamic-pituitary-adrenal axis. It has been commonly described with oral and topical steroid use, but scarce reports have documented intranasal steroid usage as the etiology in infancy. In this article...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-3845

    authors: Orton S,Censani M

    更新日期:2016-05-01 00:00:00

  • Pneumatic otoscopy in healthy full-term infants.

    abstract::Pneumatic otoscopy was performed on 81 healthy full-term babies during the first 72 hours of life and at routine well-baby follow-up visits. Only 14 of 115 (12%) of the eardrums visualized during the first three days of life moved briskly to insufflation as compared with 29 of 65 (44%) and 50 of 71 (71%) by 3 weeks an...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Cavanaugh RM Jr

    更新日期:1987-04-01 00:00:00

  • Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol.

    abstract::In summary: (1) Colestipol therapy plus diet reduced total cholesterol 19 +/- 3% in 11 hypercholesterolemic children after two months and 13 +/- 5% after two years in five children. (2) Diet therapy did not significantly reduce serum concentration of any of the fat-soluble vitamins or folate. (3) During 24 months of c...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Schwarz KB,Goldstein PD,Witztum JL,Schonfeld G

    更新日期:1980-02-01 00:00:00

  • Death of a child in the emergency department.

    abstract::The death of a child in the emergency department (ED) is one of the most challenging problems facing ED clinicians. This revised technical report and accompanying policy statement reaffirm principles of patient- and family-centered care. Recent literature is examined regarding family presence, termination of resuscita...

    journal_title:Pediatrics

    pub_type:

    doi:10.1542/peds.2014-1246

    authors: O'Malley P,Barata I,Snow S,American Academy of Pediatrics Committee on Pediatric Emergency Medicine.,American College of Emergency Physicians Pediatric Emergency Medicine Committee.,Emergency Nurses Association Pediatric Committee.

    更新日期:2014-07-01 00:00:00

  • Prevalence of household firearms and firearm-storage practices in the 50 states and the District of Columbia: findings from the Behavioral Risk Factor Surveillance System, 2002.

    abstract:OBJECTIVES:To examine the prevalence of household firearms and firearm-storage practices in the 50 states and the District of Columbia and estimate the number of children exposed to unsafe storage practices. METHODS:We analyzed data from the 2002 cross-sectional Behavioral Risk Factor Surveillance System survey of 240...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0300

    authors: Okoro CA,Nelson DE,Mercy JA,Balluz LS,Crosby AE,Mokdad AH

    更新日期:2005-09-01 00:00:00

  • Familial nonobstructive cardiomyopathy with endocardial fibroelastosis beyond infancy.

    abstract::A 10-year-old boy with congestive heart failure died in five months in spite of comprehensive medical treatment. Autopsy showed patchy areas of endocardial fibroelastosis of the left ventricle. The sister of this patient had followed a similar course at 13 years of age with death within six months of the onset of cong...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.410

    authors: Singh A,Doyle EF,Danilowicz DA,Finegold MJ

    更新日期:1978-03-01 00:00:00

  • Etiologies of NICU deaths.

    abstract:BACKGROUND AND OBJECTIVES:Infant mortality is an indicator of overall societal health, and a significant proportion of infant deaths occur in NICUs. The objectives were to identify causes of death and to define potentially preventable factors associated with death as areas for quality improvement efforts in the NICU. ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2014-2967

    authors: Jacob J,Kamitsuka M,Clark RH,Kelleher AS,Spitzer AR

    更新日期:2015-01-01 00:00:00

  • General pediatric attending physicians' and residents' knowledge of inpatient hospital finances.

    abstract:BACKGROUND AND OBJECTIVE:There is evidence suggesting that physicians have a limited foundation of knowledge on health care finances and limited awareness of hospital costs and charges. The objective was to analyze general pediatric attending physicians' and residents' knowledge of costs, charges, and reimbursements fo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1753

    authors: Rock TA,Xiao R,Fieldston E

    更新日期:2013-06-01 00:00:00

  • Pulse oximeter sensor application during neonatal resuscitation: a randomized controlled trial.

    abstract:OBJECTIVE:This study was done to compare 2 techniques of pulse oximeter sensor application during neonatal resuscitation for faster signal detection. METHODS:Sensor to infant first (STIF) and then to oximeter was compared with sensor to oximeter first (STOF) and then to infant in ≥28 weeks gestations. The primary outc...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2013-2175

    authors: Louis D,Sundaram V,Kumar P

    更新日期:2014-03-01 00:00:00

  • Prevalence and correlates of high-quality basic pediatric preventive care.

    abstract:BACKGROUND:The list of recommended pediatric preventive services has grown considerably in the past decade, and clinician variability, clinician distribution, and other correlates of provision of these basic preventive services (BPS) are not known. OBJECTIVE:To describe the proportion of high-quality basic pediatric p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-0635

    authors: Zuckerman B,Stevens GD,Inkelas M,Halfon N

    更新日期:2004-12-01 00:00:00

  • Treatment of child and adolescent obesity: reports from pediatricians, pediatric nurse practitioners, and registered dietitians.

    abstract:OBJECTIVE:The primary aim of this study was to identify interventions used by pediatric health care providers in treatment of overweight children and adolescents to identify provider educational needs. A secondary aim was to examine the association of certain provider characteristics with recommended evaluation practic...

    journal_title:Pediatrics

    pub_type: 评论,杂志文章

    doi:

    authors: Barlow SE,Trowbridge FL,Klish WJ,Dietz WH

    更新日期:2002-07-01 00:00:00

  • Predicting time to hospital discharge for extremely preterm infants.

    abstract:BACKGROUND:As extremely preterm infant mortality rates have decreased, concerns regarding resource use have intensified. Accurate models for predicting time to hospital discharge could aid in resource planning, family counseling, and stimulate quality-improvement initiatives. OBJECTIVES:To develop, validate, and compa...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0810

    authors: Hintz SR,Bann CM,Ambalavanan N,Cotten CM,Das A,Higgins RD,Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network.

    更新日期:2010-01-01 00:00:00

  • Using BMI to determine cardiovascular risk in childhood: how do the BMI cutoffs fare?

    abstract:OBJECTIVE:Although adverse health outcomes are increased among children with BMI above the 85th (overweight) and 95th (obese) percentiles, previous studies have not clearly defined the BMI percentile at which adverse health outcomes begin to increase. We examined whether the existing BMI percentile cutoffs are optimal ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2009-0179

    authors: Skinner AC,Mayer ML,Flower K,Perrin EM,Weinberger M

    更新日期:2009-11-01 00:00:00

  • Hospitalization of children with status asthmaticus: a review.

    abstract::A review of hospital admissions of patients with status asthmaticus at the Childrens Hospital of Los Angeles showed a marked increase in admissions in recent years. Asthma mortality did not increase. Patients tended to be young, boys, and black as compared with patients admitted to a general hospital. Interviews with ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Richards W

    更新日期:1989-07-01 00:00:00

  • Children, adolescents, obesity, and the media.

    abstract::Obesity has become a worldwide public health problem. Considerable research has shown that the media contribute to the development of child and adolescent obesity, although the exact mechanism remains unclear. Screen time may displace more active pursuits, advertising of junk food and fast food increases children's re...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-1066

    authors: Council on Communications and Media.,Strasburger VC

    更新日期:2011-07-01 00:00:00

  • Prenatal cocaine exposure and child behavior.

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    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.102.4.945

    authors: Delaney-Black V,Covington C,Templin T,Ager J,Martier S,Sokol R

    更新日期:1998-10-01 00:00:00

  • Long-term follow-up and outcome of phenylketonuria patients on sapropterin: a retrospective study.

    abstract:OBJECTIVE:Sapropterin dihydrochloride, the synthetic form of 6R-tetrahydrobiopterin (BH4), is an approved drug for the treatment of patients with BH4-responsive phenylketonuria (PKU). The purpose of this study was to assess genotypes and data on the long-term effects of BH4/sapropterin on metabolic control and patient-...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2012-3291

    authors: Keil S,Anjema K,van Spronsen FJ,Lambruschini N,Burlina A,Bélanger-Quintana A,Couce ML,Feillet F,Cerone R,Lotz-Havla AS,Muntau AC,Bosch AM,Meli CA,Billette de Villemeur T,Kern I,Riva E,Giovannini M,Damaj L,Leuzzi V,B

    更新日期:2013-06-01 00:00:00

  • Premedication for nonemergent neonatal intubations: a randomized, controlled trial comparing atropine and fentanyl to atropine, fentanyl, and mivacurium.

    abstract:OBJECTIVE:The purpose of this work was to investigate whether using a muscle relaxant would improve intubation conditions in infants, thereby decreasing the incidence and duration of hypoxia and time and number of attempts needed to successfully complete the intubation procedure. PATIENTS/METHODS:This was a prospectiv...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1542/peds.2006-0590

    authors: Roberts KD,Leone TA,Edwards WH,Rich WD,Finer NN

    更新日期:2006-10-01 00:00:00