Selective intrapartum prophylaxis for group B streptococcus colonization: management and outcome of newborns.

Abstract:

OBJECTIVE:Intrapartum antibiotic prophylaxis (IAP) in mothers with group B streptococcus (GBS) colonization presents difficult neonatal management decisions. IAP was instituted in response to an increased incidence of early-onset GBS sepsis (EOGBSS), and a study was conducted to evaluate the outcome of these newborns. METHODS:A study was undertaken at Truman Medical Center-East, a county hospital with a level 1 nursery. During the 20-month study period, prenatal GBS cultures were obtained on all mothers in their third trimester of pregnancy. At time of delivery, GBS-positive women who had at least one risk factor were to receive IAP. Risk factors included fever and/or amnionitis, premature labor, and prolonged rupture of membranes defined as > 6 hours. Screening laboratory tests were performed on all newborns whose mothers received IAP. Only the newborns with positive screening laboratory tests or symptoms of sepsis received further laboratory evaluation and antibiotic treatment. RESULTS:During the study, 2040 mothers gave birth to 2054 newborns. Three hundred thirty-two mothers (16.3%) were colonized with GBS and 122 (37.0%) had at least one risk factor. IAP was given to 70 GBS-positive mothers. Thirty-three (27%) GBS-positive mothers with risk factors did not receive IAP for logistical reasons. Eleven full-term newborns had EOGBSS: For case newborns, the mean duration of ruptured membranes was 13.7 hours (range 2.5 to 28 hours). Vertical transmission occurred as follows: Cutaneous colonization was found in 33 (12.5%) newborns born to 261 mothers who received no IAP, and symptomatic EOGBSS was diagnosed in 9 (3.4%). Mothers who received one dose (n = 43) had three (6.9%) newborns with GBS colonization and two (4.7%) asymptomatic newborns with EOGBSS: No newborns born to 28 mothers who received two doses IAP had GBS colonization or were ill. Cutaneous vertical transmission was reduced (P = .03). Newborns born to GBS-positive mothers with one or more risk factors who received IAP had significantly less EOGBSS (P < .05) than those who did not receive IAP. CONCLUSIONS:Selective IAP was administered safely to 21% of GBS-positive women, or 3.5% of all deliveries. IAP prevented EOGBSS when it could be given to GBS-positive mothers with a risk factor. Accurate identification of mothers with GBS colonization and their risk factors is essential for effective use of IAP. Earlier institution of IAP after rupture of membranes may reduce the risk of EOGBSS and the need for extensive infant evaluation.

journal_name

Pediatrics

journal_title

Pediatrics

authors

Pylipow M,Gaddis M,Kinney JS

subject

Has Abstract

pub_date

1994-04-01 00:00:00

pages

631-5

issue

4

eissn

0031-4005

issn

1098-4275

journal_volume

93

pub_type

临床试验,杂志文章
  • Clinical Considerations Related to the Behavioral Manifestations of Child Maltreatment.

    abstract::Children who have suffered early abuse or neglect may later present with significant health and behavior problems that may persist long after the abusive or neglectful environment has been remediated. Neurobiological research suggests that early maltreatment may result in an altered psychological and physiologic respo...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2017-0100

    authors: Sege RD,Amaya-Jackson L,AMERICAN ACADEMY OF PEDIATRICS Committee on Child Abuse and Neglect, Council on Foster Care, Adoption, and Kinship Care; AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY Committee on Child Maltreatment and Violence; NATION

    更新日期:2017-04-01 00:00:00

  • Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes.

    abstract:OBJECTIVE:Type 2 diabetes is a growing problem among adolescents, but little is known about self-management behaviors in this population. Our aim was to examine self-management behaviors and glycemic control among adolescents with type 2 diabetes. METHODS:From 2003 to 2005, a telephone survey of adolescents with type ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2007-1484

    authors: Rothman RL,Mulvaney S,Elasy TA,VanderWoude A,Gebretsadik T,Shintani A,Potter A,Russell WE,Schlundt D

    更新日期:2008-04-01 00:00:00

  • Ethical Issues Raised by the Media Portrayal of Adolescent Transplant Refusals.

    abstract::Cases of adolescents in organ failure who refuse solid organ transplant are not common, but several have been discussed in the media in the United States and the United Kingdom. Using the framework developed by Buchanan and Brock for surrogate decision-making, I examine what role the adolescent should morally play whe...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2020-0818H

    authors: Ross LF

    更新日期:2020-08-01 00:00:00

  • Twenty-year follow-up of antenatal corticosteroid treatment.

    abstract:OBJECTIVE:To study late side effects of antenatal corticosteroid treatment on health and sexual development in subjects 20 to 22 years old. METHODS:A follow-up study among young adults whose mothers had, because of a threatening delivery, participated in a randomized, double-blind, placebo- controlled trial of betamet...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:10.1542/peds.105.6.e77

    authors: Dessens AB,Haas HS,Koppe JG

    更新日期:2000-06-01 00:00:00

  • Medicaid policy statement.

    abstract::Medicaid is a vital safety net for children that must be maintained. It is the largest single insurer of children, yet millions of children who are eligible remain unenrolled. Every effort should be made to implement expanded eligibility and streamlined enrollment procedures. Early and Periodic Screening, Diagnosis, a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2005-0891

    authors: American Academy of Pediatrics Committee on Child Health Financing.

    更新日期:2005-07-01 00:00:00

  • Persistent pulmonary hypertension of the newborn treated with magnesium sulfate in premature neonates.

    abstract:OBJECTIVE:To evaluate the clinical effects of magnesium sulfate (MgSO4) in the treatment of persistent pulmonary hypertension of the newborn (PPHN) in premature infants. METHODS:This was a prospective, nonrandomized, clinical study. Seven premature neonates with PPHN were treated with MgSO4 as soon as documentation of...

    journal_title:Pediatrics

    pub_type: 临床试验,杂志文章

    doi:

    authors: Wu TJ,Teng RJ,Tsou KI

    更新日期:1995-09-01 00:00:00

  • Determination of genetic predisposition to patent ductus arteriosus in preterm infants.

    abstract:OBJECTIVE:Patent ductus arteriosus is a common morbidity associated with preterm birth. The incidence of patent ductus arteriosus increases with decreasing gestational age to approximately 70% in infants born at 25 weeks' gestation. Our major goal was to determine if genetic risk factors play a role in patent ductus ar...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2008-0313

    authors: Dagle JM,Lepp NT,Cooper ME,Schaa KL,Kelsey KJ,Orr KL,Caprau D,Zimmerman CR,Steffen KM,Johnson KJ,Marazita ML,Murray JC

    更新日期:2009-04-01 00:00:00

  • Screening children to identify families at increased risk for cardiovascular disease.

    abstract:OBJECTIVES:Atherosclerotic cardiovascular disease is the leading cause of death in the United States. Atherosclerosis begins early in life; however, children and young and middle-aged adults are not universally screened for the presence of modifiable cardiovascular disease risk factors. The purpose of this study was to...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2006-0680

    authors: Reis EC,Kip KE,Marroquin OC,Kiesau M,Hipps L Jr,Peters RE,Reis SE

    更新日期:2006-12-01 00:00:00

  • Erythema Marginatum as an Early Symptom of Hereditary Angioedema: Case Report of 2 Newborns.

    abstract::Hereditary angioedema due to C1 inhibitor deficiency (C1-INH-HAE) is a rare genetic disease that causes recurrent swelling attacks that may affect various body tissues. Angioedematous attacks can be fatal in the case of upper airway edema and are often preceded by prodromal symptoms like erythema marginatum. Initial s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2015-2411

    authors: Martinez-Saguer I,Farkas H

    更新日期:2016-02-01 00:00:00

  • Proteolysis associated with insulin resistance in cystic fibrosis.

    abstract:OBJECTIVE:We hypothesized that patients with cystic fibrosis (CF) have higher rates of protein breakdown than normal volunteers and that the infusion of insulin would result in less suppression of proteolysis. Methods. Using [1-C]leucine and a three-step hyperinsulinemic euglycemic clamp, we measured rates of leucine a...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.101.3.433

    authors: Hardin DS,LeBlanc A,Lukenbaugh S,Para L,Seilheimer DK

    更新日期:1998-03-01 00:00:00

  • Is my child normal yet? Correlates of vulnerability.

    abstract::There are some children whose parents believe them to be unusually susceptible to medical or developmental problems--"vulnerable"--despite a lack of objective evidence of any difficulty. The "vulnerable child syndrome" refers to a constellation of behaviors that are thought to develop as a result of this excessive par...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Perrin EC,West PD,Culley BS

    更新日期:1989-03-01 00:00:00

  • A note on interdisciplinary research in developmental/behavioral pediatrics/psychology.

    abstract::In sum, we have offered a few observations about the practice of interdisciplinary research. Now, in addition to our rather specific suggestions, we want to add a few general comments about the interactions of professionals who are actually involved in interdisciplinary research. Collaboration between physicians and p...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Ellison PH,Kopp CB

    更新日期:1985-05-01 00:00:00

  • Motivational Interviewing to Treat Overweight Children: 24-Month Follow-Up of a Randomized Controlled Trial.

    abstract:BACKGROUND:Pediatrician-led motivational interviewing can be an effective way of controlling BMI in overweight children in the short term. Its long-term efficacy is unknown. The primary aim was to determine whether the short-term (12-month) impact of family pediatrician-led motivational interviews on the BMI of overwei...

    journal_title:Pediatrics

    pub_type: 杂志文章,随机对照试验

    doi:10.1542/peds.2015-1979

    authors: Broccoli S,Davoli AM,Bonvicini L,Fabbri A,Ferrari E,Montagna G,Panza C,Pinotti M,Storani S,Tamelli M,Candela S,Bellocchio E,Giorgi Rossi P

    更新日期:2016-01-01 00:00:00

  • Human granulocytic ehrlichiosis presenting as abdominal pain.

    abstract::Human granulocytic ehrlichiosis (HGE) is an emerging infectious disease that primarily affects adults. Typical clinical features include fever, headache, and myalgias. This case represents the youngest reported patient with HGE. Her clinical presentation was unusual in that she presented with severe abdominal pain. In...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.106.3.602

    authors: Gershel JC

    更新日期:2000-09-01 00:00:00

  • An integrated scientific framework for child survival and early childhood development.

    abstract::Building a strong foundation for healthy development in the early years of life is a prerequisite for individual well-being, economic productivity, and harmonious societies around the world. Growing scientific evidence also demonstrates that social and physical environments that threaten human development (because of ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2011-0366

    authors: Shonkoff JP,Richter L,van der Gaag J,Bhutta ZA

    更新日期:2012-02-01 00:00:00

  • Prepubertal female genitalia: examination for evidence of sexual abuse.

    abstract::Experience with more than 375 cases of possible sexual abuse has taught us that much work still needs to be done in understanding normal prepubertal female anatomy and interpreting findings in sexual abuse cases. Because pediatric clinicians are often called upon to assess possible sexual abuse victims, knowledge of w...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Herman-Giddens ME,Frothingham TE

    更新日期:1987-08-01 00:00:00

  • Spermatic cord torsion: diagnostic limitations.

    abstract::To distinguish spermatic cord torsion from other intrascrotal pathology, scrotal ultrasound and radionuclide scanning have been highly recommended on the basis of both clinical and experimental studies. We review the data from six patients in whom ultrasound or nuclear medicine examination was misleading. We emphasize...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Stoller ML,Kogan BA,Hricak H

    更新日期:1985-12-01 00:00:00

  • Tone and reflex development before term.

    abstract::The evolution of tone and reflexes from 25 weeks postmenstrual age (gestational age plus chronologic age) to term in a population of 42 surviving infants is described. The infants were born in 1983 at the Johns Hopkins Hospital, had birth weights less than 1300 g, were examined weekly until neonatal intensive care uni...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Allen MC,Capute AJ

    更新日期:1990-03-01 00:00:00

  • Educational principles of community-based education.

    abstract::Much of medical education remains teacher centered, as exemplified by the continued emphasis on lectures. Increasingly, however, the importance of the learner is being recognized and acknowledged in medical school curricula. The distinction between teaching and learning is also an issue for graduate medical education;...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Roberts KB

    更新日期:1996-12-01 00:00:00

  • Incidence of rash after amoxicillin treatment in children with infectious mononucleosis.

    abstract:BACKGROUND:"Ampicillin rash," a phenomenon unique to patients with Epstein-Barr virus acute infectious mononucleosis (AIM) treated with ampicillin, was first reported in the 1960s. The incidence was estimated as being between 80% and 100%, and the figures have not been reviewed since those first accounts. We sought to ...

    journal_title:Pediatrics

    pub_type: 杂志文章,多中心研究

    doi:10.1542/peds.2012-1575

    authors: Chovel-Sella A,Ben Tov A,Lahav E,Mor O,Rudich H,Paret G,Reif S

    更新日期:2013-05-01 00:00:00

  • Prepregnant overweight and obesity diminish the prolactin response to suckling in the first week postpartum.

    abstract:OBJECTIVE:The population subgroups with the highest proportion of overweight and obese women often are characterized by the lowest rates of initiation and shortest durations of breastfeeding. We previously documented that these 2 population-level trends may be related. In a population of white women who lived in a rura...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.113.5.e465

    authors: Rasmussen KM,Kjolhede CL

    更新日期:2004-05-01 00:00:00

  • Renal transplantation in children ages 1 to 5 years.

    abstract::Renal transplantation was carried out in 21 children ages 1 to 5 years. Eighteen received grafts from a living, related donor (LRD). Four children died, one following rejection, and three because of infection. Five children lost their initial grafts and two have received new transplants. Cumulative patient survival tw...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.61.3.458

    authors: Hodson EM,Najarian JS,Kjellstrand CM,Simmons RL,Mauer SM

    更新日期:1978-03-01 00:00:00

  • An explosive outbreak of Mycoplasma pneumoniae infection in a summer camp.

    abstract::An outbreak of Mycoplasma pneumoniae infection occurred in the summer of 1978 in a boys' camp in northern Wisconsin and affected 139 of 196 persons (71%); 115 (59%) had laboratory evidence of infection. In 77% of the cases, onset of disease occurred within three weeks after arrival at camp, in contrast to the usually ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:

    authors: Broome CV,LaVenture M,Kaye HS,Davis AT,White H,Plikaytis BD,Fraser DW

    更新日期:1980-12-01 00:00:00

  • Discrepancies between direct and indirect blood pressure measurements using various recommendations for arm cuff selection.

    abstract:OBJECTIVE:The current recommendation for choosing an appropriate size cuff for measuring blood pressure (BP) is a bladder width to equal 40% of the upper arm circumference (UAC). However, most physicians use the older two-thirds or three-fourths upper arm length (UAL) recommendations to choose a cuff. The aim of this s...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.110.5.920

    authors: Clark JA,Lieh-Lai MW,Sarnaik A,Mattoo TK

    更新日期:2002-11-01 00:00:00

  • Functional gastrointestinal disorders in children: an Italian prospective survey.

    abstract:OBJECTIVES:To assess the prevalence and natural history of functional gastrointestinal disorders (FGIDs) in children using the Rome Criteria. METHODS:Thirteen primary care pediatricians were randomly selected from the Campania region of the Italian National Health Service. Each pediatrician completed a detailed FGID q...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.114.1.73

    authors: Miele E,Simeone D,Marino A,Greco L,Auricchio R,Novek SJ,Staiano A

    更新日期:2004-07-01 00:00:00

  • Alcohol use by youth and adolescents: a pediatric concern.

    abstract::Alcohol use continues to be a major problem from preadolescence through young adulthood in the United States. Results of recent neuroscience research have substantiated the deleterious effects of alcohol on adolescent brain development and added even more evidence to support the call to prevent and reduce underaged dr...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0438

    authors: Committee on Substance Abuse.,Kokotailo PK

    更新日期:2010-05-01 00:00:00

  • Circumcision policy statement.

    abstract::Male circumcision is a common procedure, generally performed during the newborn period in the United States. In 2007, the American Academy of Pediatrics (AAP) formed a multidisciplinary task force of AAP members and other stakeholders to evaluate the recent evidence on male circumcision and update the Academy's 1999 r...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2012-1989

    authors: American Academy of Pediatrics Task Force on Circumcision.

    更新日期:2012-09-01 00:00:00

  • Parental knowledge, attitudes, and practices associated with not receiving hepatitis A vaccine in a demonstration project in Butte County, California.

    abstract:OBJECTIVE:To determine hepatitis A vaccination coverage and factors associated with not receiving hepatitis A vaccine among children. METHODS:A random cluster sample survey was conducted of parents of children who attended kindergarten in Butte County, California, in 2000. Because of a history of recurrent epidemics, ...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.112.4.e269

    authors: Bardenheier B,González IM,Washington ML,Bell BP,Averhoff F,Massoudi MS,Hyams I,Simard EP,Yusuf H

    更新日期:2003-10-01 00:00:00

  • Effects of upgraded child restraint law designed to increase booster seat use in New York.

    abstract:OBJECTIVE:The goal was to examine the association between the New York State (NYS) upgraded child restraint law (UCRL) implemented in 2005 and the traffic injury rate among 4- to 6-year-old children in New York State. METHODS:A before/after comparison study of population-based, traffic injury rates for 4- to 6-year-ol...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2010-0249

    authors: Sun K,Bauer MJ,Hardman S

    更新日期:2010-09-01 00:00:00

  • Overcrowding crisis in our nation's emergency departments: is our safety net unraveling?

    abstract::Emergency departments (EDs) are a vital component in our health care safety net, available 24 hours a day, 7 days a week, for all who require care. There has been a steady increase in the volume and acuity of patient visits to EDs, now with well over 100 million Americans (30 million children) receiving emergency care...

    journal_title:Pediatrics

    pub_type: 杂志文章

    doi:10.1542/peds.2004-1287

    authors: American Academy of Pediatrics Committee on Pediatric Emergency Medicine.

    更新日期:2004-09-01 00:00:00